Análisis De Viabilidad Y Desafíos De La Implementación De Energías Renovables En La Isla De San Andrés (ERSA): Un Enfoque Hacia La Sostenibilidad Energética Insular

El Departamento Archipiélago de San Andrés, Providencia y Santa Catalina se enfrenta a desafíos significativos en términos de transición energética. Como parte del territorio insular de Colombia, este departamento depende en gran medida de los combustibles fósiles para su suministro energético, lo que contribuye a las emisiones de gases de efecto invernadero y al cambio climático. Sin embargo, el gobierno colombiano ha establecido metas ambiciosas para reducir las emisiones de GEI en un 51% para el año 2030, lo que requiere una transformación integral del sector energético en la región. La transición energética en el Archipiélago de San Andrés implica el cambio hacia fuentes de energía renovable y sostenible, así como la promoción de la eficiencia energética. Esto implica la implementación de políticas y regulaciones que fomenten el uso de energías limpias, así como la inversión en infraestructuras y tecnologías adecuadas. Además, es esencial promover la educación y la sensibilización sobre la importancia de la sostenibilidad y las energías renovables entre la población local. El seguimiento constante y las evaluaciones periódicas son fundamentales para garantizar el progreso y la efectividad de la transición energética en el Archipiélago de San Andrés. El monitoreo de las emisiones de GEI y la evaluación de los proyectos implementados son herramientas clave para identificar áreas de mejora y asegurar el cumplimiento de los objetivos establecidos. La normatividad clara, los incentivos financieros y el fortalecimiento de la capacidad técnica también son factores importantes para el éxito de esta transición

Sistema administrativo modular para restaurantes

No aplicaLos restaurantes enfrentan dificultades para analizar sus costos debido a la falta de un sistema de información adecuado. Esto puede hacer que sea difícil para los propietarios y gerentes de restaurantes identificar los costos de los productos y servicios y tomar decisiones informadas sobre los precios y la estrategia de negocios. El manejo de inventario también se ve afectado por la falta de un sistema de información. Sin un sistema de seguimiento de inventario, los restaurantes pueden tener dificultades para saber qué productos están disponibles, cuánto se está gastando en ellos y cuándo es necesario reponerlos. Esto puede llevar a una sobrecarga de trabajo para los empleados y a un aumento de los costos de almacenamiento. La falta de un sistema de información también puede dificultar la toma de decisiones en cuanto a la estrategia de negocio del restaurante, ya que no se cuenta con información precisa y actualizada sobre los costos y los inventarios. Es importante para los restaurantes tener un sistema de información adecuado para poder analizar sus costos y manejar sus inventarios de manera eficiente. Esto puede incluir el uso de herramientas de software de gestión de inventarios y programas de contabilidad para ayudar a los propietarios y gerentes de restaurantes a tomar decisiones informadas sobre los precios y la estrategia de negocios. En la actualidad se tiene diversos tipos de restaurantes, tenemos restaurantes de proporciones pequeñas de entrada y salida de usuarios, sin mesas para la atención, hasta restaurantes de grandes magnitudes, pensando en esto se ha logrado dividir un sistema administrativo en módulos, la definición de modulo nos muestra que es un componente de un software completo que es desarrollado de forma independiente para una función específica, el sistema que se propone en este caso, son módulo de ventas, módulo de inventario, módulo de compras, módulo de informes, todo pensando en la necesidad diferencial de cada lugar. En resumen, se puede afirmar que la falta de un sistema de información adecuado en los restaurantes puede generar dificultades en el análisis de costos y en el manejo de inventarios, lo que se traduce en una mala toma de decisiones y en un aumento de los costos de almacenamiento y trabajo.Restaurants face difficulties in analyzing their costs due to the lack of an adequate information system. This can make it difficult for restaurant owners and managers to identify the costs of products and services and make informed decisions about pricing and business strategy. Inventory management is also affected by the lack of an information system. Without an inventory tracking system, restaurants can have a hard time knowing what products are in stock, how much is being spent on them, and when they need to be restocked. This can lead to overwork for employees and increased storage costs. The lack of an information system can also make it difficult to make decisions regarding the restaurant's business strategy, since there is no accurate and updated information on costs and inventories. It is important for restaurants to have an adequate information system to be able to analyze their costs and manage their inventories efficiently. This may include the use of inventory management software tools and accounting programs to help restaurant owners and managers make informed decisions about pricing and business strategy. At present there are various types of restaurants, we have restaurants of small proportions of entrance and exit of users, without tables for attention, even restaurants of large magnitudes, thinking about this, it has been possible to divide an administrative system into modules, the definition of module shows us that it is a component of a complete software that is developed independently for a specific function, the system that is proposed in this case, are sales module, inventory module, purchasing module, reporting module, all thinking in the differential need of each place. In summary, it can be stated that the lack of an adequate information system in restaurants can generate difficulties in cost analysis and inventory management, which translates into poor decision making and increased costs. storage and work

Diet restriction in migraine, based on IgG against foods: A clinical double-blind, randomised, cross-over trial

Introduction: It is well-known that specific foods trigger migraine attacks in some patients. We aimed to investigate the effect of diet restriction, based on IgG antibodies against food antigens on the course of migraine attacks in this randomised, double blind, cross-over, headache-diary based trial on 30 patients diagnosed with migraine without aura

Propuesta de un plan de auditoria para para la empresa Estrella Gourmet basado en la norma ISO 22000:2018

Anexo A: programa de auditoría ISO 22000:2018 empresa productos alimenticioe estrella gourmet - Anexo B: Lista de chequeo ISO 22000:2018 empresa productos alimenticioe estrella gourmetEste documento hace referencia a una formulación que estructura un plan de auditoria al Sistema de Gestión de Calidad e Inocuidad ISO 22000:2018, Plan HACCP e ISO 14001:2015, adoptados en la empresa “Productos Alimenticios Estrella Gourmet. Esta evaluación parte de una verificación inicial mediante la aplicación de una lista de chequeo que permitió detectar 8 hallazgos como incumplimiento a los criterios de las normas anteriormente mencionadas. En segunda instancia estos hallazgos se revisan y se clasifican con base a la pirámide de calidad para su respectivo tratamiento mediante la elaboración de un plan de auditoría y luego un programa de auditoría donde se describe los hallazgos encontrados en los diferentes procesos y se toma como insumo para la estructuración de la auditoría. Con los planes de auditorías se pretende reconocer e identificar los procesos más vulnerables, obtener evidencias, proporcionar acciones de mejoramiento y resolver problemas potenciales que permita verificar y analizar la eficiencia y eficacia del sistema implementado por la empresa “Productos Alimenticios Estrella Gourmet”. Con este plan de auditorías se pretende evaluar y verificar la eficacia y el cumplimiento de las acciones tomadas como oportunidades de mejora en los diferentes procesos y procedimientos de control interno relacionados con la seguridad alimentaria, la calidad de los productos elaborados y el cumplimiento de las regulaciones y normativas aplicables.This document refers to a formulation that structures an audit plan for the ISO 22000:2018 Quality and Safety Management System, HACCP Plan and ISO 14001:2015, adopted in the company "Productos Alimenticios Estrella Gourmet. This evaluation starts from an initial verification through the application of a checklist that allowed detecting 8 findings as non-compliance with the criteria of the aforementioned standards. In the second instance, these findings are reviewed and classified based on the quality pyramid for their respective treatment through the preparation of an audit plan and then an audit program where the findings found in the different processes are described and taken as input. for structuring the audit. With the audit plans it is intended to recognize and identify the most vulnerable processes, obtain evidence, provide improvement actions and solve potential problems that allow verifying and analyzing the efficiency and effectiveness of the system implemented by the company "Productos Alimenticios Estrella Gourmet". This audit plan is intended to evaluate and verify the effectiveness and compliance of the actions taken as opportunities for improvement in the different internal control processes and procedures related to food safety, the quality of the products produced and compliance with regulations. and applicable regulations

Salivary cytokines as biomarkers of periodontal diseases

Periodontal disease is time consuming and expensive to treat and therefore its prevention, early detection and management are issues which, if effectively addressed, are likely to yield considerable health-care benefit (97). However, despite numerous advances in our understanding of the pathogenesis of chronic inflammatory diseases, periodontitis is still only diagnosed once connective tissue and bone destruction has occurred. Furthermore, monitoring disease progression is a highly skilled and technically demanding process, involving measurement of bleeding on probing, probing depth and attachment loss coupled with radiographic assessment and (subjective) visual observations (76). It would be highly desirable to develop biomarkers for early detection of periodontal disease and to identify progression because current diagnostic approaches do not reflect current disease activity but simply assess the cumulative effects of historical tissue destruction (53). Rational diagnosis would also have concomitant patient benefit because the paucity of evidence-based knowledge of disease progression in individual patients may lead to unintentional clinical mismanagement (97). In addition, studies of the salivary mediators associated with disease may help in the development of novel therapies aimed at controlling cytokine bioavailability (e.g. through anti-cytokine antibodies, antagonists or soluble receptors) or by targeting the intracellular signaling pathways they activate, approaches which have been successful in the treatment of other chronic inflammatory diseases, such as rheumatoid arthritis (60, 91, 95). Cytokines have been defined as soluble factors produced by one (immune) cell that act on another cell within the same milieu (26). However, it is now recognized that the range of molecules with cytokine-like activity can be extended to include, for example, growth factors and adipokines, which also have immunoregulatory functions. Importantly, cytokine functions often overlap or merge, building a complex immunoregulatory network in the immune system that is often perturbed in disease. It is increasingly appreciated that cytokines have vital roles in the development and homeostasis of numerous cell types and, in a wide range of tissues, have roles in resolution of inflammation, wound healing, repair and regeneration. In the following review, the term ‘cytokine’ will be used in this broad context. In addition to direct analysis of cytokines, the levels of molecules such as matrix metalloproteinases and tissue inhibitors of metalloproteinases, which are regulated by cytokines, have also been given considerable attention as potential periodontitis biomarkers, as reviewed elsewhere in this volume of Periodontology 2000

