Kompetenciamodell kialakítása a brit könyvtári és információs szakemberek számára

A CILIP (Chartered Institute of Library and Information Professionals) a könyvtárosok, információs szakemberek és tudásmenedzserek vezető szakmai szervezete. Tagjai számára egész pályafutásuk alatt gyakorlati támogatást nyújt, és felszólal a szakmai érdekek képviseletében. A tanulmány ismerteti a könyvtári és információs szakemberek kompetenciáinak fogalmát, a CILIP szakmai tudás- és készségbázisát, továbbá azt, hogy ez a bázis hogyan használható önértékelési eszközként. Bemutatja, hogy a tagok miként használhatják fel karrierjük fejlesztésére és arra, hogy tudásukat és készségeiket elismertessék, hogyan hasznosítják a könyvtárosképző intézmények az oktatásban, az egyes intézmények pedig munkatársaik fejlesztésében

BAT AGN Spectroscopic Survey-III. An observed link between AGN Eddington ratio and narrow emission line ratios

We investigate the observed relationship between black hole mass ($M_{\rm BH}$), bolometric luminosity ($L_{\rm bol}$), and Eddington ratio (${\lambda}_{\rm Edd}$) with optical emission line ratios ([NII] {\lambda}6583/H{\alpha}, [SII] {\lambda}{\lambda}6716,6731/H{\alpha}, [OI] {\lambda}6300/H{\alpha}, [OIII] {\lambda}5007/H{\beta}, [NeIII] {\lambda}3869/H{\beta}, and HeII {\lambda}4686/H{\beta}) of hard X-ray-selected AGN from the BAT AGN Spectroscopic Survey (BASS). We show that the [NII] {\lambda}6583/H{\alpha} ratio exhibits a significant correlation with ${\lambda}_{\rm Edd}$ ($R_{\rm Pear}$ = -0.44, $p$-value=$3\times10^{-13}$, {\sigma} = 0.28 dex), and the correlation is not solely driven by $M_{\rm BH}$ or $L_{\rm bol}$. The observed correlation between [NII] {\lambda}6583/H{\alpha} ratio and $M_{\rm BH}$ is stronger than the correlation with $L_{\rm bol}$, but both are weaker than the ${\lambda}_{\rm Edd}$ correlation. This implies that the large-scale narrow lines of AGN host galaxies carry information about the accretion state of the AGN central engine. We propose that the [NII] {\lambda}6583/H{\alpha} is a useful indicator of Eddington ratio with 0.6 dex of rms scatter, and that it can be used to measure ${\lambda}_{\rm Edd}$ and thus $M_{\rm BH}$ from the measured $L_{\rm bol}$, even for high redshift obscured AGN. We briefly discuss possible physical mechanisms behind this correlation, such as the mass-metallicity relation, X-ray heating, and radiatively driven outflows.Comment: Accepted for publication in MNRAS, 9 pages, 5 figures, 1 tabl

BAT AGN Spectroscopic Survey I: Spectral Measurements, Derived Quantities, and AGN Demographics

We present the first catalog and data release of the Swift-BAT AGN Spectroscopic Survey (BASS). We analyze optical spectra of the majority of AGN (77%, 641/836) detected based on their 14-195 keV emission in the 70-month Swift BAT all-sky catalog. This includes redshift determination, absorption and emission line measurements, and black hole mass and accretion rate estimates for the majority of obscured and un-obscured AGN (74%, 473/641) with 340 measured for the first time. With ~90% of sources at z<0.2, the survey represents a significant census of hard-X-ray selected AGN in the local universe. In this first catalog paper, we describe the spectroscopic observations and datasets, and our initial spectral analysis. The FWHM of the emission lines show broad agreement with the X-ray obscuration (~94%), such that Sy 1-1.8 have NH10^21.9 cm^-2. Seyfert 1.9 show a range of column densities. Compared to narrow line AGN in the SDSS, the X-ray selected AGN have a larger fraction of dusty host galaxies suggesting these types of AGN are missed in optical surveys. Using the most sensitive [OIII]/Hbeta and [NII]/Halpha emission line diagnostic, about half of the sources are classified as Seyferts, ~15% reside in dusty galaxies that lack an Hbeta detection, but for which the line upper limits imply either a Seyfert or LINER, ~15% are in galaxies with weak or no emission lines despite high quality spectra, and a few percent each are LINERS, composite galaxies, HII regions, or in known beamed AGN.Comment: Accepted ApJ, see www.bass-survey.com for dat

A map of open chromatin in human pancreatic islets

Tissue-specific transcriptional regulation is central to human disease(1). To identify regulatory DNA active in human pancreatic islets, we profiled chromatin by formaldehyde-assisted isolation of regulatory elements(2-4) coupled with high-throughput sequencing (FAIRE-seq). We identified similar to 80,000 open chromatin sites. Comparison of FAIRE-seq data from islets to that from five non-islet cell lines revealed similar to 3,300 physically linked clusters of islet-selective open chromatin sites, which typically encompassed single genes that have islet-specific expression. We mapped sequence variants to open chromatin sites and found that rs7903146, a TCF7L2 intronic variant strongly associated with type 2 diabetes(5), is located in islet-selective open chromatin. We found that human islet samples heterozygous for rs7903146 showed allelic imbalance in islet FAIRE signals and that the variant alters enhancer activity, indicating that genetic variation at this locus acts in cis with local chromatin and regulatory changes. These findings illuminate the tissue-specific organization of cis-regulatory elements and show that FAIRE-seq can guide the identification of regulatory variants underlying disease susceptibility

BAT AGN spectroscopic survey–II. X-ray emission and high-ionization optical emission lines

We investigate the relationship between X-ray and optical line emission in 340 nearby (z ≃ 0.04) AGN selected above 10 keV using Swift BAT. We find a weak correlation between the extinction corrected [O iii] and hard X-ray luminosity (L^(int)_([OIII])∝L_(14-195) with a large scatter (R_(Pear) = 0.64, σ = 0.62 dex) and a similarly large scatter with the intrinsic 2–10 keV to [O iii] luminosities (R_(Pear) = 0.63, σ = 0.63 dex). Correlations of the hard X-ray fluxes with the fluxes of high-ionization narrow lines ([O iii], He ii, [Ne iii] and [Ne v]) are not significantly better than with the low-ionization lines (H α, [S ii]). Factors like obscuration or physical slit size are not found to be a significant part of the large scatter. In contrast, the optical emission lines show much better correlations with each other (σ = 0.3 dex) than with the X-ray flux. The inherent large scatter questions the common usage of narrow emission lines as AGN bolometric luminosity indicators and suggests that other issues such as geometrical differences in the scattering of the ionized gas or long-term AGN variability are important

Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III

Using three different Fcγ receptor (FcγR)-deficient mouse strains, we examined the induction of autoimmune hemolytic anemia by each of the four immunoglobulin (Ig)G isotype-switch variants of a 4C8 IgM antierythrocyte autoantibody and its relation to the contributions of the two FcγR, FcγRI, and FcγRIII, operative in the phagocytosis of opsonized particles. We found that the four IgG isotypes of this antibody displayed striking differences in pathogenicity, which were related to their respective capacity to interact in vivo with the two phagocytic FcγRs, defined as follows: IgG2a > IgG2b > IgG3/IgG1 for FcγRI, and IgG2a > IgG1 > IgG2b > IgG3 for FcγRIII. Accordingly, the IgG2a autoantibody exhibited the highest pathogenicity, ∼20–100-fold more potent than its IgG1 and IgG2b variants, respectively, while the IgG3 variant, which displays little interaction with these FcγRs, was not pathogenic at all. An unexpected critical role of the low-affinity FcγRIII was revealed by the use of two different IgG2a anti–red blood cell autoantibodies, which displayed a striking preferential utilization of FcγRIII, compared with the high-affinity FcγRI. This demonstration of the respective roles in vivo of four different IgG isotypes, and of two phagocytic FcγRs, in autoimmune hemolytic anemia highlights the major importance of the regulation of IgG isotype responses in autoantibody-mediated pathology and humoral immunity

Rhizarian ‘Novel Clade 10’ Revealed as Abundant and Diverse Planktonic and Terrestrial Flagellates, including Aquavolon n. gen.

0000-0002-6719-5565The file attached is the Published/publisher’s pdf version of the articleThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited