Queer Asian Subjects: Transgressive Sexualities and Heteronormative Meanings

This special issue of Asian Studies Review explores comparatively the production and transformation of gender and sexual subjectivities across and beyond South and Southeast Asia. More specifically, papers in this special issue disclose the complex intersections of ethnicity, race, class, gender, religion and nationality through which sexual subjectivities are formed and subject positions inhabited within and across these regions. By tracing the transnational movement of people and the circulation of images and ideas, their appropriations and effects, the papers in this volume reveal mutable and multiple sexual subjectivities that are no longer fixed in place, even as state discourses, hegemonic meanings and individual actors work to attach specific meanings to particular bodies. In this special issue we ask, what are the effects of migration, forced and chosen, on forms and formulations of gender and sexuality for people's embodied and discursive entanglements? How do spatial and temporal, as well as religious, economic and political changes alter and foreclose some kinds of intimacies and subjectivities even as they open and enable others? What are the social and cultural processes through which heteronormativity is articulated, enforced, transgressed and challenged

Rare coding variants in ten genes confer substantial risk for schizophrenia

Rare coding variation has historically provided the most direct connections between gene function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 schizophrenia cases and 97,322 controls, we implicate ultra-rare coding variants (URVs) in 10 genes as conferring substantial risk for schizophrenia (odds ratios of 3-50, PPeer reviewe

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Review of Women and Households in Indonesia: Cultural Notions and Social Practices

Page range: 219-22

Webs of Power

xvi.219 hal.;22 c

In-law Conflict: Women’s Reproductive Lives and the Roles of Their Mothers and Husbands among the Matrilineal Khasi

Human behavioral ecologists have shown that the reproductive lives of women are affected by both their husbands and the grandmothers of their children. Study of the combined effect of the roles of the husbands and mothers of 650 Khasi women aged 16–50 years supports the ideas that the reproductive agendas of husbands may require more than women want to invest and that mothers provide support and protective services to their daughters and grandchildren. In the absence of the woman’s mother, the husband’s agenda appears to have more influence on her reproductive career. In a cooperative vein, women’s mothers may contribute to good marital choices. A view of reproductive pursuits that incorporates in-laws enhances behavioral ecology approaches to the evolutionary comprehension of human reproductive behavior. This view also more readily interfaces with the cultural systems that set up the ecologies of reproductive life. The article is followed by 11 sets of comments and a response by the 3 original authors