An Oxygen Abundance Gradient into the Outer Disk of M81

The extended HI disk and tidal tails of M81 present an interesting environment to study the effects of galaxy interaction on star formation and chemical evolution of the outer disk of a large spiral galaxy. We present H{\alpha} imaging of the outer disk of M81 and luminosities for 40 HII regions out to about 3 times the optical radius. We have also obtained MMT spectra for 21 HII regions out to more than twice the optical radius. We derive strong line oxygen abundances for all HII regions using R_{23} based and [NII]/[OII] based calibrations and electron temperature abundances for seven regions spanning a galactocentric distance between 5.7 and 32 kpc. We also comment on the abundances of HII regions near KDG 61 and the "tidal dwarf" candidate HoIX. Our results constitute the most radially extended metallicity study for M81 to date. With this extended data set, we find an overall oxygen abundance gradient of -0.013 dex/kpc over the entire radial range. This is significantly flatter than what has been found in previous studies which were limited to the optical disk. From our temperature based abundances, we find a gradient of -0.020 dex/kpc and present the possibility of a broken gradient from these data, but note the need to obtain more temperature based abundances at intermediate galactocentric distances (~10-20 kpc) to verify whether or not this may be the case. We discuss our main result of a rather flat gradient for M81 in the context of simulations and observations of abundance gradients in other galaxies. We find that the shallow abundance gradient of M81 is likely a result of the interaction history of this galaxy.Comment: 41 pages, 11 figures, accepted for publication in MNRA

Proceedings of Abstracts Engineering and Computer Science Research Conference 2019

© 2019 The Author(s). This is an open-access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For further details please see https://creativecommons.org/licenses/by/4.0/. Note: Keynote: Fluorescence visualisation to evaluate effectiveness of personal protective equipment for infection control is © 2019 Crown copyright and so is licensed under the Open Government Licence v3.0. Under this licence users are permitted to copy, publish, distribute and transmit the Information; adapt the Information; exploit the Information commercially and non-commercially for example, by combining it with other Information, or by including it in your own product or application. Where you do any of the above you must acknowledge the source of the Information in your product or application by including or linking to any attribution statement specified by the Information Provider(s) and, where possible, provide a link to this licence: http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/This book is the record of abstracts submitted and accepted for presentation at the Inaugural Engineering and Computer Science Research Conference held 17th April 2019 at the University of Hertfordshire, Hatfield, UK. This conference is a local event aiming at bringing together the research students, staff and eminent external guests to celebrate Engineering and Computer Science Research at the University of Hertfordshire. The ECS Research Conference aims to showcase the broad landscape of research taking place in the School of Engineering and Computer Science. The 2019 conference was articulated around three topical cross-disciplinary themes: Make and Preserve the Future; Connect the People and Cities; and Protect and Care

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Hydrogeologic Framework of the Edwards-Trinity Aquifer System, West-Central Texas

The Edwards-Trinity aquifer system underlies about 42,000 square miles of west-central Texas. Nearly flat-lying Comanche (mostly Lower Cretaceous) and Gulf (Upper Cretaceous) strata of the aquifer system thin northwestward atop generally massive pre-Cretaceous rocks that are comparatively impermeable and structurally complex. From predominately terrigenous clastic sediments in the east and terrestrial deposits in the west, the rocks of early Trinitian (Comanchean) age grade upward into supratidal and intertidal evaporitic and dolomitic rocks and shallow-marine, lagoonal, and basinal carbonate strata of late Trinitian, Fredericksburgian, and Washitan (Comanchean) age. A thick, downfaulted remnant of mostly open-shelf sediments of Eagle- fordian through Navarroan (Gulfian) age confines a small, southeast- ern part of the aquifer system. While clastic deposition prevailed upon alluvial plains inland of a westward-advancing Cretaceous sea, offshore environments were dominated by the biogenic accumulation of calcium carbonate in warm, generally clear seawater. The Trinity strata were deposited as the sea encroached upon the Llano uplift, the most prominent feature on a rolling peneplain composed of folded and faulted pre-Cretaceous rocks. The Fredericksburg and Washita strata mostly formed above the Llano uplift, on a carbonate platform sheltered from storm waves and deep ocean currents by the Stuart City reef trend. Subsequently, the entire study area was blanketed with mostly argillaceous sediments of the Eagle Ford, Austin, Taylor, and Navarro Groups. During late Oligocene through early Miocene time, large-scale normal faulting formed the Balcones fault zone, where the Cretaceous strata were displaced vertically, fractured intensively, and rotated dif- ferentially within a series of southwest-to-northeast trending fault blocks. Ground-water flow shifted toward the northeast in response to rejuvenated hydraulic gradients and high-angle barrier faults that blocked southeastward flow. Subsurface conduits lengthened i

Configuration of the base of the Edwards-Trinity aquifer system and hydrogeology of the underlying pre-Cretaceous rocks, west-central Texas

The Edwards-Trinity aquifer system is underlain by an extensive complex of rocks, ranging from Late Cambrian through Late Triassic in age, that are typically about 10 to perhaps 1,000 times less permeable than those composing the aquifer system. The Cretaceous rocks of the aquifer system are separated from the pre-Cretaceous rocks by an unconformity that spans about 60 million years of erosion during the Jurassic Period. The upper surface of the pre-Cretaceous rock complex forms the base of the Edwards-Trinity aquifer system. The configuration of the base reflects the original topography of the eroded pre-Cretaceous land surface plus the effects of subsequent deformation