Small area estimation for composite indicators: the case of multidimensional poverty incidence

This paper proposes a methodology to obtain estimates in small domains when the target is a composite indicator. These indicators are of utmost importance for studying multidimensional phenomena, but little research has been done on how to obtain estimates of these indicators under the small area context. Composite indicators are particularly complex for this purpose since their construction requires different data sources, aggregation procedures, and weighting which makes challenging not only the estimation for small domains but also obtaining uncertainty measures. As case study of our proposal, we estimate the incidence of multidimensional poverty at the municipality level in Colombia. Furthermore, we provide uncertainty measures based on a parametric bootstrap algorithm.Comment: 24 pages, 9 figure

Percepción del mensaje educativo emitido por el Instituto Municipal de Salud en el plegable sobre cáncer de mama y cérvix : Pereira 2005

CD-T 613.042 44 G586;73 p.Este trabajo de investigación pretende identificar la percepción que tiene la población del barrio Cuba de Pereira, del mensaje educativo sobre cáncer de mama y cervix, trasmitido a través de un plegable distribuido por el Instituto Municipal de Salud de Pereira, durante el año 2005, para el logro y fortalecimiento de una comunicación efectiva en los procesos educativos con la comunidad.Universidad Libre de Pereir

Responsabilidad Social Empresarial de la Empresa Serviteca Llanocar

El pensamiento estratégico es el resultado de una constante evolución continua desde tiempos de conflicto y guerra y que luego empezó a ser empleado en las organizaciones modernas como estrategia fundamental, este conocimiento estratégico ayuda a las organizaciones a adaptarse a un entorno empresarial cada vez más exigente y competitivo. A través de la realización de este trabajo se tiene como objetivo prioritario revisar el valor significativo de la RSE y cómo por medio de la gerencia estratégica se puede incidir en las organizaciones actuales de manera positiva mejorando y analizando todos los aspectos organizacionales. Comprender que la planificación estratégica permite diagnosticar diversas variables a través de instrumentos de recolección los cuales pueden dar a conocer de mejor manera la situación actual de una organización y el nivel de aplicación de la norma ISO 26000 dentro de la misma.Strategic thinking is the result of a constant continuous evolution since times of conflict and war and that then began to be used in modern organizations as a fundamental strategy, this strategic knowledge helps organizations to adapt to an increasingly demanding business environment and competitive. Through the realization of this work, the main objective is to analyze the importance of corporate social responsibility and how through strategic management it can be influenced in current organizations in a positive way improving and analyzing all organizational aspects. Understand that strategic planning allows you to diagnose various variables through collection instruments which can better make known the current situation of an organization and the level of application of the fundamental subjects of ISO 26000 within it

Comparison of Convolutional Neural Network Architectures for Classification of Tomato Plant Diseases

Tomato plants are highly affected by diverse diseases. A timely and accurate diagnosis plays an important role to prevent the quality of crops. Recently, deep learning (DL), specifically convolutional neural networks (CNNs), have achieved extraordinary results in many applications, including the classification of plant diseases. This work focused on fine-tuning based on the comparison of the state-of-the-art architectures: AlexNet, GoogleNet, Inception V3, Residual Network (ResNet) 18, and ResNet 50. An evaluation of the comparison was finally performed. The dataset used for the experiments is contained by nine different classes of tomato diseases and a healthy class from PlantVillage. The models were evaluated through a multiclass statistical analysis based on accuracy, precision, sensitivity, specificity, F-Score, area under the curve (AUC), and receiving operating characteristic (ROC) curve. The results present significant values obtained by the GoogleNet technique, with 99.72% of AUC and 99.12% of sensitivity. It is possible to conclude that this significantly success rate makes the GoogleNet model a useful tool for farmers in helping to identify and protect tomatoes from the diseases mentioned

Mesenchymal stromal cells express GARP/LRRC32 on their surface: Effects on their biology and immunomodulatory capacity

Mesenchymal stromal cells (MSCs) represent a promising tool for therapy in regenerative medicine, transplantation, and autoimmune disease due to their trophic and immunomodulatory activities. However, we are still far from understanding the mechanisms of action of MSCs in these processes. Transforming growth factor (TGF)-β1 is a pleiotropic cytokine involved in MSC migration, differentiation, and immunomodulation. Recently, glycoprotein A repetitions predominant (GARP) was shown to bind latency-associated peptide (LAP)/TGF-β1 to the cell surface of activated Foxp3+ regulatory T cells (Tregs) and megakaryocytes/platelets. In this manuscript, we show that human and mouse MSCs express GARP which presents LAP/TGF-β1 on their cell surface. Silencing GARP expression in MSCs increased their secretion and activation of TGF-β1 and reduced their proliferative capacity in a TGF-β1-independent manner. Importantly, we showed that GARP expression on MSCs contributed to their ability to inhibit T-cell responses in vitro. In summary, we have found that GARP is an essential molecule for MSC biology, regulating their immunomodulatory and proliferative activities. We envision GARP as a new target for improving the therapeutic efficacy of MSCs and also as a novel MSC marker. Stem Cells 2015;33:183-19

Morphological variability of native maize (Zea mays L.) of the west highland of Puebla and east highland of Tlaxcala, Mexico

