Solar-like oscillations in the metal-poor subgiant nu Indi: II. Acoustic spectrum and mode lifetime

Convection in stars excites resonant acoustic waves which depend on the sound speed inside the star, which in turn depends on properties of the stellar interior. Therefore, asteroseismology is an unrivaled method to probe the internal structure of a star. We made a seismic study of the metal-poor subgiant star nu Indi with the goal of constraining its interior structure. Our study is based on a time series of 1201 radial velocity measurements spread over 14 nights obtained from two sites, Siding Spring Observatory in Australia and ESO La Silla Observatory in Chile. The power spectrum of the high precision velocity time series clearly presents several identifiable peaks between 200 and 500 uHz showing regularity with a large and small spacing of 25.14 +- 0.09 uHz and 2.96 +- 0.22 uHz at 330 uHz. Thirteen individual modes have been identified with amplitudes in the range 53 to 173 cm/s. The mode damping time is estimated to be about 16 days (1-sigma range between 9 and 50 days), substantially longer than in other stars like the Sun, the alpha Cen system or the giant xi Hya.Comment: 5 pages, 7 figures, A&A accepte

Assistance at mealtimes in hospital settings and rehabilitation units for older adults from the perspective of patients, families and healthcare professionals: a mixed methods systematic review protocol

REVIEW QUESTION / OBJECTIVES The review question is: assistance at mealtimes for older adults in hospital settings and rehabilitation units: what goes on, what works and what do patients, families and healthcare professionals think about it? The specific objectives are: To determine the effectiveness of meal time assistance initiatives for improving nutritional intake and nutritional status for older adult patients in hospital settings and rehabilitation units To identify and explore the perceptions and experiences of older adult patients and those involved with their care with regard to assistance at mealtimes in hospital settings and rehabilitation units This mixed methods review seeks to develop an aggregated synthesis of quantitative and qualitative data on assistance at mealtimes for older adults in hospital settings and rehabilitation units in order to derive conclusions and recommendations useful for clinical practice and policy decision making

Atmospheric parameters and chemical properties of red giants in the CoRoT asteroseismology fields

A precise characterisation of the red giants in the seismology fields of the CoRoT satellite is a prerequisite for further in-depth seismic modelling. High-resolution FEROS and HARPS spectra were obtained as part of the ground-based follow-up campaigns for 19 targets holding great asteroseismic potential. These data are used to accurately estimate their fundamental parameters and the abundances of 16 chemical species in a self-consistent manner. Some powerful probes of mixing are investigated (the Li and CNO abundances, as well as the carbon isotopic ratio in a few cases). The information provided by the spectroscopic and seismic data is combined to provide more accurate physical parameters and abundances. The stars in our sample follow the general abundance trends as a function of the metallicity observed in stars of the Galactic disk. After an allowance is made for the chemical evolution of the interstellar medium, the observational signature of internal mixing phenomena is revealed through the detection at the stellar surface of the products of the CN cycle. A contamination by NeNa-cycled material in the most massive stars is also discussed. With the asteroseismic constraints, these data will pave the way for a detailed theoretical investigation of the physical processes responsible for the transport of chemical elements in evolved, low- and intermediate-mass stars.Comment: Accepted for publication in A&A, 25 pages, 13 colour figures (revised version after language editing

The analytic structure of 2D Euler flow at short times

Using a very high precision spectral calculation applied to the incompressible and inviscid flow with initial condition $\psi_0(x_1, x_2) = \cos x_1+\cos 2x_2$, we find that the width $\delta(t)$ of its analyticity strip follows a $\ln(1/t)$ law at short times over eight decades. The asymptotic equation governing the structure of spatial complex-space singularities at short times (Frisch, Matsumoto and Bec 2003, J.Stat.Phys. 113, 761--781) is solved by a high-precision expansion method. Strong numerical evidence is obtained that singularities have infinite vorticity and lie on a complex manifold which is constructed explicitly as an envelope of analyticity disks.Comment: 19 pages, 14 figures, published versio

Evidence for a sharp structure variation inside a red-giant star

The availability of precisely determined frequencies of radial and non-radial oscillation modes in red giants is finally paving the way for detailed studies of the internal structure of these stars. We look for the seismic signature of regions of sharp structure variation in the internal structure of the CoRoT target HR7349. We analyse the frequency dependence of the large frequency separation and second frequency differences, as well as the behaviour of the large frequency separation obtained with the envelope auto-correlation function. We find evidence for a periodic component in the oscillation frequencies, i.e. the seismic signature of a sharp structure variation in HR7349. In a comparison with stellar models we interpret this feature as caused by a local depression of the sound speed that occurs in the helium second-ionization region. Using solely seismic constraints this allows us to estimate the mass (M=1.2^{+0.6}_{-0.4} Msun) and radius (R=12.2^{+2.1}_{-1.8} Rsun) of HR7349, which agrees with the location of the star in an HR diagram.Comment: 4 pages, 5 figures, accepted in A&A Letter

Vector-soliton collision dynamics in nonlinear optical fibers

We consider the interactions of two identical, orthogonally polarized vector solitons in a nonlinear optical fiber with two polarization directions, described by a coupled pair of nonlinear Schroedinger equations. We study a low-dimensional model system of Hamiltonian ODE derived by Ueda and Kath and also studied by Tan and Yang. We derive a further simplified model which has similar dynamics but is more amenable to analysis. Sufficiently fast solitons move by each other without much interaction, but below a critical velocity the solitons may be captured. In certain bands of initial velocities the solitons are initially captured, but separate after passing each other twice, a phenomenon known as the two-bounce or two-pass resonance. We derive an analytic formula for the critical velocity. Using matched asymptotic expansions for separatrix crossing, we determine the location of these "resonance windows." Numerical simulations of the ODE models show they compare quite well with the asymptotic theory.Comment: 32 pages, submitted to Physical Review

Long-term exposure to irinotecan reduces cell migration in glioma cells.

In spite of considerable research into the therapies for glioblastoma multiforme this tumour type remains very difficult to treat. As well as having a tendency to be inherently resistant to chemotherapy, glioblastoma multiforme also displays local invasion. Cell line studies have a continued and important role to play in understanding the mechanisms associated with both chemotherapy resistance and invasion. In the current study we have utilized the C6 glioma cell line to investigate the response to long-term, clinically relevant application of topoisomerase I and II inhibitors. Treatment with etoposide resulted in an increase in resistance to this topoisomerase II inhibitor. By contrast, the continuous exposure to a topoisomerase I inhibitor did not result in increased drug resistance, but was associated with a reduction in cell migration. This data supports further investigation of topoisomerase I inhibition as a means to inhibit glioma invasion without the development of parallel chemoresistance

Transformation cloaking and radial approximations for flexural waves in elastic plates

It is known that design of elastic cloaks is much more challenging than that of acoustic cloaks, cloaks of electromagnetic waves or scalar problems of antiplane shear. In this paper, we address fully the fourth-order problem and develop a model of a broadband invisibility cloak for channelling flexural waves in thin plates around finite inclusions. We also discuss an option to employ efficiently an elastic pre-stress and body forces to achieve such a result. An asymptotic derivation provides a rigorous link between the model in question and elastic wave propagation in thin solids. This is discussed in detail to show connection with non-symmetric formulations in vector elasticity studied in earlier work

Mars sample return – a proposed mission campaign whose time is now

The analysis in Earth laboratories of samples that could be returned from Mars is of extremely high interest to the international Mars exploration community. IMEWG (the International Mars Exploration Working Group) has been evaluating options, by means of a working group referred to as iMOST, to refine the scientific objectives of MSR. The Mars 2020 sample-caching rover mission is the first component of the Mars Sample Return campaign, so its existence constitutes a critical opportunity. Finally, on April 26, 2018, NASA and ESA signed a Statement of Intent to work together to formulate, by the end of 2019, a joint plan for the retrieval missions that are essential to the completion of the MSR Campaign. All of these converged April 25-27, 2018 in Berlin, Germany, at the 2nd International Mars Sample Return Conference

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis

Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is invariably fatal if untreated. There are 60 million people at risk from the disease throughout sub-Saharan Africa. The infection progresses from the haemolymphatic stage where parasites invade the blood, lymphatics and peripheral organs, to the late encephalitic stage where they enter the central nervous system (CNS) to cause serious neurological disease. The trivalent arsenical drug melarsoprol (Arsobal) is the only currently available treatment for CNS-stage <i>T.b.rhodesiense</i> infection. However, it must be administered intravenously due to the presence of propylene glycol solvent and is associated with numerous adverse reactions. A severe post-treatment reactive encephalopathy occurs in about 10% of treated patients, half of whom die. Thus melarsoprol kills 5% of all patients receiving it. Cyclodextrins have been used to improve the solubility and reduce the toxicity of a wide variety of drugs. We therefore investigated two melarsoprol cyclodextrin inclusion complexes; melarsoprol hydroxypropyl-͎-cyclodextrin and melarsoprol randomly-methylated-β-cyclodextrin. We found that these compounds retain trypanocidal properties <i>in vitro</i> and cure CNS-stage murine infections when delivered orally, once per day for 7-days, at a dosage of 0.05 mmol/kg. No overt signs of toxicity were detected. Parasite load within the brain was rapidly reduced following treatment onset and magnetic resonance imaging showed restoration of normal blood-brain barrier integrity on completion of chemotherapy. These findings strongly suggest that complexed melarsoprol could be employed as an oral treatment for CNS-stage HAT, delivering considerable improvements over current parenteral chemotherapy