Benefits of a Fog-to-Cloud Approach in Proximity Marketing

The EC H2020 mF2C Project is working to the development of a software framework that enables the orchestration of resources and communication at fog level, as an extension of cloud computing and interacting with the IoT. In order to show the project functionalities and added-values three real world use cases have been chosen. This paper introduces one of the mF2C use cases: Smart Fog Hub Service (SFHS) use case, in the context of an airport, with the objective of proving that the adoption of the fog-to-cloud approach brings relevant benefits in terms of performance and optimization of resource usage, thus giving an objective evidence of the impact of the mF2C framework.This work is supported by the H2020 mF2C project (730929)Peer ReviewedPostprint (author's final draft

Inoculação de sementes de milho com Azospirillum brasiliense em diferentes doses de nitrogênio

The objective of this study was to evaluated the performance of maize in the presence or absence of seed inoculation with Azospirillum brasilense using different nitrogen (N) rates. One experiment was carried out in Erval Velho, Santa Catarina state, Brazil, during the 2010/11 crop season. The experimental design was a complete block with three replications in a 2 x 4factorial scheme. Seeds with and without inoculation and fve N rates (0, 40, 80, 135 and 200kg/ha) were used. As to grain yield, no interaction between inoculation and N rates was observed. However, both the inoculation and the N fertlization promoted yield increment.O objetvo deste trabalho foi avaliar o desempenho da cultura do milho na presença ou ausência de inoculação de sementes com Azospirillum brasilense com diferentes doses de nitrogênio (N) aplicado em cobertura. O experimento foi conduzido em Erval Velho, SC, no ano agrícola 2010/11, utlizando-se delineamento experimental de blocos completos, com três repetições, em esquema fatorial 2 x 5. Foram utilizadas sementes com e sem inoculação de Azospirillum brasilense e testadas cinco doses de N em cobertura: 0, 40, 80, 135 e 200kg/ha. Para produtividade de grãos não houve interação entre inoculação e doses de N. Entretanto, houve aumento da produtividade em função da inoculação e do incremento das dosesde N

Human The Distal Perforators Of Posterior Tibial Artery. A Study For The Correct Planning Of Medial Lower Leg Flaps

 The adipofascial flap, introduced by Lin in 1994 (1), has many advantages compared to fasciocutaneous or free flaps for lower limb reconstruction. Its dissection is relatively easy and fast with low donor site morbidity and it doesn’t alter the shape of the leg. The aim of this dissection study is to evaluate the anatomic localization of the most distal perforator of the posterior tibial vessels to provide an anatomical rationale for the safe harvesting of distally based medial adipofascial flaps of the leg. Thirty lower limbs from 15 cadavers were used for this study. In all the limbs, the femoral artery was cannulated. Different techniques of injection were employed. 26 specimens were injected with latex to fill the entire vascular network and ease dissection. 3 specimens were injected with a mixture of barium sulphate and gelatin and underwent a CT scan. CT scan dataset were used to make 3D reconstruction. They underwent anatomical dissection after the scan. 1 Specimen was injected with red epoxy resin mixed with barium sulphate (2). This technique is aimed to perform comparative anatomical vascular studies between CT three-dimensional reconstructions and traditional dissection techniques. A distal perforator was found in all specimens; the mean caliber was 0.77 mm. In all cases, the perforator artery passed in the septum between flexor hallucis longus m. and flexor digitorum longus m. and was accompanied by two veins. In our series, the distance between the lowest perforator and the medial malleolus ranged from 3.5 to 8.2 cm. The median was 6.75 cm, the 5th percentile 4 cm and the 95th percentile 8.1 cm. The mean distance of the perforator from the medial tibial border was 1.23 cm. The mean ratio between the distance of perforator from the medial malleolus and the total leg length was 21%. Compared to all previous researches (3), our study has found more distal perforators from posterior tibial perforator artery. This fact may have important clinical consequences because the anteromedial adipofascial flap would cover more distal soft tissue defects. Moreover, our data suggest some safety parameters to make the rising of a medial adipofascial leg flap safer in surgical practice

