Un altre urbanisme és possible. La nova praxi urbana davant del canvi d'època

Aquest article passa revista a una munió d’iniciatives que estan sorgint en el camp de la urbanística i de l’arquitectura davant la percepció general de canvi d’època. Aquesta iniciatives parteixen del fet que l’urbanisme és política, i es basen en quatre principis: estratègia del “re” (reciclar, regenerar, rehabilitar, etc.), mediació i participació social, transdisciplinarietat i Beta permanent (disseny col·laboratiu).Este artículo pasa revista a una multitud de iniciativas que están surgiendo en el campo de la urbanística y la arquitectura ante la percepción general de cambio de época. Esta iniciativas parten de que el urbanismo es política, y se basan en cuatro principios: estrategia del "re" (reciclar, regenerar, rehabilitar, etc.), mediación y participación social, transdisciplinariedad y Beta permanente (diseño colaborativo)

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Un altre urbanisme és possible : la nova praxi urbana davant del canvi d'època

Aquest article passa revista a una munió d'iniciatives que estan sorgint en el camp de la urbanística i de l'arquitectura davant la percepció general de canvi d'època. Aquesta iniciatives parteixen del fet que l'urbanisme és política, i es basen en quatre principis: estratègia del "re" (reciclar, regenerar, rehabilitar, etc.), mediació i participació social, transdisciplinarietat i Beta permanent (disseny col·laboratiu)