Characterizations of Mappings Via Z-Open Sets

The aim of this paper we introduce Z-irresolute, Z-open, Z-closed, pre-Z-open and pre-Z-closed mappings and investigate properties and characterizations of these new types of mappings

GLUT 1 expression is a supportive mean in predicting prognosis and survival estimates of endometrial carcinoma

Objectives: This study will investigate the phenotype of Glucose transporter 1 (GLUT1) in endometrial cancer and the association of its expression with tumor’s clinicopathological factors. Material and methods: Standard immunohistochemistry (IHC) staining protocol was utilized to identify the location and expression pattern of GLUT1 in a panel of 71 endometrial carcinomas compared to 30 normal tissues using tissue microarrays. Results: High scores of GLUT1 staining are more frequent in cancer cases, it was recognized in 64 (90%) endometrial cancers and 12 (40%) control cases. Tissue histotype (cancer versus non-cancerous) was associated with IHC staining of GLUT1 (p = 0.000). Significant association between strong GLUT1 staining of malignant epithelial cells and stage of tumor (p = 0.000) was observed, advanced disease stages were more prevalent with high GLUT1 staining in malignant epithelial cells. There is also a significant association between high scores of GLUT1 staining and location of expression in transformed epithelium, cytoplasmic and membranous (p = 0.000), 100% of cases with cytoplasmic and membranous expression showed high GLUT1 staining scores. Considerable varied survival models were observed with positive GLUT 1 neoplasm regarding diagnosis, grade, stage, differentiation, and recurrence (p-values 0.000, 0.000, 0.000, 0.002, and 0.000 respectively). Survival estimates are considerably healthier in positive GLUT1 staining cases of endometrial carcinoma, which have low grade, low stage and no recurrence. Conclusions: GLUT1 expression has been found upregulated in endometrial carcinoma. IHC staining of GLUT1 can be a supportive mean in predicting prognosis and survival estimates of endometrial carcinoma with specific clinical factors

Novel substitution-box generation using group theory for secure medical image encryption in E-healthcare

With the increasing need for secure transmission and storage of medical images, the development of robust encryption algorithms is of paramount importance. Securing sensitive digital medical imagery information during transmission has emerged as a critical priority in the e-Healthcare systems. Recent research has highlighted the significance of developing advanced medical image encryption algorithms to ensure secure transmission during telediagnosis and teleconsultations. In this study, we propose a novel medical image encryption algorithm which is based on a novel substitution-box generation algebraic method using a combination of a multiplicative cyclic group with an order of 256 and a permutation group with a large order. To evaluate the security performance of the proposed generated S-box, various standard security indicators are assessed and analyzed. The newly proposed medical image encryption algorithm utilizes the generated S-box, along with bit-plane slicing, circular shifting, and XOR operations, to achieve enhanced security and robustness for encrypting sensitive imagery data. In order to assess the effectiveness of the proposed encryption algorithm, a comprehensive benchmarking analyses, specifically designed for evaluating image encryption schemes, have been conducted. The results obtained from the comparison and other analyses serve to validate the optimal features and high cryptographic strength exhibited by the proposed method. Hence, the proposed algorithm demonstrates significant effectiveness and holds considerable promise in the realm of medical image encryption for secure e-Healthcare systems

IntFOLD: an integrated web resource for high performance protein structure and function prediction

The IntFOLD server provides a unified resource for the automated prediction of: protein tertiary structures with built-in estimates of model accuracy (EMA), protein structural domain boundaries, natively unstructured or disordered regions in proteins, and protein–ligand interactions. The component methods have been independently evaluated via the successive blind CASP experiments and the continual CAMEO benchmarking project. The IntFOLD server has established its ranking as one of the best performing publicly available servers, based on independent official evaluation metrics. Here, we describe significant updates to the server back end, where we have focused on performance improvements in tertiary structure predictions, in terms of global 3D model quality and accuracy self-estimates (ASE), which we achieve using our newly improved ModFOLD7 rank algorithm. We also report on various upgrades to the front end including: a streamlined submission process, enhanced visualization of models, new confidence scores for ranking, and links for accessing all annotated model data. Furthermore, we now include an option for users to submit selected models for further refinement via convenient push buttons

An innovative method for building electricity energy management in smart homes based on electric vehicle energy capacity

The surging demand for electricity, fueled by environmental concerns, economic considerations, and the integration of distributed energy resources, underscores the need for innovative approaches to smart home energy management. This research introduces a novel optimization algorithm that leverages electric vehicles (EVs) as integral components, addressing the intricate dynamics of household load management. The study’s significance lies in optimizing energy consumption, reducing costs, and enhancing power grid reliability. Three distinct modes of smart home load management are investigated, ranging from no household load management to load outages, with a focus on the time-of-use (ToU) tariff impact, inclining block rate (IBR) pricing, and the combined effect of ToU and IBR on load management outcomes. The algorithm, a multi-objective approach, minimizes the peak demand and optimizes cost factors, resulting in a 7.9% reduction in integrated payment costs. Notably, EVs play a pivotal role in load planning, showcasing a 16.4% reduction in peak loads and a 7.9% decrease in payment expenses. Numerical results affirm the algorithm’s adaptability, even under load interruptions, preventing excessive increases in paid costs. Incorporating dynamic pricing structures like inclining block rates alongside the time of use reveals a 7.9% reduction in payment costs and a 16.4% decrease in peak loads. In conclusion, this research provides a robust optimization framework for smart home energy management, demonstrating economic benefits, peak load reduction potential, and enhanced reliability through strategic EV integration and dynamic pricing

Apical Root Resorption, Microapical Surgery Management of Root Resorption

When the apical root is removed during apical surgery, the crown-to-root ratio is altered in a manner that is not desirable. The crown-to-root ratio has been utilized for teeth that have periodontal disease. It is important to note that apical root excision is not the same as periodontal bone loss here. Microsurgery in endodontics allows for the realization of a 0 degree or shallow bevel, as well as the precise length of root excision, and it also reduces the width of the osteotomy in the longitudinal direction. For the purpose of determining the prosthodontic prognosis of the teeth that have been apically removed, the crown-to-root ratio is not an acceptable metric. For the purpose of preventing endo-perio communication, it is vital to perform endodontic microsurgery with precision in order to protect the buccal bone

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p&lt;0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p&lt;0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]