Experiences, needs and expectations of welfare benefits recipients regarding the welfare to work services and their caseworker:Preliminary results from a mixed methods study.

Introduction: This study explored experiences, needs and expectations of welfare benefits recipients from a large municipality in the Netherlands, regarding their caseworker and the welfare to work (WTW) services. Preliminary results are presented, final and more extensive results will be published in a peer reviewed journal. Material and Methods: We used quantitative data from a client satisfaction survey that was held between July and December 2019 and filled in by 213 people who had received WTW services (response rate 15,6%). General satisfaction rate and agreement with 31 statements were assessed. Four group interviews with a total of 15 people receiving WTW services were conducted using a semi-structured interview guide. Verbatim transcripts were analysed using the principles of thematic analysis. Results: The survey showed that the majority of clients is reasonably satisfied with the WTW services. The qualitative data showed positive and negative experiences of clients. Most clients described the relationship with their caseworker as hierarchic and expressed the need for a collaborative and trusting relationship. Clients want to work together with their caseworker and do not want to be pushed or forced to accept any job. Conclusions: Our findings illustrate there is room for improvement in the WTW services. It is likely that WTW services that match the needs and expectations of welfare benefits recipients are more effective in terms of clients finding and keeping a job and thus no longer being dependent on welfare benefits

Blended E-health module on return to work embedded in collaborative occupational health care for common mental disorders: Design of a cluster randomized controlled trial

Background: Common mental disorders (CMD) have a major impact on both society and individual workers, so return to work (RTW) is an important issue. In The Netherlands, the occupational physician plays a central role in the guidance of sick-listed workers with respect to RTW. Evidence-based guidelines are available, but seem not to be effective in improving RTW in people with CMD. An intervention supporting the occupational physician in guidance of sick-listed workers combined with specific guidance regarding RTW is needed. A blended E-health module embedded in collaborative occupational health care is now available, and comprises a decision aid supporting the occupational physician and an E-health module, Return@Work, to support sick-listed workers in the RTW process. The cost-effectiveness of this intervention will be evaluated in this study and compared with that of care as usual. Methods: This study is a two-armed cluster randomized controlled trial, with randomization done at the level of occupational physicians. Two hundred workers with CMD on sickness absence for 4-26 weeks will be included in the study. Workers whose occupational physician is allocated to the intervention group will receive the collaborative occupational health care intervention. Occupational physicians allocated to the care as usual group will give conventional sickness guidance. Follow-up assessments will be done at 3, 6

Recognizing the Continuous Nature of Expression Heterogeneity and Clinical Outcomes in Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma (ccRCC) has been previously classified into putative discrete prognostic subtypes by gene expression profiling. To investigate the robustness of these proposed subtype classifications, we evaluated 12 public datasets, together with a new dataset of 265 ccRCC gene expression profiles. Consensus clustering showed unstable subtype and principal component analysis (PCA) showed a continuous spectrum both within and between datasets. Considering the lack of discrete delineation and continuous spectrum observed, we developed a continuous quantitative prognosis score (Continuous Linear Enhanced Assessment of RCC, or CLEAR score). Prognostic performance was evaluated in independent cohorts from The Cancer Genome Atlas (TCGA) (n = 414) and EMBL-EBI (n = 53), CLEAR score demonstrated both superior prognostic estimates and inverse correlation with anti-angiogenic tyrosine-kinase inhibition in comparison to previously proposed discrete subtyping classifications. Inverse correlation with high-dose interleukin-2 outcomes was also observed for the CLEAR score. Multiple somatic mutations (VHL, PBRM1, SETD2, KDM5C, TP53, BAP1, PTEN, MTOR) were associated with the CLEAR score. Application of the CLEAR score to independent expression profiling of intratumoral ccRCC regions demonstrated that average intertumoral heterogeneity exceeded intratumoral expression heterogeneity. Wider investigation of cancer biology using continuous approaches may yield insights into tumor heterogeneity; single cell analysis may provide a key foundation for this approach

Recognizing the Continuous Nature of Expression Heterogeneity and Clinical Outcomes in Clear Cell Renal Cell Carcinoma.

