13 research outputs found
“Willkommen im großen Karaoke, das wir Leben nennen”: Bas Böttcher und die Kulissen des Glücks
The multitude of targets for the immune system and drug therapy in the fungal cell wall
Recent studies on fungi revealed that several cytosolic and membrane components migrate to the cell wall together with secreted proteins and biosynthetic polysaccharides to build a dynamic immunoreactive structure. New aspects of fungal cell wall assembly and biosynthesis, focusing on the potential of glycolipids, melanin, heat-shock proteins, historic and surface antigens as targets of drugs and antifungal anti-bodies are discussed. (c) 2005 Elsevier SAS. All rights reserved.Univ Fed Rio de Janeiro, Inst Microbiol Professor Paulo Goes, Lab Estudos Integrados Bioquim Microbiana, CCS, BR-21941590 Rio de Janeiro, RJ, BrazilUniversidade Federal de São Paulo, Disciplina Biol Celular, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Disciplina Biol Celular, BR-04023062 São Paulo, BrazilWeb of Scienc
Textural, chemical, and isotopic effects of late-magmatic carbonatitic fluids in the carbonatite-syenite Tamazeght complex, High Atlas Mountains, Morocco
Carbonatites of the Eocene Tamazeght complex, High Atlas Mountains,
Morocco, consist of calciocarbonatites (alvikite and sovite dykes) and
magnesiocarbonatites (diatreme breccias and dykes rocks). These are
associated with ultramafic, shonkinitic, gabbroic to monzonitic and
various foid syenitic silicate units. Stable and radiogenic isotope
compositions for carbonatites and silicate rocks indicate that they
share a common source in the mantle, although for some carbonatitic
samples contamination with sedimentary rocks seems important. The
observed isotopic heterogeneity is mainly attributed to source
characteristics, fractional crystallization (accompanied by various
degrees of assimilation), and late- to post-magmatic fluid-rock
interaction. During the late fluid-rock interaction, Sr, Mn, and
possibly also Fe were mobilized and redistributed to form secondary
carbonate minerals in carbonatites. These fluids also penetrated into
the adjacent syenitic rocks, causing enrichment in the same elements
Origin of alkaline carbonates in kimberlites of the Siberian craton: Evidence from melt inclusions in mantle olivine of the Udachnaya-East pipe
Recommended from our members
Genetic studies of body mass index yield new insights for obesity biology.
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis
Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study
International audienceEnterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases. 78.9% of infections were reported in children (0-5 years); 37.9% of cases were hospitalised. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases with six reported with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of two novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale EV-D68 European upsurge with severe clinical impact and the emergence of B3-derived lineages