About the absence of musculocutaneous nerve

Introduction: Musculocutaneous nerve (C5-7) derives (90,5%) from the lateral cord of brachial plexus at the level of lateral border of pectoralis minor [1]. MC nerve pierces the coracobrachialis muscle and descends between the biceps brachii and brachialis to the lateral side of the elbow and terminates as the lateral cutaneous nerve of forearm. It supplies the biceps brachi, the coracobrachialis and the brachialis. Its terminal branch is purely sensory. Variations in the MC nerve course, distribution and termination have been reported and variably classified [2]. The most frequent variations are the presence of communicating branches with the median nerve [3] and the nerve not perforating the coracobrachialis muscle [4]. Total absence of MC nerve is less frequent (1.4 to 15%) [5]. Materials and Methods: 25 upper limbs from 13 cadavers were dissected. A skin incision was performed on deltopectoral groove and arm midline. Two fasciocutaneous flaps were raised, exposing brachial plexus and MC nerve. Results: In two specimens MC was not demonstrable. In these cases, the nerve branches to the coracobrachialis muscle and the lateral cutaneous forearm nerve originated directly from the median nerve. Conclusion: during embryogenesis MC nerve is derived relatively late, thus its absence may correspond to an incomplete differentiation of the brachial plexus. We believe this anatomical variation noteworthy because clinical procedures as plexus block or Latarjet’s procedure may be affected from MCN anomalies

Relationship between headaches and tinnitus in a Swedish study

The heterogeneity of tinnitus is likely accounting for the lack of effective treatment approaches. Headaches have been related to tinnitus, yet little is known on how headaches impact tinnitus. We use cross-sectional data from the Swedish Tinnitus Outreach Project to i) evaluate the association between headaches and tinnitus (n = 1,984 cases and 1,661 controls) and ii) investigate the phenotypic characteristics of tinnitus subjects with tinnitus (n = 660) or without (n = 1,879) headaches. In a multivariable logistic regression model, headache was significantly associated with any tinnitus (odds ratio, OR = 2.61) and more so with tinnitus as a big problem (as measured by the tinnitus functional index, TFI ≥ 48; OR = 5.63) or severe tinnitus (using the tinnitus handicap inventory, THI ≥ 58; OR = 4.99). When focusing on subjects with tinnitus, the prevalence of headaches was 26% and reached 40% in subjects with severe tinnitus. A large number of socioeconomic, phenotypic and psychological characteristics differed between headache and non-headache subjects with any tinnitus. With increasing tinnitus severity, fewer differences were found, the major ones being vertigo, neck pain and other pain syndromes, as well as stress and anxiety. Our study suggests that headaches could contribute to tinnitus distress and potentially its severity.publishedVersio

Association between Hyperacusis and Tinnitus

The following are available online at http://www.mdpi.com/2077-0383/9/8/2412/ s1We gratefully acknowledge the support and generosity of Nancy Pedersen, head of LifeGene.Many individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between hyperacusis and tinnitus is lacking. Here, we investigate this relationship in a Swedish study. A total of 3645 participants (1984 with tinnitus and 1661 without tinnitus) were enrolled via LifeGene, a study from the general Swedish population, aged 18–90 years, and provided information on socio-demographic characteristics, as well as presence of hyperacusis and its severity. Tinnitus presence and severity were self-reported or assessed using the Tinnitus Handicap Inventory (THI). Phenotypes of tinnitus with (n = 1388) or without (n = 1044) hyperacusis were also compared. Of 1661 participants without tinnitus, 1098 (66.1%) were women and 563 were men (33.9%), and the mean (SD) age was 45.1 (12.9). Of 1984 participants with tinnitus, 1034 (52.1%) were women and 950 (47.9%) were men, and the mean (SD) age was 47.7 (14.0) years. Hyperacusis was associated with any tinnitus [Odds ratio (OR) 3.51, 95% confidence interval (CI) 2.99–4.13], self-reported severe tinnitus (OR 7.43, 95% CI 5.06–10.9), and THI ≥ 58 (OR 12.1, 95% CI 7.06–20.6). The association with THI ≥ 58 was greater with increasing severity of hyperacusis, the ORs being 8.15 (95% CI 4.68–14.2) for moderate and 77.4 (95% CI 35.0–171.3) for severe hyperacusis. No difference between sexes was observed in the association between hyperacusis and tinnitus. The occurrence of hyperacusis in severe tinnitus is as high as 80%, showing a very tight relationship. Discriminating the pathophysiological mechanisms between the two conditions in cases of severe tinnitus will be challenging, and optimized study designs are necessary to better understand the mechanisms behind the strong relationship between hyperacusis and tinnitus.GENDER-NET Co-Plus Fund GNP-182Decibel Therapeutics, Inc.Svenska Lakaresallskapet SLS-779681Tysta SkolanHorselforskningsfonden 503European Union (EU) 72204655 848261NIHR Nottingham Biomedical Research CentreSwedish Medical Research Council (SMRC) K2014-99X-22478-01-3Karolinska InstitutetNational Institute for Health Research (NIHR