Clear cell renal cell carcinoma (ccRCC) has been previously classified into putative discrete prognostic subtypes by gene expression profiling. To investigate the robustness of these proposed subtype classifications, we evaluated 12 public datasets, together with a new dataset of 265 ccRCC gene expression profiles. Consensus clustering showed unstable subtype and principal component analysis (PCA) showed a continuous spectrum both within and between datasets. Considering the lack of discrete delineation and continuous spectrum observed, we developed a continuous quantitative prognosis score (Continuous Linear Enhanced Assessment of RCC, or CLEAR score). Prognostic performance was evaluated in independent cohorts from The Cancer Genome Atlas (TCGA) (n = 414) and EMBL-EBI (n = 53), CLEAR score demonstrated both superior prognostic estimates and inverse correlation with anti-angiogenic tyrosine-kinase inhibition in comparison to previously proposed discrete subtyping classifications. Inverse correlation with high-dose interleukin-2 outcomes was also observed for the CLEAR score. Multiple somatic mutations (VHL, PBRM1, SETD2, KDM5C, TP53, BAP1, PTEN, MTOR) were associated with the CLEAR score. Application of the CLEAR score to independent expression profiling of intratumoral ccRCC regions demonstrated that average intertumoral heterogeneity exceeded intratumoral expression heterogeneity. Wider investigation of cancer biology using continuous approaches may yield insights into tumor heterogeneity; single cell analysis may provide a key foundation for this approach

In situ dynamic tracking of heterogeneous nanocatalytic processes by shell-isolated nanoparticle-enhanced Raman spectroscopy

原位监测纳米催化反应过程对深入认识反应机理、设计高效催化剂具有重要意义。作为一种具有超高灵敏度的表面分析技术，表面增强拉曼光谱（SERS）是可提供反应过程中催化剂表面吸附物种的丰富信息。然而，仅有Au、Ag、Cu等少数金属在形成特定纳米结构时才能提供较强的拉曼增强，且它们会对催化剂的性质及反应过程产生严重干扰。这就极大地限制了SERS在实际多相催化体系中的应用。鉴于此，该论文发展了一种利用壳层隔绝纳米粒子增强拉曼光谱原位监测纳米催化过程的方法。通过将纳米催化剂组装于壳层隔绝纳米粒子表面，形成SHIENRS卫星结构，利用内核Au纳米粒子增强催化剂表面的拉曼信号，SiO2壳层隔绝Au对催化剂及反应的影响，从而直接获得了纳米催化剂表面物种的真实信息。利用这种SHINERS卫星策略，他们实现了CO氧化反应的原位监测，直接观测到了反应条件下催化剂表面吸附物种。并结合DFT计算，对反应机理进行了阐述。该研究表明SHINERS卫星策略可作为原位跟踪催化反应过程的有效方法，为纳米催化的原位研究提供了一种新的思路。 同时，我校也将在今年12月5-9日举办表面增强拉曼光谱国际会议(International Conference on SERS)，讨论SERS领域的最新进展。会议期间，SERS领域的先驱与权威Richard P. Van Duyne、Martin Moskovits、Andreas Otto以及相关学科的顶级学者Peter G. Bruce、Stefan A. Maier等将作大会报告（会议官方网站http://sers2017.xmu.edu.cn/）。【Abstract】Surface molecular information acquired in situ from a catalytic process can greatly promote the rational design of highly efficient catalysts by revealing structure-activity relationships and reaction mechanisms. Raman spectroscopy can provide this rich structural information, but normal Raman is not sensitive enough to detect trace active species adsorbed on the surface of catalysts. Here we develop a general method for in situ monitoring of heterogeneous catalytic processes through shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) satellite nanocomposites (Au-core silica-shell nanocatalyst-satellite structures), which are stable and have extremely high surface Raman sensitivity. By combining operando SHINERS with density functional theory calculations, we identify the working mechanisms for CO oxidation over PtFe and Pd nanocatalysts, which are typical low- and high-temperature catalysts, respectively. Active species, such as surface oxides, superoxide/peroxide species and Pd–C/Pt–C bonds are directly observed during the reactions. We demonstrate that in situ SHINERS can provide a deep understanding of the fundamental concepts of catalysis.This work was supported by the NSFC (21522508, 21427813, 21373167, 21521004, 21573178 and 21673187), Natural Science Foundation of Guangdong Province (2016A030308012), the Fundamental Research Funds for the Central Universities (20720150039 and 20720160046), ‘111’Project (B16029), and the Thousand Youth Talents Plan of China。 研究工作得到国家自然科学基金优秀青年基金、谱学分析创新研究群体和青年千人计划等资助

Complex Coacervate-based Materials for Biomedicine

There has been increasing interest in complex coacervates for deriving and trans- porting biomaterials. Complex coacervates are a dense, polyelectrolyte-rich liq- uid that results from the electrostatic complexation of oppositely charged macroions. Coacervates have long been used as a strategy for encapsulation, par- ticularly in food and personal care products. More recent efforts have focused on the utility of this class of materials for the encapsulation of small molecules, pro- teins, RNA, DNA, and other biomaterials for applications ranging from sensing to biomedicine. Furthermore, coacervate-related materials have found utility in other areas of biomedicine, including cartilage mimics, tissue culture scaffolds, and adhesives for wet, biological environments. Here, we discuss the self- assembly of complex coacervate-based materials, current challenges in the intel- ligent design of these materials, and their utility applications in the broad field of biomedicine

Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd

Colorectal liver metastases: Surgery versus thermal ablation (COLLISION) - a phase III single-blind prospective randomized controlled trial

Background: Radiofrequency ablation (RFA) and microwave ablation (MWA) are widely accepted techniques to eliminate small unresectable colorectal liver metastases (CRLM). Although previous studies labelled thermal ablation inferior to surgical resection, the apparent selection bias when comparing patients with unresectable disease to surgical candidates, the superior safety profile, and the competitive overall survival results for the more recent reports mandate the setup of a randomized controlled trial. The objective of the COLLISION trial is to prove non-inferiority of thermal ablation compared to hepatic resection in patients with at least one resectable and ablatable CRLM and no extrahepatic disease. Methods: In this two-arm, single-blind multi-center phase-III clinical trial, six hundred and eighteen patients with at least one CRLM (≤3cm) will be included to undergo either surgical resection or thermal ablation of appointed target lesion(s) (≤3cm). Primary endpoint is OS (overall survival, intention-to-treat analysis). Main secondary endpoints are overall disease-free survival (DFS), time to progression (TTP), time to local progression (TTLP), primary and assisted technique efficacy (PTE, ATE), procedural morbidity and mortality, length of hospital stay, assessment of pain and quality of life (QoL), cost-effectiveness ratio (ICER) and quality-adjusted life years (QALY). Discussion: If thermal ablation proves to be non-inferior in treating lesions ≤3cm, a switch in treatment-method may lead to a reduction of the post-procedural morbidity and mortality, length of hospital stay and incremental costs without compromising oncological outcome for patients with CRLM. Trial registration:NCT03088150 , January 11th 2017

E-health application IkHerstel: A textbook example of value-based care

In order to allow patients to recover better and faster, a lot of energy is put into improving surgical techniques. For example, new techniques are being introduced to minimize the size of the incision, such as laparoscopic and robot-assisted operations. However, it takes longer and costs more to perform and teach how to perform surgeries using minimally invasive techniques. The Gynecology and Social Medicine departments of Amsterdam UMC developed the IkHerstel application that guides patients online so that these techniques lead to optimal outcomes