Estimating Systems Engineering Reuse

Systems engineering reuse is the utilization of previously developed systems engineering products or artifacts such as architectures, requirements, and test plans across different projects. Such reuse is intended as a means of reducing development cost, project schedule, or performance risk, by avoiding the repetition of some systems engineering activities. Although projects involving systems engineering reuse are becoming more frequent, models or tools for estimating the cost, benefit, and overall impact on a project as a result of reusing products or artifacts have not yet been adequately developed. This paper provides an overview of systems engineering reuse and recent developments with the Constructive Systems Engineering Cost Model (COSYSMO) to estimate the effect of reuse on systems engineering effort. The overview of systems engineering reuse includes a review of how reuse is handled in other domains and results from an industry survey. The recent developments in COSYSMO presents on-going research in the creation of a reuse extension for the model such as the identification of categories of systems engineering reuse, reuse extensions for the size drivers in the model, and a revised set of cost drivers

A Survey on the Interplay between Software Engineering and Systems Engineering during SoS Architecting

Background: The Systems Engineering and Software Engineering disciplines are highly intertwined in most modern Systems of Systems (SoS), and particularly so in industries such as defense, transportation, energy and health care. However, the combination of these disciplines during the architecting of SoS seems to be especially challenging; the literature suggests that major integration and operational issues are often linked to ambiguities and gaps between system-level and software-level architectures. Aims: The objective of this paper is to empirically investigate: 1) the state of practice on the interplay between these two disciplines in the architecting process of systems with SoS characteristics; 2) the problems perceived due to this interplay during said architecting process; and 3) the problems arising due to the particular characteristics of SoS systems. Method: We conducted a questionnaire-based online survey among practitioners from industries in the aforementioned domains, having a background on Systems Engineering, Software Engineering or both, and experience in the architecting of systems with SoS characteristics. The survey combined multiple-choice and open-ended questions, and the data collected from the 60 respondents were analyzed using quantitative and qualitative methods. Results: We found that although in most cases the software architecting process is governed by system-level requirements, the way requirements were specified by systems engineers, and the lack of domain-knowledge of software engineers, often lead to misinterpretations at software level. Furthermore, we found that unclear and/or incomplete specifications could be a common cause of technical debt in SoS projects, which is caused, in part, by insufficient interface definitions. It also appears that while the SoS concept has been adopted by some practitioners in the field, the same is not true about the existing and growing body of knowledge on the subject in Software Engineering resulting in recurring problems with system integration. Finally, while not directly related to the interplay of the two disciplines, the survey also indicates that low-level hardware components, despite being identified as the root cause of undesired emergent behavior, are often not considered when modeling or simulating the system. Conclusions: The survey indicates the need for tighter collaboration between the two disciplines, structured around concrete guidelines and practices for reconciling their differences. A number of open issues identified by this study require further investigation

Next generation software environments : principles, problems, and research directions

The past decade has seen a burgeoning of research and development in software environments. Conferences have been devoted to the topic of practical environments, journal papers produced, and commercial systems sold. Given all the activity, one might expect a great deal of consensus on issues, approaches, and techniques. This is not the case, however. Indeed, the term "environment" is still used in a variety of conflicting ways. Nevertheless substantial progress has been made and we are at least nearing consensus on many critical issues.The purpose of this paper is to characterize environments, describe several important principles that have emerged in the last decade or so, note current open problems, and describe some approaches to these problems, with particular emphasis on the activities of one large-scale research program, the Arcadia project. Consideration is also given to two related topics: empirical evaluation and technology transition. That is, how can environments and their constituents be evaluated, and how can new developments be moved effectively into the production sector

Space Station Engineering Design Issues

Space Station Freedom topics addressed include: general design issues; issues related to utilization and operations; issues related to systems requirements and design; and management issues relevant to design

Accidental stability of dark matter

We propose that dark matter is stable as a consequence of an accidental Z2 that results from a flavour-symmetry group which is the double-cover group of the symmetry group of one of the regular geometric solids. Although model-dependent, the phenomenology resembles that of a generic Higgs portal dark matter scheme.Comment: 12 pages, final version, published in JHE

Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage

DNA vaccination elicits humoral and cellular immune responses and has been shown to confer protection against several viral, bacterial, and parasitic pathogens. Here we report that optimized codon usage of an injected DNA sequence considerably increases both humoral and cellular immune responses. We recently generated a synthetic human immunodeficiency virus type 1 gp120 sequence in which most wild-type codons were replaced with codons from highly expressed human genes (syngp120). In vitro expression of syngp120 is considerably increased in comparison to that of the respective wild-type sequence. In BALB/c mice, DNA immunization with syngp120 resulted in significantly increased antibody titers and cytotoxic T-lymphocyte reactivity, suggesting a direct correlation between expression levels and the immune response. Moreover, syngp120 is characterized by rev-independent expression and a low risk of recombination with viral sequences. Thus, synthetic genes with optimized codon usage represent a novel strategy to increase the efficacy and safety of DNA vaccination

Patents and Industrialisation. An Historical Overview of the British Case, 1624-1907

A Report to the Strategic Advisory Board on Intellectual Property Policy (SABIP), U

Insights into Land Plant Evolution Garnered from the Marchantia polymorpha Genome.

The evolution of land flora transformed the terrestrial environment. Land plants evolved from an ancestral charophycean alga from which they inherited developmental, biochemical, and cell biological attributes. Additional biochemical and physiological adaptations to land, and a life cycle with an alternation between multicellular haploid and diploid generations that facilitated efficient dispersal of desiccation tolerant spores, evolved in the ancestral land plant. We analyzed the genome of the liverwort Marchantia polymorpha, a member of a basal land plant lineage. Relative to charophycean algae, land plant genomes are characterized by genes encoding novel biochemical pathways, new phytohormone signaling pathways (notably auxin), expanded repertoires of signaling pathways, and increased diversity in some transcription factor families. Compared with other sequenced land plants, M. polymorpha exhibits low genetic redundancy in most regulatory pathways, with this portion of its genome resembling that predicted for the ancestral land plant. PAPERCLIP