Thermoelastic instability in planar solidification

A linear perturbation method is used to examine the stability of a unidirectional solidification problem in which a liquid, initially at the melting temperature, becomes solidified by heat transfer across a pressure-dependent thermal contact resistance to a plane mold. The contact pressure will be influenced by thermal distortion in response to the instantaneous temperature field in the solidified shell. The heat transfer and thermal stress problems are therefore coupled through the boundary conditions.The temperature and stress fields are assumed to consist of a unidirectional component and a small spatially-sinusoidal perturbation which can vary with time. Analysis of the thermoelastic problem for the solidified shell leads to an ordinary differential equation relating the perturbation in heat flux at the mold/casting interface and the corresponding perturbation in contact pressure. A second equation relating the same two variables is obtained by linear perturbation of the relation for heat conduction across the thermal contact resistance. These are then reduced to a single equation which is solved numerically. The results show that a small initial perturbation will grow substantially during the solidification process if the thermal contact resistance is very sensitive to pressure.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29652/1/0000741.pd

Dependence of Tc_{c} of YBa2_{2} Cu3_{3} O6.67_{6.67} on in-plane uniaxial stress

We probe the effect on $T_c$ of in-plane uniaxial stress applied to the high-temperature superconductor $YBa_2Cu_3O_{6.67}$. We find a highly anisotropic response. Under compression along the $b$ axis, which reduces the orthorhombicity of the $CuO_2$ planes, $T_c$ is broadly flat for stresses up to at least 1.7 GPa. Under compression along the $a$ axis, $T_c$ decreases steeply. For stresses beyond $≈1$ GPa the decrease is quasilinear. We hypothesize that superconductivity is suppressed by competition with uniaxial charge density wave order, which has been found to onset at $≈1$ GPa

How sukuk shapes firm performance

Peer reviewedPostprin

Robustness for a single railway line: Analytical and simulation methods

[EN] Railway scheduling has been a significant issue in the railway industry. Over the last few years, numerous approaches and tools have been developed to compute railway scheduling. However, robust solutions are necessary to absorb short disruptions. In this paper, we present the robustness problem from the point of view of railway operators and we propose analytical and simulation methods to measure robustness in a single railway line. In the analytical approach, we have developed some formulas to measure robustness based on the study of railway line infrastructure topology and buffer times. In the simulation approach, we have developed a software tool to assess the robustness for a given schedule. These methods have been inserted in MOM (More information can be found at the MOM web page http://www.dsic.upv.es/users/ia/gps/MOM), which is a project in collaboration with the Spanish Railway Infrastructure Manager (ADIF). © 2012 Elsevier Ltd. All rights reserved.This work has been partially supported by the research project TIN2010-20976-C02-01 (Min. de Economia y Competitividad, Spain) and project PIRSES-GA-2011-294931 (FP7-PEOPLE-2011-IRSES).Salido Gregorio, MA.; Barber Sanchís, F.; Ingolotti Hetter, LP. (2012). Robustness for a single railway line: Analytical and simulation methods. Expert Systems with Applications. 39(18):13305-13327. https://doi.org/10.1016/j.eswa.2012.05.071S1330513327391

A human MAP kinase interactome.

Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other cellular machinery and to assemble these data into functional modules. Multiple lines of evidence including conservation with yeast supported a core network of 641 interactions. Using small interfering RNA knockdowns, we observed that approximately one-third of MAPK-interacting proteins modulated MAPK-mediated signaling. We uncovered the Na-H exchanger NHE1 as a potential MAPK scaffold, found links between HSP90 chaperones and MAPK pathways and identified MUC12 as the human analog to the yeast signaling mucin Msb2. This study makes available a large resource of MAPK interactions and clone libraries, and it illustrates a methodology for probing signaling networks based on functional refinement of experimentally derived protein-interaction maps

Pastoral power in the community pharmacy: a Foucauldian analysis of services to promote patient adherence to new medicine use

Community pharmacists play a growing role in the delivery of primary healthcare. This has led manyto consider the changing power of the pharmacy profession in relation to other professions and patient groups. This paper contributes to these debates through developing a Foucauldian analysis of the changing dynamics of power brought about by extended roles in medicines management and patient education. Examining the New Medicine Service, the study considers how both patient and pharmacist subjectivities are transformed as pharmacists seek to survey patient’s medicine use, diagnose non-adherence to prescribed medicines, and provide education to promote behaviour change. These extended roles in medicines management and patient education expand the ‘pharmacy gaze’ to further aspects of patient health and lifestyle, and more significantly, established a form of ‘pastoral power’ as pharmacists become responsible for shaping patients’ self-regulating subjectivities. In concert, pharmacists are themselves enrolled within a new governing regime where their identities are conditioned by corporate and policy rationalities for the modernisation of primary care