1,134 research outputs found
Somatosympathetic Vasoconstrictor Reflexes in Human Spinal Cord Injury: Responses to Innocuous and Noxious Sensory Stimulation below Lesion
It is known that the sudden increases in blood pressure associated with autonomic dysreflexia in people with spinal cord injury (SCI) are due to a spinally mediated reflex activation of sympathetic vasoconstrictor neurons supplying skeletal muscle and the gut. Apart from visceral inputs, such as those originating from a distended bladder, there is a prevailing opinion that autonomic dysreflexia can be triggered by noxious stimulation below the lesion. However, do noxious inputs really cause an increase in blood pressure in SCI? Using microelectrodes inserted into a peripheral nerve to record sympathetic nerve activity we had previously shown that selective stimulation of small-diameter afferents in muscle or skin, induced by bolus injection of hypertonic saline into the tibialis anterior muscle or the overlying skin, evokes a sustained increase in muscle sympathetic nerve activity and blood pressure and a transient increase in skin sympathetic nerve activity and decrease in skin blood flow in able-bodied subjects. We postulated that these sympathetic responses would be exaggerated in SCI, with a purely noxious stimulus causing long-lasting increases in blood pressure and long-lasting decreases in skin blood flow. Surprisingly, though, we found that intramuscular or subcutaneous injection of hypertonic saline into the leg caused negligible changes in these parameters. Conversely, weak electrical stimulation over the abdominal wall, which in able-bodied subjects is not painful and activates large-diameter cutaneous afferents, caused a marked increase in blood pressure in SCI but not in able-bodied subjects. This suggests that it is activation of large-diameter somatic afferents, not small-diameter afferents, that triggers increases in sympathetic outflow in SCI. Whether the responses to activation of large-diameter afferents reflect plastic changes in the spinal cord in SCI is unknown
Andalán : periódico quincenal aragonés: Número 183 - (15/09/78)
Acute pain triggers adaptive physiological responses that serve as protective mechanisms that prevent continuing damage to tissues and cause the individual to react to remove or escape the painful stimulus. However, an extension of the pain response beyond signaling tissue damage and healing, such as in chronic pain states, serves no particular biological function; it is maladaptive. The increasing number of chronic pain sufferers is concerning, and the associated disease burden is putting healthcare systems around the world under significant pressure. The incapacitating effects of long-lasting pain are not just psychological – reflexes driven by nociceptors during the establishment of chronic pain may cause serious physiological consequences on regulation of other body systems. The sympathetic nervous system is inherently involved in a
host of physiological responses evoked by noxious stimulation. Experimental animal and human models demonstrate a diverse array of heterogeneous reactions to nociception. The purpose of this review is to understand how pain affects the sympathetic nervous system by investigating the reflex cardiovascular and neural responses to acute pain and the long-lasting physiological responses to prolonged (tonic) pain. By observing the sympathetic responses to long-lasting pain, we can begin to understand the physiological consequences of long-term pain on cardiovascular regulation
Heat flux distribution of Antarctica unveiled
Antarctica is the largest reservoir of ice on Earth. Understanding its ice sheet dynamics is crucial to unraveling past global climate change and making robust climatic and sea level predictions. Of the basic parameters that shape and control ice flow, the most poorly known is geothermal heat flux. Direct observations of heat flux are difficult to obtain in Antarctica, and until now continent-wide heat flux maps have only been derived from low-resolution satellite magnetic and seismological data. We present a high resolution heat flux map and associated uncertainty derived from spectral analysis of the most advanced continental compilation of airborne magnetic data. Small-scale spatial variability and features consistent with known geology are better reproduced than in previous models, between 36% and 50%. Our high-resolution heat-flux map and its uncertainty distribution provide an important new boundary condition to be used in studies on future subglacial hydrology, ice-sheet dynamics and sea-level chang
The X-ray to [Ne V]3426 flux ratio: discovering heavily obscured AGN in the distant Universe
We investigate the possibility of using the ratio between the 2-10 keV flux
and the [Ne V]3426 emission line flux (X/NeV) as a diagnostic diagram to
discover heavily obscured, possibly Compton-Thick Active Galactic Nuclei (AGN)
up to z~1.5. First, we calibrate a relation between X/NeV and the cold
absorbing column density N_H using a sample of 74 bright, nearby Seyferts with
both X-ray and [Ne V] data available in the literature. Similarly to what is
found for the X-ray to [O III]5007 flux ratio (X/OIII), we found that the X/NeV
ratio decreases towards large column densities. Essentially all local Seyferts
with X/NeV values below 15 are found to be Compton-Thick objects. Second, we
apply this diagnostic diagram to different samples of distant obscured and
unobscured QSOs in the SDSS: blue, unobscured, type-1 QSOs in the redshift
range z=[0.1-1.5] show X/NeV values typical of unobscured Seyfert 1s in the
local Universe. Conversely, SDSS type-2 QSOs at z~0.5 classified either as
Compton-Thick or Compton-Thin on the basis of their X/OIII ratio, would have
been mostly classified in the same way based on the X/NeV ratio. We apply the
X/NeV diagnostic diagram to 9 SDSS obscured QSOs in the redshift range
z=[0.85-1.31], selected by means of their prominent [Ne V]3426 line and
observed with Chandra ACIS-S for 10ks each. Based on the X/NeV ratio,
complemented by X-ray spectral analysis, 2 objects appear good Compton-Thick
QSO candidates, 4 objects appear as Compton-Thin QSOs, while 3 have an
ambiguous classification. When excluding from the sample broad lined QSOs with
a red continuum and thus considering only genuine narrow-line objects, the
efficiency in selecting Compton-Thick QSOs through the [Ne V] line is about 50%
(with large errors, though), more similar to what is achieved with [O III]
selection. [abridged]Comment: 17 pages, 8 figures. Accepted for publication in A&A
United classification of cosmic gamma-ray bursts and their counterparts
United classification of gamma-ray bursts and their counterparts is
established on the basis of measured characteristics: photon energy E and
emission duration T. The founded interrelation between the mentioned
characteristics of events consists in that, as the energy increases, the
duration decreases (and vice versa). The given interrelation reflects the
nature of the phenomenon and forms the E-T diagram, which represents a natural
classification of all observed events in the energy range from 10E9 to 10E-6 eV
and in the corresponding interval of durations from about 10E-2 up to 10E8 s.
