Detecting Driver Sleepiness Using Consumer Wearable Devices in Manual and Partial Automated Real-Road Driving

Driver sleepiness constitutes a well-known traffic safety risk. With the introduction of automated driving systems, the chance of getting sleepy and even falling asleep at wheel could increase further. Conventional sleepiness detection methods based on driving performance and behavior may not be available under automated driving. Methods based on physiological measurements such as heart rate variability (HRV) becomes a potential solution under automated driving. However, with reduced task load, HRV could potentially be affected by automated driving. Therefore, it is essential to investigate the influence of automated driving on the relation between HRV and sleepiness. Data from real-road driving experiments with 43 participants were used in this study. Each driver finished four trials with manual and partial automated driving under normal and sleep-deprived condition. Heart rate was monitored by consumer wearable chest bands. Subjective sleepiness based on Karolinska sleepiness scale was reported at five min interval as ground truth. Reduced heart rate and increased overall variability were found in association with severe sleepy episodes. A binary classifier based on the AdaBoost method was developed to classify alert and sleepy episodes. The results indicate that partial automated driving has small impact on the relationship between HRV and sleepiness. The classifier using HRV features reached area under curve (AUC) = 0.76 and it was improved to AUC = 0.88 when adding driving time and day/night information. The results show that commercial wearable heart rate monitor has the potential to become a useful tool to assess driver sleepiness under manual and partial automated driving

Effect of spherical blockage configurations on film cooling

With increasing inlet temperature of gas turbines, turbine blades need to be effectively protected by using cooling technologies. However, the deposition from the fuel impurities and dust particles in the air is often found inside film holes, which results in partial hole blockage. In this paper, the deposition geometry is simplified as a rectangular channel, and the effect of three blockage ratios is investigated by using the computational fluid dynamics. In addition, water droplets are also released from the coolant inlet to provide a comparison of the results with and without mist injection. It is found that the lateral film cooling effectiveness is reduced with increasing blockage ratio. For all the cases with the blowing ratio 0.6, 1% mist injection provides an improvement of the cooling performance by approximately 10%

GWAS of Follicular Lymphoma Reveals Allelic Heterogeneity at 6p21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-cell Lymphoma

Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL cases and 791 controls followed by validation in 1,049 cases and 5,790 controls, we identified a second independent FL–associated locus on 6p21.32, rs2647012 (ORcombined = 0.64, Pcombined = 2×10−21) located 962 bp away from rs10484561 (r2<0.1 in controls). After mutual adjustment, the associations at the two SNPs remained genome-wide significant (rs2647012:ORadjusted = 0.70, Padjusted = 4×10−12; rs10484561:ORadjusted = 1.64, Padjusted = 5×10−15). Haplotype and coalescence analyses indicated that rs2647012 arose on an evolutionarily distinct haplotype from that of rs10484561 and tags a novel allele with an opposite (protective) effect on FL risk. Moreover, in a follow-up analysis of the top 6 FL–associated SNPs in 4,449 cases of other NHL subtypes, rs10484561 was associated with risk of diffuse large B-cell lymphoma (ORcombined = 1.36, Pcombined = 1.4×10−7). Our results reveal the presence of allelic heterogeneity within the HLA class II region influencing FL susceptibility and indicate a possible shared genetic etiology with diffuse large B-cell lymphoma. These findings suggest that the HLA class II region plays a complex yet important role in NHL

Economic Analysis of Knowledge: The History of Thought and the Central Themes

Following the development of knowledge economies, there has been a rapid expansion of economic analysis of knowledge, both in the context of technological knowledge in particular and the decision theory in general. This paper surveys this literature by identifying the main themes and contributions and outlines the future prospects of the discipline. The wide scope of knowledge related questions in terms of applicability and alternative approaches has led to the fragmentation of research. Nevertheless, one can identify a continuing tradition which analyses various aspects of the generation, dissemination and use of knowledge in the economy

The trans-ancestral genomic architecture of glycemic traits

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution. A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Peer reviewe

Increased Level of Myeloid-Derived Suppressor Cells, Programmed Death Receptor Ligand 1/Programmed Death Receptor 1, and Soluble CD25 in Sokal High Risk Chronic Myeloid Leukemia

Peer reviewe