76 research outputs found
Evaluating the Effectiveness of the Blood Pressure Plus Program at Thomas Jefferson University
Thomas Jefferson University Hospital’s Blood Pressure Plus program enhances the role of the community in chronic disease prevention and management. There is much evidence that controlling disease and cost is greatly improved through the involvement of community leaders and resources. By offering free blood pressure screenings, the BP+ program was able to document the current status of many underserved individuals in the city of Philadelphia, provide the necessary education and referrals. Perhaps more importantly, the program allowed us to foster relationships with individuals who could further the efforts of chronic care management within their communities. More and more we’re seeing that the challenge of care does not begin and end with the hospital/health care system but rather locally, with those who have the respect of their peers and the power to produce change
Diagnosing Achilles tendinopathy is like delicious spaghetti carbonara:It is all about key ingredients, but not all chefs use the same recipe
Which treatment is most effective for patients with Achilles tendinopathy?:A living systematic review with network meta-analysis of 29 randomised controlled trials
Objective: To provide a consistently updated overview of the comparative effectiveness of treatments for Achilles tendinopathy. Design: Living systematic review and network meta-analysis. Data sources: Multiple databases including grey literature sources were searched up to February 2019. Study eligibility criteria: Randomised controlled trials examining the effectiveness of any treatment in patients wit
Screen-printed digital microfluidics combined with surface acoustic wave nebulization for hydrogen-deuterium exchange measurements
International audienc
Bacterial Disease and Antimicrobial Susceptibility Patterns in HIV-Infected, Hospitalized Children: A Retrospective Cohort Study
The orginal version is available at www.plosone.orgBackground: Serious bacterial infections are a major source of morbidity and mortality in HIV-infected children. The
spectrum of disease is wide, and responsible organisms vary according to setting. The use of antibiotic prophylaxis and the
emergence of multi-drug resistant bacteria necessitate examination of responsible organisms and their antibiotic
susceptibility.
Methodology/Principal Findings: A retrospective cohort study of all HIV-positive pediatric admissions at an urban public
sector hospital in Cape Town between January 2002 and June 2006 was conducted. Children between the ages of one
month and nine years with laboratory confirmed HIV status, serious bacterial infection, and a hospital length of stay of 5
days or more, were eligible for inclusion. Organisms isolated from blood, urine, and cerebral spinal fluid cultures and their
antimicrobial susceptibility were examined, and compared according to timing of isolation to distinguish nosocomial versus
community-acquired. One hundred and forty-one children were identified (median age 1.2 years), 39% of whom were on
antiretrovirals started before or during this hospitalization. Bacterial infections involved all organ systems, however
pneumonia was most common (67%). S. pneumoniae and S. aureus were the most common gram positive and K.
pneumoniae was the most common gram negative organism. K pneumoniae isolates were resistant to many first and second
line antibiotics, and were all considered nosocomial. All S. aureus isolates were methicillin resistant, some of which were
community-acquired.
Conclusions/Significance: Bacterial infections are an important source of co-morbidity in HIV-infected children in resourcelimited
settings. Clinicians should have a low threshold to initiate antibiotics in children requiring hospitalization. Broadspectrum
antibiotics should be used judiciously. Clinicians caring for HIV-infected children should be cognizant of the most
common organisms affecting such children, and of their local antimicrobial susceptibilities, when treating empirically for
serious bacterial infections.Publisher's versio
On the CO Near-IR Band and the Line Splitting Phenomenon in the Yellow Hypergiant Rho Cassiopeiae
We report on multi-epoch optical and near-infrared spectroscopy around the
first overtone ro-vibrational band of CO in the pulsating yellow hypergiant Rho
Cas, one of the most massive stars in the Galaxy and a candidate SN II
progenitor. We argue that the double cores of the CO absorption lines, that
have previously been attributed to separate circumstellar shells expelled
during its recurrent outbursts, result in fact from a superposition of a wide
absorption line and a narrow central emission line. The CO line doubling
returns over subsequent pulsation cycles, where the superposed line emission
assumes its largest intensity near phases of maximum light. We find that the
morphology and behavior of the CO band closely resemble the remarkable
"line-splitting phenomenon" also observed in optical low-excitation atomic
lines. Based on radiative transport calculations we present a simplified model
of the near-IR CO emission emerging from cooler atmospheric layers in the
immediate vicinity of the photosphere. We speculate that the kinetic
temperature minimum in our model results from a periodical pulsation-driven
shock wave. We further discuss a number of alternative explanations for the
origin of the ubiquitous emission line spectrum, possibly due to a
quasi-chromosphere or a steady shock wave at the interface of a fast expanding
wind and the ISM. We present a number of interesting spectroscopic similarities
between Rho Cas and other types of cool variable supergiants such as the RV Tau
and R CrB stars. We further propose a possibly common mechanism for the
enigmatic outburst behavior of these luminous pulsating cool stars.Comment: accepted to ApJ; 3 color fig
LSST: from Science Drivers to Reference Design and Anticipated Data Products
(Abridged) We describe here the most ambitious survey currently planned in
the optical, the Large Synoptic Survey Telescope (LSST). A vast array of
science will be enabled by a single wide-deep-fast sky survey, and LSST will
have unique survey capability in the faint time domain. The LSST design is
driven by four main science themes: probing dark energy and dark matter, taking
an inventory of the Solar System, exploring the transient optical sky, and
mapping the Milky Way. LSST will be a wide-field ground-based system sited at
Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m
effective) primary mirror, a 9.6 deg field of view, and a 3.2 Gigapixel
camera. The standard observing sequence will consist of pairs of 15-second
exposures in a given field, with two such visits in each pointing in a given
night. With these repeats, the LSST system is capable of imaging about 10,000
square degrees of sky in a single filter in three nights. The typical 5
point-source depth in a single visit in will be (AB). The
project is in the construction phase and will begin regular survey operations
by 2022. The survey area will be contained within 30,000 deg with
, and will be imaged multiple times in six bands, ,
covering the wavelength range 320--1050 nm. About 90\% of the observing time
will be devoted to a deep-wide-fast survey mode which will uniformly observe a
18,000 deg region about 800 times (summed over all six bands) during the
anticipated 10 years of operations, and yield a coadded map to . The
remaining 10\% of the observing time will be allocated to projects such as a
Very Deep and Fast time domain survey. The goal is to make LSST data products,
including a relational database of about 32 trillion observations of 40 billion
objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures
available from https://www.lsst.org/overvie
A Search for Extragalactic Fast Blue Optical Transients in ZTF and the Rate of AT2018cow-like Transients
We present a search for extragalactic fast blue optical transients (FBOTs)
during Phase I of the Zwicky Transient Facility (ZTF). We identify 38
candidates with durations above half-maximum light 1 d < t1/2 < 12 d, of which
28 have blue (g-r<-0.2 mag) colors at peak light. Of the 38 transients (28
FBOTs), 19 (13) can be spectroscopically classified as core-collapse supernovae
(SNe): 11 (8) H- or He-rich (Type II/IIb/Ib) SNe, 6 (4) interacting (Type
IIn/Ibn) SNe, and 2 (1) H&He-poor (Type Ic/Ic-BL) SNe. Two FBOTs (published
previously) had high-S/N predominantly featureless spectra and luminous radio
emission: AT2018lug and AT2020xnd. Seven (five) did not have a definitive
classification: AT 2020bdh showed tentative broad H in emission, and AT
2020bot showed unidentified broad features and was 10 kpc offset from the
center of an early-type galaxy. Ten (six) have no spectroscopic observations or
redshift measurements. We present multiwavelength (radio, millimeter, and/or
X-ray) observations for five FBOTs (three Type Ibn, one Type IIn/Ibn, one Type
IIb). Additionally, we search radio-survey (VLA and ASKAP) data to set limits
on the presence of radio emission for 22 of the transients. All X-ray and radio
observations resulted in non-detections; we rule out AT2018cow-like X-ray and
radio behavior for five FBOTs and more luminous emission (such as that seen in
the Camel) for four additional FBOTs. We conclude that exotic transients
similar to AT2018cow, the Koala, and the Camel represent a rare subset of
FBOTs, and use ZTF's SN classification experiments to measure the rate to be at
most 0.1% of the local core-collapse SN rate.Comment: Replaced following peer-review process. 46 pages, 20 figures.
Accepted for publication in Ap
Impulsive behaviour induced by both NMDA receptor antagonism and GABAA receptor activation in rat ventromedial prefrontal cortex
Further Defining Spectral Type "Y" and Exploring the Low-mass End of the Field Brown Dwarf Mass Function
We present the discovery of another seven Y dwarfs from the Wide-field
Infrared Survey Explorer (WISE). Using these objects, as well as the first six
WISE Y dwarf discoveries from Cushing et al., we further explore the transition
between spectral types T and Y. We find that the T/Y boundary roughly coincides
with the spot where the J-H colors of brown dwarfs, as predicted by models,
turn back to the red. Moreover, we use preliminary trigonometric parallax
measurements to show that the T/Y boundary may also correspond to the point at
which the absolute H (1.6 um) and W2 (4.6 um) magnitudes plummet. We use these
discoveries and their preliminary distances to place them in the larger context
of the Solar Neighborhood. We present a table that updates the entire stellar
and substellar constituency within 8 parsecs of the Sun, and we show that the
current census has hydrogen-burning stars outnumbering brown dwarfs by roughly
a factor of six. This factor will decrease with time as more brown dwarfs are
identified within this volume, but unless there is a vast reservoir of cold
brown dwarfs invisible to WISE, the final space density of brown dwarfs is
still expected to fall well below that of stars. We also use these new Y dwarf
discoveries, along with newly discovered T dwarfs from WISE, to investigate the
field substellar mass function. We find that the overall space density of
late-T and early-Y dwarfs matches that from simulations describing the mass
function as a power law with slope -0.5 < alpha < 0.0; however, a power-law may
provide a poor fit to the observed object counts as a function of spectral type
because there are tantalizing hints that the number of brown dwarfs continues
to rise from late-T to early-Y. More detailed monitoring and characterization
of these Y dwarfs, along with dedicated searches aimed at identifying more
examples, are certainly required.Comment: 91 pages, 15 figures, accepted for publication in The Astrophysical
Journa
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