11 research outputs found
Microfabrication of Ceramics by Co-extrusion
- Publication venue
- 'Wiley'
- Publication date
- 01/01/1998
- Field of study
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65777/1/j.1151-2916.1998.tb02307.x.pd
Aurora A–Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy
- Author
- Aggarwal Amit
- Baquero Carmen
- Barda David A.
- Barnard Darlene S.
- Beckmann Richard P.
- Bhagwat Shripad V.
- Bhattachar Shobha
- Bian Huimin
- Boehnke Karsten
- Bogner Sarah M.
- Buchanan Sean G.
- Campbell Robert M.
- Capen Andrew
- Chapman Sonya C.
- Chio Li-Chun
- Chu Shaoyou
- Dempsey Jack A.
- Dieter Matthew Z.
- Donoho Gregory P.
- Dowless Michele S.
- Du Jian
- Foreman Robert T.
- Gong Xueqian
- Halstead Bartley W.
- Henry James R.
- Hui Yu-Hua
- Iversen Phillip W.
- Kreklau Emiko L.
- Lallena Maria Jose
- Manro Jason R.
- Marshall Mark S.
- Martinez Ricardo
- Marugán Carlos
- Patel Bharvin K. R.
- Plowman Gregory D.
- Qian Yuewei
- Reinhard Christoph
- Stancato Louis F.
- Torres Raquel
- Van Horn Robert D.
- Walgren Jennie L.
- Webster Yue W.
- Yan Lei
- Yang Yanzhu
- Ye Xiang S.
- Zeng Yi
- Publication venue
- 'American Association for Cancer Research (AACR)'
- Publication date
- 01/12/2019
- Field of study
Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression. Aurora A depletion primarily leads to mitotic spindle formation defects and consequently prometaphase arrest, whereas Aurora B/C inactivation primarily induces polyploidy from cytokinesis failure. Aurora B/C inactivation phenotypes are also epistatic to those of Aurora A, such that the concomitant inactivation of Aurora A and B, or all Aurora isoforms by nonisoform–selective Aurora inhibitors, demonstrates the Aurora B/C-dominant cytokinesis failure and polyploidy phenotypes. Several Aurora inhibitors are in clinical trials for T/B-cell lymphoma, multiple myeloma, leukemia, lung, and breast cancers. Here, we describe an Aurora A–selective inhibitor, LY3295668, which potently inhibits Aurora autophosphorylation and its kinase activity in vitro and in vivo, persistently arrests cancer cells in mitosis, and induces more profound apoptosis than Aurora B or Aurora A/B dual inhibitors without Aurora B inhibition–associated cytokinesis failure and aneuploidy. LY3295668 inhibits the growth of a broad panel of cancer cell lines, including small-cell lung and breast cancer cells. It demonstrates significant efficacy in small-cell lung cancer xenograft and patient-derived tumor preclinical models as a single agent and in combination with standard-of-care agents. LY3295668, as a highly Aurora A–selective inhibitor, may represent a preferred approach to the current pan-Aurora inhibitors as a cancer therapeutic agent
A first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdollahi Hamed
- Abdullah Tala
- Abecasis Goncalo R.
- Abedalthagafi Malak
- Abul-Husn Noura S.
- Acquilini Donatella
- Adams Emma L.
- Adamsara Alireza
- Adeleye Olumide
- Adra Darin
- Afilalo Jonathan
- Afilalo Marc
- Afrasiabi Zaman
- Agüero Daiana
- Ahmadi Saeideh
- Akhtar Shaheen
- Aksentijevich Alexandra
- Al-Afghani Hani
- Al-Awdah Laila
- Alaamery Manal
- Alahmadey Ziab Z.
- Alaverdian Diana
- Alavere Helene
- Albader Anoud
- Albaiceta Guillermo M.
- Albakri Jehad K.
- AlBardis Hadeel
- Albeladi Maha
- Albesher Nour
- Albrich W. C.
- Albrich Werner
- AlDhawi Nouf
- Aleagha Afshar Etemadi
- Alghamdi Bader
- Alghamdi Jahad
- Ali Altaf
- Aliannejad Rasoul
- Aljawini Nora
- AlJohani Sameera
- Alkwai Sarah
- Allos Raili
- AlMalik Abdulaziz
- Almalki Faisal
- Almohammed Iman
- Almutairi Mansour
- Alotaibi Sara
- Alowayn Albandary M.
- Alqahtani Saleh
- Alqubaishi Fatimah
- Alrashed May
- Alshareef Abdulraheem
- Alsolm Ebtehal
- Alswailm Moneera
- AlZahrani Deema
- Amirsavadkouhi Ali
- Amitrano Sara
- Andolfo Immacolata
- Andretta Francesca
- Andreucci Elena
- Andrews Shea J.
- Anedda Federico
- Anemoli Valentina
- Angelantonio Emanuele Di
- Annis Aubrey
- Antinori Andrea
- Antoni Melania Degli
- Anwar Mohammad
- Arabi Yaseen M.
- Arciero Elena
- Armstrong Jacob
- Arning Nicolas
- Arranz Maria J.
- Arribas Elisa
- Artuso Rosangela
- Arumugam Prabhu
- Ascolillo Steven
- Ashraf Samina
- Atkinson Elizabeth G.
- Aucella Filippo
- Auld Daniel
- AZARZAR Samira
- Bachetti Tiziana
- Baillie J. Kenneth
- Balaconis Mary K.
- Baldassarri Margherita
- Ball Catherine A.
- Baltzell Asher Haug
- Band Gavin
- Bandini Maria
- Baraka Dona
- Baras Aris
- Baratti Stefano
- Barbieri Chiara
- Barda B.
- Bargagli Elena
- Barhoush Eman
- Barnes Kathleen C.
- Baroni Silvia
- Bartels Meike
- Bassetti Matteo
- Batini Chiara
- Baya Nikolas
- Beck Andrew
- Beckmann Noam D.
- Bedini Josep L.
- Bee Catherine E.
- Beguin Yves
- Belbin Gillian M.
