Erythropoietic (Congenital) Porphyria in a Bantu Girl

A CAJM article on congenital porphyria in an African child in the 1950's in Southern Africa.The case here presented is of congenital porphyria occurring in a three-year-old Bantu girl of the Bapedi tribe. This is the second case of this rare type of porphyria recorded in the Bantu of Southern Africa. The patient was admitted to the Jane Furse Memorial Hospital from a district clinic on 6th December, 1955, with a provisional diagnosis of scurvy. The history was that she had had measles a few weeks previously, and two weeks before admission developed weakness and tenderness of the legs and could not walk

Exact results of a mixed spin-1/2 and spin-S Ising model on a bathroom tile (4-8) lattice: effect of uniaxial single-ion anisotropy

Effect of uniaxial single-ion anisotropy upon magnetic properties of a mixed spin-1/2 and spin-S (S>=1) Ising model on a bathroom tile (4-8) lattice is examined within the framework of an exact star-triangle mapping transformation. The particular attention is focused on the phase diagrams established for several values of the quantum spin number S. It is shown that the mixed-spin bathroom tile lattice exhibits very similar phase boundaries as the mixed-spin honeycomb lattice whose critical points are merely slightly enhanced with respect to the former ones. The influence of uniaxial single-ion anisotropy upon the total magnetization vs. temperature dependence is particularly investigated as well.Comment: 12 pages, 4 figure

Nurses\u27 Alumnae Association Bulletin, June 1964

President\u27s Message Officers and Committee Chairmen Financial Report Hospital and School of Nursing Report Student Activities Jefferson Expansion Program Resume of Alumnae Meetings Staff Nurses Private Duty Social Committee Reports Program Scholarship Bulletin Committee Report Annual Luncheon Notes Membership and Dues Units in Jefferson Expansion Program Center Annual Giving Drive 1963 Report of Ways and Means Committee Jefferson Building Fund Contributions Annual Giving Contributions 1964 Jefferson Building Fund Report Help the Building Fund Committee! Vital Statistics Class News Notice

How to develop rapid reviews of diagnostic tests according to experts: A qualitative exploration of researcher views

Background: Rapid reviews (RRs) have been used to provide timely evidence for policymakers, health providers, and the public in several healthcare scenarios, most recently during the coronavirus disease 2019 pandemic. Despite the essential role of diagnosis in clinical management, data about how to perform RRs of diagnostic tests are scarce. We aimed to explore the views and perceptions of experts in evidence synthesis and diagnostic evidence about the value of methods used to accelerate the review process. Methods: We performed semistructured interviews with a purposive sample of experts in evidence synthesis and diagnostic evidence. We carried out the interviews in English between July and December 2021. Initial reading and coding of the transcripts were performed using NVIVO qualitative data analysis software. Results: Of a total of 23 invited experts, 16 (70%) responded. We interviewed all 16 participants representing key roles in evidence synthesis. We identified 14 recurring themes including the review question, characteristics of the review team, and use of automation, as the topics with the highest number of quotes. Some participants considered several methodological “shortcuts” to be ineffective or risky, such as automating quality appraisal, using only one reviewer for diagnostic data extraction and only performing descriptive analysis. The introduction of limits might depend on whether the test being assessed is a new test, the availability of alternative tests, the needs of providers and patients, and the availability of high‐quality systematic reviews. Conclusions: Our findings suggest that organizational strategies (e.g., defining the review question, availability of a highly experienced team) may have a role in conducting RRs of diagnostic tests. Several methodological shortcuts were considered inadequate for accelerating the review process, though they need to be assessed in well‐designed studies. Improved reporting of RRs would support evidence‐based decision‐making and help users of RRs understand their limitations

The Naturalized Gender Order Of Rock and Roll

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66933/2/10.1177_019685999501900104.pd

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Stephen F Austin State University Journal of Education Vol. 3 No. 1

https://scholarworks.sfasu.edu/edjournal/1002/thumbnail.jp

Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes

In the last few years, many efforts have been made to search for potent and selective human A3 adenosine antagonists. In particular, one of the most promising human A3 adenosine receptor antagonists is represented by the pyrazolo-triazolo-pyrimidine family. This class of compounds has been strongly investigated from the point of view of structure-activity relationships. In particular, it has been observed that fundamental requisites for having both potency and selectivity at the human A3 adenosine receptors are the presence of a small substituent at the N8 position and an unsubstitued phenyl carbamoyl moiety at the N5 position. In this study, we report the role of the N5-bond type on the affinity and selectivity at the four adenosine receptor subtypes. The observed structure-activity relationships of this class of antagonists are also exhaustively rationalized using the recently published ligand-based homology modeling approach