The proposed classification results in the consequences, which are principal
for the theory and practical study of the phenomenon.Comment: Keywords Gamma rays: burst
Near infrared flares of Sagittarius A*: Importance of near infrared polarimetry
We report on the results of new simulations of near-infrared (NIR)
observations of the Sagittarius A* (Sgr A*) counterpart associated with the
super-massive black hole at the Galactic Center. The observations have been
carried out using the NACO adaptive optics (AO) instrument at the European
Southern Observatory's Very Large Telescope and CIAO NIR camera on the Subaru
telescope (13 June 2004, 30 July 2005, 1 June 2006, 15 May 2007, 17 May 2007
and 28 May 2008). We used a model of synchrotron emission from relativistic
electrons in the inner parts of an accretion disk. The relativistic simulations
have been carried out using the Karas-Yaqoob (KY) ray-tracing code. We probe
the existence of a correlation between the modulations of the observed flux
density light curves and changes in polarimetric data. Furthermore, we confirm
that the same correlation is also predicted by the hot spot model. Correlations
between intensity and polarimetric parameters of the observed light curves as
well as a comparison of predicted and observed light curve features through a
pattern recognition algorithm result in the detection of a signature of
orbiting matter under the influence of strong gravity. This pattern is detected
statistically significant against randomly polarized red noise. Expected
results from future observations of VLT interferometry like GRAVITY experiment
are also discussed.Comment: 26 pages, 38 figures, accepted for publication by A&
Statistical Characterization of the Chandra Source Catalog
The first release of the Chandra Source Catalog (CSC) contains ~95,000 X-ray
sources in a total area of ~0.75% of the entire sky, using data from ~3,900
separate ACIS observations of a multitude of different types of X-ray sources.
In order to maximize the scientific benefit of such a large, heterogeneous
data-set, careful characterization of the statistical properties of the
catalog, i.e., completeness, sensitivity, false source rate, and accuracy of
source properties, is required. Characterization efforts of other, large
Chandra catalogs, such as the ChaMP Point Source Catalog (Kim et al. 2007) or
the 2 Mega-second Deep Field Surveys (Alexander et al. 2003), while
informative, cannot serve this purpose, since the CSC analysis procedures are
significantly different and the range of allowable data is much less
restrictive. We describe here the characterization process for the CSC. This
process includes both a comparison of real CSC results with those of other,
deeper Chandra catalogs of the same targets and extensive simulations of
blank-sky and point source populations.Comment: To be published in the Astrophysical Journal Supplement Series (Fig.
52 replaced with a version which astro-ph can convert to PDF without issues.
The Astropy Problem
The Astropy Project (http://astropy.org) is, in its own words, "a community
effort to develop a single core package for Astronomy in Python and foster
interoperability between Python astronomy packages." For five years this
project has been managed, written, and operated as a grassroots,
self-organized, almost entirely volunteer effort while the software is used by
the majority of the astronomical community. Despite this, the project has
always been and remains to this day effectively unfunded. Further, contributors
receive little or no formal recognition for creating and supporting what is now
critical software. This paper explores the problem in detail, outlines possible
solutions to correct this, and presents a few suggestions on how to address the
sustainability of general purpose astronomical software
Manipulation of an Innate Escape Response in Drosophila: Photoexcitation of acj6 Neurons Induces the Escape Response
Background: The genetic analysis of behavior in Drosophila melanogaster has linked genes controlling neuronal connectivity and physiology to specific neuronal circuits underlying a variety of innate behaviors. We investigated the circuitry underlying the adult startle response, using photoexcitation of neurons that produce the abnormal chemosensory jump 6 (acj6) transcription factor. This transcription factor has previously been shown to play a role in neuronal pathfinding and neurotransmitter modality, but the role of acj6 neurons in the adult startle response was largely unknown. Principal Findings: We show that the activity of these neurons is necessary for a wild-type startle response and that excitation is sufficient to generate a synthetic escape response. Further, we show that this synthetic response is still sensitive to the dose of acj6 suggesting that that acj6 mutation alters neuronal activity as well as connectivity and neurotransmitter production. Results/Significance: These results extend the understanding of the role of acj6 and of the adult startle response in general. They also demonstrate the usefulness of activity-dependent characterization of neuronal circuits underlying innat
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