Centro de arte contemporáneo de Valencia

Proyecto de un centro de arte contemporáneo. Se trata de un edificio público con clara intención de revitalizar la zona, de tejido urbano menor y un tanto degradada (al menos arquitectónicamente). Se encuentra entre dos vías principales de tráfico rodado del barrio (las avenidas del Oeste y María Cristina). El objetivo es proyectar una volumetría adaptada al entorno y hacer un edificio atractivo.Díaz Úbeda, A. (2011). Centro de arte contemporáneo de Valencia. http://hdl.handle.net/10251/32950.Archivo delegad

Conocimientos y Prácticas de los adolescentes de 15 a 19 años de edad en el uso de los métodos anticonceptivos en el municipio de Matagalpa, barrio Sor María Romero en el II semestre 2018

Nicaragua es un país con una población estimada de 5.8 millones de habitantes donde la mayor parte de la población es joven. Alrededor del 60 % de la población es menor de 25 años de edad, 51% está en edad reproductiva (entre 15 y 49 años de edad) y cerca del 51% está constituido por mujeres.Esta investigación es de gran importancia para la sociedad en general debido a que en nuestro país la mayoría de los embarazos ocurre en jóvenes adolescentes los cuales son los más perjudicados debido a su edad, por lo cual el tema abarca los conocimientos y prácticas de los jóvenes de 15 a 19 años de edad del barrio sor maría romero del departamento de Matagalpa municipio de Matagalpa, tiene una población total de 4,590 habitantes de estos se tomó un universo total de 20 jóvenes para el estudio entre las edades de 15 a 19 años de edad ,en la investigación se abordan las características sociales, socioeconómicas y culturales de los adolescentes. Cabe mencionar que también se abordan los conocimientos y prácticas de estos jóvenes hacia los métodos anticonceptivos es un estudio cualicuantitativo, analítico, descriptivo y de cohorte transversal. Es de gran importancia saber que estos jóvenes poseen el conocimiento empírico sobre el uso de los métodos anticonceptivos, las prácticas sexuales de estos jóvenes no es muy segura, a los jóvenes antes mencionados se les brido consejería sobre el uso adecuado de los métodos anticonceptivos segura así podrán realizar prácticas sexuales seguras sin temor de embarazos no deseados y trasmisión de ITS y así puedan decidir cuándo tener sus hijos y por ende la erradicación de la pobreza y el aumento de embarazos en jóvenes de este barri

The impact of childhood RSV infection on children’s and parents’ quality of life: a prospective multicenter study in Spain

Background: Several immunisation candidates against RSV are in late-stage clinical trials. To evaluate the benefts of a potential vaccination programme, both economic and health benefts will be needed. Health benefts are usually measured in Health-related Quality of Life (HRQoL) loss using standardised questionnaires. However, there are no RSV-specifc questionnaires validated for children under 2 years, in whom most RSV episodes occur. Therefore, HRQoL estimates are taken from literature or inadequate tools. We determined HRQoL loss and direct costs due to an RSV episode in children younger than 2 years and their caregivers during a month of follow up, using a new questionnaire administered online. Methods: An observational prospective multicentre surveillance study was conducted in children aged younger than two years. Children were recruited from 8 primary care centres and 1 hospital in the Valencia region and Cata‑ lonia (Spain). RSV-positive cases were obtained by immunochromatographic test. HRQoL was assessed using a new ad-hoc 38 item-questionnaire developed. Parents of infected children completed 4 questionnaires at four timepoints (day 0, 7, 14 and 30) after diagnosis. Results: 117 children were enrolled in the study and 86 (73.5%) were RSV+. Median (interquartile range; IQR) scores were 0.52 (0.42–0.68), 0.65 (0.49–0.79), 0.82 (0.68–0.97) and 0.94 (0.81–1), for days 0, 7, 14 and 30, respectively. Compared to total recovery (Q30), HRQoL loss was 37.5%, 31.5% and 8.9% on days 0, 7 and 14 since diagnosis of the disease. The total median cost per patient (including treatments) was €598.8 (IQR: 359.63–2425.85). Conclusions: RSV had almost 40% impact on HRQoL during the frst week since onset of symptoms and the median cost per episode and patient was about €600. These results represent a substantial input for health-economic evalua‑ tions of future RSV-related interventions such as vaccination.This study was funded by Conselleria d’Educació, Cultura i Esport of The Valencia Region of Spain.Medicin

Spatial and pregnancy-related changes in the protein, amino acid, and carbohydrate composition of bovine oviduct fluid

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Knowledge of how the biochemical composition of the bovine oviduct is altered due to the oviduct anatomy or the presence of an embryo is lacking. Thus, the aim of this study was to assess the effect of (І) oviduct anatomy and (ІІ) embryo presence on oviductal fluid (OF) protein, amino acid, and carbohydrate composition. Cross-bred beef heifers (n = 19) were synchronized and those in standing estrus were randomly allocated to a cyclic (non-bred) or pregnant (artificially inseminated) group. All heifers were slaughtered on Day 3 after estrus. The oviducts ipsilateral to the corpus luteum from each animal were isolated, straightened and cut, separating ampulla and isthmus. Each portion was flushed with 500 μµl of PBS enabling recovery of the oocyte/embryo. Recovered unfertilized oocytes (cyclic group) and embryos (8-cell embryos; pregnant group) were located in the isthmus of the oviduct. Samples of flushing medium from the isthmus and ampulla were used for proteomic (n = 2 per group), amino acid (n = 5), and carbohydrate (n = 5) analysis. For proteomic analysis, total protein from cyclic and pregnant samples were labelled with different cyanine fluorescent probes and separated according to the isoelectric point using immobilized pH gradient strips (pH 3–10, 17 cm, Protean® IEF cell system, Bio Rad). Second dimension was performed in a polyacrylamide gel (12%) in the presence of SDS using a Protean II XL system (Bio Rad). Images were obtained with a Typhoon 9410 scanner and analyzed with Progenesis SameSpots software v 4.0. Amino acid content in the OF was determined by high performance liquid chromatography (HPLC). Glucose, lactate, and pyruvate were quantified using microfluorometric enzyme-linked assays. For the proteomic assessment, the results of the image analysis were compared by ANOVA. For both amino acid and carbohydrate analyses, statistical analysis was carried out by 2-way ANOVA with the Holm-Sidak nonparametric post hoc analysis. On Day 3 post-estrus, OF composition varied based on (І) anatomical region, where isthmic metabolites were present in lower (i.e., lactate, glycine, and alanine) or higher (i.e., arginine) concentrations compared to the ampulla; and (ІІ) embryo presence, which was correlated with greater, arginine, phosphoglycerate kinase 1, serum albumin, α-1-antiproteinase and IGL@ protein concentrations. In conclusion, data indicate that the composition of bovine OF is anatomically dynamic and influenced by the presence of an early embryo

Plan estratégico de marketing para la Empresa Automotriz Berrios, S. A, ubicado en la ciudad de Managua

Presenta el diseño de un plan estratégico de marketing para la empresa Automotriz Berrios, S. A, ubicado en la ciudad de Managua. Con la realización de este plan se pretende que la empresa disponga de estrategias de mercado exitosas, que le permitan satisfacer las necesidades de sus clientes, ampliar la variedad de servicio que oferta, buscar oportunidades

Aprendizaje colaborativo a través de la elaboración de documentales audiovisuales y el uso del edublog

[EN] The aim of this work was to promote a higher implication of the students in the development of a subject from the Physical Activity and Sport Sciences bachelor belonging to University of Valencia, through a collaborative learning strategy in which the creation, in small groups, of audiovisual documentaries and their subsequent presentation in a edublog, was used. 48 students from the Ontinyent campus were involved. A high participaion of students in the experience was observed (97.96% of the registered students), a great implication in the documentary making and also in the individual comments to them in the specific posts published in the edublog, whose average comments on these posts (25.89) was higher than the general average of comments in edublog (14.39). It was also remarkably the high quality of most of the 9 documentaries performed, considering the teacher's opinion, the content of the comments published in the post and the peer assessment of the documentaries done by the different groups.[ES] El objetivo del presente trabajo fue generar una mayor implicación del alumnado en el desarrollo de una asigantura del plan de estudios del Grado en Ciencias de la Actividad Física y el Deporte de la Universitat de València, mediante una estrategia de aprendizaje colaborativo en la que se utilizó la elaboración, en pequeños equipos, de documentales audiovisuales y su posterior comentario en un edublog. Participaron 48 estudiantes matriculados en el campus d’Ontinyent. Se constata una elevada participación del alumnado en la experiencia desarrollada (97,96% de los matriculados), una gran implicación en la elaboración de los documentales y también en la realización de comentarios individuales a los mismos en posts específicos publicados en el edublog de la asignatura, cuya media de comentarios a estos posts (25,89) fue mayor a la media general de comentarios a los posts del edublog (14,39). También cabe destacar la buena calidad de gran parte de los 9 documentales que se realizaron, a juzgar por la valoración del profesor de la asignatura, y también por el contenido de los comentarios publicados en los posts y por la coevaluación que realizaron los diferentes equipos sobre los documentales de sus compañeros.Molina, P.; Martínez Baena, A.; Úbeda Colomer, J.; Lizandra, J.; Gómez Gozalvo, F.; Valenciano, J. (2016). Aprendizaje colaborativo a través de la elaboración de documentales audiovisuales y el uso del edublog. En In-Red 2016. II Congreso nacional de innovación educativa y docencia en red. Editorial Universitat Politècnica de València. https://doi.org/10.4995/INRED2016.2016.4394OC

Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions

Background: To assess the performance of Candida albicans germ tube antibody (CAGTA), (1???3)-ß-D-glucan (BDG), mannan antigen (mannan-Ag), anti-mannan antibodies (mannan-Ab), and Candida DNA for diagnosing invasive candidiasis (IC) in ICU patients with severe abdominal conditions (SAC). Methods: A prospective study of 233 non-neutropenic patients with SAC on ICU admission and expected stay?=?7 days. CAGTA (cutoff positivity?=?1/160), BDG (=80, 100 and 200 pg/mL), mannan-Ag (=60 pg/mL), mannan-Ab (=10 UA/mL) were measured twice a week, and Candida DNA only in patients treated with systemic antifungals. IC diagnosis required positivities of two biomarkers in a single sample or positivities of any biomarker in two consecutive samples. Patients were classified as neither colonized nor infected (n?=?48), Candida spp. colonization (n?=?154) (low-grade, n?=?130; high-grade, n?=?24), and IC (n?=?31) (intra-abdominal candidiasis, n?=?20; candidemia, n?=?11). Results: The combination of CAGTA and BDG positivities in a single sample or at least one of the two biomarkers positive in two consecutive samples showed 90.3 % (95 % CI 74.2–98.0) sensitivity, 42.1 % (95 % CI 35.2–98.8) specificity, and 96.6 % (95 % CI 90.5–98.8) negative predictive value. BDG positivities in two consecutive samples had 76.7 % (95 % CI 57.7–90.1) sensitivity and 57.2 % (95 % CI 49.9–64.3) specificity. Mannan-Ag, mannan-Ab, and Candida DNA individually or combined showed a low discriminating capacity. Conclusions: Positive Candida albicans germ tube antibody and (1???3)-ß-D-glucan in a single blood sample or (1???3)-ß-D-glucan positivity in two consecutive blood samples allowed discriminating invasive candidiasis from Candida spp. colonization in critically ill patients with severe abdominal conditions. These findings may be helpful to tailor empirical antifungal therapy in this patient population

Promoviendo los juegos tradicionales nicaragüenses. Una experiencia de animación sociocultural

El presente artículo sistematiza la práctica de juegos tradicionales nicaragüenses llevada a cabo mediante una experiencia de animación sociocultural con niños, adolescentes y adultos del barrio Otoniel Arauz del municipio de Matagalpa. El estudio surgió ante la evidente crisis que afrontan los juegos tradicionales con la irrupción de los nuevos dispositivos tecnológicos que ha traído consigo la modernidad, mismos que han capturado a las generaciones actuales impidiéndoles que conozcan y practiquen estos juegos. En este sentido, el equipo de investigadores se planteó fomentar los juegos tradicionales nicaragüenses y a la vez desarrollar una cultura de paz y reconciliación mediante tales juegos, así pues, con un enfoque de investigación acción participativa, se realizó un diagnóstico sobre la práctica de los juegos, luego se elaboró y se ejecutó un plan de acción y finalmente, se evaluó el impacto de la intervención sociocultural. Este proceso investigativo aporta un conjunto de resultados significativos que apuntan a que los juegos tradicionales nicaragüenses representan un enorme valor cultural, y que estos son propicios para desarrollar un conjunto de valores culturales, sociales y colectivos en las sociedade

Gut colonization by a novel Clostridium species is associated with the onset of epizootic rabbit enteropathy

Epizootic rabbit enteropathy (ERE) represents one of the most devastating diseases affecting rabbit farms. Previous studies showing transmissibility of disease symptoms through oral inoculation of intestinal contents from sick animals suggested a bacterial infectious origin for ERE. However, no etiological agent has been identified yet. On the other hand, ERE is associated with major changes in intestinal microbial communities, pinpointing dysbiosis as an alterna‑ tive cause for the disease. To better understand the role of intestinal bacteria in ERE development, we have performed a prospective longitudinal study in which intestinal samples collected from the same animals before, during and after disease onset were analyzed using high‑throughput sequencing. Changes in hundreds of bacterial groups were detected after the initiation of ERE. In contrast, before ERE onset, the microbiota from rabbits that developed ERE did not differ from those that remained healthy. Notably, an expansion of a single novel Clostridium species (Clostridium cuniculi) was detected the day of ERE onset. C. cuniculi encodes several putative toxins and it is phylogenetically related to the two well‑characterized pathogens C. botulinum and C. perfringens. Our results are consistent with a bac‑ terial infectious origin of ERE and discard dysbiosis as the initial trigger of the disease. Although experimental valida‑ tion is required, results derived from sequencing analysis, propose a key role of C. cuniculi in ERE initiation

Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions

BACKGROUND: To assess the performance of Candida albicans germ tube antibody (CAGTA), (1 → 3)-ß-D-glucan (BDG), mannan antigen (mannan-Ag), anti-mannan antibodies (mannan-Ab), and Candida DNA for diagnosing invasive candidiasis (IC) in ICU patients with severe abdominal conditions (SAC). METHODS: A prospective study of 233 non-neutropenic patients with SAC on ICU admission and expected stay ≥ 7 days. CAGTA (cutoff positivity ≥ 1/160), BDG (≥80, 100 and 200 pg/mL), mannan-Ag (≥60 pg/mL), mannan-Ab (≥10 UA/mL) were measured twice a week, and Candida DNA only in patients treated with systemic antifungals. IC diagnosis required positivities of two biomarkers in a single sample or positivities of any biomarker in two consecutive samples. Patients were classified as neither colonized nor infected (n = 48), Candida spp. colonization (n = 154) (low-grade, n = 130; high-grade, n = 24), and IC (n = 31) (intra-abdominal candidiasis, n = 20; candidemia, n = 11). RESULTS: The combination of CAGTA and BDG positivities in a single sample or at least one of the two biomarkers positive in two consecutive samples showed 90.3 % (95 % CI 74.2–98.0) sensitivity, 42.1 % (95 % CI 35.2–98.8) specificity, and 96.6 % (95 % CI 90.5–98.8) negative predictive value. BDG positivities in two consecutive samples had 76.7 % (95 % CI 57.7–90.1) sensitivity and 57.2 % (95 % CI 49.9–64.3) specificity. Mannan-Ag, mannan-Ab, and Candida DNA individually or combined showed a low discriminating capacity. CONCLUSIONS: Positive Candida albicans germ tube antibody and (1 → 3)-ß-D-glucan in a single blood sample or (1 → 3)-ß-D-glucan positivity in two consecutive blood samples allowed discriminating invasive candidiasis from Candida spp. colonization in critically ill patients with severe abdominal conditions. These findings may be helpful to tailor empirical antifungal therapy in this patient population