The GALEX Arecibo SDSS Survey. I. Gas Fraction Scaling Relations of Massive Galaxies and First Data Release

We introduce the GALEX Arecibo SDSS Survey (GASS), an on-going large program that is gathering high quality HI-line spectra using the Arecibo radio telescope for an unbiased sample of ~1000 galaxies with stellar masses greater than 10^10 Msun and redshifts 0.025<z<0.05, selected from the SDSS spectroscopic and GALEX imaging surveys. The galaxies are observed until detected or until a low gas mass fraction limit (1.5-5%) is reached. This paper presents the first Data Release, consisting of ~20% of the final GASS sample. We use this data set to explore the main scaling relations of HI gas fraction with galaxy structure and NUV-r colour. A large fraction (~60%) of the galaxies in our sample are detected in HI. We find that the atomic gas fraction decreases strongly with stellar mass, stellar surface mass density and NUV-r colour, but is only weakly correlated with galaxy bulge-to-disk ratio (as measured by the concentration index of the r-band light). We also find that the fraction of galaxies with significant (more than a few percent) HI decreases sharply above a characteristic stellar surface mass density of 10^8.5 Msun kpc^-2. The fraction of gas-rich galaxies decreases much more smoothly with stellar mass. One of the key goals of GASS is to identify and quantify the incidence of galaxies that are transitioning between the blue, star-forming cloud and the red sequence of passively-evolving galaxies. Likely transition candidates can be identified as outliers from the mean scaling relations between gas fraction and other galaxy properties. [abridged]Comment: 25 pages, 12 figures. Accepted for publication in MNRAS. Version with high resolution figures available at http://www.mpa-garching.mpg.de/GASS/pubs.ph

The use of adherence aids by adults with diabetes: A cross-sectional survey

BACKGROUND: Adherence with medication taking is a major barrier to physiologic control in diabetes and many strategies for improving adherence are in use. We sought to describe the use of mnemonic devices and other adherence aids by adults with diabetes and to investigate their association with control of hyperglycemia, hyperlipidemia and hypertension. METHODS: Cross sectional survey of diabetic adults randomly selected from Primary Care practices in the Vermont Diabetes Information System. We used linear regression to examine the associations between the use of various aids and physiologic control among subjects who used oral agents for hyperglycemia, hypercholesterolemia, and hypertension. RESULTS: 289 subjects (mean age 65.4 years; 51% female) used medications for all three conditions. Adherence aids were reported by 80%. The most popular were day-of-the-week pill boxes (50%), putting the pills in a special place (41%), and associating pill taking with a daily event such as a meal, TV show, or bedtime (11%). After adjusting for age, sex, marital status, income, and education, those who used a special place had better glycemic control (A1C -0.36%; P = .04) and systolic blood pressure (-5.9 mm Hg; P = .05) than those who used no aids. Those who used a daily event had better A1C (-0.56%; P = .01) than patients who used no aids. CONCLUSION: Although adherence aids are in common use among adults with diabetes, there is little evidence that they are efficacious. In this study, we found a few statistically significant associations with adherence aids and better diabetes control. However, these findings could be attributed to multiple comparisons or unmeasured confounders. Until more rigorous evaluations are available, it seems reasonable to recommend keeping medicines in a special place for diabetic adults prescribed multiple medications

The RMS Survey: Resolving kinematic distance ambiguities towards a sample of compact HII regions using HI absorption

We present high-resolution HI data obtained using the Australia Telescope Compact Array to resolve the near/far distance ambiguities towards a sample of compact HII regions from the Red MSX Source (RMS) survey. The high resolution data are complemented with lower resolution archival HI data extracted from the Southern and VLA Galactic Plane surveys. We resolve the distance ambiguity for nearly all of the 105 sources where the continuum was strong enough to allow analysis of the HI absorption line structure. This represents another step in the determination of distances to the total RMS sample, which with over 1,000 massive young stellar objects and compact HII regions, is the largest and most complete sample of its kind. The full sample will allow the distribution of massive star formation in the Galaxy to be examined.Comment: Accepted by MNRAS. This paper consists of 15 pages and contains 10 figures and 5 table

Chronic Exposure to Complex Metal Oxide Nanoparticles Elicits Rapid Resistance in Shewanella Oneidensis MR-1

Engineered nanoparticles are incorporated into numerous emerging technologies because of their unique physical and chemical properties. Many of these properties facilitate novel interactions, including both intentional and accidental effects on biological systems. Silver-containing particles are widely used as antimicrobial agents and recent evidence indicates that bacteria rapidly become resistant to these nanoparticles. Much less studied is the chronic exposure of bacteria to particles that were not designed to interact with microorganisms. For example, previous work has demonstrated that the lithium intercalated battery cathode nanosheet, nickel manganese cobalt oxide (NMC), is cytotoxic and causes a significant delay in growth of Shewanella oneidensis MR-1 upon acute exposure. Here, we report that S. oneidensis MR-1 rapidly adapts to chronic NMC exposure and is subsequently able to survive in much higher concentrations of these particles, providing the first evidence of permanent bacterial resistance following exposure to nanoparticles that were not intended as antibacterial agents. We also found that when NMC-adapted bacteria were subjected to only the metal ions released from this material, their specific growth rates were higher than when exposed to the nanoparticle. As such, we provide here the first demonstration of bacterial resistance to complex metal oxide nanoparticles with an adaptation mechanism that cannot be fully explained by multi-metal adaptation. Importantly, this adaptation persists even after the organism has been grown in pristine media for multiple generations, indicating that S. oneidensis MR-1 has developed permanent resistance to NMC

Prior biosphere model impact on global terrestrial CO2 fluxes estimated from OCO-2 retrievals

This study assesses the impact of different state of the art global biospheric CO2 flux models, when applied as prior information, on inverse model &ldquo;top-down&rdquo; estimates of terrestrial CO2 fluxes obtained when assimilating Orbiting Carbon Observatory 2 (OCO-2) observations. This is done with a series of observing system simulation experiments (OSSEs) using synthetic CO2 column-average dry air mole fraction (XCO2) retrievals sampled at the OCO-2 satellite spatiotemporal frequency. The OSSEs utilized a 4-D variational (4D-Var) assimilation system with the GEOS-Chem global chemical transport model (CTM) to estimate CO2 net ecosystem exchange (NEE) fluxes using synthetic OCO-2 observations. The impact of biosphere models in inverse model estimates of NEE is quantified by conducting OSSEs using the NASA-CASA, CASA-GFED, SiB-4, and LPJ models as prior estimates and using NEE from the multi-model ensemble mean of the Multiscale Synthesis and Terrestrial Model Intercomparison Project as the &ldquo;truth&rdquo;. Results show that the assimilation of simulated XCO2 retrievals at OCO-2 observing modes over land results in posterior NEE estimates which generally reproduce &ldquo;true&rdquo; NEE globally and over terrestrial TransCom-3 regions that are well-sampled. However, we find larger spread among posterior NEE estimates, when using different prior NEE fluxes, in regions and seasons that have limited OCO-2 observational coverage and a large range in &ldquo;bottom-up&rdquo; NEE fluxes. Seasonally averaged posterior NEE estimates had standard deviations (SD) of &sim;10&thinsp;% to &sim;50&thinsp;% of the multi-model-mean NEE for different TransCom-3 land regions with significant NEE fluxes (regions/seasons with a NEE flux &ge;0.5&thinsp;PgC&thinsp;yr&minus;1). On a global average, the seasonally averaged residual impact of the prior model NEE assumption on the posterior NEE spread is &sim;10&thinsp;%&ndash;20&thinsp;% of the posterior NEE mean. Additional OCO-2 OSSE simulations demonstrate that posterior NEE estimates are also sensitive to the assumed prior NEE flux uncertainty statistics, with spread in posterior NEE estimates similar to those when using variable prior model NEE fluxes. In fact, the sensitivity of posterior NEE estimates to prior error statistics was larger than prior flux values in some regions/times in the tropics and Southern Hemisphere where sufficient OCO-2 data were available and large differences between the prior and truth were evident. Overall, even with the availability of spatiotemporally dense OCO-2 data, noticeable residual differences (up to &sim;20&thinsp;%&ndash;30&thinsp;% globally and 50&thinsp;% regionally) in posterior NEE flux estimates remain that were caused by the choice of prior model flux values and the specification of prior flux uncertainties.</p

The GALEX Arecibo SDSS Survey II: The Star Formation Efficiency of Massive Galaxies

We use measurements of the HI content, stellar mass and star formation rates in ~190 massive galaxies with stellar masses greater than 10^10 Msun, obtained from the Galex Arecibo SDSS Survey (GASS) described in Paper I (Catinella et al. 2010) to explore the global scaling relations associated with the bin-averaged ratio of the star formation rate over the HI mass, which we call the HI-based star formation efficiency (SFE). Unlike the mean specific star formation rate, which decreases with stellar mass and stellar mass surface density, the star formation efficiency remains relatively constant across the sample with a value close to SFE = 10^-9.5 yr^-1 (or an equivalent gas consumption timescale of ~3 Gyr). Specifically, we find little variation in SFE with stellar mass, stellar mass surface density, NUV-r color and concentration. We interpret these results as an indication that external processes or feedback mechanisms that control the gas supply are important for regulating star formation in massive galaxies. An investigation into the detailed distribution of SFEs reveals that approximately 5% of the sample shows high efficiencies with SFE > 10^-9 yr^-1, and we suggest that this is very likely due to a deficiency of cold gas rather than an excess star formation rate. Conversely, we also find a similar fraction of galaxies that appear to be gas-rich for their given specific star-formation rate, although these galaxies show both a higher than average gas fraction and lower than average specific star formation rate. Both of these populations are plausible candidates for "transition" galaxies, showing potential for a change (either decrease or increase) in their specific star formation rate in the near future. We also find that 36+/-5% of the total HI mass density and 47+/-5% of the total SFR density is found in galaxies with stellar mass greater than 10^10 Msun. [abridged]Comment: 18 pages, 11 figures. Accepted for publication in MNRAS. GASS publications and released data can be found at http://www.mpa-garching.mpg.de/GASS/index.ph

Unique V3 Loop Sequence Derived from the R2 Strain of HIV-Type 1 Elicits Broad Neutralizing Antibodies

DNA vaccines expressing the envelope (Env) of the human immunodeficiency virus type 1 (HIV-1) have been relatively ineffective at generating high-titer, long-lasting, neutralizing antibodies. In this study, DNA vaccines were constructed to express the gp120 subunit of Env from the isolate HIV-1R2 using both wild-type and codon- ptimized gene sequences. Three copies of the murine C3d were added to the carboxyl terminus to enhance the immunogenicity of the expressed fusion protein. Mice (BALB/c) vaccinated with DNA plasmid expressing the gp120R2 using codon-optimized Env sequences elicited high-titer anti-Env antibodies regardless of conjugation to C3d. In contrast, only mice vaccinated with DNA using wild-type gp120R2 sequences fused to mC3d3, had detectable anti- Env antibodies. Interestingly, mice vaccinated with DNA expressing gp120R2 from codon-optimized sequences elicited antibodies that neutralized both homologous and heterologous HIV-1 isolates. To determine if the unique sequence found in the crown of the V3 loop of the EnvR2 was responsible for the elicitation of the cross-clade neutralizing antibodies, the codons encoding for the Pro-Met (amino acids 313–314) were introduced into the sequences encoding the gp120ADA (R5) or gp12089.6 (R5X4). Mice vaccinated with gp120ADA–mC3d3–DNA with the Pro–Met mutation had antibodies that neutralized HIV-1 infection, but not the gp12089.6–mC3d3–DNA. Therefore, the use of the unique sequences in the EnvR2 introduced into an R5 tropic envelope, in conjunction with C3d fusion, was effective at broadening the number of viruses that could be neutralized. However, the introduction of this same sequence into an R5X4-tropic envelope was ineffective in eliciting improved cross-clade neutralizing antibodies. Originally published AIDS Research and Human Retroviruses, Vol. 20, No. 11, Nov 200

Triggered star formation on the borders of the Galactic HII region RCW 82

We are engaged in a multi-wavelength study of several Galactic HII regions that exhibit signposts of triggered star formation on their borders, and where the collect and collapse process could be at work. When addressing the question of triggered star formation it is critically important to ensure the real association between the ionized gas and the neutral material observed nearby. In this paper we stress this point, and present CO observations of the RCW 82 star forming region. The velocity distribution of the molecular gas is combined with the study of young stellar objects (YSOs) detected in the direction of RCW 82. We discuss the YSO's evolutionary status using near- and mid-IR data. The spatial and velocity distributions of the molecular gas are used to discuss the possible scenarios for the star formation around RCW 82.Comment: 17 pages, 20 figures. Accepted by A&