Body mass index and sperm quality: effects of overweight and underweight

2 p.We previously reported a negative association between body mass index (BMI) and sperm motility and seminal alpha-glucosidase concentrations (NAG), suggesting that epididymis may be a target organ for weight-linked alterations. In this study, we analyzed a possible association between BMI and semen quality in 4876 patients with no genitourinary diseases or toxin exposure, including morbidly-obese and underweight patients. We performed multivariate regression analysis using BMI,, age and abstinence as independent variables and demonstrated that BMI was inversely and significantly associated with semen volume, total sperm count, motility and NAG (slopes: -0.01, -1.33, -0.18, -0.75; p<0.05); in addition, we found a significant negative associations between BMI and viability, morphology and HOST.Fil: Martini, Ana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Fisiología Humana; ArgentinaFil: Martini, Ana. Centro Integral de Ginecología, Obstetricia y Reproducción (CIGOR); ArgentinaFil: Martini, Ana. Laboratorio de Andrología y Reproducción (LAR); ArgentinaFil: Tissera, Andrea. Laboratorio de Andrología y Reproducción (LAR)Fil: Tissera, Andrea. Centro Integral de Ginecología, Obstetricia y Reproducción (CIGOR); ArgentinaFil: Tissera, Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Fisiología Humana. ArgentinaFil; Vincenti, Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Fisología Humana; ArgentinaFil: Vincenti, Laura. Laboratorio de Andrología y Reproducción (LAR); ArgeninaFil: Vincenti, Laura. Centro Integral de Ginecología, Obstetricia y Reproducción (CIGOR); ArgentinaFil: Beltramone, Fernando. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Fisiología Humana; ArgentinaFil: Beltramone, Fernando. Centro Integral de Ginecología, Obstetricia y Reproducción (CIGOR); ArgentinaFil: Beltramone, Fernando. Laboratorio de Andrología y Reproducción (LAR); ArgentinaFil: Sad, José. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Fisiología Humana; ArgentinaFil: Sad, José. Laboratorio de Andrología y Reproducción (LAR); ArgentinaFil: Sad, José. Centro Integral de Ginecología, Obstetricia y Reproducción (CIGOR); ArgentinaFil: Ruíz, Rubén. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Fisiología Humana; ArgentinaFil: Ruíz, Rubén. Centro Integral de Ginecología, Obstetricia y Reproducción (CIGOR); ArgentinaFil: Ruíz, Rubén. Laboratorio de Andrología y Reproducción (LAR); ArgentinaFil: Fiol de Cuneo, Marta. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Fisiología Humana; ArgentinaFil: Fiol de Cuneo. Laboratorio de Andrología y Reproducción (LAR); ArgentinaFil: Fiol de Cúneo. Centro Integral de Ginecología, Obstetricia y Reproducción (CIGOR); ArgentinaOtras Ciencias de la Salu

Introducing the Catalytic Amination of Silanes via Nitrene Insertion

The direct functionalization of Si−H bonds by the nitrene insertion methodology is described. A copper(I) complex bearing a trispyrazolylborate ligand catalyzes the transfer of a nitrene group from PhINTs to the Si−H bond of silanes, disilanes, and siloxanes, leading to the exclusive formation of Si−NH moieties in the first example of this transformation. The process tolerates other functionalities in the substrate such as several C−H bonds and alkyne and alkene moieties directly bonded to the silicon center. Density functional theory (DFT) calculations provide a mechanistic interpretation consisting of a Si−H homolytic cleavage and subsequent rebound to the Si-centered radical.We thank the Ministerio de Ciencia e Innovación for Grants PID2020-113797RB-C21, PID2020-112825RB-I00, and CEX2019-000925-S as well as FEDER for “Una manera de hacer Europa” funding. We also thank Junta de Andalucía (P20-00348) and Universidad de Huelva (P.O.Feder UHU202016). A.M.R. and R.P.-S. thank Ministerio de Universidades for the FPU fellowships (FPU17/02738 and FPU18/ 01138, respectively), and J.P.-R. thanks Fondo de Garantía Juvenil for a research contract. CERCA Programme/Generalitat de Catalunya is also acknowledged. We thank Prof. T. R. Belderrain for helpful discussions on 29Si NMR spectroscopy. Funding for open access charge: Universidad de Huelva / CBU

