Advanced Compton Telescope Designs and SN Science

The Advanced Compton Telescope (ACT) has been suggested to be the optimal next-generation instrument to study nuclear gamma-ray lines. In this work, we investigate the potential of three hypothetical designs of the ACT to perform SN science. We provide estimates of 1) the SN detection rate, 2) the SN Ia discrimination rate, and 3) which gamma-ray lines would be detected from specific supernova remnants. We find that the prompt emission from a SN Ia is such that it is unlikely that one would be within the range that an INTERMEDIATE ACT would be able to distinguish between explosion scenarios, although such an instrument would detect a handful of SNRs. We further find that the SUPERIOR ACT design would be a truly breakthrough instrument for SN science. By supplying these estimates, we intend to assist the gamma-ray astrophysics community in deciding the course of the next decade of gamma-ray SN science.Comment: 10 pages, accepted for publication in New astronomy Reviews (Astronomy with Radioactivities III

Can a supernova be located by its neutrinos?

A future core-collapse supernova in our Galaxy will be detected by several neutrino detectors around the world. The neutrinos escape from the supernova core over several seconds from the time of collapse, unlike the electromagnetic radiation, emitted from the envelope, which is delayed by a time of order hours. In addition, the electromagnetic radiation can be obscured by dust in the intervening interstellar space. The question therefore arises whether a supernova can be located by its neutrinos alone. The early warning of a supernova and its location might allow greatly improved astronomical observations. The theme of the present work is a careful and realistic assessment of this question, taking into account the statistical significance of the various neutrino signals. Not surprisingly, neutrino-electron forward scattering leads to a good determination of the supernova direction, even in the presence of the large and nearly isotropic background from other reactions. Even with the most pessimistic background assumptions, SuperKamiokande (SK) and the Sudbury Neutrino Observatory (SNO) can restrict the supernova direction to be within circles of radius $5^\circ$ and $20^\circ$, respectively. Other reactions with more events but weaker angular dependence are much less useful for locating the supernova. Finally, there is the oft-discussed possibility of triangulation, i.e., determination of the supernova direction based on an arrival time delay between different detectors. Given the expected statistics we show that, contrary to previous estimates, this technique does not allow a good determination of the supernova direction.Comment: 11 pages including 2 figures. Revised version corrects typos, adds some brief comment

Lichenometric dating (lichenometry) and the biology of the lichen genus rhizocarpon:challenges and future directions

Lichenometric dating (lichenometry) involves the use of lichen measurements to estimate the age of exposure of various substrata. Because of low radial growth rates and considerable longevity, species of the crustose lichen genus Rhizocarpon have been the most useful in lichenometry. The primary assumption of lichenometry is that colonization, growth and mortality of Rhizocarpon are similar on surfaces of known and unknown age so that the largest thalli present on the respective faces are of comparable age. This review describes the current state of knowledge regarding the biology of Rhizocarpon and considers two main questions: (1) to what extent does existing knowledge support this assumption; and (2) what further biological observations would be useful both to test its validity and to improve the accuracy of lichenometric dates? A review of the Rhizocarpon literature identified gaps in knowledge regarding early development, the growth rate/size curve, mortality, regeneration, competitive effects, colonization, and succession on rock surfaces. The data suggest that these processes may not be comparable on different rock surfaces, especially in regions where growth rates and thallus turnover are high. In addition, several variables could differ between rock surfaces and influence maximum thallus size, including rate and timing of colonization, radial growth rates, environmental differences, thallus fusion, allelopathy, thallus mortality, colonization and competition. Comparative measurements of these variables on surfaces of known and unknown age may help to determine whether the basic assumptions of lichenometry are valid. Ultimately, it may be possible to take these differences into account when interpreting estimated dates

Supernova pointing with low- and high-energy neutrino detectors

A future galactic SN can be located several hours before the optical explosion through the MeV-neutrino burst, exploiting the directionality of $\nu$-$e$-scattering in a water Cherenkov detector such as Super-Kamiokande. We study the statistical efficiency of different methods for extracting the SN direction and identify a simple approach that is nearly optimal, yet independent of the exact SN neutrino spectra. We use this method to quantify the increase in the pointing accuracy by the addition of gadolinium to water, which tags neutrons from the inverse beta decay background. We also study the dependence of the pointing accuracy on neutrino mixing scenarios and initial spectra. We find that in the ``worst case'' scenario the pointing accuracy is $8^\circ$ at 95% C.L. in the absence of tagging, which improves to $3^\circ$ with a tagging efficiency of 95%. At a megaton detector, this accuracy can be as good as $0.6^\circ$. A TeV-neutrino burst is also expected to be emitted contemporaneously with the SN optical explosion, which may locate the SN to within a few tenths of a degree at a future km$^2$ high-energy neutrino telescope. If the SN is not seen in the electromagnetic spectrum, locating it in the sky through neutrinos is crucial for identifying the Earth matter effects on SN neutrino oscillations.Comment: 13 pages, 7 figures, Revtex4 format. The final version to be published in Phys. Rev. D. A few points in the original text are clarifie

