The Role of Glycogen Synthase Kinase-3 (GSK-3) in Alzheimer’s Disease

Open access peer-reviewed chapter.MM acknowledges grant support from EU-FP7 (Neuro.GSK3, project # 223276) and from CDTI’s CENIT program (DENDRIA, project # CEN-20101023).Peer reviewe

Significado psicológico de vida y muerte en jóvenes

Abstract. The objective was to investigate the psychological meaning of life and death for young people. The investigation was conducted with 60 subjects of both sexes, distributed equally. The technique of natural semantic networks was used and the applications were made collective. It was found that life was defined by women in terms of enjoyment, problems and emotional attachments, in comparison to men who related to life's biological and natural aspects. Regarding death, both groups experienced bereavement stages; however, women manifested these aspects more openly, in contrast to men who mentioned the consequences and favorable aspects of death. The study did not lose sight of the fact that one's conception of life and death depends to a great extent on one's social and cultural context.

Chapter The Role of Glycogen Synthase Kinase-3 (GSK-3) in Alzheimer’s Disease

Physiological & neuro-psychology, biopsycholog

Fitting in a Blended Learning Educational System

Scholarship-holders have more pressure than regular students (keeping a GPA ≥3.5/4, managing financial stress, and completing some scholarship’ duties). The research intends to determinate the significant self-regulatory and technological variables that help scholarship-holders (N=402) in a blended learning environment to reach a high GPA and avoid learning burnout. A validated online survey was employed to collect data that were analyzed using descriptive, inferential, and predictive statistical tests under a quantitative research method. It was found that discipline (p=0.000); self-efficacy (p=0.018); task management (p=0.043); goal setting (p=0.021), task persistence (p=0.004) and previous ICT experience (p=0.033) were statistically significant. Regardless limitations, some practical implications are discussed for the scholars

Factores de riesgo y consumo de drogas lícitas e ilícitas en estudiantes de bachillerato

Tesis (Maestría en Ciencias de Enfermería con Enfasis en Salud Comunitaria) U.A.N.L.UANLhttp://www.uanl.mx

Gestión educativa y la calidad de enseñanza de los docentes en la I.E. N° 81003 César Abraham Vallejo Mendoza de Trujillo 2022

Esta investigación que lleva por título Gestión educativa y la calidad de enseñanza de los docentes en la Institución Educativa No 81003 César A. Vallejo Mendoza de Trujillo 2022, cuyo objetivo general fue determinar la relación que existe entre la variable gestión educativa y la variable calidad de enseñanza en los miembros del cuerpo docente de la institución, para lo cual se utilizó como tipo de investigación básica, llegando a un nivel de estudio descriptivo correlacional, también el diseño de investigación propuesto en el estudio fue no experimental y la información se tomó en un solo momento por ello fue de corte fue transversal, el tamaño de la muestra para el estudio fue designado por 51 docentes activos que se encontraban laborando en la institución educativa. Para la recopilación de datos se utilizó como técnica la encuesta apoyada en un instrumento de cuestionario para cada variable estudiada, primero para la variable gestión educativa y segundo para la variable calidad de enseñanza, además la validez de cada uno de los instrumentos fue validada con el método de juicio de expertos alcanzando valores aplicables y la confiabilidad de la información se obtuvo mediante el estadístico alfa de Cronbach cuyos resultados fueron superiores a 0.7 para cada instrumento. los resultados del estadístico Rho (coeficiente de correlación) de Spearman se estableció que las variables gestión educativa y la calidad de enseñanza se relacionan de manera positiva (r = 0.834) y un p-valor de 0.0. En conclusión, se confirmó la correlación significativa entre la gestión educativa y la calidad de enseñanza

Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene

Indexación: Scopus.Synaptic abnormalities have been described in individuals with autism spectrum disorders (ASD). The cell-adhesion molecule Neuroligin-3 (Nlgn3) has an essential role in the function and maturation of synapses and NLGN3 ASD-associated mutations disrupt hippocampal and cortical function. Here we show that Wnt/β-catenin signaling increases Nlgn3 mRNA and protein levels in HT22 mouse hippocampal cells and primary cultures of rat hippocampal neurons. We characterized the activity of mouse and rat Nlgn3 promoter constructs containing conserved putative T-cell factor/lymphoid enhancing factor (TCF/LEF)-binding elements (TBE) and found that their activity is significantly augmented in Wnt/β-catenin cell reporter assays. Chromatin immunoprecipitation (ChIP) assays and site-directed mutagenesis experiments revealed that endogenous β-catenin binds to novel TBE consensus sequences in the Nlgn3 promoter. Moreover, activation of the signaling cascade increased Nlgn3 clustering and co-localization with the scaffold PSD-95 protein in dendritic processes of primary neurons. Our results directly link Wnt/β-catenin signaling to the transcription of the Nlgn3 gene and support a functional role for the signaling pathway in the dysregulation of excitatory/inhibitory neuronal activity, as is observed in animal models of ASD.https://www.nature.com/articles/s41398-018-0093-y.pd

Molecular phylogeny of the liolaemus kriegi complex (Iguania, Liolaemini)

We provide a well-supported phylogenetic hypothesis for all recognized lineages of the Liolaemus kriegi complex based on a multilocus dataset. We used 29 individuals from the eight taxa included in this complex for which we sequenced eight gene regions (two mitochondrial and six nuclear). We implemented maximum likelihood and Bayesian inference methods for the mitochondrial, nuclear, and concatenated sequences and employed BEAST to estimate the species tree. The all genes concatenated analyses and the species trees recovered the L. kriegi complex as monophyletic with high support, including three described species (L. kriegi, Liolaemus ceii, and Liolaemus buergeri) and three previously identified candidate species (Liolaemus sp. A, Liolaemus sp. C, and Liolaemus sp. D), with Liolaemus tregenzai as a closely related taxon. Another previously proposed candidate species (L. sp. B) has a labile topological position that varies depending on the type of markers and analytical methods used. In the mitochondrial gene tree, L. sp. B is recovered within the L. kriegi complex whereas in the "all genes concatenated" analyses and in the nuclear species tree analyses, it is recovered outside of this complex as sister to Liolaemus petrophilus (a representative of the L. petrophilus group). Morphologically, L. sp. B is indistinguishable from L. austromendocinus (also included in the L. petrophilus group); thus, we do not consider L. sp. B as part of the L. kriegi complex. We estimated divergence times for the major clades of the complex based on the species tree hypothesis, and all were inferred to have a Pleistocene origin.Fil: Medina, Cintia Débora. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Avila, Luciano Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Sites, Jack W.. University Brigham Young; Estados UnidosFil: Morando, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentin

Toward common mechanisms for risk factors in Alzheimer's syndrome

The global strategic goal of reducing health care cost, especially the prospects for massive increases due to expanding markets for health care services demanded by aging populations and/or people with a wide range of chronic disorders-disabilities, is a complex and formidable challenge with many facets. Current projection s predict marked increases in the demand for health driven by both the exponential climb in the prevalence of chronic disabilities and the increases in the absolute numbers of people in need of some form of health care. Thus, the looming predicament for the economics of health care systems worldwide mandates the formulation of a strategic goal to foster significant expansion of global R & D efforts to discover and develop wide-ranging interventions to delay and/or prevent the onset of chronic disabling conditions. The rationale for adopting such a tactical objective is based on the premise that the costs and prevalence of chronic disabling conditions will be reduced by half even if a modest delay of 5 years in the onset of disability is obtained by a highly focused multinational research initiative. Because of the recent history of many failures in drug trials, the central thesis of this paper is to argue for the exploration-adoption of novel mechanistic ideas, theories, and paradigms for developing wide range and/or types of interventions. Although the primary focus of our discussion has been on biological approaches to therapy, we recognize the importance of emerging knowledge on nonpharmacological interventions and their potential impact in reducing health care costs. Although we may not find a drug to cure or prevent dementia for a long time, research is starting to demonstrate the potential contributes of nonpharmacological interventions toward the economics of health care in terms of rehabilitation, promoting autonomy, and potential to delay institutionalization, thus promoting healthy aging and reductions in the cost of care