Sociological knowledge and colonial power in Bombay around the First World War

By the turn of the twentieth century a distinct ‘social domain’ – along with its constituent parts, problems and internal dynamics – was turned into a political entity, and a concern for state bureaucracies existed across the industrializing world. Specific motivations for this trend may have varied from location to location, but included arguments for higher industrial productivity and less political discontent, often intertwined with a humanitarian impulse in calls for better housing, expanded public health or improved working conditions. As has been well documented, the politicization of the social domain in early twentieth-century Britain owes much to the consolidation of British sociology as a distinct discipline. Yet while the link between the rise of social politics and sociology has been established with regard to Britain, little has been said about the occurrence of this coupling elsewhere in the twentieth-century British Empire. This article aims to rectify that omission by showing the interplay between newly raised social concerns of the colonial administration in the Bombay Presidency, Western British India, and the establishing of sociological research within the borders of the Presidency around the time of the First World War. The article will explore how the colonial administration in Bombay planned to meet new demands for sociological knowledge in colonial state policy, how sociology was subsequently introduced into the Presidency as a research subject, and how new sociological methods were applied in actual colonial government

Knowledge Appropriation: Turning social research into political action in colonial India

In this essay, I will discuss a conflation of knowledge and demands for political reform in mid-nineteenth-century India. At the centre of my discussion is an objection to the often-reiterated argument that emphasizes how colonial forms of knowledge underpinned the British regime in its bid to control and subjugate Indians. Rather, I would suggest that Indians appropriated and put to work data and institutional forms for making and communicating knowledge that the British initially had monopolized, in political activities challenging the British administration

Indian Revolutionaries Abroad: Revisiting their silent moments

In this article I relate Indian revolutionaries Virendranath Chattopadhyaya’s and Lala Har Dayal’s experiences of exile in Sweden to recent attempts to reformulate perspectives on Indian anti-colonial protest. These attempts have in various ways focused on the global dimension of Indian anti-colonialism, showing how displaced Indian intellectuals and activists connected outside the Subcontinent, to labour for the freedom of India. While appreciating the need for a fresh approach to studies of anti-colonial movements, this article issues a note of caution. Several recent studies treat life in exile as one of connectivity and creativity. In fact, connectivity becomes so important for these studies that it is only when in conversation with others sharing their objective that the views of Indian activists are included. Yet, many exiles lived long periods nearly or actually disconnected from the movement of which they wished to form a part. Such moments of silence are wishfully glossed over in the emerging literature. By way of revisiting Har Dayal and Chattopadhyaya in Sweden, I suggest that periods of silence or disconnection are important, simply because they existed, and formed a decisive part of the reality of exile. By omitting them, one risks romanticising exile, and subjecting experiences of displacement to academic programmatic concerns, however noble the cause

Social imperialism and how it was applied in the Bombay Presidency, 1895-1925.

This thesis traces how British imperialism, as an ideology of empire, developed a social dimension by the turn of the twentieth century. Drawing on archival sources, the thesis explores what motivated British social imperialism, how knowledge and political thought operated within it, and how it translated into local colonial policy in the Bombay Presidency, British India, between 1895-1925. The study uses Michel Foucault's concept of bio-politics to engage the ways in which emerging social liberalism, and British sociology, enabled the conceptualisation and politicisation of a distinct social domain, and helped putting 'the social' into British imperialism. Sociology and social liberalism defined the social in vague terms. Yet, I will show, it was seen as key to stability and progress. It was perceived by contemporaries as contingent of, but not determined by, industrial capitalism and the emergence of modem industrial society. Liberalism, the thesis points out, had always been closely related to British imperialism in general, and the British administration of India in particular. The introduction of a social element in liberalism did not end that relationship; rather, it enabled a shift in preferred domain of intervention from the moral to the social. I outline what constituted social liberalism and how it influenced imperial thought. Sociology, in turn, delineated the social domain and made it known. I revisit turn of the twentieth-century debates within British sociology and trace how these debates informed the official introduction of sociological research into colonial India. The study examines various angles of how social imperialism translated into the Presidency. It shows how administrators began to frame interventions through social-political language, and how they utilised sociological methodology and research. It analyses actual social interventions of sanitation, education, and housing. 1 suggest that social interventions, evoked in the name of stability and progress, formed as measures to draw on and channel movements and tendencies within colonial society, while simultaneously promoting the state as vehicle for reform. Social interventions widened the scope of colonial state action, and so limited society and market based approaches to conditions of life

A Fluorescent Chromatophore Changes the Level of Fluorescence in a Reef Fish

Body coloration plays a major role in fish ecology and is predominantly generated using two principles: a) absorbance combined with reflection of the incoming light in pigment colors and b) scatter, refraction, diffraction and interference in structural colors. Poikilotherms, and especially fishes possess several cell types, so-called chromatophores, which employ either of these principles. Together, they generate the dynamic, multi-color patterns used in communication and camouflage. Several chromatophore types possess motile organelles, which enable rapid changes in coloration. Recently, we described red fluorescence in a number of marine fish and argued that it may be used for private communication in an environment devoid of red. Here, we describe the discovery of a chromatophore in fishes that regulates the distribution of fluorescent pigments in parts of the skin. These cells have a dendritic shape and contain motile fluorescent particles. We show experimentally that the fluorescent particles can be aggregated or dispersed through hormonal and nervous control. This is the first description of a stable and natural cytoskeleton-related fluorescence control mechanism in vertebrate cells. Its nervous control supports suggestions that fluorescence could act as a context-dependent signal in some marine fish species and encourages further research in this field. The fluorescent substance is stable under different chemical conditions and shows no discernible bleaching under strong, constant illumination

How Molecular Motors Are Arranged on a Cargo Is Important for Vesicular Transport

The spatial organization of the cell depends upon intracellular trafficking of cargos hauled along microtubules and actin filaments by the molecular motor proteins kinesin, dynein, and myosin. Although much is known about how single motors function, there is significant evidence that cargos in vivo are carried by multiple motors. While some aspects of multiple motor function have received attention, how the cargo itself —and motor organization on the cargo—affects transport has not been considered. To address this, we have developed a three-dimensional Monte Carlo simulation of motors transporting a spherical cargo, subject to thermal fluctuations that produce both rotational and translational diffusion. We found that these fluctuations could exert a load on the motor(s), significantly decreasing the mean travel distance and velocity of large cargos, especially at large viscosities. In addition, the presence of the cargo could dramatically help the motor to bind productively to the microtubule: the relatively slow translational and rotational diffusion of moderately sized cargos gave the motors ample opportunity to bind to a microtubule before the motor/cargo ensemble diffuses out of range of that microtubule. For rapidly diffusing cargos, the probability of their binding to a microtubule was high if there were nearby microtubules that they could easily reach by translational diffusion. Our simulations found that one reason why motors may be approximately 100 nm long is to improve their ‘on’ rates when attached to comparably sized cargos. Finally, our results suggested that to efficiently regulate the number of active motors, motors should be clustered together rather than spread randomly over the surface of the cargo. While our simulation uses the specific parameters for kinesin, these effects result from generic properties of the motors, cargos, and filaments, so they should apply to other motors as well

Pigmentation plasticity enhances crypsis in larval newts: Associated metabolic cost and background choice behaviour

In heterogeneous environments, the capacity for colour change can be a valuable adaptation enhancing crypsis against predators. Alternatively, organisms might achieve concealment by evolving preferences for backgrounds that match their visual traits, thus avoiding the costs of plasticity. Here we examined the degree of plasticity in pigmentation of newt larvae (Lissotriton boscai) in relation to predation risk. Furthermore, we tested for associated metabolic costs and pigmentation-dependent background choice behaviour. Newt larvae expressed substantial changes in pigmentation so that light, high-reflecting environment induced depigmentation whereas dark, low-reflecting environment induced pigmentation in just three days of exposure. Induced pigmentation was completely reversible upon switching microhabitats. Predator cues, however, did not enhance cryptic phenotypes, suggesting that environmental albedo induces changes in pigmentation improving concealment regardless of the perceived predation risk. Metabolic rate was higher in heavily pigmented individuals from dark environments, indicating a high energetic requirement of pigmentation that could impose a constraint to larval camouflage in dim habitats. Finally, we found partial evidence for larvae selecting backgrounds matching their induced phenotypes. However, in the presence of predator cues, larvae increased the time spent in light environments, which may reflect a escape response towards shallow waters rather than an attempt at increasing crypsisFinancial support was provided by the Spanish Ministry of Science and Innovation (MICINN), Grant CGL2012-40044 to IGM, and by the Universidad Autónoma de Madrid, Short Stay Grant to NPC. Additional financial support was provided by the MICINN, Grant CGL2015-68670-R to NP

The N-terminal region of centrosomal protein 290 (CEP290) restores vision in a zebrafish model of human blindness

The gene coding for centrosomal protein 290 (CEP290), a large multidomain protein, is the most frequently mutated gene underlying the non-syndromic blinding disorder Leber's congenital amaurosis (LCA). CEP290 has also been implicated in several cilia-related syndromic disorders including Meckel–Gruber syndrome, Joubert syndrome, Senor–Loken syndrome and Bardet–Biedl syndrome (BBS). In this study, we characterize the developmental and functional roles of cep290 in zebrafish. An antisense oligonucleotide [Morpholino (MO)], designed to generate an altered cep290 splice product that models the most common LCA mutation, was used for gene knockdown. We show that cep290 MO-injected embryos have reduced Kupffer's vesicle size and delays in melanosome transport, two phenotypes that are observed upon knockdown of bbs genes in zebrafish. Consistent with a role in cilia function, the cep290 MO-injected embryos exhibited a curved body axis. Patients with LCA caused by mutations in CEP290 have reduced visual perception, although they present with a fully laminated retina. Similarly, the histological examination of retinas from cep290 MO-injected zebrafish revealed no gross lamination defects, yet the embryos had a statistically significant reduction in visual function. Finally, we demonstrate that the vision impairment caused by the disruption of cep290 can be rescued by expressing only the N-terminal region of the human CEP290 protein. These data reveal that a specific region of the CEP290 protein is sufficient to restore visual function and this region may be a viable gene therapy target for LCA patients with mutations in CEP290

The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells

The protein product of the ocular albinism type 1 gene, named OA1, is a pigment cell-specific G protein-coupled receptor exclusively localized to intracellular organelles, namely lysosomes and melanosomes. Loss of OA1 function leads to the formation of macromelanosomes, suggesting that this receptor is implicated in organelle biogenesis, however the mechanism involved in the pathogenesis of the disease remains obscure. We report here the identification of an unexpected abnormality in melanosome distribution both in retinal pigment epithelium (RPE) and skin melanocytes of Oa1-knock-out (KO) mice, consisting in a displacement of the organelles from the central cytoplasm towards the cell periphery. Despite their depletion from the microtubule (MT)-enriched perinuclear region, Oa1-KO melanosomes were able to aggregate at the centrosome upon disruption of the actin cytoskeleton or expression of a dominant-negative construct of myosin Va. Consistently, quantification of organelle transport in living cells revealed that Oa1-KO melanosomes displayed a severe reduction in MT-based motility; however, this defect was rescued to normal following inhibition of actin-dependent capture at the cell periphery. Together, these data point to a defective regulation of organelle transport in the absence of OA1 and imply that the cytoskeleton might represent a downstream effector of this receptor. Furthermore, our results enlighten a novel function for OA1 in pigment cells and suggest that ocular albinism type 1 might result from a different pathogenetic mechanism than previously thought, based on an organelle-autonomous signalling pathway implicated in the regulation of both membrane traffic and transport

Genomic Hotspots for Adaptation: The Population Genetics of Müllerian Mimicry in the Heliconius melpomene Clade

Wing patterning in Heliconius butterflies is a longstanding example of both Müllerian mimicry and phenotypic radiation under strong natural selection. The loci controlling such patterns are “hotspots” for adaptive evolution with great allelic diversity across different species in the genus. We characterise nucleotide variation, genotype-by-phenotype associations, linkage disequilibrium, and candidate gene expression at two loci and across multiple hybrid zones in Heliconius melpomene and relatives. Alleles at HmB control the presence or absence of the red forewing band, while alleles at HmYb control the yellow hindwing bar. Across HmYb two regions, separated by ∼100 kb, show significant genotype-by-phenotype associations that are replicated across independent hybrid zones. In contrast, at HmB a single peak of association indicates the likely position of functional sites at three genes, encoding a kinesin, a G-protein coupled receptor, and an mRNA splicing factor. At both HmYb and HmB there is evidence for enhanced linkage disequilibrium (LD) between associated sites separated by up to 14 kb, suggesting that multiple sites are under selection. However, there was no evidence for reduced variation or deviations from neutrality that might indicate a recent selective sweep, consistent with these alleles being relatively old. Of the three genes showing an association with the HmB locus, the kinesin shows differences in wing disc expression between races that are replicated in the co-mimic, Heliconius erato, providing striking evidence for parallel changes in gene expression between Müllerian co-mimics. Wing patterning loci in Heliconius melpomene therefore show a haplotype structure maintained by selection, but no evidence for a recent selective sweep. The complex genetic pattern contrasts with the simple genetic basis of many adaptive traits studied previously, but may provide a better model for most adaptation in natural populations that has arisen over millions rather than tens of years