Wnt5a Regulates Midbrain Dopaminergic Axon Growth and Guidance

During development, precise temporal and spatial gradients are responsible for guiding axons to their appropriate targets. Within the developing ventral midbrain (VM) the cues that guide dopaminergic (DA) axons to their forebrain targets remain to be fully elucidated. Wnts are morphogens that have been identified as axon guidance molecules. Several Wnts are expressed in the VM where they regulate the birth of DA neurons. Here, we describe that a precise temporo-spatial expression of Wnt5a accompanies the development of nigrostriatal projections by VM DA neurons. In mice at E11.5, Wnt5a is expressed in the VM where it was found to promote DA neurite and axonal growth in VM primary cultures. By E14.5, when DA axons are approaching their striatal target, Wnt5a causes DA neurite retraction in primary cultures. Co-culture of VM explants with Wnt5a-overexpressing cell aggregates revealed that Wnt5a is capable of repelling DA neurites. Antagonism experiments revealed that the effects of Wnt5a are mediated by the Frizzled receptors and by the small GTPase, Rac1 (a component of the non-canonical Wnt planar cell polarity pathway). Moreover, the effects were specific as they could be blocked by Wnt5a antibody, sFRPs and RYK-Fc. The importance of Wnt5a in DA axon morphogenesis was further verified in Wnt5a−/− mice, where fasciculation of the medial forebrain bundle (MFB) as well as the density of DA neurites in the MFB and striatal terminals were disrupted. Thus, our results identify a novel role of Wnt5a in DA axon growth and guidance

Measurement of the J/ψ\psi photoproduction cross section over the full near-threshold kinematic region

We report the total and differential cross sections for $J/\psi$ photoproduction with the large acceptance GlueX spectrometer for photon beam energies from the threshold at 8.2~GeV up to 11.44~GeV and over the full kinematic range of momentum transfer squared, $t$. Such coverage facilitates the extrapolation of the differential cross sections to the forward ($t = 0$) point beyond the physical region. The forward cross section is used by many theoretical models and plays an important role in understanding $J/\psi$ photoproduction and its relation to the $J/\psi-$proton interaction. These measurements of $J/\psi$ photoproduction near threshold are also crucial inputs to theoretical models that are used to study important aspects of the gluon structure of the proton, such as the gluon Generalized Parton Distribution (GPD) of the proton, the mass radius of the proton, and the trace anomaly contribution to the proton mass. We observe possible structures in the total cross section energy dependence and find evidence for contributions beyond gluon exchange in the differential cross section close to threshold, both of which are consistent with contributions from open-charm intermediate states.Comment: 15 pages 18 figure

Low-Energy Physics in Neutrino LArTPCs

In this white paper, we outline some of the scientific opportunities and challenges related to detection and reconstruction of low-energy (less than 100 MeV) signatures in liquid argon time-projection chamber (LArTPC) detectors. Key takeaways are summarized as follows. 1) LArTPCs have unique sensitivity to a range of physics and astrophysics signatures via detection of event features at and below the few tens of MeV range. 2) Low-energy signatures are an integral part of GeV-scale accelerator neutrino interaction final states, and their reconstruction can enhance the oscillation physics sensitivities of LArTPC experiments. 3) BSM signals from accelerator and natural sources also generate diverse signatures in the low-energy range, and reconstruction of these signatures can increase the breadth of BSM scenarios accessible in LArTPC-based searches. 4) Neutrino interaction cross sections and other nuclear physics processes in argon relevant to sub-hundred-MeV LArTPC signatures are poorly understood. Improved theory and experimental measurements are needed. Pion decay-at-rest sources and charged particle and neutron test beams are ideal facilities for experimentally improving this understanding. 5) There are specific calibration needs in the low-energy range, as well as specific needs for control and understanding of radiological and cosmogenic backgrounds. 6) Novel ideas for future LArTPC technology that enhance low-energy capabilities should be explored. These include novel charge enhancement and readout systems, enhanced photon detection, low radioactivity argon, and xenon doping. 7) Low-energy signatures, whether steady-state or part of a supernova burst or larger GeV-scale event topology, have specific triggering, DAQ and reconstruction requirements that must be addressed outside the scope of conventional GeV-scale data collection and analysis pathways