Zentyal como infraestructura Linux, que brinda soluciones basadas en Ubuntu a las pequeñas y medianas empresas en Colombia.

Las pequeñas y medianas empresas en Colombia (PYMES), enfrentan situaciones complejas para surgir y mantenerse vigentes debido a los costos enormes que implican su sostenibilidad en el mediano y largo plazo. Lo anterior no solo por los asfixiantes impuestos legales, que sumados les demandan más del 70% de su producción. En términos generales, de 100 pesos producidos una PYME debe facturar 70 pesos en obligaciones fiscales. Sumado a lo anterior, los costos de infraestructura TI, tan necesarios para su implementación son abrumadoramente costosos, sobre tecnologías ya conocidas como Windows. En estos tiempos tan difíciles para la pequeña y mediana empresa en Colombia, agravados por la condición pandémica por la que atraviesa la economía del país, es indispensable ofrecer soluciones de infraestructura de TI de Linux, fáciles de usar y con un soporte en los servicios que no implique sobrecostos. En este punto es de enorme beneficio que por primera vez Canonical proporciona soporte integrado de Ubuntu para una solución de otro proveedor de código abierto como lo es Zentyal. Este articulo presenta la forma de instalar y brindar una configuración inicial básica de Zentyal, que le permita ejercer los roles de servidor y firewall dentro de una infraestructura de TI, al tiempo que gestiona los servicios de DNS, DHCP, Proxy, File Server, Print Server y VPN, solicitados por las estaciones de trabajo dentro de una LAN.Small and medium-sized companies in Colombia (SMEs) face complex situations to emerge and remain in force due to the enormous costs involved in their sustainability in the medium and long term. This is not only due to the suffocating legal taxes, which together demand more than 70% of their production. In general terms, out of 100 pesos produced, an SME must invoice 70 pesos in tax obligations. In addition to the above, the IT infrastructure costs, so necessary for its implementation, are overwhelmingly expensive, compared to already known technologies such as Windows. In these difficult times for small and medium-sized companies in Colombia, aggravated by the pandemic condition that the country's economy is experiencing, it is essential to offer Linux IT infrastructure solutions, easy to use and with support in the services that do not imply cost overruns. At this point it is of enormous benefit that for the first time Canonical provides built-in Ubuntu support for a third-party open source solution such as Zentyal. This article presents how to install and provide a basic initial configuration of Zentyal, which allows you to exercise the roles of server and firewall within an IT infrastructure, while managing the services of DNS, DHCP, Proxy, File Server, Print Server and VPN, requested by workstations within a LAN

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Heavy element production in a compact object merger observed by JWST

The mergers of binary compact objects such as neutron stars and black holes are of central interest to several areas of astrophysics, including as the progenitors of gamma-ray bursts (GRBs) 1, sources of high-frequency gravitational waves (GWs) 2 and likely production sites for heavy-element nucleosynthesis by means of rapid neutron capture (the r-process) 3. Here we present observations of the exceptionally bright GRB 230307A. We show that GRB 230307A belongs to the class of long-duration GRBs associated with compact object mergers 4–6 and contains a kilonova similar to AT2017gfo, associated with the GW merger GW170817 (refs. 7–12). We obtained James Webb Space Telescope (JWST) mid-infrared imaging and spectroscopy 29 and 61 days after the burst. The spectroscopy shows an emission line at 2.15 microns, which we interpret as tellurium (atomic mass A = 130) and a very red source, emitting most of its light in the mid-infrared owing to the production of lanthanides. These observations demonstrate that nucleosynthesis in GRBs can create r-process elements across a broad atomic mass range and play a central role in heavy-element nucleosynthesis across the Universe