Recovery Strategies to Sustain Religious Tourism Post-COVID-19: Evidence from Iran

Religious tourism, as one of the most significant types of tourism, is among the most seriously affected economic sectors worldwide as a result of the coronavirus (COVID-19) pandemic. This study sought to identify and prioritise the strategies for sustaining post-COVID-19 religious tourism. The study was an applied survey that drew on a mixed research design. The results of the qualitative data analysis obtained through a systematic literature review revealed that the recovery strategies to boost businesses in the field of religious tourism in the post-COVID-19 future could be divided into four main strategies (dimensions) and 24 sub-strategies (criteria). Furthermore, the quantitative analysis, conducted through the R-SWARA technique, showed that ‘making it mandatory to maintain a distance from sacred monuments (e.g., tombs) and prohibiting touching or having any physical contact with such monuments’, ‘Understanding religious tourists’ health-related expectations’, ‘making it mandatory to use masks and other health-related equipment in sacred/religious locations’, and ‘reducing the capacity for welcoming tourists in sacred and tourism sites while holding religious ceremonies with a small number of attendants’ were the most significant strategies that could boost religious tourism post-COVID-19. These factors were prioritised by experts and activists in the industry who shared their opinions in this study

Proposing a Model for Religious Tourism Development: Evidence from Iran

This study proposes a model for religious tourism as one of the most promising types of tourism worldwide, by focusing on the conditions of Iran as a potentially popular destination for religious tourism. The study relies on a mixed (qualitative and quantitative) method. The qualitative phase identifies the model dimensions and strategies. To do this, practitioners and experts were interviewed and the data collected were investigated through the thematic analysis method. This process revealed four main dimensions and 18 subsidiary strategies. In the quantitative phase, the dimensions and strategies identified were arranged in a questionnaire and through the survey method, were prioritised by experts in the Iranian tourism industry. The data analysis results, based on intuitionistic fuzzy AHP, revealed that the most important dimensions in religious tourism, as assessed by experts and practitioners in the Iranian tourism industry, were: ‘marketing strategies’, ‘HR training and development’, ‘reinforcing executive management structures’, and ‘implementing information technology.’ Finally, following a comparison of the results with those of another studies in this field, some executive and research-related suggestions are proposed

Talent management and the Tourism and Hospitality industry : evidence from Iran

This study investigates the notion of talent in the tourism and hospitality (TH) industry, proposing a comprehensive talent management (TM) model that is specific to this industry. This study primarily explores the notion of talent, TM, and the importance of these in the industry. A mixed method approach (qualitative and quantitative) was used to fulfill the research objectives. Qualitative content analysis was used to address interview responses from a panel of experts and a survey method was applied to collect data from a wider industry population through questionnaires. The data collected were analysed in SPSS and LISREL. Based on the findings, a model is proposed for talent definition in the Iranian TH industry

Inhibition of AGS cancer cell proliferation following siRNA-mediated downregulation of VEGFR2

Vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) play important roles in angiogenesis of different developmental mechanisms such as wound healing, embryogenesis and diseases, including different types of cancer. VEGFR2 is associated with cell proliferation, migration, and vascular permeability of endothelial cells. Blocking VEGF and its receptors is suggested as a therapeutic approach to prevent tumor growth. In this study, we aim to block VEGF signaling via small interfering RNA (siRNA) inhibition of VEGFR2. Materials and Methods: In this experimental study, we used the RNA interference (RNAi) mechanism to suppress expression of the VEGFR2 gene. We conducted the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay, real-time polymerase chain reaction (PCR), Western blot, and?ow cytometry analyses of VEGFR2 expression. Results: Real-time PCR and Western blot results showed that VEGFR2 expression signifcantly downregulated. This suppression was followed by inhibition of cell proliferation, reduction of viability, and induction of apoptosis in the cancer cells. Conclusion: These findings suggest that VEGFR2 has a role in cell proliferation and tumor growth. Accordingly, it is suggested that VEGFR2 can be a therapeutic target for controlling tumor growth and proliferation

Investigating the impact of organizational spirituality on human resources productivity in manufacturing organizations

Human resource productivity is one of the vital notions in the management of modern organizations. Many studies concerned with this notion have tried to identify the factors affecting productivity and its improvement. One of these important factors is organizational spirituality. The present study investigated the impact of organizational spirituality, from an Islamic perspective, on human resources productivity in BELFA Co., Iran, as a manufacturing organization. The study relied on a descriptive survey method and used structural equation modeling to analyze data in Smart-PLS software to fit the measurement model and the structural model. Results revealed that spirituality could predict 26% of the variance of Human resources productivity in the company, proving to be an effective factor

The unfinished agenda of communicable diseases among children and adolescents before the COVID-19 pandemic, 1990-2019: a systematic analysis of the Global Burden of Disease Study 2019

BACKGROUND: Communicable disease control has long been a focus of global health policy. There have been substantial reductions in the burden and mortality of communicable diseases among children younger than 5 years, but we know less about this burden in older children and adolescents, and it is unclear whether current programmes and policies remain aligned with targets for intervention. This knowledge is especially important for policy and programmes in the context of the COVID-19 pandemic. We aimed to use the Global Burden of Disease (GBD) Study 2019 to systematically characterise the burden of communicable diseases across childhood and adolescence. METHODS: In this systematic analysis of the GBD study from 1990 to 2019, all communicable diseases and their manifestations as modelled within GBD 2019 were included, categorised as 16 subgroups of common diseases or presentations. Data were reported for absolute count, prevalence, and incidence across measures of cause-specific mortality (deaths and years of life lost), disability (years lived with disability [YLDs]), and disease burden (disability-adjusted life-years [DALYs]) for children and adolescents aged 0-24 years. Data were reported across the Socio-demographic Index (SDI) and across time (1990-2019), and for 204 countries and territories. For HIV, we reported the mortality-to-incidence ratio (MIR) as a measure of health system performance. FINDINGS: In 2019, there were 3·0 million deaths and 30·0 million years of healthy life lost to disability (as measured by YLDs), corresponding to 288·4 million DALYs from communicable diseases among children and adolescents globally (57·3% of total communicable disease burden across all ages). Over time, there has been a shift in communicable disease burden from young children to older children and adolescents (largely driven by the considerable reductions in children younger than 5 years and slower progress elsewhere), although children younger than 5 years still accounted for most of the communicable disease burden in 2019. Disease burden and mortality were predominantly in low-SDI settings, with high and high-middle SDI settings also having an appreciable burden of communicable disease morbidity (4·0 million YLDs in 2019 alone). Three cause groups (enteric infections, lower-respiratory-tract infections, and malaria) accounted for 59·8% of the global communicable disease burden in children and adolescents, with tuberculosis and HIV both emerging as important causes during adolescence. HIV was the only cause for which disease burden increased over time, particularly in children and adolescents older than 5 years, and especially in females. Excess MIRs for HIV were observed for males aged 15-19 years in low-SDI settings. INTERPRETATION: Our analysis supports continued policy focus on enteric infections and lower-respiratory-tract infections, with orientation to children younger than 5 years in settings of low socioeconomic development. However, efforts should also be targeted to other conditions, particularly HIV, given its increased burden in older children and adolescents. Older children and adolescents also experience a large burden of communicable disease, further highlighting the need for efforts to extend beyond the first 5 years of life. Our analysis also identified substantial morbidity caused by communicable diseases affecting child and adolescent health across the world. FUNDING: The Australian National Health and Medical Research Council Centre for Research Excellence for Driving Investment in Global Adolescent Health and the Bill & Melinda Gates Foundation

Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000–2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe