Convocation P.I.P.E. [Proud Indigenous Peoples for Education] 4/20/1989 Part 1

Part 1 of 2: Jack Weatherford gives a speech as part of activities for Native American History Week, sponsored by PIPE (Proud Indigenous People for Education). The week culminated in the first powwow to be held at Macalester. Reel #316, 40:0

LOX-container-rupture fire hazards Final report, Aug. 29 - Oct. 16, 1967

Liquid oxygen container rupture fire hazards - impingement effects of compressed oxygen gas and cryogenic supercritical oxygen against Mylar superinsulation in ai

Small Businesses, Public Health, and Scientific Integrity

This report examines the activities of an independent office within the Small Business Administration: the Office of Advocacy. The Office of Advocacy has responsibility for ensuring that federal agencies evaluate the small business impacts of the rules they adopt. Scientific assessments are not "rules" and do not regulate small business, yet the Office of Advocacy decided to comment on technical, scientific assessments of the cancer risks of formaldehyde, styrene, and chromium. By its own admission, Advocacy lacks the scientific expertise to evaluate the merits of such assessments.The report analyzes correspondence and materials received through a Freedom of Information Act request made by staff at the Center for Effective Government. Our inquiry was driven by two questions: Why did the Office of Advocacy get involved in the debate over scientific assessments that do not regulate small business? Whose interests does the Office of Advocacy of the Small Business Administration actually serve?We found that the Office of Advocacy's comments on these assessments raised no issues of specific concern to small business and relied almost exclusively on talking points provided by trade associations dominated by big chemical companies. Between 2005 and 2012, the American Chemistry Council (ACC) and its members spent over $333 million lobbying Congress and federal agencies on, among other things, a protracted campaign to prevent government agencies from designating formaldehyde, styrene, and chromium as carcinogens. The Formaldehyde Council, Styrene Industry Research Council, and Chrome Coalition spent millions more. These groups asked the Office of Advocacy for assistance, and the Office became their willing partner.We conclude that the Office of Advocacy's decision to comment on scientific assessments of the cancer risks of certain chemicals constitutes a significant and unwarranted expansion of its role and reach beyond its statutory responsibilities. We recommend that Congress ask the Government Accountability Office (GAO) to investigate the Office of Advocacy and exert morerigorous oversight of its activities to ensure its work does not undermine the efforts of other federal agencies to fulfill the goals Congress has assigned them

The Real Cost of China’s Rare Earth Export Quotas on American Job Security

The populist appeal for job creation currently dominating U.S. politics has spurred copious discussion about whether regulatory policy is responsible for the present economic condition. Although this debate centers primarily on domestic regulations, recent congressional action confirms reports that China’s economic policies, particularly its export restraints and currency manipulation, have not only increased the already significant trade deficit between the U.S. and China, but have cost approximately 2.8 million U.S. jobs. Of specific concern are China’s export quotas on Rare Earth Minerals (“REMs”)

Anime for Architects: A new Perspective on Architecture

The primary argument of this study is that the medium of anime and manga, Japanese cartoons and comics, has the potential to offer a new perspective on the representation of architectural space. This might come as a surprise due to a preconceived notion that cartoons and comics are an immature art form without any value outside of the entertainment realm. Hence it is the goal of this dissertation to reveal how the methodology of manga, in particular, has the ability to enhance architectural representations in terms of the multi-sensory and space-time perception of architecture through characteristics of manga, such as narrative, portrayal of the invisible realm and the expression of both space and time by panel arrangements. To do this, a foundation with the beginnings, development, and basic visual vocabulary and grammar of comics is described and compared to other art forms. Through this comparison, the communicative power of comics is assessed by its combination of picture and word, ability to make visible the invisible through iconic images, and closure, which creates sequencing and narrative. Next, a comparison is made to show how manga is unique and visually distinctive from Western comics. Manga is found to make more use of the “masking” effect, aspectto- aspect and moment-to-moment panel transitions, length, hyper-stylization, and minimalist art. In order to argue that these manga differences have a better relationship in representing architectural space, important characteristics of architectural space are identified. These characteristics are the built environments presence in a multi-sensory world, space-time, and its association with experiential and lived space. These are then examined in relationship to the ability manga methodology has in representing these three characteristics. Finally, manga is compared to the current methods of representing architectural space such as conventional architectural drawings and writings, 3d architectural animations, virtual reality, and film. It can be concluded that manga is a more complete way of representing architectural space. As a demonstration of this, a sample manga that focuses on one particular area in Tokyo, Ikebukuro, is drawn to illustrate how this method can work utilizing the characteristics of manga, such as narrative, portrayal of the invisible realm and expression of both space and time by panel arrangements

Functions Of Atr/mec1 In Meiosis And The Cell Cycle

Mec1 is a protein kinase in S. cerevisiae that is critical for the DNA damage checkpoint response, and is the yeast orthologue of the human ATR protein. Cancer cells rely on ATR to arrest the cell cycle and allow sufficient time to repair DNA damage before proceeding through the cell cycle, and ATR inhibitors have been developed as possible anti-cancer agents. DBF4 is the regulatory subunit of DBF4-dependent kinase (DDK) that regulates initiation of DNA replication and is overexpressed in a number of different cancer types. To better understand ATR and DBF4 function, we took advantage of yeast genetics to examine the role of Mec1 and Dbf4 in prevention of DNA rereplication during meiosis. We found that Dbf4 phosphorylation sites and Mec1 were essential for prevention of DNA rereplication when the meiotic recombination checkpoint was activated by deletion of DMC1. We further found evidence that Dbf4 was phosphorylated by a kinase other than the canonical Rad53 or Mek1 protein kinases. We also examined genes that synthetically interact with MEC1 in order to better understand the function of Mec1 during the normal cell cycle. Synthetic genetic interactions occur when fitness is not affected by a single mutation of one of two genes, but when both of the two genes are mutated a significant loss in fitness occurs. Among the many genes identified to synthetically interact with MEC1, many are involved in mRNA transcription, including several subunits of the Mediator complex. We also found genes involved in DNA replication to synthetically interact with MEC1, such as RAD27 and DBF4. We assessed whether these synthetic interactions exist in human non-small cell lung cancer (NSCLC) cell lines. We discovered that inhibitors of ATR and DDK act synergistically in p53 null cell lines but not in p53 wild type cell lines. This data suggests a synthetic interaction between ATR and genes involved in transcriptional regulation or DNA replication in NSCLC cells that is dependent on the absence of p53. These studies have provided insight into novel targets to inhibit in combination with ATR inhibitors as a treatment regimen for NSCLC

My Treaties on Social Justice

This paper explores and defines Social Justice