Gender equality to achieve the sustainable development goals through the implementation of an innovative strategy

El objetivo de esta investigación fue incentivar el manejo y conocimiento de la igualdad de género a través de la realidad que involucran los conflictos familiares en el proceso de enseñanza de los estudiantes, con el fin de transformar y mejorar el nivel de inglés de los niños y niñas del Gimnasio Bilingüe Moderno; las cuales se encuentran ubicadas a lo largo del territorio colombiano y todos los esfuerzos se concentraron en diseñar estrategias didácticas y metodológicas para el uso del inglés como lengua extranjera, utilizando las competencias para la vida y los Objetivos de Desarrollo Sostenible ODS, que reconocen los derechos sociales, económicos, políticos y sociales. las necesidades demográficas como referencia para el educador, quien reconoce que las personas involucradas en el proceso educativo son más que los dos actores principales (estudiantes y docentes); teniendo en cuenta a los padres, tutores y comunidades aledañas a la institución. Por lo tanto, se utilizó un enfoque cualitativo en este estudio. Entre los resultados, se pudo observar una apropiación del tema propuesto y también una clara señal de aceptacion del tema de la mujer mostrada como igual al hombre demostrando la importancia del genero &nbsp;The objective of this research was to encourage the management and knowledge of gender equality through the reality that family conflicts involve in the teaching process of students, in order to transform and improve the English level of the boys and girls of Gimnasio Bilingue Moderno; which are located throughout the Colombian territory and all efforts were focused on designing didactic and methodological strategies for the use of English as a foreign language, using the competencies for life and the Sustainable Development Goals SDG, which recognize the social, economic, political, and demographic needs as a reference for the educator, who acknowledges that persons involved in the educational process are more than the two main actors (students and teachers); taking into account parents, tutors and communities surrounding the institution. Thus, a qualitative approach was using in this study. Among the results, it was possible to observe an appropriation of the proposed topic and also a clear sign of acceptance of the topic of women shown as equal to men demonstrating the importance of gender based

Imported malaria in Spain (2009-2016) : results from the +REDIVI Collaborative Network

Imported malaria is a frequent diagnosis in travellers and migrants. The objective of this study was to describe the epidemiological and clinical characteristics of patients diagnosed with imported malaria within a Spanish collaborative network registering imported diseases (+REDIVI). In addition, the possible association between malaria and type of case, gender, age or area of exposure was explored. Cases of imported malaria were identified among all cases registered in the +REDIVI database during the period October 2009-October 2016. Demographic, epidemiological and clinical characteristics were analysed. In total, 11,816 cases of imported infectious diseases were registered in +REDIVI's database between October 2009 and October 2016. Immigrants seen for the first time after migration accounted for 60.2% of cases, 21.0% of patients were travellers, and 18.8% were travellers/immigrants visiting friends and relatives (VFRs). There were 850 cases of malaria (850/11,816, 7.2%). Malaria was significantly more frequent in men than in women (56.8% vs 43.2%) and in VFR-immigrants (52.6%) as compared to travellers (21.3%), immigrants (20.7%) and VFR-travellers (5.4%) (p < 0.001). Although this data was not available for most patients with malaria, only a minority (29/217, 13.4%) mentioned correct anti-malarial prophylaxis. Sub-Saharan Africa was found to be the most common region of acquisition of malaria. Most common reason for consultation after travel was a febrile syndrome although an important proportion of immigrants were asymptomatic and presented only for health screening (27.3%). Around 5% of travellers presented with severe malaria. The most prevalent species of Plasmodium diagnosed was Plasmodium falciparum (81.5%). Malaria due to Plasmodium ovale/Plasmodium vivax was frequent among travellers (17%) and nearly 5% of all malaria cases in immigrants were caused by Plasmodium malariae. Malaria was among the five most frequent diagnoses registered in +REDIVI's database. Some significant differences were found in the distribution of malaria according to gender, type of case, species. Among all malaria cases, the most frequent diagnosis was P. falciparum infection in VFR-immigrant men

Marc de referència sobre la COMPETÈNCIA DE RESPONSABILITAT ÈTICA a la universitat

Aquesta guia s'ha elaborat en el marc del projecte Diagnosi, disseny i avaluació de pràctiques docents per al desenvolupament de la Competència de Responsabilitat Ètica en el marc dels Objectius de Desenvolupament Sostenible de la convocatòria de Projectes d'Innovació i de Millora de la Qualitat Docent 2020 de la Universitat Autònoma de Barcelona.Aquest document va adreçat principalment a professorat i té dos propòsits. En primer lloc, promoure i facilitar la reflexió sobre aquest aprenentatge en l'àmbit universitari, en particular, en les assignatures que conformen els graus i els postgraus. En segon lloc, oferir uns quants recursos per poder posar-se a la feina. Així doncs, no es presenten receptes ni directrius a seguir; en darrer terme, aquí només es vol mostrar que, a l'ensenyament superior, la tasca és alhora oportuna i possible

Jardins per a la salut

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia. Assignatura: Botànica farmacèutica. Curs: 2014-2015. Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són el recull de les fitxes botàniques de 128 espècies presents en el Jardí Ferran Soldevila de l’Edifici Històric de la UB. Els treballs han estat realitzats manera individual per part dels estudiants dels grups M-3 i T-1 de l’assignatura Botànica Farmacèutica durant els mesos de febrer a maig del curs 2014-15 com a resultat final del Projecte d’Innovació Docent «Jardins per a la salut: aprenentatge servei a Botànica farmacèutica» (codi 2014PID-UB/054). Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pels professors de l’assignatura. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica. També s’ha pretès motivar els estudiants a través del retorn de part del seu esforç a la societat a través d’una experiència d’Aprenentatge-Servei, deixant disponible finalment el treball dels estudiants per a poder ser consultable a través d’una Web pública amb la possibilitat de poder-ho fer in-situ en el propi jardí mitjançant codis QR amb un smartphone

Aula itinerante de Patrimonio Cultural II

Memoria final del PIMCD UCM 2020/2021 número 31

Impact of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients: A nationwide study in Spain

Objective To assess the effect of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients in Spain. Settings The initial flood of COVID-19 patients overwhelmed an unprepared healthcare system. Different measures were taken to deal with this overburden. The effect of these measures on neurosurgical patients, as well as the effect of COVID-19 itself, has not been thoroughly studied. Participants This was a multicentre, nationwide, observational retrospective study of patients who underwent any neurosurgical operation from March to July 2020. Interventions An exploratory factorial analysis was performed to select the most relevant variables of the sample. Primary and secondary outcome measures Univariate and multivariate analyses were performed to identify independent predictors of mortality and postoperative SARS-CoV-2 infection. Results Sixteen hospitals registered 1677 operated patients. The overall mortality was 6.4%, and 2.9% (44 patients) suffered a perioperative SARS-CoV-2 infection. Of those infections, 24 were diagnosed postoperatively. Age (OR 1.05), perioperative SARS-CoV-2 infection (OR 4.7), community COVID-19 incidence (cases/10 5 people/week) (OR 1.006), postoperative neurological worsening (OR 5.9), postoperative need for airway support (OR 5.38), ASA grade =3 (OR 2.5) and preoperative GCS 3-8 (OR 2.82) were independently associated with mortality. For SARS-CoV-2 postoperative infection, screening swab test <72 hours preoperatively (OR 0.76), community COVID-19 incidence (cases/10 5 people/week) (OR 1.011), preoperative cognitive impairment (OR 2.784), postoperative sepsis (OR 3.807) and an absence of postoperative complications (OR 0.188) were independently associated. Conclusions Perioperative SARS-CoV-2 infection in neurosurgical patients was associated with an increase in mortality by almost fivefold. Community COVID-19 incidence (cases/10 5 people/week) was a statistically independent predictor of mortality. Trial registration number CEIM 20/217

Famílies botàniques de plantes medicinals

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia, Assignatura: Botànica Farmacèutica, Curs: 2013-2014, Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són els recull de 175 treballs d’una família botànica d’interès medicinal realitzats de manera individual. Els treballs han estat realitzat per la totalitat dels estudiants dels grups M-2 i M-3 de l’assignatura Botànica Farmacèutica durant els mesos d’abril i maig del curs 2013-14. Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pel professor de l’assignatura i revisats i finalment co-avaluats entre els propis estudiants. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio