72 research outputs found
Quantifying nanoparticle dispersion: application of the Delaunay network for objective analysis of sample micrographs
Measuring quantitatively the nanoparticle dispersion of a composite material requires more than choosing a particular parameter and determining its correspondence to good and bad dispersion. It additionally requires anticipation of the measure’s behaviour towards imperfect experimental data, such as that which can be obtained from a limited number of samples. It should be recognised that different samples from a common parent population can give statistically different responses due to sample variation alone and a measure of the likelihood of this occurring allows a decision on the dispersion to be made. It is also important to factor into the analysis the quality of the data in the micrograph with it: (a) being incomplete because some of the particles present in the micrograph are indistinguishable or go unseen; (b) including additional responses which are false. With the use of our preferred method, this article investigates the effects on the measured dispersion quality of nanoparticles of the micrograph’s magnification settings, the role of the fraction of nanoparticles visible and the number of micrographs used. It is demonstrated that the best choice of magnification, which gives the clearest indication of dispersion type, is dependent on the type of nanoparticle structure present. Furthermore, it is found that the measured dispersion can be modified by particle loss, through the limitations of micrograph construction, and material/microscope imperfections such as cut marks and optical aberrations which could lead to the wrong conclusions being drawn. The article finishes by showing the versatility of the dispersion measure by characterising various different spatial features. <br/
Quantum critical point in the spin glass-antiferromagnetism competition for fermionic Ising Models
The competition between spin glass () and antiferromagnetic order ()
is analyzed in two sublattice fermionic Ising models in the presence of a
transverse and a parallel magnetic fields. The exchange
interaction follows a Gaussian probability distribution with mean and
standard deviation , but only spins in different sublattices can
interact. The problem is formulated in a path integral formalism, where the
spin operators have been expressed as bilinear combinations of Grassmann
fields. The results of two fermionic models are compared. In the first one, the
diagonal operator has four states, where two eigenvalues vanish (4S
model), which are suppressed by a restriction in the two states 2S model. The
replica symmetry ansatz and the static approximation have been used to obtain
the free energy. The results are showing in phase diagrams ( is the
temperature) {\it versus} , , and . When is
increased, (transition temperature to a nonergodic phase) reduces and
the Neel temperature decreases towards a quantum critical point. The field
always destroys ; however, within a certain range, it favors the
frustration. Therefore, the presence of both fields, and , produces
effects that are in competition. The critical temperatures are lower for the 4S
model and it is less sensitive to the magnetic couplings than the 2S model.Comment: 15 pages, 6 figures, accepted in Physica
Systematic review and network meta-analysis on the efficacy of evolocumab and other therapies for the management of lipid levels in hyperlipidemia
Background: The proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors evolocumab and alirocumab substantially reduce low‐density lipoprotein cholesterol (LDL‐C) when added to statin therapy in patients who need additional LDL‐C reduction.
Methods and Results: We conducted a systematic review and network meta‐analysis of randomized trials of lipid‐lowering therapies from database inception through August 2016 (45 058 records retrieved). We found 69 trials of lipid‐lowering therapies that enrolled patients requiring further LDL‐C reduction while on maximally tolerated medium‐ or high‐intensity statin, of which 15 could be relevant for inclusion in LDL‐C reduction networks with evolocumab, alirocumab, ezetimibe, and placebo as treatment arms. PCSK9 inhibitors significantly reduced LDL‐C by 54% to 74% versus placebo and 26% to 46% versus ezetimibe. There were significant treatment differences for evolocumab 140 mg every 2 weeks at the mean of weeks 10 and 12 versus placebo (−74.1%; 95% credible interval −79.81% to −68.58%), alirocumab 75 mg (−20.03%; 95% credible interval −27.32% to −12.96%), and alirocumab 150 mg (−13.63%; 95% credible interval −22.43% to −5.33%) at ≥12 weeks. Treatment differences were similar in direction and magnitude for PCSK9 inhibitor monthly dosing. Adverse events were similar between PCSK9 inhibitors and control. Rates of adverse events were similar between PCSK9 inhibitors versus placebo or ezetimibe.
Conclusions: PCSK9 inhibitors added to medium‐ to high‐intensity statin therapy significantly reduce LDL‐C in patients requiring further LDL‐C reduction. The network meta‐analysis showed a significant treatment difference in LDL‐C reduction for evolocumab versus alirocumab
Fermionic van Hemmen Spin Glass Model with a Transverse Field
In the present work it is studied the fermionic van Hemmen model for the spin
glass (SG) with a transverse magnetic field . In this model, the spin
operators are written as a bilinear combination of fermionic operators, which
allows the analysis of the interplay between charge and spin fluctuations in
the presence of a quantum spin flipping mechanism given by . The
problem is expressed in the fermionic path integral formalism. As results,
magnetic phase diagrams of temperature versus the ferromagnetic interaction are
obtained for several values of chemical potential and . The
field suppresses the magnetic orders. The increase of alters the
average occupation per site that affects the magnetic phases. For instance, the
SG and the mixed SG+ferromagnetic phases are also suppressed by . In
addition, can change the nature of the phase boundaries introducing a
first order transition.Comment: 9 pages, 4 figures, accepted for publication in Phys. Lett.
Stability conditions for fermionic Ising spin-glass models in the presence of a transverse field
The stability of spin-glass (SG) phase is analyzed in detail for a fermionic
Ising SG (FISG) model in the presence of a magnetic transverse field .
The fermionic path integral formalism, replica method and static approach have
been used to obtain the thermodynamic potential within one step replica
symmetry breaking ansatz. The replica symmetry (RS) results show that the SG
phase is always unstable against the replicon. Moreover, the two other
eigenvalues of the Hessian matrix (related to the diagonal
elements of the replica matrix) can indicate an additional instability to the
SG phase, which enhances when is increased. Therefore, this result
suggests that the study of the replicon can not be enough to guarantee the RS
stability in the present quantum FISG model, especially near the quantum
critical point. In particular, the FISG model allows changing the occupation
number of sites, so one can get a first order transition when the chemical
potential exceeds a certain value. In this region, the replicon and the
indicate instability problems for the SG solution close to all
range of first order boundary.Comment: 15 pages, 4 figures, accepted in Physica
Adaptive cluster expansion for the inverse Ising problem: convergence, algorithm and tests
We present a procedure to solve the inverse Ising problem, that is to find
the interactions between a set of binary variables from the measure of their
equilibrium correlations. The method consists in constructing and selecting
specific clusters of variables, based on their contributions to the
cross-entropy of the Ising model. Small contributions are discarded to avoid
overfitting and to make the computation tractable. The properties of the
cluster expansion and its performances on synthetic data are studied. To make
the implementation easier we give the pseudo-code of the algorithm.Comment: Paper submitted to Journal of Statistical Physic
Using electronic structure changes to map the H-T phase diagram of alpha'-NaV2O5
We report polarized optical reflectance studies of \alpha'-NaV2O5 as a
function of temperature (4-45 K) and magnetic field (0-60 T). Rung directed
electronic structure changes, as measured by near-infrared reflectance ratios
\Delta R(H)=R(H)/R(H=0 T), are especially sensitive to the phase boundaries. We
employ these changes to map out an H-T phase diagram. Topological highlights
include the observation of two phase boundaries slightly below T_{SG}, enhanced
curvature of the 34 K phase boundary above 35 T, and, surprisingly, strong
hysteresis effects of both transitions with applied field.Comment: 4 pages, 3 figures, PRB accepte
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