593 research outputs found
The Role of Mammalian Reservoir Hosts in Tick-Borne Flavivirus Biology
Small-to-medium sized mammals and large animals are lucrative sources of blood meals for ixodid ticks that transmit life-threatening tick-borne flaviviruses (TBFVs). TBFVs have been isolated from various organs obtained from wild-caught Myodes and Apodemus species in Europe and Asia. Thus, these rodents are well-established reservoirs of TBFVs. Wild-caught Peromyscus species have demonstrated seropositivity against Powassan virus, the only TBFV known to circulate in North America, suggesting that they may play an important role in the biology of the virus in this geographic region. However, virus isolation from Peromyscus species is yet to be demonstrated. Wild-caught medium-sized mammals, such as woodchucks (Marmota monax) and skunks (Mephitis mephitis) have also demonstrated seropositivity against POWV, and virus was isolated from apparently healthy animals. Despite the well-established knowledge that small-to-medium sized animals are TBFV reservoirs, specific molecular biology addressing host-pathogen interactions remains poorly understood. Elucidating these interactions will be critical for gaining insight into the mechanism(s) of viral pathogenesis and/or resistance
Are Swift Long-Lag Gamma-Ray Bursts in the Local Supercluster?
A sample of 18 long-lag (tau_{lag} > 1 s) Gamma-Ray Bursts (GRBs) has been
drawn from our catalog of all Swift long GRBs. Four different tests are done on
this sample to test the prediction that a large fraction of long-lag GRBs are
from our Local Supercluster. The results of these four tests come out that: (1)
the distribution of these GRBs shows no tendency towards the Supergalactic
plane; (2) the distribution shows no tendency towards the Virgo or Coma
Cluster; (3) no associated bright host galaxies (m <=15) in the Local
Supercluster are found for any of the 18 GRBs; (4) 17 of these 18 GRBs have
redshifts of z>0.5, which are too far to be in the Local Supercluster. All
these results disproved the hypothesis that any significant fraction of
long-lag GRBs are from Local Supercluster. Hence these long-lag GRBs can not be
counted in the calculation of LIGO detection rates. An explanation of why we
can detect long-lag GRBs at high redshift is presented.Comment: 14 pages, 1 figure, ApJ accepte
Observation of contemporaneous optical radiation from a gamma-ray burst
The origin of gamma-ray bursts (GRBs) has been enigmatic since their
discovery. The situation improved dramatically in 1997, when the rapid
availability of precise coordinates for the bursts allowed the detection of
faint optical and radio afterglows - optical spectra thus obtained have
demonstrated conclusively that the bursts occur at cosmological distances. But,
despite efforts by several groups, optical detection has not hitherto been
achieved during the brief duration of a burst. Here we report the detection of
bright optical emission from GRB990123 while the burst was still in progress.
Our observations begin 22 seconds after the onset of the burst and show an
increase in brightness by a factor of 14 during the first 25 seconds; the
brightness then declines by a factor of 100, at which point (700 seconds after
the burst onset) it falls below our detection threshold. The redshift of this
burst, approximately 1.6, implies a peak optical luminosity of 5 times 10^{49}
erg per second. Optical emission from gamma-ray bursts has been generally
thought to take place at the shock fronts generated by interaction of the
primary energy source with the surrounding medium, where the gamma-rays might
also be produced. The lack of a significant change in the gamma-ray light curve
when the optical emission develops suggests that the gamma-rays are not
produced at the shock front, but closer to the site of the original explosion.Comment: 10 pages, 2 figures. Accepted for publication in Nature. For
additional information see http://www.umich.edu/~rotse
A statistical study of gamma-ray burst afterglows measured by the Swift Ultra-violet Optical Telescope
We present the first statistical analysis of 27 UVOT optical/ultra-violet
lightcurves of GRB afterglows. We have found, through analysis of the
lightcurves in the observer's frame, that a significant fraction rise in the
first 500s after the GRB trigger, that all lightcurves decay after 500s,
typically as a power-law with a relatively narrow distribution of decay
indices, and that the brightest optical afterglows tend to decay the quickest.
We find that the rise could either be produced physically by the start of the
forward shock, when the jet begins to plough into the external medium, or
geometrically where an off-axis observer sees a rising lightcurve as an
increasing amount of emission enters the observers line of sight, which occurs
as the jet slows. We find that at 99.8% confidence, there is a correlation, in
the observed frame, between the apparent magnitude of the lightcurves at 400s
and the rate of decay after 500s. However, in the rest frame a Spearman Rank
test shows only a weak correlation of low statistical significance between
luminosity and decay rate. A correlation should be expected if the afterglows
were produced by off-axis jets, suggesting that the jet is viewed from within
the half-opening angle theta or within a core of uniform energy density
theta_c. We also produced logarithmic luminosity distributions for three rest
frame epochs. We find no evidence for bimodality in any of the distributions.
Finally, we compare our sample of UVOT lightcurves with the XRT lightcurve
canonical model. The range in decay indices seen in UVOT lightcurves at any
epoch is most similar to the range in decay of the shallow decay segment of the
XRT canonical model. However, in the XRT canonical model there is no indication
of the rising behaviour observed in the UVOT lightcurves.Comment: 16 pages, 9 figures, accepted MNRA
The Host Galaxies of Short-Duration Gamma-Ray Bursts: Luminosities, Metallicities, and Star Formation Rates
The association of some short-duration gamma-ray bursts (GRBs) with
elliptical galaxies established that their progenitors, unlike those of long
GRBs, belong to an old stellar population. However, the majority of short GRBs
appear to occur in star forming galaxies, raising the possibility that some
progenitors are related to recent star formation activity. Here we present
optical spectroscopy of these hosts and measure their luminosities, star
formation rates, and metallicities. We find luminosities of L_B~0.1-1.5 L*,
star formation rates of SFR~0.2-6 M_sun/yr, and metallicities of
12+log(O/H)~8.5-8.9 (Z~0.6-1.6 Z_sun). A detailed comparison to the hosts of
long GRBs reveals systematically higher luminosities, lower specific star
formation rates (SFR/L_B) by about an order of magnitude, and higher
metallicities by about 0.6 dex. The K-S probability that the short and long GRB
hosts are drawn from the same underlying galaxy distribution is only 10^-3. On
the other hand, short GRB hosts exhibit excellent agreement with the specific
star formation rates and the luminosity-metallicity relation of field galaxies
at z~0.1-1. We thus conclude that short GRB hosts are not dominated by young
stellar populations like long GRBs hosts. Instead, short GRB hosts appear to be
drawn uniformly from the underlying galaxy distribution, indicating that the
progenitors have a wide age distribution of several Gyr.Comment: Submitted to Ap
Framework for Leadership and Training of Biosafety Level 4 Laboratory Workers
One-sentence summary for table of contents: Training should include theoretical consideration of biocontainment principles, practical hands-on training, and mentored on-the-job experience
Demonstration of Universal Parametric Entangling Gates on a Multi-Qubit Lattice
We show that parametric coupling techniques can be used to generate selective
entangling interactions for multi-qubit processors. By inducing coherent
population exchange between adjacent qubits under frequency modulation, we
implement a universal gateset for a linear array of four superconducting
qubits. An average process fidelity of is estimated for
three two-qubit gates via quantum process tomography. We establish the
suitability of these techniques for computation by preparing a four-qubit
maximally entangled state and comparing the estimated state fidelity against
the expected performance of the individual entangling gates. In addition, we
prepare an eight-qubit register in all possible bitstring permutations and
monitor the fidelity of a two-qubit gate across one pair of these qubits.
Across all such permutations, an average fidelity of
is observed. These results thus offer a path to a scalable architecture with
high selectivity and low crosstalk
Dust and Metal Column Densities in Gamma-Ray Burst Host Galaxies
In this paper we present the results from the analysis of a sample of 28
gamma-ray burst (GRB) afterglow spectral energy distributions, spanning the
X-ray through to near-infrared wavelengths. This is the largest sample of GRB
afterglow spectral energy distributions thus far studied, providing a strong
handle on the optical depth distribution of soft X-ray absorption and
dust-extinction systems in GRB host galaxies. We detect an absorption system
within the GRB host galaxy in 79% of the sample, and an extinction system in
71% of the sample, and find the Small Magellanic Cloud (SMC) extinction law to
provide an acceptable fit to the host galaxy extinction profile for the
majority of cases, consistent with previous findings. The range in the soft
X-ray absorption to dust-extinction ratio, N_{H,X}/Av, in GRB host galaxies
spans almost two orders of magnitude, and the typical ratios are significantly
larger than those of the Magellanic Clouds or Milky Way. Although dust
destruction could be a cause, at least in part, for the large N_{H,X}/Av
ratios, the good fit provided by the SMC extinction law for the majority of our
sample suggests that there is an abundance of small dust grains in the GRB
environment, which we would expect to have been destroyed if dust destruction
were responsible for the large N_{H,X}/Av ratios. Instead, our analysis
suggests that the distribution of N_{H,X}/Av in GRB host galaxies may be mostly
intrinsic to these galaxies, and this is further substantiated by evidence for
a strong negative correlation between N_{H,X}/Av and metallicity for a
subsample of GRB hosts with known metallicity. Furthermore, we find the
N_{H,X}/Av ratio and metallicity for this subsample of GRBs to be comparable to
the relation found in other more metal-rich galaxies.Comment: 23 pages, 10 figures, accepted for publication in MNRA
Assessment of higher order cognitive skills in undergraduate education: modified essay or multiple choice questions? Research paper
Background: Reliable and valid written tests of higher cognitive function are difficult to produce, particularly for the assessment of clinical problem solving. Modified Essay Questions (MEQs) are often used to assess these higher order abilities in preference to other forms of assessment, including multiple-choice questions (MCQs). MEQs often form a vital component of end-of-course assessments in higher education. It is not clear how effectively these questions assess higher order cognitive skills. This study was designed to assess the effectiveness of the MEQ to measure higher-order cognitive skills in an undergraduate institution. Methods: An analysis of multiple-choice questions and modified essay questions (MEQs) used for summative assessment in a clinical undergraduate curriculum was undertaken. A total of 50 MCQs and 139 stages of MEQs were examined, which came from three exams run over two years. The effectiveness of the questions was determined by two assessors and was defined by the questions ability to measure higher cognitive skills, as determined by a modification of Bloom's taxonomy, and its quality as determined by the presence of item writing flaws. Results: Over 50% of all of the MEQs tested factual recall. This was similar to the percentage of MCQs testing factual recall. The modified essay question failed in its role of consistently assessing higher cognitive skills whereas the MCQ frequently tested more than mere recall of knowledge. Conclusion: Construction of MEQs, which will assess higher order cognitive skills cannot be assumed to be a simple task. Well-constructed MCQs should be considered a satisfactory replacement for MEQs if the MEQs cannot be designed to adequately test higher order skills. Such MCQs are capable of withstanding the intellectual and statistical scrutiny imposed by a high stakes exit examination.Edward J Palmer, Peter G Devit
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