- Belhaj Yasmine
- Beligni Giada
- Belisle Alexandre
- Belli Mary Ann
- Below Jennifer
- Benetti Elisa
- Bennett David
- Bergantini Laura
- Bergomi Paola
- Berkowitz Nathan
- Bernardo David
- Biagio Antonio Di
- Bianchi Francesco
- Bibert Stéphanie
- Bibert Stéphanie
- Biesecker Les
- Biscarini Filippo
- Blay Natalia
- Bochud M.
- Bochud P. Y.
- Bochud P. Y.
- Bochud Pierre-Yves
- Bochud Pierre-Yves
- Boezen Marike
- Boillat Noémie
- Boillat-Blanco N.
- Bottà Giordano
- Bouab Meriem
- Boughton Andrew P.
- Bouras K.
- Bradford Yuki
- Brahier T.
- Brassard Nathalie
- Breen Gerome
- Brenner Bluma
- Britvan Bari
- Brumpton Ben M.
- Bruno Raffaele
- Bruttini Mirella
- Bryant Sam
- Bryant Sam
- Buring Julie E.
- Busani Stefano
- Bussotti Maurizio
- Butler-Laporte Guillaume
- Butterworth Adam S.
- Buxbaum Joseph D.
- Caldarelli Gian Piero
- Callier Shawneequa
- Cameli Paolo
- Campbell Archie
- Campbell Archie
- Canaccini Anna
- Cantarini Luca
- Cantor Michael N.
- Capasso Mario
- Capitani Katia
- Cappelli Silvia
- Carella Massimo
- Carey Dave J.
- Carreras Anna
- Carriero Miriam Lucia
- Castaño-Vinyals Gemma
- Castelli Francesco
- Castori Marco
- Catena Emanuele
- Caulfield Mark J.
- Ceri Stefano
- Cerny A.
- Chamnanphon Monpat
- Chan Georgia
- Chang Xiao
- Chang Xiao
- Chariyavilaskul Pajaree
- Charney Alexander W.
- Chasman Daniel I.
- Chassot J.
- Chassé Michaël
- Chaudhary Kumardeep
- Chavan Sameer
- Chen Hung-Hsin
- Cheng Nathan
- Chetruengchai Wanna
- Chittoor Geetha
- Cho Judy H.
- Cho Kelly
- Choi Sam
- Chowdhury Maharun
- Chung Raymond
- Churchhouse Claire
- Chwialkowska Karolina
- Claassen Sabine
- Claringbould Annique
- Clerc O.
- Coignet Marie
- Coiro Gabriella
- Colligan Grainne
- Collins Brett L.
- Colobrán Roger
- Colombo Riccardo
- Conen A.
- Conticini Edoardo
- Cordioli Mattia
- Cordioli Mattia
- Corridi Marta
- Cortés Beatriz
- Cossarizza Andrea
- Coto Eliecer
- Coviello Domenico A.
- Croci Leonardo
- Croci Susanna
- Crook Derrick W.
- Crooks Kristy
- Crotti Lia
- Cullell Natalia
- Curtis Charles J.
- Cusick Caroline
- Cárcel-Márquez Jara
- Daga Sergio
- Dalmau David
- Daly Mark
- Daly Mark J.
- Danesh John
- Darcis Gilles
- Davis Lea
- Daya Michelle
- de Cid Rafael
- de Felipe Mimbrera Alicia
- de geus Eco E. J. C.
- de la Cal-Sabater Paloma
- DeDiego Marta L.
- Deelen Patrick
- Dei Simona
- Deloukas Panos
- Desanctis Elena
- Desgranges F.
- di Bartolomeo C.
- Dietl Beatriz
- Do Ron
- Dobaño Carlota
- Doddato Gabriella
- Domenico Paolo Di
- Domingo Carlos
- Domínguez-Mayoral Anna
- Donati Alice
- Donner Kati
- Durand Madeleine
- Durham Ceri
- D’Acremont V.
- D’Alessandro Miriana
- D’Arminio Monforte Antonella
- D’Mellow Kenton
- Earle Sarah G.
- Egger T.
- Eid Mohammed A.
- El-Jawhari Jehan J.
- El-Lawaty Walaa M.
- El-shanshory Mohamed R.
- El-Sherbiny Yasser M.
- Elhadidy Tamer A.
- Elnagdy Marwa H.
- Eltoukhy Madonna M.
- Emiliozzi Arianna
- Emma Duncan
- Erard Véronique
- Erard Véronique
- Esko Tõnu
- Estoppey Younes S.
- Fabbiani Massimiliano
- Falcone Marco
- Fallerini Chiara
- Farré Xavier
- Fava Francesca
- Fawns-Ritchie Chloe
- Fawns-Ritchie Chloe
- fawzy Mohammad S.
- Felemban Walaa A.
- Feng Yen-Chen Anne
- Feri Marco
- Fernandez-Cadenas Israel
- Ferreira Manuel A. R.
- Ferri Claudio
- Filipovic M.
- Filippidis P.
- Finer Sarah
- Finer Sarah
- Finucane Hilary
- Fiorentino Giuseppe
- Fiz-López Aida
- Forgetta Vincenzo
- Foucras S.
- Fowler Tom
- Franchi Federico
- Francisci Daniela
- Franco Giulianini
- Franke Lude
- Frediani Bruno
- Free Robert C.
- Frenckell Christian Von
- Friolet R.
- Frippiat Frédéric
- Frischknecht M.
- Frithiof Robert
- Frullanti Elisa
- Furini Simone
- Gabbi Chiara
- Gabrieli Arianna
- Gaddis Michael
- Galván-Femenía Iván
- Ganna Andrea
- Garcia-Aymerich Judith
- García-Clemente Marta
- García-Madrona Sebastian
- Gass Matthew C.
- Gatti Francesca
- Gaziano J. Michael
- Georges Michel
- Gettler Kyle
- Ghosh Biswarup
- Giannattasio Ferdinando
- Gignoux Christopher R.
- Giliberti Annarita
- Giorli Alessia
- Giot Jean-Baptiste
- Girardis Massimo
- Girshick Ahna
- Glessner Joseph R.
- Glessner Joseph T.
- Gofflot Stéphanie
- Goldstein Jacqueline I.
- Gomez Juan
- Gonseth Nussle S.
- González-Villa Esther
- Gori Marco
- Grassi Davide
- Green Robert C.
- Griffiths Chris
- Griffiths Christopher J.
- Grip Jonathan
- Guarnaccia Alessandra
- Guerrini Susanna
- Guidelli Luca
- Guillet A.
- Guindo-Martinez Marta
- Guiot Julien
- Guntz Julien
- Gupta Rahul
- Guturu Harendra
- Guyat-Jacques C.
- Guyatt Anna L.
- Guzman Charlotte
- Guéry B.
- Haefliger D.
- Hakonarson Hakon
- Hakonarson Hakon
- Halawani Roaa T.
- Harerimana Nadia
- Harris Jennifer R.
- Harthi Fawz Al
- Hasanato Rana
- Hayward Caroline
- Hayward Caroline
- Hegazy Mohamed A. F.
- Helgeland Øyvind
- Henry Danielle
- Hensen Kati
- Hiester Liam L.
- Hirankarn Nattiya
- Ho Yuk-Lam
- Hoggart Clive
- Hollox Edward J.
- Hong Eurie L.
- Horowitz Julie E.
- Hosseini Abdolmajid
- Hottenga Jouke Jan
- Huang Qin Qin
- Huang Qin Qin
- Huckins Laura M.
- Huffman Jennifer E.
- Hultström Michael
- Hunt Karen A.
- Hunt Karen A.
- Hurles Matt
- Hussain Shapna
- Huynen Pascale
- Hveem Kristian
- Hügli O.
- Iglesias Lara Lloret
- Ikram M. Arfan
- Iolascon Achille
- Islam Kamrul
- Itan Yuval
- Jacques Jessica
- Jantarabenjakul Watsamon
- Jaquet M.
- Jiménez-Xarrié Elena
- John Catherine
- Jordan Daniel M.
- Josyula Navya Shilpa
- Jung Junghyun
- Justice Anne E.
- Kahlert C. R.
- Kallaste Anne
- Kamdar Dhryata
- Kamdar Dhryata
- Kampouri E. E.
- Kanai Masahiro
- Kanai Masahiro
- Karczewski Konrad J.
- Karjalainen Juha
- Karlson Elizabeth W.
- Karp Avromie
- Kaufmann Daniel E.
- Kaunisto Mari
- Keller Katherine
- Kenny Eimear E.
- Kerchberger V. Eric
- Kerr Shona M.
- Khafaga Walid T.
- Khan Ahsan
- Khan Amara
- Khattab Amin K.
- Kimchi Nofar
- King Daniel
- Kisand Kai
- Kivinen Katja
- Kleger G-R.
- Knapp C.
- Knight Spencer
- Koelling Nils
- Kogevinas Manolis
- Koskelainen Sami
- Kosmicki Jack A.
- Kousathanas Athanasios
- Kristiansson Kati
- Laane Edward
- Labkowsky Alexander
- Laisk Triin
- Lambermont Bernard
- Lannepoudenx Y.
- Lanting Pauline
- Lathrop G. Mark
- Lauren Petty E.
- Laurent Laetitia
- Lavery Cath
- Leader Joseph B.
- Lee Paul H.
- Lee Sang Hyuck
- Lee Sulggi
- Lee Yunsung
- LeFaive Jonathon
- Lena Fabio
- Lepage Pierre
- Lepamets Maarja
- Lerner Robin
- Levy Tess
- Li Binglan
- Li Kevin W.
- Li Rui
- Liao Rachel G.
- Lin Shang-Kuan
- Lipcsey Miklos
- Lista Mirjam
- Llucià-Carol Laia
- Loos Ruth J. F.
- Lopera Esteban
- Lorubbio Maria
- Lozano Francisco
- Lu Wenhan
- Lucas Anastasia
- Luchi Sauro
- Ludovisi Serena
- Läll Kristi
- Léonard Philippe
- MacArthur Daniel
- MacLaughlin Bev
- Maggiolo Franco
- Magnus Per
- Mahmoud Ebrahim S.
- Malaise Olivier
- Mamlouk Noor
- Mancarella Sandro
- Mandalà Marco
- Mangino Massimo
- Mangul Serghei
- Manson JoAnn E.
- Mantovani Stefania
- Manuel O.
- Marcantonio Simona
- MARCHETTI Oreste
- Marciano Carmen
- Mari Francesca
- Maricic Tomislav
- Martin Alicia R.
- Martin Hilary
- Martin Hilary C.
- Martinelli Enrico
- Martí-Fàbregas Joan
- Martín-Nalda Andrea
- Martínez Alba Parra
- Masjuan Jaime
- Mason Dan
- Mason Dan
- Massadeh Salam
- Masucci Luca
- Mazzei Maria Antonietta
- McCormick Joseph B.
- McCurdy Shannon
- Medina-Gomez Carolina
- Meigs James B.
- Meloni Ilaria
- Menatti Elisabetta
- Mencarelli Maria Antonietta
- Menéndez-Valladares Paloma
- Mercader Josep
- Mercader Josep Maria
- Merla Giuseppe
- Metsalu Kristjan
- Metspalu Andres
- Meuris Christelle
- Meuwly J. Y.
- Miah Shefa
- Milani Lili
- Miraglia Federica Gaia
- Mirshahi Tooraj
- Misset Benoît
- Moahmed Hanteera S.
- Moghaddam Seyed Behrooz Mohseni
- Mohamed Attia A. S.
- Mondelli Mario Umberto
- Monica Matteo Della
- Montagnani Francesca
- Montillier P.
- Mooser Vincent
- Moreno Victor
- Morris Marcela
- Morrison David R.
- Moutschen Michel
- Moutsianas Loukas
- Muiño Elena
- Munting A.
- Murphy Shawn N.
- Mussini Cristina
- Mutairi Amal Al
- Márquez Leonardo
- Mägi Reedik
- Naaber Paul
- Naderpour Zeinab
- Nadkarni Girish N.
- Nakanishi Tomoko
- Neale Benjamin M.
- Neale Benjamin M.
- Negro T. Rochat
- Nencioni Cesira
- Neofytos Dionysios
- Neofytos Dionysios
- Newman Bill
- Nguyen Huy
- Niavarani Ahmadreza
- Niblo Kristi
- Niemi Mari E. K.
- Nilaratanakul Voraphoj
- Nivard Michel M. G.
- Nkambul Lindo
- Nkambul Lindokuhle
- Nkambule Lindokuhle
- Nkambule Lindokuhle
- North Kari
- Noto Keith
- Nussle Semira Gonseth
- Oddo M.
- Odhams Christopher A.
- Ognibene Agostino
- Okasha Kamal
- Oliveira Maureen
- Ori Anil P. S.
- O’Connell Anne Marie
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- O’Mahony L.
- O’Reilly Paul
- Paciosi Francesco
- Packer Richard J.
- Pagani J. L.
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- Palmer Duncan S.
- Palmieri Maria
- Palotie Aarno
- Palotie Aarno
- Pancrazzi Alessandro
- Panese Sandro
- Pantet O.
- Papadimitriou-Olivgeris M.
- Parati Gianfranco
- Parisi Saverio Giuseppe
- Park Danny
- Parravicini Pierpaolo
- Partha Raghavendran
- Pasko Dorota
- Pathak Gita A.
- Pavlovic Milos
- Peloso Gina
- Perez Emma F.
- Perez-Tur Jordi
- Perna Rita
- Perola Markus
- Perrella Antonio
- Perret A.
- Peruggia Michael
- Pessina Gloria
- Pesukova Jaana
- Peterson Pärt
- Petitjean Louis
- Petrocelli Paola
- Phokaew Chureerat
- Piacentini Paolo
- Picchiotti Nicola
- Pietro Massimo Di
- Pigazzini Sara
- Pinoli Pietro
- Pinto Anna Maria
- Pirinen Matti
- Piscopo Carmelo
- Planas Anna M.
- Polikowski Hannah
- Polimanti Renato
- Polymeropoulos Christos
- Polymeropoulos Mihael H.
- Polymeropoulos Vasilios
- Pongpanich Monnat
- Porteous David J.
- Porteous David J.
- Portopena L.
- Poscente Monica
- Preuss Michael
- Priest James
- Przychodzen Bartlomiej P.
- Pugin J.
- Putchareon Opass
- Puthanakit Thanyawee
- Puusepp Mairo
- Quinodoz Mathieu
- Quinodoz Mathieu
- Quiros-Roldan Eugenia
- Rader Daniel
- Rafaels Nicholas
- Raggi Pamela
- Ragoussis Jiannis
- Rahmouni Souad
- Raimondi Francesco
- Rancan Ilaria
- Rand Kristin
- Ravaglia Sabrina
- Regina J.
- Reimann Ene
- Rendon Augusto
- Renieri Alessandra
- Rezk Nardin
- Rhead Brooke
- Rhodes Daniel
- Richards J. Brent
- Richmond Anne
- Richmond Anne
- Rico Veronica
- Ridker Paul M.
- Rime M.
- Ringmets Inge
- Ripamonti Diego
- Ripatti Samuli
- Ritchie Marylyn D.
- Riva Agostino
- Rivolta Carlo
- Rivolta Carlo
- Rizzi Marco
- Rizzo Caterina Lo
- Roberts Genevieve
- Robles Veronica
- Rochat-Stettler L.
- Rogne Tormod
- Rojo Silvia
- Romani Davide
- Rooyackers Olav
- Rossetti Barbara
- Rovere Maria Teresa La
- Rudkin Justine K.
- Ruiz Luong
- Ruiz-Jaén Francisca
- Ruotsalainen Sanni
- Rusconi Stefano
- Russo Roberta
- Sabrina Ravaglia
- Saeedi Morteza
- Safa Nishat
- Safieh Leen Abu
- Salerni Lorenzo
- Salib Irene
- Samir Amr
- Sanarico Maurizio
- Sanguinetti Maurizio
- Sankaran Vijay G.
- Sarma Gopal
- Sarno Laura Di
- Sarzi-Braga Simona
- Satterstrom F. Kyle
- Sauvage Anne-Sophie
- Sawaji Mona
- Scaggiante Renzo
- Scala Raffaele
- Schadt Eric E.
- Schiaroli Elisabetta
- Schurr Erwin
- Scolletta Sabino
- Scott Richard H.
- Scotton Pier Giorgio
- Sealfon Stuart C.
- Sebra Robert P.
- Seed Cotton
- Segala Francesco Vladimiro
- Segura Tomás
- Serra-Llovich Alex
- Serrano-Heras Gemma
- Sesso Howard D.
- Shahin Doaa
- Sharififard Bahareh
- Shaw Douglas M.
- Shortt Jonathan
- Shotelersuk Vorasuk
- Shrine Nick
- Siano Matteo
- Sloofman Laura G.
- Smieszek Sandra P.
- Smith Albert V.
- Smoller Jordan W.
- Sobh Ali
- Sodsai Pimpayao
- Soler Pere
- Solligard Erik
- Solomonson Matthew
- Solomonson Matthew
- Soranzo Nicole
- Soriano Alex
- Spargi Genni
- Spector Tim D.
- Spencer Chris C. A.
- Spertilli Chiara
- Squeo Gabriella Maria
- Starkopf Joel
- Stella Alessandra
- Stevens Christine
- Stuckey Alex
- Suardi Claudia
- Suchartlikitwong Pintip
- Suh N.
- Suh Noémie
- Suliman Bandar A.
- Sumoy Lauro
- Sun Yan V.
- Suttels V.
- Suttichet Thitima B.
- Tabri Jekaterina
- Tacconi Danilo
- Tadi Hengameh Ansari
- Tadini E.
- Tahmasebi Farah
- Tamm Anu
- Tanfoni Marco
- Tang Lara
- Tardif Nicolas
- Tavecchia Luisa
- Tenesa Albert
- Thompson Ryan C.
- THYS Marie
- Timmers Paul R. H. J.
- Tiseo Giusy
- Tita Rossella
- Tobin Martin D.
- Tommasi Andrea
- Torky Mohamed S.
- Torrents David
- Torvorapanit Pattama
- Trankiem Amy
- Trembath Richard C.
- Trembath Richard C.
- Trivedi Bhavi
- Trivedi Bhavi
- Trogstad Lill-Iren S.