The objective of this research was to assess the morphological variability of maize landraces native of the west highland of Puebla and east highland of Tlaxcala, México, in order to, besides define it, related it to races, commercial varieties and with the altitude of the localities of seed collection. The genetic resources evaluated were 134 accessions collected in 34 localities, along with 10 controls. Experiments were established on three localities using a Lattice 12 x 12. Thirty-two morphological traits were analyzed, 27 of them resulting with highly significant differences, reflecting the high variability at the level of morphological characters, many of them of agronomic interest. From variance analysis 16 traits were selected for use in a cluster analysis through the Modified Localization Method, which joint the populations in six groups, most of them in the group 1, with morphological traits of long cycle varieties: high plants, with greater primary branches of the tassel, greater ear diameter and length, and greater grain length and width. The conclusions indicate that the morphological variability of Landraces is not associated with the altitude of localities of seed collection and that these have more relation with Chalqueño race, small with Conico race, absent with Conico Norteño and Palomero Toluqueño races and almost absent with commercial varieties.The objective of this research was to assess the morphological variability of maize landraces native of the west highland of Puebla and east highland of Tlaxcala, México, in order to, besides define it, related it to races, commercial varieties and with the altitude of the localities of seed collection. The genetic resources evaluated were 134 accessions collected in 34 localities, along with 10 controls. Experiments were established on three localities using a Lattice 12 x 12. Thirty-two morphological traits were analyzed, 27 of them resulting with highly significant differences, reflecting the high variability at the level of morphological characters, many of them of agronomic interest. From variance analysis 16 traits were selected for use in a cluster analysis through the Modified Localization Method, which joint the populations in six groups, most of them in the group 1, with morphological traits of long cycle varieties: high plants, with greater primary branches of the tassel, greater ear diameter and length, and greater grain length and width. The conclusions indicate that the morphological variability of Landraces is not associated with the altitude of localities of seed collection and that these have more relation with Chalqueño race, small with Conico race, absent with Conico Norteño and Palomero Toluqueño races and almost absent with commercial varieties

Gene Therapy Corrects Mitochondrial Dysfunction in Hematopoietic Progenitor Cells and Fibroblasts from Coq9R239X Mice

This study has been submitted to the patent's offices at the "University of Granada" and "Fundación Progreso y Salud". Please note that the results of this manuscript have been submitted to patent protection (application number P201630630; title: “Uses of Coenzyme Q biosynthetic proteins”; date:05/16/2016).Recent clinical trials have shown that in vivo and ex vivo gene therapy strategies can be an option for the treatment of several neurological disorders. Both strategies require efficient and safe vectors to 1) deliver the therapeutic gene directly into the CNS or 2) to genetically modify stem cells that will be used as Trojan horses for the systemic delivery of the therapeutic protein. A group of target diseases for these therapeutic strategies are mitochondrial encephalopathies due to mutations in nuclear DNA genes. In this study, we have developed a lentiviral vector (CCoq9WP) able to overexpress Coq9 mRNA and COQ9 protein in mouse embryonic fibroblasts (MEFs) and hematopoietic progenitor cells (HPCs) from Coq9R239X mice, an animal model of mitochondrial encephalopathy due to primary Coenzyme Q (CoQ) deficiency. Ectopic over-expression of Coq9 in both cell types restored the CoQ biosynthetic pathway and mitochondrial function, improving the fitness of the transduced cells. These results show the potential of the CCoq9WP lentiviral vector as a tool for gene therapy to treat mitochondrial encephalopathies.This work was supported by grants from Ministerio de Economía y Competitividad (Spain) and the European Regional Development Fund (ERDF) from the European Union, to LCL through the research grants SAF2013-47761-R and SAF2015-65786-R; by Fondo de Investigaciones Sanitarias ISCIII (Spain) and the European Regional Development Fund (ERDF) from the European Union through the research grants PI12/01097 and ISCIII Red de Terapia Celular TerCel RD12/0019/0006 to FM; by the Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía-FEDER/Fondo de Cohesion Europeo (FSE) de Andalucía through the research grants P10-CTS-6133 to LCL; P09-CTS-04532, PI-57069, PI-0001/2009 and PAIDI-Bio-326 to F.M.; PI-0160/2012 to KB and PI-0407/2012 to MC; by the NIH through the research P01HD080642 to LCL and by the foundation “todos somos raros, todos somos únicos” to LCL. LCL is supported by the ‘Ramón y Cajal’ National Programme, Ministerio de Economía y Competitividad, Spain (RYC-2011-07643)

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Guía Mexicana para el Diagnóstico y el Tratamiento de la Urticaria

La urticaria es una enfermedad que padece una quinta parte de la población en algún momento de su vida. Las guías inter- nacionales recientes han propuesto unos cambios de fondo en su diagnóstico y tratamiento, por lo que había la necesidad de crear una guía nacional y multidisciplinaria, con base amplia en los gremios de especialistas y médicos de primer contacto en México. ABSTRACT Urticaria is a disease that a fifth of the population shall suffer once in a lifetime. Recent clinical guidelines have proposed some fundamental changes in the diagnosis and treatment of urticaria, making the development of a national, multidisciplinary guideline, with wide acceptability among different professional groups –both specialists and primary health care workers–, necessary in Mexico

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio