Play in an English reception classroom: how children navigate classroom rules during their self-initiated play

In the recent past, a number of concerns have been raised, by educators and researchers alike, about the nature of the provision of child-initiated play in English reception classrooms, owing to the pressure from present and successive governments on educators to prepare young children for statutory schooling. These concerns provide the background to this research and the broad external context in which it is situated. Emerging from these broad concerns, this study examines how five young children navigated a classroom’s rules during their self-initiated play, over the course of the 2012-13 school year. In employing a broadly ethnographic methodology, the main research methods used to appreciate the minutiae of the children’s experiences and endeavours were participant observation and informal discussions; these were supplemented with child-led tours, interviews, and both participant children’s and their peers’ observations and interpretations. The research shows how the children deployed a range of ‘tactics’ to realise their play interests, which were based on their understandings of how each of the educators enforced classroom rules, and where they were located during each instance. It also shows the ways in which the children actively applied several classroom rules, and encouraged their peers to act in accordance with these. The research highlights that whilst it was the case that some of these rules ‘constrained’ the children’s play, it was owing to the various ‘conditions’ (relative freedom, choice and autonomy; and extended free play sessions) of the teacher’s play provision that they were also able to follow and realise their needs, interests and overall motivations. Concerns are raised about how the various assessment-related developments that have taken place since the fieldwork was conducted may be – in the present times – impacting on teachers’ play provisions, and accordingly opportunities for children to exercise agency in their play

A comparative study of the viscoelastic constitutive models for frictionless contact interfaces in solids

The nature of the constitutive contact force law utilized to describe contact-impact events in solid contact interfaces plays a key role in predicting the response of multibody mechanical systems and in the simulation of engineering applications. The goal of this work is to present a comparative study on the most relevant existing viscoelastic contact force models. In the sequel of this process, their fundamental characteristics are examined and their performances evaluated. Models developed based on the Hertz contact theory and augmented with a damping term to accommodate the dissipation of energy during the impact process, which typically is a function of the coefficient of restitution between the contacting solids, are considered in this study. In particular, the identified contact force models are compared in the present study for simple solid impact problems with the sole purpose of comparing the performance of the various models and examining the corresponding system behavior. The outcomes indicate that the prediction of the dynamic behavior of contacting solids strongly depends on the selection of the contact force model.Fundação para a Ciência e a Tecnologia (FCT

Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection

BACKGROUND Clostridium difficile is the most common cause of infectious diarrhea in hospitalized patients. Recurrences are common after antibiotic therapy. Actoxumab and bezlotoxumab are human monoclonal antibodies against C. difficile toxins A and B, respectively. METHODS We conducted two double-blind, randomized, placebo-controlled, phase 3 trials, MODIFY I and MODIFY II, involving 2655 adults receiving oral standard-of-care antibiotics for primary or recurrent C. difficile infection. Participants received an infusion of bezlotoxumab (10 mg per kilogram of body weight), actoxumab plus bezlotoxumab (10 mg per kilogram each), or placebo; actoxumab alone (10 mg per kilogram) was given in MODIFY I but discontinued after a planned interim analysis. The primary end point was recurrent infection (new episode after initial clinical cure) within 12 weeks after infusion in the modified intention-to-treat population. RESULTS In both trials, the rate of recurrent C. difficile infection was significantly lower with bezlotoxumab alone than with placebo (MODIFY I: 17% [67 of 386] vs. 28% [109 of 395]; adjusted difference, −10.1 percentage points; 95% confidence interval [CI], −15.9 to −4.3; P<0.001; MODIFY II: 16% [62 of 395] vs. 26% [97 of 378]; adjusted difference, −9.9 percentage points; 95% CI, −15.5 to −4.3; P<0.001) and was significantly lower with actoxumab plus bezlotoxumab than with placebo (MODIFY I: 16% [61 of 383] vs. 28% [109 of 395]; adjusted difference, −11.6 percentage points; 95% CI, −17.4 to −5.9; P<0.001; MODIFY II: 15% [58 of 390] vs. 26% [97 of 378]; adjusted difference, −10.7 percentage points; 95% CI, −16.4 to −5.1; P<0.001). In prespecified subgroup analyses (combined data set), rates of recurrent infection were lower in both groups that received bezlotoxumab than in the placebo group in subpopulations at high risk for recurrent infection or for an adverse outcome. The rates of initial clinical cure were 80% with bezlotoxumab alone, 73% with actoxumab plus bezlotoxumab, and 80% with placebo; the rates of sustained cure (initial clinical cure without recurrent infection in 12 weeks) were 64%, 58%, and 54%, respectively. The rates of adverse events were similar among these groups; the most common events were diarrhea and nausea. CONCLUSIONS Among participants receiving antibiotic treatment for primary or recurrent C. difficile infection, bezlotoxumab was associated with a substantially lower rate of recurrent infection than placebo and had a safety profile similar to that of placebo. The addition of actoxumab did not improve efficacy. (Funded by Merck; MODIFY I and MODIFY II ClinicalTrials.gov numbers, NCT01241552 and NCT01513239.

Results from the second WHO external quality assessment for the molecular detection of respiratory syncytial virus, 2019-2020

BACKGROUND: External quality assessments (EQAs) for the molecular detection of human respiratory syncytial virus (RSV) are necessary to ensure the standardisation of reliable results. The Phase II, 2019-2020 World Health Organization (WHO) RSV EQA included 28 laboratories in 26 countries. The EQA panel evaluated performance in the molecular detection and subtyping of RSV-A and RSV-B. This manuscript describes the preparation, distribution, and analysis of the 2019-2020 WHO RSV EQA. METHODS: Panel isolates underwent whole genome sequencing and in silico primer matching. The final panel included nine contemporary, one historical virus and two negative controls. The EQA panel was manufactured and distributed by the UK National External Quality Assessment Service (UK NEQAS). National laboratories used WHO reference assays developed by the United States Centers for Disease Control and Prevention, an RSV subtyping assay developed by the Victorian Infectious Diseases Reference Laboratory (Australia), or other in-house or commercial assays already in use at their laboratories. RESULTS: An in silico analysis of isolates showed a good match to assay primer/probes. The panel was distributed to 28 laboratories. Isolates were correctly identified in 98% of samples for detection and 99.6% for subtyping. CONCLUSIONS: The WHO RSV EQA 2019-2020 showed that laboratories performed at high standards. Updating the composition of RSV molecular EQAs with contemporary strains to ensure representation of circulating strains, and ensuring primer matching with EQA panel viruses, is advantageous in assessing diagnostic competencies of laboratories. Ongoing EQAs are recommended because of continued evolution of mismatches between current circulating strains and existing primer sets