Moyo Vol. I N 1

JDB, Greek to Me . 1. Hood, Richard. Hood Advocates Off-Campus Living . 3. Rinehart, Dawn. Beta Press Biggio on Plan B . 10. Boyden, Ode on a Grecian Turn: An Interview with President Michele T. Myers . 6. Rogers, Kirstin. The Social Auction . 11. Bosari, David. Bosari on Brotherhood . 13. Mason, Amy. A Pledge in a Sea of Screaming Girls . 13. Kruse, Kristina. Kruse, Urges Thinking Hard . 14. O\u27Hare, Kimberly. Never Uncertain . 15. Howard, Tressie. D.U.\u27s New Face from Bucknell . 15. Pryor, Derrick. AΦA: A Fraternity of a Different Color . 16. Norpell, Bradley F. The Year of 1950: Looking Back on Fraternity Life . 18. Rogers, Kirstin. Freshman Lambert Co-Authors Book . 19. Bergstrom, Ida. Defending the System . 20. Bristow, Vernall. Meding D.U.\u27s Broken Reputation . 20

Optimising Machine-Experiment Interventions in HL-LHC

The luminosity reach of the HL-LHC experiments implies new constraints for the protection of the inner triplets from the machine debris. In general activation levels will increase a factor of 15-30 from the 2015 values (LS1), affecting both radiation tolerance of equipment and maintenance scenarios. The design of new equipment takes into account these constraints and the entire layout of tunnel equipment near the interaction regions will al-low for simplified maintenance. In particular, new ab-sorbers will replace the existing protection of the ma-chine-experiment cavern boundaries, with an optimised layout of the region. This paper summarises the main constraints (both physical and operational) existing at the region, together with the solutions adopted to reduce worker's dose

Bottleneck-mediated quasispecies restriction during spread of an RNA virus from inoculation site to brain

The amplification of RNA viruses such as poliovirus is associated with high error rates, and the resulting diversity likely facilitates viral survival within an infected host. However, within individual tissues of infected hosts, there may be barriers to viral spread that limit genome sampling. We tested whether poliovirus population diversity was maintained during viral spread to the brain of poliovirus receptor-expressing mice. Each of four restriction enzyme site-tagged viruses was shown to be able to replicate in the mouse brain. However, when infection was initiated by i.m., i.v., or i.p. routes, only a subset of the members of the injected pool was detectable in the brain. This jackpot effect was the result of a bottleneck in viral transit from the inoculation site to the brain. The bottleneck was difficult to overcome, requiring a 10(7) increase in viral inoculum to allow representation of all or most members of the infecting pool. Therefore, the bottleneck is not likely to be a physical barrier but an antiviral state induced by a founder virus. We suggest that the innate immune response can limit viral pathogenicity by limiting the number and therefore the diversity of viruses during spread to vulnerable tissues