Supernova Interaction with a Circumstellar Medium

The explosion of a core collapse supernova drives a powerful shock front into the wind from the progenitor star. A layer of shocked circumstellar gas and ejecta develops that is subject to hydrodynamic instabilities. The hot gas can be observed directly by its X-ray emission, some of which is absorbed and re-radiated at lower frequencies by the ejecta and the circumstellar gas. Synchrotron radiation from relativistic electrons accelerated at the shock fronts provides information on the mass loss density if free-free absorption dominates at early times or the size of the emitting region if synchrotron self-absorption dominates. Analysis of the interaction leads to information on the density and structure of the ejecta and the circumstellar medium, and the abundances in these media. The emphasis here is on the physical processes related to the interaction.Comment: 22 pages, 7 figures, to appear as a Chapter in "Supernovae and Gamma-Ray Bursts," edited by K. W. Weiler (Springer-Verlag

A Study Of Human T-Cell Lines Generated From Multiple Sclerosis Patients And Controls By Stimulation With Peptides Of Myelin Basic Protein

We generated T-cell lines from the peripheral blood of controls and of patients with multiple sclerosis (MS) by stimulation with overlapping synthetic peptides representing the entire sequences of all four isoforms of human myelin basic protein (MBP). The T-cell lines reacted to a wide range of epitopes in the major isoforms of MBP and to epitopes that were present only in the minor isoforms. Many MS patients and controls had T-cells responding to one or more cryptic MBP epitopes, as indicated by the generation of a peptide-specific T-cell line(s) by stimulation with synthetic peptides but not by stimulation with whole MBP. About one-third of the peptide-generated lines were cytotoxic. Although we have shown that this technique of peptide stimulation is effective in generating human antiviral cytotoxic CD8+ T-cell lines, all the cytotoxic MBP-specific lines generated by this method were predominantly CD4+. Our study did not reveal any significant differences, between MS patients and controls, in reactivity to epitopes within any of the isoforms of MBP

Measurement of the Charged Multiplicities in b, c and Light Quark Events from Z0 Decays

Average charged multiplicities have been measured separately in $b$, $c$ and light quark ($u,d,s$) events from $Z^0$ decays measured in the SLD experiment. Impact parameters of charged tracks were used to select enriched samples of $b$ and light quark events, and reconstructed charmed mesons were used to select $c$ quark events. We measured the charged multiplicities: $\bar{n}_{uds} = 20.21 \pm 0.10 (\rm{stat.})\pm 0.22(\rm{syst.})$, $\bar{n}_{c} = 21.28 \pm 0.46(\rm{stat.}) ^{+0.41}_{-0.36}(\rm{syst.})$ $\bar{n}_{b} = 23.14 \pm 0.10(\rm{stat.}) ^{+0.38}_{-0.37}(\rm{syst.})$, from which we derived the differences between the total average charged multiplicities of $c$ or $b$ quark events and light quark events: $\Delta \bar{n}_c = 1.07 \pm 0.47(\rm{stat.})^{+0.36}_{-0.30}(\rm{syst.})$ and $\Delta \bar{n}_b = 2.93 \pm 0.14(\rm{stat.})^{+0.30}_{-0.29}(\rm{syst.})$. We compared these measurements with those at lower center-of-mass energies and with perturbative QCD predictions. These combined results are in agreement with the QCD expectations and disfavor the hypothesis of flavor-independent fragmentation.Comment: 19 pages LaTex, 4 EPS figures, to appear in Physics Letters

STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): An international consortium of randomised placebo-controlled trials

Background: Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcomes. The objective of the Sildenafil TheRapy In Dismal prognosis Early onset fetal growth Restriction (STRIDER) collaboration is to evaluate the effectiveness of sildenafil versus placebo in achieving healthy perinatal survival through the conduct of randomised clinical trials and systematic review including individual patient data meta-analysis.  Methods: Five national/bi-national multicentre randomised placebo-controlled trials have been launched. Women with a singleton pregnancy between 18 and 30 weeks with severe fetal growth restriction of likely placental origin, and where the likelihood of perinatal death/severe morbidity is estimated to be significant are included. Participants will receive either sildenafil 25 mg or matching placebo tablets orally three times daily from recruitment to 32 weeks gestation.  Discussion: The STRIDER trials were conceived and designed through international collaboration. Although the individual trials have different primary outcomes for reasons of sample size and feasibility, all trials will collect a standard set of outcomes including survival without severe neonatal morbidity at time of hospital discharge. This is a summary of all the STRIDER trial protocols and provides an example of a prospectively planned international clinical research collaboration. All five individual trials will contribute to a pre-planned systematic review of the topic including individual patient data meta-analysis