- Trotta Tullio
- Tsao Phil
- Tschopp J.
- Tselios Chris
- Tsuo Kristin
- Tumbarello Mario
- Turley Patrick
- Uitterlinden Andre G.
- Underwood Slayton J.
- Vaghi Massimo
- Valente Serafina
- Valentino Floriana
- van Blokland Irene
- van Heel David
- van Heel David A.
- van Heel David A.
- Van Singer M.
- Vecchia Marco
- Veerapen Kumar
- Venn Laura D.
- Venturelli Sophie
- Vergori Alessandra
- Verma Anurag
- Verma Shefali S.
- Verzuri Agnese
- Viala B.
- Villalonga Joan Montaner
- Vincenti Antonella
- Viollet R. Merlet
- Vivo Oreste De
- Voide Cathy
- Voide Cathy
- Vollenweider P.
- Vollenweider P.
- von Hohenstaufen Kathrin Aprile
- von Mering C.
- Vonk Judith. M.
- Vulesevic Branka
- Wain Louise V.
- Walker Susan
- Walters Raymond K.
- Wang Jiongming
- Wang Xueyang
- Wanying Zhu
- Warmerdam Robert
- Weiss Scott T.
- Wicks Stephen J.
- Willer Cristen
- Williams Alexander T.
- Wilson Daniel J.
- Wilson James F.
- Wolford Brooke
- Wolford Brooke
- Wolford Brooke
- Woolley Ann E.
- Wozniak H.
- Wright John
- Wright John
- Wyllie David H.
- Xue Xiaoqing
- Yadav Ashish
- Yassen Amr M.
- Zanella Isabella
- Zeberg Hugo
- Zguro Kristina
- Zhang Miao
- Zhao Jing Hua
- Zhou Wei
- Zhou Wei
- Zlatopolsky Menachem
- zu Bentrup F. Meyer
- Zucchi Patrizia
- Zyndorf Marissa
- Zöllner Sebastian
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
peer reviewe
Is serum‐derived exosomal hTERT transcript a marker of oncogenic activity in primary brain tumors? An exploratory study
- Author
- Publication venue
- Wiley
- Publication date
- 01/01/2024
- Field of study
Abstract Background In order to proliferate indefinitely, all tumors require a telomere maintenance mechanism. The expression of human telomerase reverse transcriptase (hTERT) enables telomere maintenance and provides cancer cells with limitless replicative potential. As such, it may serve as an attractive biomarker for oncogenic activity. This study explored whether a liquid biopsy that analyses blood derived exosomal hTERT transcript (e‐hTERT‐trans) may serve as such a biomarker in gliomas and meningiomas when compared to healthy controls. Methods Exosomes were isolated from the pre‐operative sera of patients' samples stored in the biobank of both Rabin and Sheba Medical Centers. The levels of e‐hTERT‐trans were measured in 81 healthy controls, 117 meningiomas, 17 low‐grade gliomas, and 61 glioblastomas. Clinical parameters of the patients were collected retrospectively and compared to the levels of the e‐hTERT‐trans. Results The upper normal limit of controls e‐hTERT‐trans was 1.85 relative quantitation (RQ). The rate of detection increased with rising tumor grade and correlated with tumor recurrence in meningiomas: mean RQ without recurrence (2.17 ± 11.7) versus with recurrence (3.59 ± 4.42; p = 0.002). In glioblastomas, preoperative measurements correlated with tumor volume and with the disease course on serial sampling. Conclusions We demonstrated for the first time that the expression of e‐hTERT‐trans transcript can be measured in the serum of primary brain tumors. This exosomal marker carries the potential to serve as a biomarker once used in conjunction with other clinical and radiological parameters. Future studies are required to investigate whether the sensitivity could be augmented and whether it can be implemented into routine patients care
Mapping the human genetic architecture of COVID-19
- Author
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- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
Identifying thresholds for classifying moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR
- Author
- Ahmed Zeynudin
- Andrew C. Kotze
- Antonio Montresor
- AV Easton
- B Barda
- B Barda
- B Levecke
- B Levecke
- B Nikolay
- B Speich
- Bertrand Guillard
- Bruno Levecke
- Cécile Angebault
- Dang Thi Cam Thach
- Daniel Dana
- Deepthi Kattula
- DJ Hoekendijk
- EM O'Connell
- Eurion Thomas
- G Cringoli
- G Cringoli
- Gagandeep Kang
- GBD 2015
- GBD 2017 DALYs and HALE Collaborators
- Giuseppe Cringoli
- Greg Mirams
- J Bethony
- J Vercruysse
- J Vlaminck
- J Vlaminck
- Jaco J. Verweij
- James S. McCarthy
- Jeffrey M. Bethony
- Jennifer Keiser
- Jerzy M. Behnke
- JJ Verweij
- JJ Verweij
- Johnny Vlaminck
- Jozef Vercruysse
- Laura Rinaldi
- Laurentine Sumo
- Leonardo F. Matoso
- Louis-Albert Tchuem-Tchuenté
- M Ayana
- M Ayana
- M Papaiakovou
- M Papaiakovou
- Marco Albonico
- Maria P. Maurelli
- Maria V. Periago
- Matthew C Freeman
- MD Lim
- Mio Ayana
- MMM Kaisar
- Nguyen Thi Viet Hoa
- P Cools
- Piet Cools
- PJ Diggle
- Rodrigo Corrêa Oliveira
- S Llewellyn
- Shaali Ame
- Simone A. Pinto
- Somphou Sayasone
- TA Alonzo
- W Moser
- X Robin
- Zeleke Mekonnen
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling
- Author
- A Babich
- A Babich
- A Grakoui
- A Zanin-Zhorov
- AH Sharpe
- Alan D. Leard
