67 research outputs found
The chronology of Late Glacial and Holocene dune development in the northern Central European lowland reconstructed by optically stimulated luminescence (OSL) dating
The study is concerned with the reconstruction of dune formation and reactivation by means of optically stimulated luminescence (OSL) dating of dunes developed throughout the last 20,000 years in the central part of the so-called "European Sand Belt" (ESB) in northeast Germany and adjacent areas in Poland. In order to create a data set with regional validity dune sites in five different study areas are investigated which are located in the Elbe-, the Glogow-Baruth-, and in the Torun-Eberswalde-ice marginal valleys and in the glacio-lacustrine basins of the "Ueckermuender Heide" and "Altdarss" area. In total 183 sediment samples from aeolian, fluvial, glacio-fluvial and glacio-lacustrine deposits were sampled at twenty different sites. Fundamental questions were, if several phases of aeolian activity and periods of stabilisation and soil development could be defined and if similarities or differences regarding their intensity, beginning and ending exist on a regional scale. The summary of OSL ages allows conclusions regarding climate driven phases of aeolian activity during the Late Glacial and Late Holocene man made dune remobilisation in accordance with the settlement history. The study demonstrates that by application of a consistent methodical approach to a large data set, OSL dating has the potential to resolve the dune record of the last 20,000 years in northeastern Germany into individual phases of dune sand deposition. The conclusions drawn from this study provide new information for both, the application of OSL dating and the interpretation of the aeolian record of the study area
Evolution of small-scale flow barriers in German Rotliegend siliciclastics
Many siliciclastic reservoirs contain millimetre-scale diagenetic and structural phenomena affecting fluid flow. We identified three major types of small-scale flow barriers in a clastic Rotliegend hydrocarbon reservoir: cataclastic deformation bands; dissolution seams; and bedding-parallel cementation. Deformation bands of various orientations were analysed on resistivity image logs and in core material. They are mainly conjugates, and can be used to validate seismically observable faults and infer subseismic faults. Bedding-parallel dissolution seams are related to compaction and post-date at least one set of deformation bands. Bedding-parallel cementation is accumulated in coarser-grained layers and depends on the amount of clay coatings.
Apparent permeability data related to petrographical image interpretation visualizes the impact of flow barriers on reservoir heterogeneity. Transmissibility multiplier calculations indicate the small efficiency of the studied deformation bands on flow properties in the reservoir. Deformation bands reduce the host-rock permeability by a maximum of two orders of magnitude. However, host-rock anisotropies are inferred to reduce the permeability by a maximum of four orders of magnitude. The relative timing of these flow barriers, as well as the assessment of reservoir heterogeneities, are the basis for state-of-the-art reservoir prediction modelling
Химический состав березового сока в бассейне среднего течения р. Малая Ушайка (Томская область)
Protocol of a randomized, double-blind, placebo-controlled, parallel-group, multicentre study of the efficacy and safety of nicotinamide in patients with Friedreich ataxia (NICOFA)
Introduction: Currently, no treatment that delays with the progression of Friedreich ataxia is available. In the majority of patients Friedreich ataxia is caused by homozygous pathological expansion of GAA repeats in the first intron of the FXN gene. Nicotinamide acts as a histone deacetylase inhibitor. Dose escalation studies have shown, that short term treatment with dosages of up to 4 g/day increase the expression of FXN mRNA and frataxin protein up to the levels of asymptomatic heterozygous gene carriers. The long-term effects and the effects on clinical endpoints, activities of daily living and quality of life are unknown.Methods: The aim of the NICOFA study is to investigate the efficacy and safety of nicotinamide for the treatment of Friedreich ataxia over 24 months. An open-label dose adjustment wash-in period with nicotinamide (phase A: weeks 1-4) to the individually highest tolerated dose of 2-4 g nicotinamide/day will be followed by a 2 (nicotinamide group): 1 (placebo group) randomization (phase B: weeks 5-104). In the nicotinamide group, patients will continue with their individually highest tolerated dose between 2 and 4 g/d per os once daily and the placebo group patients will be receiving matching placebo. Safety assessments will consist of monitoring and recording of all adverse events and serious adverse events, regular monitoring of haematology, blood chemistry and urine values, regular measurement of vital signs and the performance of physical examinations including cardiological signs. The primary outcome is the change in the Scale for the Assessment and Rating of Ataxia (SARA) over time as compared with placebo in patients with Friedreich ataxia based on the linear mixed effect model (LMEM) model. Secondary endpoints are measures of quality of life, functional motor and cognitive measures, clinician's and patient's global impression-change scales as well as the up-regulation of the frataxin protein level, safety and survival/death.Perspective: The NICOFA study represents one of the first attempts to assess the clinical efficacy of an epigenetic therapeutic intervention for this disease and will provide evidence of possible disease modifying effects of nicotinamide treatment in patients with Friedreich ataxia
Luminiscente dating of fluvial deposits in the rock shelter of Cueva Antón, Spain.
The fluvial sediments at Cueva Antón, a Middle Palaeolithic rock shelter located in the valley of the River Mula (Southeast Spain), produced abundant lithic assemblages of Mousterian affinities. Radiocarbon dates are available for the upper part of the archaeological succession, while for the middle to lower parts chronometric data have been missing. Here we present luminescence dating results for these parts of the succession. Quartz OSL on small aliquots and single grain measurements yield ages ranging from 69 ± 7 ka to 82 ± 8 ka with a weighted mean of 72 ± 4 ka for sub-complexes AS2 to AS5. Equivalent dose estimates from large aliquots were highest and inconsistent with those from single grains and small multiple grain aliquots. This is probably caused by the presence of oversaturating grains, which have been quantified by single grain measurements. Additional post-IR IRSL measurements on coarse grained feldspar give strong support to a well-bleached quartz OSL signal. While independent chronometric control is missing, the results are within the expected age range and support the notion of a rapid accumulation of the fluvial deposits
Geoarchaeology in the Upper Khabur Basin of Northeastern Syria: case studies from the 5th till 2nd millennium BC
Middle Pleistocene to Holocene geochronology of the River Aguas terrace sequence (Iberian Peninsula): Fluvial response to Mediterranean environmental change
Our results from the River Aguas basin suggest that fluvial archives, travertine and slope deposits provide sensitive resolution records of environmental changes during the last 170 kyr. From the chronostratigraphic data sets we have established a model of middle and late Pleistocene river response for littoral basins on the southern Iberian Peninsula.
U/Th and OSL dating indicate the major periods of travertine formation of the Alfaix travertine platform, which range from 169 to 26 kyr. At least four incision events interrupted this aggradation period: between 167 and 148 kyr, between 148 and 110 kyr, around 95 kyr and at 71 kyr. Aggradation ceased after 26 kyr and incision occurred during OIS 2. Subsequently, the terraces T4a and T4b were deposited. OSL dating of the T4a channel deposit provides maximum ages of 28, 20 and 18 kyr. However, short climatic events, such as the Younger Dryas, produced two more river incision episodes during OIS 2.
Nonetheless, for river systems influenced by tectonics, climate and sea-level changes it is difficult to assess the weight of each controlling factor. Regarding the three mechanisms of Pleistocene river dynamics in middle-size catchment areas of the littoral region of southeastern Spain, our results support the hypothesis that large scale tectonics triggered the general downcutting trend, whereas the main aggradation and incision phases occurred during periods of major sea-level changes. Over short-time scales the influence of climate variability, as documented by pollen records, plays a decisive role. Thus, the river responses to the three cyclic mechanisms operate at different time scales although synergetic processes should be considered with respect to the magnitude of abrupt incision/aggradation events.Peer reviewe
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