3,420 research outputs found
Jet Energy Density in Hadron-Hadron Collisions at High Energies
The average particle multiplicity density dN/deta is the dynamical quantity
which reflects some regularities of particle production in low-pT range. The
quantity is an important ingredient of z-scaling. Experimental results on
charged particle density are available for pp, pA and AA collisions while
experimental properties of the jet density are still an open question. The goal
of this work is to find the variable which will reflect the main features of
the jet production in low transverse energy range and play the role of the
scale factor for the scaling function psi(z) and variable z in data
z-presentation. The appropriate candidate is the variable we called "scaled jet
energy density". Scaled jet energy density is the probability to have a jet
with defined ET in defined xT and pseudorapidity regions. The PYTHIA6.2 Monte
Carlo generator is used for calculation of scaled jet energy density in
proton-proton collisions over a high energy range (sqrt s = 200-14000 GeV) and
at eta = 0. The properties of the new variable are discussed and sensitivity to
"physical scenarios" applied in the standard Monte Carlo generator is noted.
The results of scaled jet energy density at LHC energies are presented and
compared with predictions based on z-scaling.Comment: 11 pages, LaTeX, 8 figures, Presented at the XVII International
Baldin Seminar on High Energy Physics Problems "Relativistic Nuclear Physics
& Quantum Chromodynamics", Dubna, Russia, September 27 - October 2, 200
Studies of multiplicity in relativistic heavy-ion collisions
In this talk I'll review the present status of charged particle multiplicity
measurements from heavy-ion collisions. The characteristic features of
multiplicity distributions obtained in Au+Au collisions will be discussed in
terms of collision centrality and energy and compared to those of p+p
collisions. Multiplicity measurements of d+Au collisions at 200 GeV
nucleon-nucleon center-of-mass energy will also be discussed. The results will
be compared to various theoretical models and simple scaling properties of the
data will be identified.Comment: "Focus on Multiplicity" Internationsl Workshop on Particle
Multiplicity in Relativistic Heavy Ion Collisions, Bari, Italy, June 17-19,
2003, 16 pages, 15 figure
Charged particle densities from Au+Au collisions at sqrt{s_{NN}}=130 GeV
We present charged particle densities as a function of pseudorapidity and
collision centrality for the 197Au+197Au reaction at sqrt{s_{NN}}=130 GeV. An
integral charged particle multiplicity of 3860+/-300 is found for the 5% most
central events within the pseudorapidity range -4.7 <= eta <= 4.7. At
mid-rapidity an enhancement in the particle yields per participant nucleon pair
is observed for central events. Near to the beam rapidity, a scaling of the
particle yields consistent with the ``limiting fragmentation'' picture is
observed. Our results are compared to other recent experimental and theoretical
discussions of charged particle densities in ultra-relativistic heavy-ion
collisions.Comment: 14 pages, 4 figures; to be published in Phys. Lett.
Limiting fragmentation in hadron-hadron collisions at high energies
Limiting fragmentation in proton-proton, deuteron-nucleus and nucleus-nucleus
collisions is analyzed in the framework of the Balitsky-Kovchegov equation in
high energy QCD. Good agreement with experimental data is obtained for a wide
range of energies. Further detailed tests of limiting fragmentation at RHIC and
the LHC will provide insight into the evolution equations for high energy QCD.Comment: 28 pages, 10 figures (2 new figures, text slightly expanded, and some
additional references
Forward and midrapidity like-particle ratios from p+p collisions at sqrt(s)=200 GeV
We present a measurement of pi-\pi+, K-/K+ and pbar/p from p+p collisions at
sqrt(s) = 20 0GeV over the rapidity range 0<y<3.4. For pT < 2.0 GeV/c we see no
significant transverse momentum dependence of the ratios. All three ratios are
independent of rapidity for y ~< 1.5 and then steadily decline from y ~ 1.5 to
y ~ 3. The pi-\pi+ ratio is below unity for y > 2.0. The pbar/p ratio is very
similar for p+p and 20% central Au+Au collisions at all rapidities. In the
fragmentation region the three ratios seem to be independent of beam energy
when viewed from the rest frame of one of the protons. Theoretical models based
on quark-diquark breaking mechanisms overestimate the pbar/p ratio up to y ~<
3. Including additional mechanisms for baryon number transport such as baryon
junctions leads to a better description of the data.Comment: 15 pages, 4 figures, uses elsart.sty. Changes to references and
discussion based on referee comments, resubmitted to Phys. Lett.
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India
We investigated the significance of these self-reactive antibodies in clinically well-defined groups of P. falciparum infected patients manifesting mild malaria (MM), severe non-cerebral malaria (SM), or cerebral malaria (CM) and in control subjects from Gondia, a malaria epidemic site in central India using quantitative immunoprinting and multivariate statistical analyses. A two-fold complete-linkage hierarchical clustering allows classifying the different patient groups and to distinguish the CM from the others on the basis of their profile of IgG reactivity to brain proteins defined by PANAMA Blot. We identified beta tubulin III (TBB3) as a novel discriminant brain antigen in the prevalence of CM. In addition, circulating IgG from CM patients highly react with recombinant TBB3. Overall, correspondence analyses based on singular value decomposition show a strong correlation between IgG anti-TBB3 and elevated concentration of cluster-II cytokine (IFNγ, IL1β, TNFα, TGFβ) previously demonstrated to be a predictor of CM in the same populatio
Inflammatory control in AIDS-resistant non human primates
International audienceAfrican non human primates are natural hosts of SIV. The infection is non-pathogenic despite plasma viral load levels similar to those in HIV-1 infected humans and SIVmac-infected macaques (MAC) progressing towards AIDS. The most striking difference between non-pathogenic SIV and pathogenic HIV-1/SIVmac infections is the lack of chronic T cell activation in natural hosts. In HIV and SIVmac infections, chronic T cell activation is known to drive CD4+T cell depletion. Intense research efforts are worldwide put on the search of the mechanisms that can control chronic T cell activation in HIV/SIV infections. Innate immune responses play a determinant role in the regulation of T cell activation profiles. Type I interferons (IFN-I) are part of the first-wave response of the innate immune system in viral infections. We compared the IFN-I responses between pathogenic (MAC) and non-pathogenic SIV infections (African Green monkey, AGM) at the level of blood and lymph nodes (LN) during the early and chronic stage of infection. During the acute SIVagm infection, we detected high amounts of IFN-α in the plasma of AGMs, although the mean levels at the peak were three times lower than in MAC. The microarray data revealed a rapid and strong up-regulation of type I Interferon-Stimulated Genes (ISG) in AGMs during acute SIVagm infection. ISGs denote the in vivo activity of IFN-I. Using a functional assay, we demonstrated that low IFN-α concentrations (50 times lower than the IFN-α levels in plasma at the peak) were sufficient to induce strong ISG responses in AGM and MAC cells. Surprisingly, our direct comparison of blood and LNs showed that ISG induction was broader in blood of AGMs than in MAC, while in LN, it was the contrary. Thus, in AGMs, less ISG were induced in LNs as compared to MAC already during the acute phase of infection. Moreover, our tight kinetic analysis showed that this ISG expression was efficiently controlled after day 28 post-infection in AGMs, while in MAC the ISGs expression remained uncontrolled. Finally, we identified genes that were differentially expressed between the two species and which might be involved in the discriminating responses. Altogether, this shows that AGMs are capable to mount a well coordinated and efficient regulative response to innate immune activation
Airway structural cells regulate TLR5-mediated mucosal adjuvant activity
Antigen-presenting cell (APC) activation is enhanced by vaccine adjuvants. Most vaccines are based on the assumption that adjuvant activity of Toll-like receptor (TLR) agonists depends on direct, functional activation of APCs. Here, we sought to establish whether TLR stimulation in non-hematopoietic cells contributes to flagellin’s mucosal adjuvant activity. Nasal administration of flagellin enhanced T-cell-mediated immunity, and systemic and secretory antibody responses to coadministered antigens in a TLR5-dependent manner. Mucosal adjuvant activity was not affected by either abrogation of TLR5 signaling in hematopoietic cells or the presence of flagellin-specific, circulating neutralizing antibodies. We found that flagellin is rapidly degraded in conducting airways, does not translocate into lung parenchyma and stimulates an early immune response, suggesting that TLR5 signaling is regionalized. The flagellin-specific early response of lung was regulated by radioresistant cells expressing TLR5 (particularly the airway epithelial cells). Flagellin stimulated the epithelial production of a small set of mediators that included the chemokine CCL20, which is known to promote APC recruitment in mucosal tissues. Our data suggest that (i) the adjuvant activity of TLR agonists in mucosal vaccination may require TLR stimulation of structural cells and (ii) harnessing the effect of adjuvants on epithelial cells can improve mucosal vaccines.Fil: Van Maele, Laurye. Institut Pasteur de Lille. Lille; Francia. Univ Lille Nord de France. Lille; Francia. Institut National de la Santé et de la Recherche Médicale; FranciaFil: Fougeron, Delphine. Institut Pasteur de Lille. Lille; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Univ Lille Nord de France. Lille; FranciaFil: Janot, Laurent. University of Orléans. Orléans; Francia. Institut de Transgenose. Orleans; FranciaFil: Didierlaurent, A.. Imperial College of London. Londres; Reino UnidoFil: Cayet, D.. Institut Pasteur de Lille. Lille; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Univ Lille Nord de France. Lille; FranciaFil: Tabareau, J.. Institut Pasteur de Lille. Lille; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Univ Lille Nord de France. Lille; FranciaFil: Rumbo, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Corvo Chamaillard, S.. Institut Pasteur de Lille. Lille; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Univ Lille Nord de France. Lille; FranciaFil: Boulenoir, S.. Institut Pasteur de Lille. Lille; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Univ Lille Nord de France. Lille; FranciaFil: Jeffs, S. Imperial College of London. Londres; Reino UnidoFil: Vande Walle, L. Department of Medical Protein Research. Ghent; Bélgica. University of Ghent; BélgicaFil: Lamkanfi, M.. Department of Medical Protein Research. Ghent; Bélgica. University of Ghent; BélgicaFil: Lemoine, Y.. Univ Lille Nord de France. Lille; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Institut Pasteur de Lille. Lille; FranciaFil: Erard, F.. Institut de Transgenose. Orleans; Francia. University of Orléans. Orléans; FranciaFil: Hot, D.. Univ Lille Nord de France. Lille; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Institut Pasteur de Lille. Lille; FranciaFil: Hussell, Tracy. Imperial College of London. Londres; Reino Unido. University of Manchester; Reino UnidoFil: Ryffel, B.. Institut de Transgenose. Orleans; Francia. University of Orléans. Orléans; FranciaFil: Benecke, Arndt G.. Institut des Hautes Études Scientifiques and Centre National de la Recherche Scientifique; FranciaFil: Sirard, J.C.. Univ Lille Nord de France. Lille; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Institut Pasteur de Lille. Lille; Franci
Multiplicity Studies and Effective Energy in ALICE at the LHC
In this work we explore the possibility to perform ``effective energy''
studies in very high energy collisions at the CERN Large Hadron Collider (LHC).
In particular, we focus on the possibility to measure in collisions the
average charged multiplicity as a function of the effective energy with the
ALICE experiment, using its capability to measure the energy of the leading
baryons with the Zero Degree Calorimeters. Analyses of this kind have been done
at lower centre--of--mass energies and have shown that, once the appropriate
kinematic variables are chosen, particle production is characterized by
universal properties: no matter the nature of the interacting particles, the
final states have identical features. Assuming that this universality picture
can be extended to {\it ion--ion} collisions, as suggested by recent results
from RHIC experiments, a novel approach based on the scaling hypothesis for
limiting fragmentation has been used to derive the expected charged event
multiplicity in interactions at LHC. This leads to scenarios where the
multiplicity is significantly lower compared to most of the predictions from
the models currently used to describe high energy collisions. A mean
charged multiplicity of about 1000-2000 per rapidity unit (at ) is
expected for the most central collisions at .Comment: 12 pages, 19 figures. In memory of A. Smirnitski
Global Observations from PHOBOS
Particle production in Au+Au collisions has been measured in the PHOBOS
experiment at RHIC for a range of collision energies. Three empirical
observations have emerged from this dataset which require theoretical
examination. First, there is clear evidence of limiting fragmentation. Namely,
particle production in central Au+Au collisions, when expressed as
(), becomes energy independent at high energy for a
broad region of around . This energy-independent region grows
with energy, allowing only a limited region (if any) of longitudinal
boost-invariance. Second, there is a striking similarity between particle
production in e+e- and Au+Au collisions (scaled by the number of participating
nucleon pairs). Both the total number of produced particles and the
longitudinal distribution of produced particles are approximately the same in
e+e- and in scaled Au+Au. This observation was not predicted and has not been
explained. Finally, particle production has been found to scale approximately
with the number of participating nucleon pairs for . This scaling
occurs both for the total multiplicity and for high \pT particles (3 <\pT<
4.5 GeV/c).Comment: QM2002 plenary talk, 10 pages, 11 figure
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