Designing Wiimprovisation for Mediation in Group Music Therapy with Children Suffering from Behavioral Disorders

International audienceWe present qualitative experimental evidence that the "Wiimprovisation" process of using Nintendo Wiimotes as virtual instruments linked to a musical sound system within the framework of Group Music Therapy sessions can provide effective psychodynamic mediation for patients. We designed and implemented specific modalities for movement-based sound control and tested our tool in two clinical settings with children (age 7 to 12) suffering from behavioral disorders. Our preliminary results show immediate acceptance of, long term motivation for and meaningful expression through our system by patients. Future work will focus on assessing the therapeutic potential of our platform's personalization features in a controlled experiment

Field Evaluation with Cognitively-Impaired Older Adults of Attention Management in the Embodied Conversational Agent Louise

International audienceWe present the first experiment we conducted to evaluate the attention monitoring performance of Louise, following a Wizard of Oz method, during the interactions with a cohort of 8 elderly users in a day hospital environment. Louise is a new, semi-automatic prototype of an Embodied Conversational Agent (ECA), a virtual character interacting with users through social-like communication, adapted to the special needs of older adults with cognitive impairment; it is intended to ultimately provide assistance in their activities of daily living. We recorded and analyzed both videos of the conversation-like interactions and Louise's tracking data. In our experiment, Louise's attention estimation algorithm achieved about 80% accuracy; moreover, in almost all cases, the user's attention was successfully recaptured by Louise after a planned, experimenter-induced distraction. These results are in line with what was observed in previous experiments involving only younger adults, thus suggesting that attention measurement tools embedded in cognitive prostheses will not need to be adapted to elderly patients. Finally, to gain further insights on conversation management and provide evidence-based suggestions for future work, we performed an anthropological analysis of the whole experiment

Virtual Promenade: A New Serious Game for the Rehabilitation of Older Adults with Post-fall Syndrome

International audience—We introduce a novel rehabilitation tool to treat Post-Fall Syndrome (PFS) in older adults: a serious game, called Virtual Promenade, combined with a haptic chair imitating the hips movements of human walk. We report on the user-centered design of our prototype, following " living lab " principles, which was well received by our test participants. This system aims at addressing the psycho-motor consequences of older adults' falls; they are often neglected in current post-fall care practices. We first checked for feasibility and tolerability of such interventions. We then applied a living lab participatory design approach, involving health care professionals and older adults, to build the Virtual Promenade prototype. We found that patients with PFS tolerated the system well and that there were no major obstacles to feasibility. We also report that the aesthetics of the virtual environment is an important motivational factor for older adults and discuss our results in searching for the most suitable game controller for this type of patients and game. Finally, we observed that the chairs' movements improved the immersion in the game

Evaluation en EHPAD de MINDs, un jeu vidéo musical développé pour et avec des personnes souffrant de la maladie d'Alzheimer

National audienceIl existe de nombreux jeux vidéo "sérieux" à destination des personnes âgées. Parmi eux, MINDs est un jeu médical développé pour et avec des personnes souffrant de la maladie d'Alzheimer ou des troubles apparentés. Il propose une activité musicale agréable et adaptée à leurs capacités et leurs spécificités. Issu des travaux de recherche du Dr. Benveniste (MINES ParisTech/CEN STIMCO) sous la direction de Pierre Jouvelot (MINES ParisTech), il a été conçu avec des soignants et des patients en milieu hospitalier en collaboration avec le Dr. Péquignot (H. Saint-Maurice). Une étude pilote indépendante à l'hôpital Broc a démontré qu'il était bien adapté à cette population. Le but de la présente étude était d'évaluer l'efficacité et l'impact de MINDs en établissement d'hébergement pour personnes âgées dépendantes (EHPAD) et de tester la faisabilité d'un déploiement à plus grande échelle

MicroRNA-31 is required for astrocyte specification

Previously, we determined microRNA-31 (miR-31) is a noncoding tumor suppressive gene frequently deleted in glioblastoma (GBM); miR-31 suppresses tumor growth, in part, by limiting the activity of NF-κB. Herein, we expand our previous studies by characterizing the role of miR-31 during neural precursor cell (NPC) to astrocyte differentiation. We demonstrate that miR-31 expression and activity is suppressed in NPCs by stem cell factors such as Lin28, c-Myc, SOX2 and Oct4. However, during astrocytogenesis, miR-31 is induced by STAT3 and SMAD1/5/8, which mediate astrocyte differentiation. We determined miR-31 is required for terminal astrocyte differentiation, and that the loss of miR-31 impairs this process and/or prevents astrocyte maturation. We demonstrate that miR-31 promotes astrocyte development, in part, by reducing the levels of Lin28, a stem cell factor implicated in NPC renewal. These data suggest that miR-31 deletions may disrupt astrocyte development and/or homeostasis

Digital transformation of health and care to sustain Planetary Health : The MASK proof-of-concept for airway diseases-POLLAR symposium under the auspices of Finland's Presidency of the EU, 2019 and MACVIA-France, Global Alliance against Chronic Respiratory Diseases (GARD, WH0) demonstration project, Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing

In December 2019, a conference entitled "Europe That Protects: Safeguarding Our Planet, Safeguarding Our Health" was held in Helsinki. It was co-organized by the Finnish Institute for Health and Welfare, the Finnish Environment Institute and the European Commission, under the auspices of Finland's Presidency of the EU. As a side event, a symposium organized as the final POLLAR (Impact of air POLLution on Asthma and Rhinitis) meeting explored the digital transformation of health and care to sustain planetary health in airway diseases. The Finnish Allergy Programme collaborates with MASK (Mobile Airways Sentinel NetworK) and can be considered as a proof-of-concept to impact Planetary Health. The Good Practice of DG Sante (The Directorate-General for Health and Food Safety) on digitally-enabled, patient-centred care pathways is in line with the objectives of the Finnish Allergy Programme. The ARIACARE-Digital network has been deployed in 25 countries. It represents an example of the digital cross-border exchange of real-world data and experience with the aim to improve patient care. The integration of information technology tools for climate, weather, air pollution and aerobiology in mobile Health applications will enable the development of an alert system. Citizens will thus be informed about personal environmental threats, which may also be linked to indicators of Planetary Health and sustainability. The digital transformation of the public health policy was also proposed, following the experience of the Agency for Health Quality and Assessment of Catalonia (AQuAS).Peer reviewe

Unifying Theories of Reactive Design Contracts

Design-by-contract is an important technique for model-based design in which a composite system is specified by a collection of contracts that specify the behavioural assumptions and guarantees of each component. In this paper, we describe a unifying theory for reactive design contracts that provides the basis for modelling and verification of reactive systems. We provide a language for expression and composition of contracts that is supported by a rich calculational theory. In contrast with other semantic models in the literature, our theory of contracts allow us to specify both the evolution of state variables and the permissible interactions with the environment. Moreover, our model of interaction is abstract, and supports, for instance, discrete time, continuous time, and hybrid computational models. Being based in Unifying Theories of Programming (UTP), our theory can be composed with further computational theories to support semantics for multi-paradigm languages. Practical reasoning support is provided via our proof framework, Isabelle/UTP, including a proof tactic that reduces a conjecture about a reactive program to three predicates, symbolically characterising its assumptions and guarantees about intermediate and final observations. This allows us to verify programs with a large or infinite state space. Our work advances the state-of-the-art in semantics for reactive languages, description of their contractual specifications, and compositional verification

Next-generation care pathways for allergic rhinitis and asthma multimorbidity:a model for multimorbid non-communicable diseases-Meeting Report (Part 1)

International audienceIn all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system for integrated care with organizational health literacy. MASK (Mobile Airways Sentinel NetworK) (1), a new development of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health) (2), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life integrated care pathways (ICPs) (3)-centred around the patient with rhinitis and using mHealth monitoring of environmental exposure (4).An expert meeting took place at the Pasteur Institute in Paris, December 3, 2018. The aim was to discuss next-generation care pathways: (I) Patient participation, health literacy and self-care through technology-assisted “patient activation”; (II) Implementation of care pathways by pharmacists and (III) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) assessed by mobile technology.The EU (5) and global political agendas are of great importance in supporting health care transformation. MASK has been recognized by DG Santé as a Good Practice (6) in the field of digitally-enabled, integrated, person-centred care.The one-day meeting objectives were clear (Figure 1). The meeting was followed by a workshop. The present paper reports the background of the two-day meeting