Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter study

Serotonin type 3 receptors (5-HT3) are involved in learning, cognition and emotion, and have been implicated in various psychiatric phenotypes. However, their contribution to the pathomechanism of these disorders remains elusive. Three single nucleotide polymorphisms (SNPs) in the HTR3A and HTR3B genes (rs1062613, rs1176744 and rs3831455) have been associated with bipolar affective disorder (BPAD) in pilot studies, and all of them are of functional relevance. We performed a European multicenter study to confirm previous results and provide further evidence for the relevance of these SNPs to the etiology of neuropsychiatric disorders. This involved analysis of the distribution of the three SNPs among 1804 BPAD cases and 2407 healthy controls. A meta-analysis revealed a pooled odds ratio of 0.881 (P=0.009, 95% confidence intervals=0.802–0.968) for the non-synonymous functional SNP HTR3B p.Y129S (rs1176744), thereby confirming previous findings. In line with this, the three genome-wide association study samples BOMA (Bonn-Mannheim)-BPAD, WTCCC (Wellcome Trust Case Control Consortium)-BPAD and GAIN (Genetic Association Information Network)-BPAD, including >3500 patients and 5200 controls in total, showed an overrepresentation of the p.Y129 in patients. Remarkably, the meta-analysis revealed a P-value of 0.048 (OR=0.934, fixed effect model). We also performed expression analyses to gain further insights into the distribution of HTR3A and HTR3B mRNA in the human brain. HTR3A and HTR3B were detected in all investigated brain tissues with the exception of the cerebellum, and large differences in the A:B subunit ratio were observed. Interestingly, expression of the B subunit was most prominent in the brain stem, amygdalae and frontal cortex, regions of relevance to psychiatric disorders. In conclusion, the present study provides further evidence for the presence of impaired 5-HT3 receptor function in BPAD

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

publisher: Elsevier articletitle: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes journaltitle: Cell articlelink: https://doi.org/10.1016/j.cell.2018.05.046 content_type: article copyright: © 2018 Elsevier Inc

Stable carbon isotope Composition of c9,t11-conjugated linoleic acid in cow's milk as related to dietary fatty acids

This study explores the potential use of stable carbon isotope ratios (delta C-13) of single fatty acids (FA) as tracers for the transformation of FA from diet to milk, with focus on the metabolic origin of c9,t11-18:2. For this purpose, dairy cows were fed diets based exclusively on C-3 and C-4 plants. The FA in milk and feed were fractionated by silver-ion thin-layer chromatography and analyzed for their delta C-13 values. Mean delta C-13 values of FA from C-3 milk were lower compared to those from C-4 milk (-30.1aEuro degrees vs. -24.9aEuro degrees, respectively). In both groups the most negative delta C-13 values of all FA analyzed were measured for c9,t11-18:2 (C-3 milk = -37.0 +/- A 2.7aEuro degrees; C-4 milk -31.4 +/- A 1.4aEuro degrees). Compared to the dietary precursors 18:2n-6 and 18:3n-3, no significant C-13-depletion was measured in t11-18:1. This suggests that the delta C-13-change in c9,t11-18:2 did not originate from the microbial biohydrogenation in the rumen, but most probably from endogenous desaturation of t11-18:1. It appears that the natural delta C-13 differences in some dietary FA are at least partly preserved in milk FA. Therefore, carbon isotope analyses of individual FA could be useful for studying metabolic transformation processes in ruminants

Литература о Свердловской области: [указатель]. 1954. Вып. 3-4

0|5|Предисловие [c. 5]0|6|Схема классификации летописи литературы о Свердловской области [c. 6]0|9|Коммунистическая партия Советского Союза [c. 9]1|9|Партийное строительство. Руководство партии хозяйственным и культурным строительством [c. 9]1|15|Пропаганда и агитация. Партийное просвещение [c. 15]1|17|История Коммунистической партии Советского Союза [c. 17]0|18|ВЛКСМ. [c. 18]0|21|Пионерские организации и внешкольная работа [c. 21]0|22|История гор. Свердловска и Свердловской области [c. 22]0|23|Социалистическое строительство в Свердловской области [c. 23]0|23|Финансы [c. 23]0|24|Труд [c. 24]1|26|Профессиональные союзы [c. 26]1|27|Социалистическое соревнование. Общие материалы [c. 27]1|28|Соревнование городов [c. 28]0|28|Советское строительство [c. 28]1|28|Выборы в Верховный Совет РСФСР [c. 28]1|28|Местные органы государственной власти [c. 28]1|29|Органы юстиции. Суд и прокуратура [c. 29]0|31|Природа Свердловской области [c. 31]1|31|Геология. Палеонтология. Археология [c. 31]1|32|География [c. 32]1|32|Животный и растительный мир [c. 32]0|32|Техника. Промышленность [c. 32]1|32|История техники и промышленности [c. 32]1|33|Общие вопросы [c. 33]1|34|Производство предметов народного потребления [c. 34]1|35|Строительство. Строительные материалы. Строительная промышленность [c. 35]1|35|Строительство заводов железобетонных изделий [c. 35]1|40|Энергетическая промышленность [c. 40]1|41|Горная промышленность [c. 41]1|44|Металлургическая промышленность [c. 44]1|51|Машиностроительная промышленность [c. 51]1|57|Химическая промышленность [c. 57]1|58|Лесная промышленность [c. 58]1|60|Легкая промышленность [c. 60]1|60|Камнерезное дело [c. 60]1|61|Местная и кооперативная промышленность [c. 61]0|62|Транспорт. Связь [c. 62]1|62|Транспорт [c. 62]1|65|Связь [c. 65]0|65|Сельское хозяйство [c. 65]1|65|Свердловская область на сельскохозяйственной выставке [c. 65]1|69|Трудящиеся города — сельскому хозяйству [c. 69]1|70|Общие вопросы. Колхозы. Совхозы [c. 70]1|72|Освоение целинных и залежных земель [c. 72]1|73|Механизация. Электрификация. МТС [c. 73]1|77|Агротехника. Общее растениеводство. Почвоведение [c. 77]1|79|Частное растениеводство [c. 79]2|79|Зерновые и бобовые культуры [c. 79]2|79|Кормовые культуры . Луга. Пастбища [c. 79]2|79|Садоводство. Плодоводство [c. 79]2|80|Овощеводство [c. 80]1|82|Животноводство [c. 82]0|86|Охота. Рыбоводство [c. 86]0|86|Торговля. Общественное питание [c. 86]0|89|Гражданское строительство. Коммунальное хозяйство. Бытовое обслуживание населения [c. 89]0|91|Здравоохранение. Медицина [c. 91]0|92|Физическая культура. Спорт. Игры [c. 92]0|94|Культура. Просвещение. Наука [c. 94]1|94|Общие вопросы культуры и просвещения. Наука [c. 94]1|95|Семья и быт [c. 95]1|96|Дошкольное воспитание [c. 96]1|96|Начальное и среднее образование [c. 96]1|98|Политехническое обучение в школах [c. 98]1|98|Высшее и среднее специальное образование [c. 98]1|101|Ремесленные училища. Фабрично-заводское обучение. Технические училища [c. 101]1|102|Культурно-просветительная работа [c. 102]0|105|Литературоведение. Художественная литература. Фольклор [c. 105]1|105|Литературная критика и библиография [c. 105]1|107|Художественная литература [c. 107]2|107|Проза [c. 107]2|108|Поэзия [c. 108]2|109|Драматургия [c. 109]2|109|Фельетоны [c. 109]0|111|Искусство [c. 111]1|111|Архитектура [c. 111]1|111|Изобразительное искусство [c. 111]1|112|Театр. Зрелищные предприятия [c. 112]1|114|Музыка [c. 114]1|114|Художественная самодеятельность [c. 114]1|115|Кино [c. 115]1|115|Религия. Наука и религия. Атеизм [c. 115]1|116|Печать [c. 116

Biological insights from 108 schizophrenia-associated genetic loci

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia