On rr-gaps between zeros of the Riemann zeta-function

Under the Riemann Hypothesis, we prove for any natural number $r$ there exist infinitely many large natural numbers $n$ such that $(\gamma_{n+r}-\gamma_n)/(2\pi /\log \gamma_n) > r + \Theta\sqrt{r}$ and $(\gamma_{n+r}-\gamma_n)/(2\pi /\log \gamma_n) < r - \vartheta\sqrt{r}$ for explicit absolute positive constants $\Theta$ and $\vartheta$, where $\gamma$ denotes an ordinate of a zero of the Riemann zeta-function on the critical line. Selberg published announcements of this result several times but did not include a proof. We also suggest a general framework which might lead to stronger statements concerning the vertical distribution of nontrivial zeros of the Riemann zeta-function.Comment: to appear in the Bulletin of the London Mathematical Societ

An effective Chebotarev density theorem for families of number fields, with an application to ℓ\ell-torsion in class groups

We prove a new effective Chebotarev density theorem for Galois extensions $L/\mathbb{Q}$ that allows one to count small primes (even as small as an arbitrarily small power of the discriminant of $L$); this theorem holds for the Galois closures of "almost all" number fields that lie in an appropriate family of field extensions. Previously, applying Chebotarev in such small ranges required assuming the Generalized Riemann Hypothesis. The error term in this new Chebotarev density theorem also avoids the effect of an exceptional zero of the Dedekind zeta function of $L$, without assuming GRH. We give many different "appropriate families," including families of arbitrarily large degree. To do this, we first prove a new effective Chebotarev density theorem that requires a zero-free region of the Dedekind zeta function. Then we prove that almost all number fields in our families yield such a zero-free region. The innovation that allows us to achieve this is a delicate new method for controlling zeroes of certain families of non-cuspidal $L$-functions. This builds on, and greatly generalizes the applicability of, work of Kowalski and Michel on the average density of zeroes of a family of cuspidal $L$-functions. A surprising feature of this new method, which we expect will have independent interest, is that we control the number of zeroes in the family of $L$-functions by bounding the number of certain associated fields with fixed discriminant. As an application of the new Chebotarev density theorem, we prove the first nontrivial upper bounds for $\ell$-torsion in class groups, for all integers $\ell \geq 1$, applicable to infinite families of fields of arbitrarily large degree.Comment: 52 pages. This shorter version aligns with the published paper. Note that portions of Section 8 of the longer v1 have been developed as a separate paper with identifier arXiv:1902.0200

Hepatocellular oxidant stress following intestinal ischemia-reperfusion injury,

Reperfusion of ischemic intestine results in acute liver dysfunction characterized by hepatocellular enzyme release into plasma, reduction in bile flow rate, and neutrophil sequestration within the liver. The pathophysiology underlying this acute hepatic injury is unknown. This study was undertaken to determine whether oxidants are associated with the hepatic injury and to determine the relative value of several indirect methods of assessing oxidant exposure in vivo. Rats were subjected to a standardized intestinal ischemia-reperfusion injury. Hepatic tissue was assayed for lipid peroxidation products and oxidized and reduced glutathione. There was no change in hepatic tissue total glutathione following intestinal ischemia--reperfusion injury. Oxidized glutathione (GSSG) increased significantly following 30 and 60 min of reperfusion. There was no increase in any of the products of lipid peroxidation associated with this injury. An increase in GSSG within hepatic tissue during intestinal reperfusion suggests exposure of hepatocytes to an oxidant stress. The lack of a significant increase in products of lipid peroxidation suggests that the oxidant stress is of insufficient magnitude to result in irreversible injury to hepatocyte cell membranes. These data also suggest that the measurement of tissue GSSG may be a more sensitive indicator of oxidant stress than measurement of products of lipid peroxidation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29014/1/0000043.pd

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks