1,017 research outputs found

    LESIONES GÁSTRICAS, HEPÁTICAS Y RENALES EN EL SÍNDROME DE ÚLCERAS GÁSTRICAS EN EQUINOS PURA SANGRE DE CARRERA.

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    The aim of this study was to describe gastric, hepatic, and renal lesions inThoroughbred Racing horses associated to the equine gastric ulcer syndrome. Thirtyhorses with a history of gastric ulcer syndrome and recurrent colic during 2006 to 2007 atthe Race Track «La Rinconada», Caracas, Venezuela were evaluated. Horses were euthanized and the necropsy was conducted. Tissue samples were collected from stomach,liver and kidney, and processed by conventional histological methods. In the stomach,the mucosa was intact but areas of hyperaemia and hyperkeratosis were observed in 6cases, multifocal small erosions or ulcers in 6 cases, multifocal large ulcers with areas ofextensive erosion in 12 cases and extensive areas of ulceration with exposure of thesubmucosa in 6 cases. The macroscopic evaluation of the liver showed evidenthepatomegaly in 22 cases and lobular pattern in 18 cases. The kidneys showed severecongestion in all cases, loss of cortico-medullar ratio in 20 cases, cortical necrosis in 18cases, acute tubular necrosis in all cases, papillary necrosis in 6 cases, and adherence ofthe capsule with interstitial fibroplasia in 4 cases. Lesions in the gastric mucosa, liver andkidney were associated with extended treatment with non-steroidal anti-inflammatorydrugsEl objetivo del estudio fue describir lesiones gástricas, hepáticas y renales en caballos Pura Sangre de Carreras enmarcadas en el síndrome ulceroso gástrico equino. Se trabajó con 30 ejemplares Pura Sangre de Carrera con historia de síndrome ulceroso gástrico y cólico recurrentes entre 2006 y 2007, en el Hipódromo «La Rinconada», Caracas, Venezuela. A los animales se les practicó la eutanasia y se colectó nuestras de tejido gástrico, hepático y renal. Las muestras fueron procesadas por los métodos histológicos convencionales. En el estómago se observó mucosa intacta, pero con áreas de hiperemia y/o hiperqueratosis en 6 casos, pequeñas erosiones multifocales o úlceras en 30 casos, úlceras grandes multifocales con regiones extensas de erosión en 12 casos, y úlceras extensivas con áreas de exposición de la submucosa en 6 casos. La evaluación macroscópica del hígado evidenció icteria en 22 casos, así como hepatomegalia y patrón lobulillar en 18 casos. Los riñones mostraron congestión severa en todos los casos, pérdida de la relación córtico medular en 20 casos, necrosis cortical 18 casos, necrosis tubular aguda en todos los casos, necrosis papilar confluente en 6 casos y adherencia de la cápsula con fibroplasia intersticial en 4 casos. Las lesiones observadas en la mucosa gástrica, hígado y riñón estuvieron asociadas con terapéuticas prolongadas con antiinflamatorios no esteroideos

    CATASTROPHIC MUSCULOSKELETAL INJURIES IN THOROUGHBRED HORSES, CARACAS-VENEZUELA

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    Se hizo un estudio clínico-patológico de las lesiones músculo-esqueléticas catastróficas ocurridas en pruebas públicas en el Hipódromo “La Rinconada”, Caracas, Venezuela, entre el 2000 al 2007. Se trabajó con 78 equinos Pura Sangre de Carrera con lesiones del aparato locomotor. Se colectó muestras de sangre para estudio hematológico, bioquímico y hormonal (paratohormona), así como muestras de orina para determinar niveles de fosfatos. Se les practicó la eutanasia debido a la severidad de las lesiones y se realizó la necropsia. Se tomó secciones de tejido óseo para determinación de calcio y fósforo, y de tejido muscular, tendinoso, gástrico, renal y hepático para estudio histológico. Los exámenes clínicos revelaron claudicación grado IV-V en todos los animales. La pérdida de continuidad ósea (fracturas) ocurrió en todos los casos, y exposición de estructuras óseas, articulares, rupturas de tendones, ligamentos y compromiso vascular en el 60%. Las fracturas fueron de tipo multifragmentaria (60%), oblicua (25%) y espiral (15%). Los valores sanguíneos y de orina estuvieron afectados. En la necropsia se observó el síndrome ulceroso gástrico equino, congestión hepática y necrosis tubular aguda renal. El análisis histológico reveló gastritis aguda superficial severa, úlceras gástricas, necrosis periacinar hepática, osteomalacia y necrosis del hueso subcondral, condromalacia y capsulitis severa.A clinical and pathological study was conducted on musculoskeletal catastrophic lesions of the locomotive apparatus occurred in 78 Thoroughbred horses in the racetrack «La Rinconada», Caracas, Venezuela, during 2000 to 2007. Blood samples were collected for hematological, biochemical and parathormone analysis in blood. Also, urine samples for phosphate levels. All animals were euthanized due to severe lesions, and bone, tendons, stomach, kidney and liver samples were taken for by histopathology evaluation. Clinical exams revealed lameness grade IV-V in all animals. Losses of bone continuity (fracture) occurred in all cases, and exposition of bone structures, joint damage, rupture of tendons and ligaments and vascular destruction were observed in 60% of them. The types of fractures were comminuted (60%), oblique (25%) and spiral (15%). Blood and urine values were affected. Necropsy showed equine gastric ulcer syndrome, liver congestion and renal acute tubular necrosis. Histopathological analysis showed acute and severe gastritis, gastric ulcers, hepatic periacinar necrosis, osteomalacia and necrosis in subchondral bone, chondromalacia and severe capsulitis

    Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

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    A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

    Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

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    Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

    Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

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    MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

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    Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

    Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

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    The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe

    Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

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    A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe
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