420 research outputs found
698pphase ii efficacy and safety data for the met inhibitor tepotinib in patients pts with sorafenib treated advanced hepatocellular carcinoma hcc
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Strong Phase Separation in a Model of Sedimenting Lattices
We study the steady state resulting from instabilities in crystals driven
through a dissipative medium, for instance, a colloidal crystal which is
steadily sedimenting through a viscous fluid. The problem involves two coupled
fields, the density and the tilt; the latter describes the orientation of the
mass tensor with respect to the driving field. We map the problem to a 1-d
lattice model with two coupled species of spins evolving through conserved
dynamics. In the steady state of this model each of the two species shows
macroscopic phase separation. This phase separation is robust and survives at
all temperatures or noise levels--- hence the term Strong Phase Separation.
This sort of phase separation can be understood in terms of barriers to
remixing which grow with system size and result in a logarithmically slow
approach to the steady state. In a particular symmetric limit, it is shown that
the condition of detailed balance holds with a Hamiltonian which has
infinite-ranged interactions, even though the initial model has only local
dynamics. The long-ranged character of the interactions is responsible for
phase separation, and for the fact that it persists at all temperatures.
Possible experimental tests of the phenomenon are discussed.Comment: To appear in Phys Rev E (1 January 2000), 16 pages, RevTex, uses
epsf, three ps figure
assessment of disease burden in the phase iii celestial trial of cabozantinib c versus placebo p in advanced hepatocellular carcinoma hcc
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Seasonal development and pathological changes associated with the parasitic nematode Philometroides sanguineus in wild crucian carp Carassius carassius (L.) in England
Pathological changes associated with the parasitic nematode Philometroides sanguineus (Rudolphi, 1819) are described for the first time from observations of infections in wild crucian carp Carassius carassius (L.) in England. The damage caused by P. sanguineus was influenced strongly by host size, parasite development and the seasonal migrations of female nematodes within host tissues. Male and unfertilized female nematodes located on the swim-bladder wall caused only minor, localized changes. In contrast, the migration of gravid female nematodes into the fins during autumn provoked an acute inflammatory response comprising neutrophils, eosinophils and lymphocytes. This was accompanied by fin distortion, swelling of the dorsal and caudal tissues, degenerative changes and localized oedema. The encapsulation of female nematodes in connective tissue throughout winter limited additional tissue damage. The emergence of gravid nematodes from the fins in spring to facilitate larval dispersal caused necrosis, hyperplasia and loss of skin integrity. This activity was again accompanied by acute inflammatory reactions. Pathological changes were more severe in crucian carp measuring less than 60 mm in length, with no signs of debilitation in larger fish. These observations suggest that any impact of P. sanguineus is strictly seasonal and may be limited to fry. Lesions caused by this parasite, only recently recorded in Britain, may represent an additional pressure upon wild crucian carp populations already threatened by hybridization, competition and habitat loss
59pdfinal analysis of serum biomarkers in patients pts from the phase iii study of lenvatinib len vs sorafenib sor in unresectable hepatocellular carcinoma uhcc reflect
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Le partage de la ressource en eau sur la Durance en 2050 : vers une Ă©volution du mode de gestion des grands ouvrages duranciens ?
CongrÚs SHF: Water Tensions in Europe and in the Mediterranean: water crisis by 2050?, Paris, FRA, 08-/10/2015 - 09/10/2015International audienceUne vision prospective de la gestion de l'eau du bassin de la Durance et des territoires alimentés par ses eaux à l'horizon 2050 a été élaborée, appuyée par une chaine de modÚles incluant des représentations du climat, de la ressource naturelle, des demandes en eau et du fonctionnement des grands ouvrages hydrauliques (Serre-Ponçon, Castillon et Sainte-Croix), sous contraintes de respect des débits réservés, de cotes touristiques dans les retenues et de restitution d'eau stockée pour des usages en aval. Cet ensemble, validé en temps présent, a été alimenté par des projections climatiques et paramétré pour intégrer les évolutions du territoire décrites par des scénarios de développement socio-économique avec une hypothÚse de conservation des rÚgles de gestion actuelles. Les résultats suggÚrent à l'horizon 2050 : une hausse de la température moyenne de l'air impactant l'hydrologie de montagne ; une évolution incertaine des précipitations ; une réduction des stocks de neige et une fonte avancée dans l'année qui induisent une réduction des débits au printemps ; une diminution de la ressource en eau en période estivale ; une diminution de la demande globale en eau à l'échelle du territoire, cette demande étant fortement conditionnée par les scénarios territoriaux élaborés ici ; la satisfaction des demandes en eau en aval des ouvrages considérées comme prioritaires, au détriment de la production d'énergie en hiver (flexibilité moindre en période de pointe) et du maintien de cotes touristiques en été ;une diminution de la production d'énergie due notamment à la réduction des apports en amont des ouvrages hydroélectriques
Inactivation of serum response factor contributes to decrease vascular muscular tone and arterial stiffness in mice
RATIONALE: Vascular smooth muscle (SM) cell phenotypic modulation plays an important role in arterial stiffening associated with aging. Serum response factor (SRF) is a major transcription factor regulating SM genes involved in maintenance of the contractile state of vascular SM cells. OBJECTIVE: We investigated whether SRF and its target genes regulate intrinsic SM tone and thereby arterial stiffness. METHODS AND RESULTS: The SRF gene was inactivated SM-specific knockout of SRF (SRF(SMKO)) specifically in vascular SM cells by injection of tamoxifen into adult transgenic mice. Fifteen days later, arterial pressure and carotid thickness were lower in SRF(SMKO) than in control mice. The carotid distensibility/pressure and elastic modulus/wall stress curves showed a greater arterial elasticity in SRF(SMKO) without modification in collagen/elastin ratio. In SRF(SMKO), vasodilation was decreased in aorta and carotid arteries, whereas a decrease in contractile response was found in mesenteric arteries. By contrast, in mice with inducible SRF overexpression, the in vitro contractile response was significantly increased in all arteries. Without endothelium, the contraction was reduced in SRF(SMKO) compared with control aortic rings owing to impairment of the NO pathway. Contractile components (SM-actin and myosin light chain), regulators of the contractile response (myosin light chain kinase, myosin phosphatase target subunit 1, and protein kinase C-potentiated myosin phosphatase inhibitor) and integrins were reduced in SRF(SMKO). CONCLUSIONS: SRF controls vasoconstriction in mesenteric arteries via vascular SM cell phenotypic modulation linked to changes in contractile protein gene expression. SRF-related decreases in vasomotor tone and cell-matrix attachment increase arterial elasticity in large arteries
flavour tagging using charm decays at the LHCb experiment
An algorithm is described for tagging the flavour content at production of
neutral mesons in the LHCb experiment. The algorithm exploits the
correlation of the flavour of a meson with the charge of a reconstructed
secondary charm hadron from the decay of the other hadron produced in the
proton-proton collision. Charm hadron candidates are identified in a number of
fully or partially reconstructed Cabibbo-favoured decay modes. The algorithm is
calibrated on the self-tagged decay modes and using of data collected by the LHCb
experiment at centre-of-mass energies of and
. Its tagging power on these samples of
decays is .Comment: All figures and tables, along with any supplementary material and
additional information, are available at
http://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2015-027.htm
A Theory for the High-T_c Cuprates: Anomalous Normal-State and Spectroscopic Properties, Phase Diagram, and Pairing
A theory of highly correlated layered superconducting materials isapplied for
the cuprates. Differently from an independent-electron approximation, their
low-energy excitations are approached in terms of auxiliary particles
representing combinations of atomic-like electron configurations, where the
introduction of a Lagrange Bose field enables treating them as bosons or
fermions. The energy spectrum of this field accounts for the tendency of
hole-doped cuprates to form stripe-like inhomogeneities. Consequently, it
induces a different analytical behavior for auxiliary particles corresponding
to "antinodal" and "nodal" electrons, enabling the existence of different
pairing temperatures at T^* and T_c. This theory correctly describes the
observed phase diagram of the cuprates, including the non-Fermi-liquid to FL
crossover in the normal state, the existence of Fermi arcs below T^* and of a
"marginal-FL" critical behavior above it. The qualitative anomalous behavior of
numerous physical quantities is accounted for, including kink- and
waterfall-like spectral features, the drop in the scattering rates below T^*
and more radically below T_c, and an effective increase in the density of
carriers with T and \omega, reflected in transport, optical and other
properties. Also is explained the correspondence between T_c, the
resonance-mode energy, and the "nodal gap".Comment: 28 pages, 7 figure
Low-lying octupole isovector excitation in Nd-144
International audienceThe nature of low-lying 3â levels in Nd144 was investigated in the Nd143(n,γγ) cold neutron-capture reaction. The combination of the high neutron flux from the research reactor at the Institut Laue-Langevin and the high Îł-ray detection efficiency of the EXILL setup allowed the recording of γγ coincidences. From the coincidence data precise branching ratios were extracted. Furthermore, the octagonal symmetry of the setup allowed angular-distribution measurements to determine multipole-mixing ratios. Additionally, in a second measurement the ultra-high resolution spectrometer GAMS6 was employed to conduct lifetime measurements using the gamma-ray induced Doppler-shift technique (GRID). The confirmed strong M1 component in the 33ââ31â decay strongly supports the assignment of the 33â level at 2779keV as low-lying isovector octupole excitation. Microscopic calculations within the quasiparticle phonon model confirm an isovector component in the wave function of the 33â level, firmly establishing this fundamental mode of nuclear excitation in near-spherical nuclei
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