- Andrew Herman
- B Purtic
- BF Lillemeier
- C Wülfing
- Christoph Wülfing
- CR Monks
- D Dombroski
- Danielle J. Clark
- DD Billadeau
- E Sherman
- Emily M. Mace
- GD Rak
- GM Griffiths
- I Tskvitaria-Fuller
- I Tskvitaria-Fuller
- I Tskvitaria-Fuller
- I Tskvitaria-Fuller
- J Yi
- JA Rosado
- JC Nolz
- JK Burkhardt
- Jon C.D. Houtman
- Jordan S. Orange
- KL McDonald
- KL Singleton
- KL Singleton
- KL Singleton
- Kole T. Roybal
- KQ Liu
- KT Roybal
- LI Salazar-Fontana
- LJ Berg
- M Barda-Saad
- MM Davis
- MR Bubb
- Paul Verkade
- R Varma
- RS Flannagan
- TA Lyubchenko
- W Paster
- Y Kaizuka
- Y Kim
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Aurora A–Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy
- Author
- Amit Aggarwal
- Andrew Capen
- Bartley W. Halstead
- Bharvin K.R. Patel
- Carlos Marugán
- Carmen Baquero
- Chen
- Christoph Reinhard
- Darlene S. Barnard
- David A. Barda
- de Groot
- Dickson
- Emiko L. Kreklau
- Goldenson
- Gregory D. Plowman
- Gregory P. Donoho
- Huimin Bian
- Jack A. Dempsey
- James R. Henry
- Jason R. Manro
- Jennie L. Walgren
- Jian Du
- Karsten Boehnke
- Karthigeyan
- Lei Yan
- Li-Chun Chio
- Louis F. Stancato
- Maria Jose Lallena
- Mark S. Marshall
- Matthew Z. Dieter
- Michele S. Dowless
- Nair
- Opyrchal
- Phillip W. Iversen
- Raquel Torres
- Ren
- Ricardo Martinez
- Richard P. Beckmann
- Robert D. Van Horn
- Robert M. Campbell
- Robert T. Foreman
- Sarah M. Bogner
- Sean G. Buchanan
- Shaoyou Chu
- Shobha Bhattachar
- Shripad V. Bhagwat
- Sonya C. Chapman
- Venkatakrishnan
- Xiang S. Ye
- Xueqian Gong
- Yanzhu Yang
- Yi Zeng
- Yu-Hua Hui
- Yue W. Webster
- Yuewei Qian
- Publication venue
- 'American Association for Cancer Research (AACR)'
- Publication date
- Field of study
COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19
- Author
- A Cerny (13566592)
- A Conen (13566478)
- A Guillet (13566487)
- A Munting (13566535)
- A Perret (13566628)
- Aarno Palotie (41342)
- Abdolmajid Hosseini (13566952)
- Abdulaziz AlMalik (5215085)
- Abdulraheem Alshareef (3532520)
- Achille Iolascon (206310)
- Adam S Butterworth (3810055)
- Afshar Etemadi Aleagha (13566937)
- Agnese Verzuri (13566721)
- Agostino Ognibene (5624702)
- Agostino Riva (393458)
- Ahmadreza Niavarani (711998)
- Ahna Girshick (13566238)
- Ahsan Khan (12068159)
- Aida Fiz-Lopez (13567297)
- Alba Parra Martinez (13567294)
- Albandary M Alowayn (13567099)
- Albert Smith (5520185)
- Albert Tenesa (107674)
- Alessandra Guarnaccia (13566751)
- Alessandra Renieri (383439)
- Alessandra Stella (28791)
- Alessandra Vergori (4540474)
- Alessandro Pancrazzi (13566727)
- Alessia Giorli (13566760)
- Alex Serra-Llovich (13567288)
- Alex Soriano (3091062)
- Alex Stuckey (13567192)
- Alexander Labkowsky (13567030)
- Alexander T Williams (8950472)
- Alexander W Charney (13567054)
- Alexandra Aksentijevich (13567027)
- Alexandre Belisle (13566310)
- Ali Amirsavadkouhi (13566931)
- Ali Sobh (13566367)
- Alice Donati (6876746)
- Alicia de Felipe Mimbrera (13567321)
- Alicia R Martin (12556807)
- Alireza Adamsara (13566946)
- Altaf Ali (13566445)
- Amal Al Mutairi (13567102)
- Amara Khan (10835145)
- Amin K Khattab (13567138)
- Amr M Yassen (13566409)
- Amr Samir (13566385)
- Amy Trankiem (13566163)
- Anastasia Lucas (3118140)
- Andre G Uitterlinden (8950781)
- Andrea Antinori (103654)
- Andrea Cossarizza (295123)
- Andrea Ganna (419008)
- Andrea Martin-Nalda (8583555)
- Andrea Tommasi (7884968)
- Andres Metspalu (61760)
- Andrew Beck (389972)
- Andrew P Boughton (13566916)
- Anil PS Ori (13566979)
- Ann E Woolley (13566982)
- Anna Canaccini (13566718)
- Anna Carreras (2111431)
- Anna Dominguez-Mayoral (13567327)
- Anna L Guyatt (8810699)
- Anna M Planas (8560464)
- Anna Maria Pinto (10764936)
- Annarita Giliberti (9265079)
- Anne E Justice (9357193)
- Anne Kallaste (13566439)
- Anne Marie O'Connell (13567225)
- Anne Richmond (5854361)
- Anne-Sophie Sauvage (11397734)
- Annique Claringbould (4798920)
- Anoud Albader (13567165)
- Antonella D'Arminio Monforte (13566733)
- Antonella Vincenti (13566796)
- Antonio Di Biagio (316138)
- Antonio Perrella (13566790)
- Anu Tamm (9759596)
- Anurag Verma (669308)
- Archie Campbell (669891)
- Arianna Emiliozzi (9656599)
- Arianna Gabrieli (129726)
- Aris Baras (5542184)
- Asher Haug Baltzell (13566241)
- Ashish Yadav (1585054)
- Athanasios Kousathanas (493642)
- Attia AS Mohamed (13566373)
- Aubrey Annis (13566922)
- Augusto Rendon (147779)
- Avromie Karp (13567033)
- B Barda (11168379)
- B Guery (13566523)
- B Viala (13566559)
- Bader Alghamdi (13231077)
- Bahareh Sharififard (12287944)
- Bandar A Suliman (13567114)
- Barbara Rossetti (2817193)
- Bari Britvan (10879598)
- Bartlomiej P Przychodzen (13567243)
- Beatriz Cortes (13566640)
- Beatriz Dietl (13567285)
- Ben M Brumpton (8453574)
- Benjamin M Neale (3809995)
- Benoit Misset (3496388)
- Bernard Lambermont (685528)
- Bev MacLaughlin (13566898)
- Bhavi Trivedi (13566865)
- Bill Newman (13566904)
- Binglan Li (10702138)
- Biswarup Ghosh (9302363)
- Bjorn Olav Asvold (8616621)
- Bluma Brenner (641164)
- Branka Vulesevic (474225)
- Brett L Collins (13567015)
- Brooke Rhead (5917274)
- Brooke Wolford (10217251)
- Bruno Frediani (7377530)
- C di Bartolomeo (13566634)
- C Guyat-Jacques (13566490)
- C Knapp (13566622)
- C von Mering (13566598)
- Carlo Rivolta (121162)
- Carlos Domingo (10956519)
- Carlota Dobano (13566646)
- Carmelo Piscopo (8976893)
- Carmen Marciano (13566826)
- Carolina Medina-Gomez (152852)
- Caroline Cusick (13566265)
- Caroline Hayward (149856)
- Caterina Lo Rizzo (10764927)
- Cath Lavery (13566889)
- Catherine A Ball (13566217)
- Catherine E Bee (8950487)
- Catherine John (7757003)
- Cathy Voide (10898880)
- Ceri Durham (13566880)
- Cesira Nencioni (13566700)
- Charles J Curtis (13566871)
- Charlotte Guzman (13566298)
- Chiara Barbieri (573298)
- Chiara Batini (3259911)
- Chiara Fallerini (9265073)
- Chiara Gabbi (625063)
- Chiara Spertilli (13566685)
- Chloe Fawns-Ritchie (2624947)
- Chris CA Spencer (13567216)
- Chris Griffiths (119288)
- Chris Tselios (13566304)
- Christelle Meuris (11397737)
- Christian Von Frenckell (13566283)
- Christine Stevens (401796)
- Christopher A Odhams (13567195)
- Christopher J Griffiths (13566913)
- Christopher J O'Donnell (7949609)
- Christopher R Gignoux (13566346)
- Christos Polymeropoulos (13567234)
- Chureerat Phokaew (16229)
- Claire Churchhouse (6204794)
- Claudia Suardi (13566841)
- Claudio Ferri (8615857)
- Clive Hoggart (256669)
- Cotton Seed (7865942)
- CR Kahlert (13566607)
- Cristen Willer (189988)
- Cristina Mussini (237788)
- D Haefliger (13566526)
- Daiana Aguero (13567264)
- Dan Mason (3438803)
- Daniel Auld (7300523)
- Daniel Chasman (198704)
- Daniel E Kaufmann (13566319)
- Daniel J Wilson (3183402)
- Daniel King (1964263)
- Daniel M Jordan (13567039)
- Daniel MacArthur (3577367)
- Daniel Rader (3550616)
- Daniel Rhodes (1467298)
- Daniela Francisci (167519)
- Danielle Henry (13566292)
- Danilo Tacconi (146800)
- Danny Park (9565462)
- Darin Adra (13566307)
- Dave J Carey (13567078)
- David A van Heel (13566856)
- David Bennett (69181)
- David Bernardo (164703)
- David Dalmau (221136)
- David H Wyllie (13567222)
- David J Porteous (7948334)
- David R Morrison (13566286)
- David Torrents (17960)
- David van Heel (187571)
- Davide Grassi (7835198)
- Davide Romani (13566793)
- Deema AlZahrani (13567156)
- Derrick W Crook (9552821)
- Dhryata Kamdar (13566454)
- Diana Alaverdian (11283260)
- Diego Ripamonti (3844000)
- Dionysios Neofytos (759954)
- Doaa Shahin (13566355)
- Domenico A Coviello (13566775)
- Dona Baraka (13567120)
- Donatella Acquilini (13566850)
- Dorota Pasko (3810187)
- Douglas M Shaw (13566325)
- Duncan Emma (13567186)
- Duncan S Palmer (13566187)
- E Tadini (13566550)
- Ebrahim S Mahmoud (13567135)
- Ebtehal Alsolm (13567096)
- Eco EJC de Geus (13567081)
- Edoardo Conticini (9656608)
- Edward J Hollox (7692299)
- Edward Laane (13566427)
- EE Kampouri (13566529)
- Eimear E Kenny (13567051)
- Elena Andreucci (224653)
- Elena Arciero (840544)
- Elena Bargagli (8467728)
- Elena Desanctis (13566709)
- Elena Jimenez-Xarrie (13567318)
- Elena Muino (13567249)
- Eliecer Coto (58914)
- Elisa Arribas (13567300)
- Elisa Benetti (3804865)
- Elisa Frullanti (553477)
- Elisabetta Menatti (13566832)
- Elisabetta Schiaroli (167530)
- Elizabeth G Atkinson (12556642)
- Elizabeth W Karlson (9559317)
- Eman Barhoush (79416)
- Emanuele Catena (9333452)
- Emanuele Di Angelantonio (79027)
- Emma F Perez (13566988)
- Emma L Adams (8950484)
- Ene Reimann (667292)
- Enrico Martinelli (13566838)
- Eric E Schadt (13567012)
- Erik Solligard (13566967)
- Erwin Schurr (238686)
- Esteban Lopera (13566970)
- Esther Gonzalez-Villa (13567312)
- Eugenia Quiros-Roldan (363429)
- Eurie L Hong (13566235)
- F Desgranges (13566517)
- F Kyle Satterstrom (13566196)
- F Meyer zu Bentrup (13566475)
- Fabio Lena (13566835)
- Faisal Almalki (8101943)
- Farah Tahmasebi (13566910)
- Fatimah Alqubaishi (8604696)
- Fawz Al Harthi (13567093)
- Federica Gaia Miraglia (13566736)
- Federico Anedda (9656602)
- Federico Franchi (4355680)
- Ferdinando Giannattasio (13566766)
- Filippo Aucella (821349)
- Filippo Biscarini (3167496)
- Floriana Valentino (9265076)
- Francesca Andretta (13566745)
- Francesca Fava (1739860)
- Francesca Gatti (182206)
- Francesca Mari (383438)
- Francesca Montagnani (459741)
- Francesco Bianchi (13566664)
- Francesco Castelli (746687)
- Francesco Paciosi (13566739)
- Francesco Raimondi (228519)
- Francesco Vladimiro Segala (9338937)
- Francisca Ruiz-Jaen (13567270)
- Francisco Lozano (253720)
- Franco Maggiolo (372561)
- Frederic Frippiat (13566277)
- G Mark Lathrop (13566313)
- G-R Kleger (13566604)
- Gabriella Coiro (13566772)
- Gabriella Doddato (10764909)
- Gabriella Maria Squeo (13566820)
- Gavin Band (415106)
- Geetha Chittoor (716141)
- Gemma Castano-Vinyals (13566643)
- Gemma Serrano-Heras (13016304)
- Genevieve Roberts (9596631)
- Genni Spargi (13566694)
- Georgia Chan (13567198)
- Gerome Breen (15025)
- Giada Beligni (11283254)
- Gian Piero Caldarelli (13566715)
- Gianfranco Parati (299443)
- Gilles Darcis (777607)
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- Serena Ludovisi (13566814)
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- Sergio Daga (11283239)
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- Shaheen Akhtar (192582)
- Shang-Kuan Lin (13567207)
- Shannon McCurdy (11944312)
- Shapna Hussain (13566886)
- Shawn N Murphy (4802670)
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- Shea J Andrews (13566199)
- Shefa Miah (13566901)
- Shefali S Verma (13567090)
- Shona M Kerr (8950520)
- Silvia Baroni (2156290)
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- Simona Dei (13566808)
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- Simone Furini (173392)
- Slayton J Underwood (13566208)
- Sophie Venturelli (9326809)
- Souad Rahmouni (320501)
- Spencer Knight (13566223)
- Stefania Mantovani (202342)
- Stefano Baratti (13566817)
- Stefano Busani (735718)
- Stefano Ceri (3614225)
- Stefano Rusconi (237803)
- Stephanie Bibert (316131)
- Stephanie Gofflot (790863)
- Stephen J Wicks (13566349)
- Steven Ascolillo (13566991)
- Stuart C Sealfon (13566205)
- Sulggi Lee (5979596)
- Susan Walker (469919)
- Susanna Croci (11283263)
- Susanna Guerrini (13566682)
- T Brahier (13566565)
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- Tala Abdullah (10905739)
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- Victor Moreno (748751)
- Vijay G Sankaran (13566175)
- Vincent Mooser (47546)
- Vincenzo Forgetta (756326)
- Voraphoj Nilaratanakul (13566964)
- Vorasuk Shotelersuk (581000)
- Walaa A Felemban (13567150)
- Walaa M El-Lawaty (13566397)
- Walid T Khafaga (13566394)
- Wanna Chetruengchai (9659225)
- Wanying Zhu (1567963)
- Watsamon Jantarabenjakul (9504660)
- WC Albrich (13566586)
- Wei Zhou (24328)
- Wenhan Lu (8908976)
- Werner Albrich (5541584)
- Xavier Farre (10317580)
- Xiao Chang (43560)
- Xiaoqing Xue (6116318)
- Xueyang Wang (6813818)
- Y Lannepoudenx (13566508)
- Yan Sun (22436)
- Yaseen M Arabi (12041017)
- Yasmine Belhaj (13566250)
- Yasser M El-Sherbiny (13566358)
- Yen-Chen Anne Feng (9983636)
- Yuk-Lam Ho (7010873)
- Yuki Bradford (496693)
- Yunsung Lee (10670517)
- Yuval Itan (260527)
- Yves Beguin (264097)
- Zaman Afrasiabi (10905751)
- Zeinab Naderpour (10054118)
- Ziab Z Alahmadey (13567144)
- Publication venue
- Publication date
- 03/08/2022
- Field of study
The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.</p
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
- Acquilini D
- Acquilini D
- Adachi T
- Adachi Y
- Adams C
- Adams K
- Adanini O
- Adeleye O
- Adeniji K
- Adra D
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agranoff D
- Agrawal S
- Aguirre LA
- Agwuh K
- Ahmad HF
- Ahmad N
- Ahmed A
- Ahmed C
- Ahmed KA
- Ai M
- Ail D
- Akeroyd L
- Akhtar MN
- Akhtar S
- Akinkugbe O
- Aksentijevich A
- Al Thani A
- Al-Muftah W
- Al-Sarraj Y
- Alarcon C
- Alarcon-Riquelme ME
- Alasdair F
- Alaverdian D
- Alavere H
- Albertos R
- Albillos A
- Albrecht W
- Albrich W
- Albrich WC
- Aldera EL
- Aldridge J
- Alegria A
- Alex B
- Alexander P
- Alfonso J
- Algera AG
- Ali A
- Ali IMA
- Ali S
- Aliberti S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen S
- Allibone S
- Allison KS
- Allos R
- Ally SM
- Almaden-Boyle C
- Altabaibeh A
- Altmueller J
- Alvaro A
- Amar D
- Amin V
- Amitrano S
- Amiya S
- Ampuero J
- Anan R
- Anania S
- Anastasescu E
- Anderson F
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andolfo I
- Andrade V
- Andretta F
- Andreucci E
- Andreucci E
- Andrew A
- Andrew B
- Andrew G
- Andrews E
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrikopoulos P
- Anedda F
- Aneli S
- Anemoli V
- Angelini C
- Angus B
- Annis A
- Antcliffe D
- Antinori A
- Antoni MD
- Anumakonda V
- Anwar M
- Anzai T
- Apetri E
- Arai D
- Arana E
- Arbane G
- Archer K
- Arciero E
- Arden T
- Arias SS
- Arif S
- Arimura K
- Armstrong J
- Armstrong JA
- Armstrong L
- Armstrong R
- Arning N
- Arnold S
- Arora J
- Artuso R
- Arumugam P
- Asakura T
- Asano K
- Aschard H
- Ascolillo S
- Ashish A
- Ashley E
- Ashraf S
- Ashraf S
- Ashton L
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- Costantino G
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- De la Horra C
- De Neef M
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- Zanelli G
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- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease