12 research outputs found
Coeficientes de la superficie en modo deslizante directamente en la magnitud de control, un enfoque de esfuerzo reducido
- Author
- Publication venue
- Universitat Politecnica de Valencia
- Publication date
- 01/04/2023
- Field of study
Se presenta un procedimiento de diseño para el control en modo deslizante de primer orden aplicado a un sistema en forma de cadena de integradores pura o perturbada, (forma canĂłnica controlable perturbada). La ley de control se propone de forma novedosa. La magnitud de control se define directamente por los coeficientes del polinomio de la superficie  de deslizamiento. Se muestra que este procedimiento minimiza en cierto sentido el esfuerzo de control para alcanzar la superficie diseñada. Los cĂĄlculos son aĂșn mĂĄs sencillos que los de las tĂ©cnicas clĂĄsicas en modo deslizante. AdemĂĄs, la elecciĂłn de una dinĂĄmica de superficie estable garantiza un tiempo de alcance finito a la misma. El esfuerzo de control y el castañeteo (chattering) son bajos. Las perturbaciones y tĂ©rminos conocidos que provocan inestabilidad se aprovechan en ciertas condiciones del alcance a la superficie. Se presentan simulaciones que ilustran los resultados y comparando el comportamiento de mĂ©todos de control en modo deslizante existentes en la literatura con el propuesto en este artĂculo
Multiancestry analysis of the HLA locus in Alzheimerâs and Parkinsonâs diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
- Adarmes-GĂłmez A.D.
- Adarmes-GĂłmez Ad
- Aguilera N.
- Aguilera Nuria
- Ahmad Shahzad
- Al-Chalabi Ammar
- Al-Chalabi Ammar
- Alarcon E.
- AlarcĂłn-MartĂn E.
- AlarcĂłn-MartĂn Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M.D.
- Alvarez Ignacio
- Alvarez Victoria
- Ambati Aditya
- Amer-Ferrer G.
- Amin Najaf
- Amouyel Philippe
- Amouyel Philippe
- Amouyel Phillippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Andreoni Simona
- Annuar Azlina Ahmad
- Antequera M.
- Anthoula Tsolaki
- Antikainen Riitta
- Antonell Anna
- AntĂșnez C.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arfan Ikram M.
- Arias Pastor Alfonso
- Ariel Prestia Federico
- Armstrong Nicola J.
- Arosio Beatrice
- Arosio Beatrice
- Assogna Francesca
- Athanasiu Lavinia
- Athanasiu Lavinia
- Au Wing-Lok
- Bahrami Shahram
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Becker Tim
- Belezhanska Diyana
- Bellenguez CĂ©line
- Bellenguez CĂ©line
- Bellenguez CĂ©line
- Belloy Michael E.
- Belén Pastor Ana
- Ben-Shlomo Yoav
- Benussi Alberto
- Benussi Luisa
- Benussi Luisa
- Bergh Sverre
- Bernal M.
- Bernardo-Harrington Mateus
- Berr Claudine
- Berr Claudine
- Besse CĂ©line
- Bessi Valentina
- Binetti Giuliano
- Bizarro Alessandra
- Bjerke Maria
- Blennow Kaj
- Blesa R.
- Blesa Rafael
- Boada M.
- Boada M.
- Boada MercĂš
- Boada MercĂš
- Boecker Henning
- Boland Anne
- Boland Anne
- Borroni Barbara
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- BossĂč Paola
- Brayne Carol
- Brayne Carol
- Bresner Catherine
- Brice Alexis
- Brodaty Henry
- Brookes Keeley J.
- Brown Kristelle
- Brown Kristelle S.
- BrÄthen Geir
- BrÄthen Geir
- Buendia M.
- Buendia Mar
- Buiza-Rueda D.
- Buiza-Rueda Dolores
- Bullido M.J.
- Bullido MarĂa J.
- Bullido MarĂa J.
- Burguera J.A.
- Burholt Vanessa
- BĂrger Katharina
- Caffarra Paolo
- Calero M.
- Calero Miguel
- campion Dominique
- Campos-Martin Rafael
- Cano A.
- Carracedo A.
- Carracedo Ăngel
- Carrillo F.
- Carrillo F.
- Carrion-Claro M.
- CarriĂłn-Claro M.
- Casajeros M.J.
- Castaño Eduardo M.
- Castillo Morales Atahualpa
- Cañabate P.
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Chan Anne Y.Y.
- Chao Yinxia
- Chapuis Julien
- Charbonnier Camille
- Chen Ling
- Chen Yongping
- Chene GeneviĂšve
- Chew Elaine Guo Yan
- Chillotti Caterina
- Chipi Elena
- Chung Sun Ju
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A.H.R.
- Clarimon Jordi
- Clarimon Jordi
- Clarimon Jordi
- ClarimĂłn J.
- Clark Christopher
- Clarke Robert
- Collinge John
- Collinge John
- Conti Elisa
- CorbatĂłn-Anchuelo A.
- Cores Valeria
- Corma-GĂłmez AnaĂŻs
- Costa Marcos R
- Costantini Emanuele
- Craig David
- Craig David
- Cruz-Gamero J.M.
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Damotte Vincent
- Daniele Antonio
- Daniele Antonio
- Dardiotis Efthimios
- Darling Daniel
- Dartigues Jean-Francois
- Dartigues Jean-François
- David Smith A.
- David Smith A.
- Davies Chloe
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Pancorbo M.M.
- De Roeck Ellen
- de Rojas I.
- de Rojas I.
- de Rojas Itziar
- de Rojas Itziar
- Debette Stéphanie
- Debette Stéphanie
- Deckert JĂŒrgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean-François
- Deleuze Jean-François
- Deloukas Panagiotis
- Deloukas Pangiotis
- den Bussche Hendrik
- Denning Nicola
- Denning Nicola
- Deramecourt Vincent
- Dermecourt Vincent
- Dichgans Martin
- Dichgans Martin
- Dichgans Martin
- Diego S.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen M.
- Diez-Fairen MĂłnica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Djurovic Srdjan
- Dolores Alonso MarĂa
- Dowzell Kimberley
- Drichel Dmitriy
- Dubois Bruno
- Dufouil Carole
- Dufouil Carole
- Dufouil Carole
- During Emmanuel
- Duron Emmanuelle
- DĂŒzel Emrah
- DĂŒzel Emrah
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Escott-Price Valentina
- Escott-Price Valentina
- Escuela R.
- Escuela R.
- Espinosa A.
- Espinosa Ana
- Etchepareborda Ignacio
- Eugenia SĂĄez MarĂa
- Ewers Michael
- Fabrizio Tagliavini
- Fallgaard Nielsen Sune
- Farotti Lucia
- Fenoglio Chiara
- FernĂĄndez-Fuertes Marta
- Ferrarese Carlo
- Ferreira Catarina B
- Ferri Evelyn
- Feulner Thomas
- Fievet Nathalie
- Fievet Nathalie
- Fin Bertrand
- Fischer Peter
- Fisher Elizabeth
- Fladby Tormod
- Fladby Tormod
- FlieĂbach Klaus
- Foo Jia Nee
- Foo Jia Nee
- Forsell Charlotte
- Fortea J.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick
- Fox Nick C.
- Fox Nick C.
- Franco E.
- Franco-MacĂas Emlio
- Frank-GarcĂa A.
- Frank-GarcĂa Ana
- Frikke-Schmidt Ruth
- Frikke-Schmidt Ruth
- Froelich Lutz
- Frölich Lutz
- Gailhajenet A.
- Gailhajenet Anna
- Galeano Pablo
- Galimberti Daniela
- Galimberti Daniela
- Gan-Or Ziv
- Garcia Madrona S.
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas G.
- Garcia-Ribas Guillermo
- Garcia-Ribas Guillermo
- GarcĂa-Alberca J.M.
- GarcĂa-Alberca JosĂ© MarĂa
- GarcĂa-GonzĂĄlez P.
- GarcĂa-GonzĂĄlez Pablo
- GarcĂa-GonzĂĄlez Pablo
- Garrote-Espina L.
- Garrote-Espina L.
- Germani Sandra
- Gerrish Amy
- Gerrish Amy
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giedraitis Vilmantas
- Giegling Ina
- Giegling Ina
- Gill Michael
- Gill Michael
- Gill Michael
- Gim Jungsoo
- Giorgio Giaccone
- Goldhardt Oliver
- Goldhardt Oliver
- GonzĂĄlez-PĂ©erez A.
- GonzĂĄlez-PĂ©rez Antonio
- Graff Caroline
- Graff Caroline
- Grande Giulia
- Green Emma
- Greicius Michael D.
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grimmer Timo
- GrĂŒnblatt Edna
- GrĂŒnblatt Edna
- Gu Wei
- Guerreiro Rita
- Guetta-Baranes Tamar
- Guitart M.
- Guitart Marina
- Gurling Hugh
- Gwilliam Rhian
- Gwilliam Rhian
- GĂłmez-Garre P.
- GĂłmez-Garre P.
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Hampel Harald
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hanon Olivier
- Hanon Olivier
- Hardy John
- Hardy John
- Hardy John
- Harold Denise
- Harold Denise
- Hartmann Annette M.
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Hausner Lucrezia
- He Zihuai
- Heilmann-Heimbach Stefanie
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- HernĂĄndez Isabel
- Herold Christine
- Herrmann Martin J.
- Heun Reinhard
- Heuser Isabella
- Hevilla S.
- Hiltunen Mikko
- Hiltunen Mikko
- Hodges Angela
- Hoffmann Per
- Hoffmann Per
- Hollingworth Paul
- Hollingworth Paul
- Holmans Peter
- Holmans Peter A.
- Holmes Clive
- Holmes Clive
- Holstege Henne
- Holstege Henne
- Hooper Nigel M.
- Hort Jakub
- Hort Jakub
- Huerto Vilas Raquel
- Hulsman Marc
- HĂŒll Michael
- Ibarria M.
- Ibarria Marta
- Ignacio Bacha Juan
- Ignacio Brusco Luis
- Ikeuchi Takeshi
- Ingelsson Martin
- Ingelsson Martin
- Ingino Carlos
- Jan Biessels Geert
- Janowitz Daniel
- Jansen Iris
- Jansen Iris
- Jeon Beom S.
- Jessen Frank
- Jessen Frank
- Jessen Frank
- JesĂșs S.
- JesĂșs S.
- Jiang Lulu
- Johansson Charlotte
- Johnston Janet A.
- Johnston Jarret A.
- Jones Lesley
- Jones Lesley
- Jung Yoo Jin
- Jöckel Karl-Heinz
- JĂŒrgen Deckert
- Kauwe John
- Kehoe Patrick
- Kehoe Patrick G.
- Kehoe Patrick G.
- Kern Silke
- Khor Chiea Chuen
- Kilander Lena
- Kinhult StÄhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Klopp Norman
- Kochen Silvia
- Koh Woon-Puay
- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kornhuber Johannes
- Kornhuber Johannes
- Kosmidis Mary H.
- Kuulasmaa Teemu
- Kuulasmaa Teemu
- Kölsch Heike
- KĂŒĂ§ĂŒkali Fahri
- KĂŒĂ§ĂŒkali Fahri
- Laatikainen Tiina
- Labrador Espinosa M.A.
- Labrador Ma
- Lacidogna Giordano
- Lacour ndré
- Laczo Jan
- Lafuente A.
- Lafuente AsunciĂłn
- Lage C.
- Lage Carmen
- Lage Carmen
- Lambert Jean-Charles
- Lambert Jean-Charles
- Lambert Jean-Charles
- Laske Christoph
- Laukka Erika J
- Lauria Alessandra
- Lawlor Brian
- Lawlor Brian
- Le Guen Yann
- Lee Kun Ho
- Legaz A.
- Lehtisalo Jenni
- Lerch Ondrej
- Lian Michelle M.
- Lian Michelle Mulan
- Lim Jia Lun
- Lim Shen-Yang
- Lin Juei-Jueng
- Lin Ling
- Lindström Jaana
- Lis Palacio Dana
- Lisso Julieta
- Liu Chunfeng
- Liu Jianjun
- Livingston Gill
- Livingston Gill
- LleĂł Alberto
- LleĂło A.
- Lord Jenny
- Love Seth
- Love Seth
- Lovestone Simon
- Lovestone Simon
- Luckcuck Lauren
- Luckcuck Lauren
- Luis Royo Jose
- Luo Guo
- Lupton Michelle
- Lupton Michelle
- LuĂs Royo Jose
- Lynch Aoibhinn
- Lynch Aoibhinn
- LĂłopez de MunĂĄin A.
- LĂłpez-GarcĂa S.
- LĂłpez-GarcĂa Sara
- Löwemark Malin
- Macias J.
- Macias-GarcĂa D.
- Macias-GarcĂa D.
- MacLeod Catherine A.
- MacĂas Juan
- Magda Tsolaki
- Maier Wolfgang
- Maier Wolfgang
- Malik Rainer
- Mangialasche Francesca
- Mangone Carlos
- Mann David
- Mann David
- Manzanares S.
- Mao Chengjie
- Marco Spallazzi
- Maria GarcĂa-Alberca Jose
- Maroñas O.
- Marquié M.
- Marquié M.
- Marquié Marta
- Marshall Rachel
- Marshall Rachel
- MartĂn Montes A.
- MartĂn Montes Angel
- MartĂn E.
- MartĂn Elvira
- MartĂnez RodrĂguez Carmen
- MartĂnez B.
- MartĂnez C.
- MartĂnez M.T.
- MartĂnez V.
- MartĂnez-Lage Ălvarez A.
- MarĂn M.
- MarĂn M.
- MarĂn T.
- MarĂn-Muñoz J.
- Masullo Carlo
- Masullo Carlo
- Mata Ignacio
- Mather Karen
- Matoska Vaclav
- MauleĂłn Ana
- Mayhaus Manuel
- Mayo Kevin
- McGuinness Bernadette
- McGuinness Bernadette
- McQuillin Andrew
- McQuillin Andrew
- Mead Simon
- Mead Simon
- Meah Wee-Yang
- Mecocci Patrizia
- Mecocci Patrizia
- Medel Nancy
- Medina M.
- Medina Miguel
- Meggy Alun
- Meggy Alun
- Mehrabian Shima
- Mehrabian Shima
- Mendioroz Iriarte M.
- Mendoza Silvia
- Menéndez-Gonzålez M.
- Menéndez-Gonzålez Manuel
- Mignot Emmanuel
- Mir P.
- Mir Pablo
- Mir Pablo
- Miyashita Akinori
- Moebus Susanne
- Moebus Susanne
- Moebus Susanne
- Mok Shi Qi
- Mok Vincent
- Mol Merel
- Molina-Porcel Laura
- Montrreal L.
- Montrreal L.
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno Fermin
- Moreno M.
- Moreno Mariona
- Moreno-Grau S.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Kevin
- Morizono Takashi
- Morris John
- Muchnik Carolina
- Mummery Catherine
- Möthen Markus M
- Nacmias Benedetta
- Nacmias Benedetta
- Naito Tatsuhiko
- Nash William
- Natunen Teemu
- Ng Ebonne Y.
- Ngandu Tiia
- Nicolas Aude
- Nicolas Gael
- Nicolas Gael
- Niida Shumpei
- Nordestgaard BĂžrge G.
- Nordestgaard BĂžrge G.
- Novack Gisela
- Nuñez-Llaves R.
- Nöthen Markus M.
- O'Donovan Michael
- O'Donovan Michael C.
- Okada Yukinori
- Olaso Robert
- Olivar Natividad
- Olivé C.
- Orellana A.
- Orellana A.
- Orellana Adelina
- Orsini Michela
- Ortega G.
- Ortega Gemma
- Ortiz Cecilia
- Owen Michael
- Owen Michael J.
- Ozaki Kouichi
- Pablo Tartan Juan
- Padovani Alessandro
- Pancho A.
- Pancho Ana
- Paola Zoia Chiara
- Paolo Caffarra
- Papenberg Goran
- Papenberg Goran
- Papma Janne
- Park Hyeonseul
- Parnetti Lucilla
- Parnetti Lucilla
- Parveen Kayenat
- Parveen Kayenat
- Pasquier Florence
- Pasquier Florence
- Pasquier Florence
- Passmore Peter
- Passmore Peter
- Pastor P.
- Pastor Pau
- Pastor Pau
- Patel Yogen
- Pei Zhong
- Peixoto Leal Thiago
- PelejĂ E.
- PelejĂ Esther
- Peltonen Markku
- Peng Rong
- Pericard Pierre
- Periñån Mt
- Periñån-Tocino T.
- Perneczky Robert
- Peters Oliver
- Peters Oliver
- Pickering-Brown Stuart
- Pijnenburg Yolande A. L.
- Pijnenburg Yolande A.L.
- Pinchler Sabrina
- Pineda J.A.
- Pineda Juan A.
- Pineda-SĂĄnchez R.
- Pineda-SĂĄnchez R.
- Piras Fabrizio
- Piras Federica
- Pisanu Claudia
- Piñol Ripoll G.
- Piñol-Ripoll Gerard
- Piñol-Ripoll Gerard
- Polak Thomas
- Politis Daniel G.
- Popp Julius
- Popp Julius
- Porcel Laura Molina
- Posthuma Danielle
- Powell John
- Powell John F.
- Prakash Kumar-M.
- Preckler S.
- Preckler Silvia
- Priller Josef
- Proitsi Petra
- Proitsi Petra
- Prokic Ivana
- Puerta R.
- Puerta Raquel
- Puerta Raquel
- PĂ©erez Tur J.
- PĂ©rez-Cordon A.
- PĂ©rez-CordĂłn Alba
- PĂ©rez-Tur Jordi
- PĂ©rez-Tur Jordi
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- Quintela I.
- Quintela Inés
- Qvist Thomassen Jesper
- Rainero Innocenzo
- Rainero Innocenzo
- Ramakers Inez
- Ramakers Inez
- Ramirez Alfredo
- Ramirez Alfredo
- Ramirez Alfredo
- Real de AsĂșa D.
- Real L.M.
- Real Luis M.
- Real Luis M.
- Reinders Marcel J.T.
- Reyes Toso Carlos
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riederer Peter
- Riemenschneider Matthias
- Rios Mario
- Ritchie Karen
- Roberto Natalia
- Rodrigo S.
- Rodrigo-Herrero Silvia
- Rodriguez-Rodriguez Eloy
- Rodriguez-Rodriguez Eloy
- RodrĂguez-RodrĂguez E.
- Rojo Matias
- Rong Zhang Bao
- Rongve Arvid
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca M.
- Rosende-Roca Maitée
- Ross Owen A.
- Rossi Giacomina
- Rossi Giacomina
- Rossor Martin
- Rossor Martin
- Roveta Fausto
- Royo J.L.
- Rubino Elisa
- Rubinsztein David C.
- Rubinsztein David C.
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- Ruiz AgustĂn
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- Ryan Nathalie
- RĂĄabano A.
- RĂĄbano Alberto
- Sachdev Perminder
- Saenz Aldo
- Sakka Paraskevi
- Sala Gessica
- Saltvedt Ingvild
- Saltvedt Ingvild
- Salvadori Nicola
- Sanabria A.
- Sanabria Ăngela
- Sanchez Abalos Mariana
- Sanchez del Valle DĂaz R.
- Sanchez-Garcia Florentino
- Sando Sigrid B.
- Sando Sigrid B.
- Sastre MerlĂn Isabel
- Sastre I.
- Satake Wataru
- Scamosci Michela
- Scarmeas Nikolaos
- Scarmeas Nikolaos
- Scarpini Elio
- Scheltens Philip
- Scheltens Philip
- Scherbaum Norbert
- Scherbaum Norbert
- Scherer Martin
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schneider Anja
- Schott Jonathan M.
- Schott Jonathan M.
- SchĂŒrmann Britta
- SelbĂŠk Geir
- SelbĂŠk Geir
- Selnes Per
- Sempere Vicente
- Seripa Davide
- Seripa Davide
- Serpente Maria
- Serrano-Rios M.
- Sevillano Zulma
- Shadrin Alexey A.
- Shadrin Alexey A.
- Shang Hui-Fang
- Shaw Christopher E.
- Shaw Christopher E.
- Shi Chang-He
- Shofany Jacob
- Sims Rebecca
- Sims Rebecca
- Sims Rebecca
- Singleton Andrew B.
- Skoog Ingmar
- Skrobot Olivia
- Sleegers Kristel
- Sleegers Kristel
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Song Kyuyoung
- Sorbi Sandro
- Sotolongo-Grau O.
- Sotolongo-Grau O.
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Squassina Alessio
- Stordal Eystein
- Stordal Eystein
- Strandberg Timo
- Sussams Rebecca
- SĂĄez M.E.
- SĂĄnchez Juan Pascual
- SĂĄnchez-Arjona MarĂa Bernal
- SĂĄnchez-Juan P.
- SĂĄnchez-Juan Pascual
- SĂĄnchez-Valle Raquel
- SĂĄnchez-Valle Raquel
- Takalo Mari
- Talyansky Seth D.
- Tan Ai Huey
- Tan Eng-King
- Tan Eng-King
- Tan Louis C.S.
- Tandiono Moses
- Tegos Thomas
- Teipel Stefan
- Teresa MartĂnez-Larrad MarĂa
- TesĂ Niccolo
- Teunissen Charlotte
- Thalamuthu Anbupalam
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg HĂ„kan
- Toda Tatsushi
- Todd Stephen
- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
- Tremolizzo Lucio
- Tsolaki Magda
- Tsolaki Magda
- Tuomilehto Jaakko
- Turton James
- TybjĂŠrg-Hansen Anne
- Tzourio Christophe
- TĂĄarraga L.
- TĂĄrraga LluĂs
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Ulstein Ingun
- Uphill James
- Vacca Alessandro
- Valero S.
- Valero S.
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- Van Duin Cornelia
- van Rooij Jeroen
- van Swieten John
- van Swieten John
- Vandenberghe Rik
- Vardy Emma
- Vargas L.
- Vargas Liliana
- Verhey Frans
- Verhey Frans
- Vicente M.P.
- Vidal Jean-SĂ©bastien
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Vyhnalek Martin
- Waern Margda
- Wagner Michael
- Wallon David
- Wallon David
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weber Heike
- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
- Williams Julie
- Williams Julie
- Williams Julie
- Wiltfang Jens
- Wiltfang Jens
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Ălvarez I.
- Ălvarez V.
- Ălvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinsonâs disease (PD) and Alzheimerâs disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased AÎČ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Validation of a Classical Sliding Mode Control Applied to a Physical Robotic Arm with Six Degrees of Freedom
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 14/12/2022
- Field of study
The control of robotic manipulators has become increasingly difficult over recent years due to their high accuracy, performance, speed, and reliability in a variety of applications, such as industry, medicine, research, etc. These serial manipulator systems are extremely complex because their dynamic models include perturbations, parametric variations, coupled nonlinear dynamics, and non-modular dynamics, all of which require robust control for trajectory tracking. This paper compares two control techniques: computational torque control (CTC) and sliding mode control (SMC). In this study, the latter was used for a physical robotic arm with six degrees of freedom (DOF) and online experiments were conducted, which have received little attention in the literature. As a result, the contribution of this work was based on the real-time application of this controller via a self-developing interface. The great resilience of sliding mode controllers to disturbances was also demonstrated in this study
Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries
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- Yazdanpanah Y.
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- Zaheri S.
- Zahonero N.
- Zeng A.
- Zucman D.
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2014
- Field of study
Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis. Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting. Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis. Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries
A polygenic resilience score moderates the genetic risk for schizophrenia.
- Author
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Albus Margot
- Alexander Madeline
- Als Thomas D
- Amin Farooq
- Andreassen Ole A
- Arranz Maria J
- Bacanu Silviu A
- Bakker Steven
- Band Gavin
- Barroso Ines
- Begemann Martin
- Bellenguez CĂ©line
- Belliveau Richard A
- Bender Stephan
- Bene Judit
- Bergen Sarah E
- Bevilacqua Elizabeth
- Bigdeli Tim B
- Black Donald W
- Blackburn Hannah
- Blackwell Jenefer M
- Blackwood Douglas H R
- Bramon Elvira
- Brown Matthew A
- Bruggeman Richard
- Buccola Nancy G
- Buckner Randy L
- Bulik-Sullivan Brendan
- Bumpstead Suzannah J
- Buxbaum Joseph D
- Byberg-Grauholm Jonas
- Byerley William
- BĂŠkvad-Hansen Marie
- BĂžrglum Anders D
- Cahn Wiepke
- Cai Guiqing
- Cairns Murray J
- Campion Dominique
- Cantor Rita M
- Carr Vaughan J
- Carrera Noa
- Casas Juan P
- Catts Stanley V
- Chambert Kimberley D
- Chan Raymond C K
- Chan Ronald Y L
- Chen Eric Y H
- Cheng Wei
- Cheung Eric F C
- Chong Siow Ann
- Cichon Sven
- Clair David St
- Cloninger C Robert
- Cohen David
- Cohen Nadine
- Collier David A
- Consortium Schizophrenia Working Group of the Psychiatric Genomics
- Cormican Paul
- Corvin Aiden
- Craddock Nick
- Crespo-Facorro Benedicto
- Crowley James J
- Curtis David
- Daly Mark J
- Darvasi Ariel
- Davidson Michael
- Davis Kenneth L
- de Haan Lieuwe
- Degenhardt Franziska
- Del Favero Jurgen
- DeLisi Lynn E
- Deloukas Panos
- Demontis Ditte
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Domenici Enrico
- Donnelly Peter
- Donohoe Gary
- Drapeau Elodie
- Dronov Serge
- Duan Jubao
- Dudbridge Frank
- Duncanson Audrey
- Durmishi Naser
- Edenberg Howard J
- Edkins Sarah
- Ehrenreich Hannelore
- Eichhammer Peter
- Eriksson Johan
- Escott-Price Valentina
- Esko TÔnu
- Essioux Laurent
- Fanous Ayman H
- Faraone Stephen V
- Farh Kai-How
- Farrell Martilias S
- Frank Josef
- Franke Lude
- Freedman Robert
- Freeman Colin
- Freimer Nelson B
- Friedl Marion
- Friedman Joseph I
- Fromer Menachem
- Gejman Pablo V
- Genovese Giulio
- Georgieva Lyudmila
- Gershon Elliot S
- Giannoulatou Eleni
- Giegling Ina
- Gill Michael
- Gillman Matthew
- Giusti-RodrĂguez Paola
- Glatt Stephen J
- Godard Stephanie
- Goldstein Jacqueline I
- Golimbet Vera
- Gopal Srihari
- Gratten Jacob
- Gray Emma
- Greenwood Tiffany A
- Grove Jakob
- Gurling Hugh
- Gwilliam Rhian
- Hall Jeremy
- Hammer Christian
- Hammond Naomi
- Hamshere Marian L
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Hartmann Annette M
- Hellenthal Garrett
- Henskens Frans A
- Herms Stefan
- Hess Jonathan L
- Hirschhorn Joel N
- Hoffmann Per
- Hofman Andrea
- Hollegaard Mads V
- Holmans Peter
- Hougaard David M
- Huang Hailiang
- Hultman Christina M
- Hunt Sarah E
- Ikeda Masashi
- Iwata Nakao
- Iyegbe Conrad
- Jablensky Assen V
- Jankowski Janusz
- Jayakumar Alagurevathi
- Joa Inge
- JuliĂ Antonio
- Jönsson Erik G
- Kahn René S
- Kalaydjieva Luba
- Karachanak-Yankova Sena
- Karjalainen Juha
- Kavanagh David
- Keller Matthew C
- Kelly Brian J
- Kendler Kenneth S
- Kennedy James L
- Khrunin Andrey
- Kim Yunjung
- Kirov George
- Klovins Janis
- Knight Jo
- Knowles James A
- Konte Bettina
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kuzelova-Ptackova Hana
- KĂ€hler Anna K
- Lam Max
- Langford Cordelia
- Laurent Claudine
- Lawrie Stephen
- Lee Jimmy
- Lee Phil
- Lee S Hong
- Legge Sophie E
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F
- Lewis Cathryn M
- Li Miaoxin
- Li Qingqin S
- Li Tao
- Liang Kung-Yee
- Liddle Jennifer
- Lieberman Jeffrey
- Limborska Svetlana
- Lin Kuang
- Linszen Don H
- Liu Jianjun
- Loughland Carmel M
- Lubinski Jan
- Lönnqvist Jouko
- Macek Milan
- Magnusson Patrik K E
- Maher Brion S
- Maier Wolfgang
- Malhotra Anil K
- Mallet Jacques
- Markus Hugh S
- Marsal Sara
- Mata Ignacio
- Mathew Christopher G
- Mattheisen Manuel
- Mattingsdal Morten
- McCann Owen T
- McCarley Robert W
- McCarroll Steven A
- McCarthy Mark I
- McDonald Colm
- McIntosh Andrew M
- McQuillin Andrew
- Meier Sandra
- Meijer Carin J
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I
- Metspalu Andres
- Michie Patricia T
- Milani Lili
- Milanova Vihra
- Mokrab Younes
- Moran Jennifer L
- Morris Derek W
- Mors Ole
- Mortensen Preben Bo
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- Murphy Kieran C
- Murray Robin M
- Myin-Germeys Inez
- MĂŒller-Myhsok Bertram
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- Nelis Mari
- Nenadic Igor
- Nertney Deborah A
- Nestadt Gerald
- Nicodemus Kristin K
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nordentoft Merete
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- O'Callaghan Eadbhard
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- Olsen Line
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- Papiol Sergi
- Parkhomenko Elena
- Pato Carlos N
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- Paunio Tiina
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- Pejovic-Milovancevic Milica
- Perkins Diana O
- Pers Tune H
- Petryshen Tracey L
- PietilÀinen Olli
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- Pirinen Matti
- Plomin Robert
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- Potter Simon C
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- Price Alkes
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- Quested Digby
- Rasmussen Henrik B
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- Ravindrarajah Radhi
- Reichenberg Abraham
- Reimers Mark A
- Research Lundbeck Foundation Initiative for Integrative Psychiatric
- Richards Alexander L
- Ricketts Michelle
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- Riley Brien P
- Ripke Stephan
- Roffman Joshua L
- Roussos Panos
- Ruderfer Douglas M
- Rujescu Dan
- Salomaa Veikko
- Sanders Alan R
- Sawcer Stephen J
- Schall Ulrich
- Schubert Christian R
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- Scolnick Edward M
- Scott Rodney J
- Seidman Larry J
- Sham Pak C
- Shi Jianxin
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M
- Sim Kang
- Sklar Pamela
- Slominsky Petr
- Smoller Jordan W
- So Hon-Cheong
- Spencer Chris C A
- Stahl Eli A
- StefĂĄnsson Hreinn
- StefĂĄnsson KĂĄri
- Steinberg Stacy
- Stogmann Elisabeth
- Strange Amy
- Straub Richard E
- Strengman Eric
- Strohmaier Jana
- Stroup T Scott
- Su Zhan
- Subramaniam Mythily
- Sullivan Patrick F
- Suvisaari Jaana
- Svrakic Dragan M
- Szatkiewicz Jin P
- Söderman Erik
- Tashakkori-Ghanbaria Avazeh
- Thirumalai Srinivas
- Toncheva Draga
- Tooney Paul A
- Tosato Sarah
- Trembath Richard C
- Tsuang Ming T
- Tylee Daniel S
- Van Os Jim
- Veijola Juha
- Visscher Peter M
- Viswanathan Ananth C
- Vukcevic Damjan
- Waddington John
- Waller Matthew
- Walsh Dermot
- Walshe Muriel
- Walters James T R
- Wang Dai
- Wang Qiang
- Webb Bradley T
- Weinberger Daniel R
- Weisbrod Matthias
- Weiser Mark
- Wendland Jens R
- Werge Thomas
- Weston Paul
- Whittaker Pamela
- Widaa Sara
- Wiersma Durk
- Wildenauer Dieter B
- Williams Nigel M
- Williams Stephanie
- Witt Stephanie H
- Wolen Aaron R
- Wong Emily H M
- Wood Nicholas W
- Wormley Brandon K
- Wray Naomi R
- Wu Jing Qin
- Xi Hualin Simon
- Zai Clement C
- Zheng Xuebin
- Zimprich Fritz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531-538, 2016) of rare variants that confer resistance to Mendelian disease, and protective alleles for some complex diseases, we posited the existence of genetic variants that promote resilience to highly heritable polygenic disorders1,0 such as schizophrenia. Resilience has been traditionally viewed as a psychological construct, although our use of the term resilience refers to a different construct that directly relates to the Resilience Project, namely: heritable variation that promotes resistance to disease by reducing the penetrance of risk loci, wherein resilience and risk loci operate orthogonal to one another. In this study, we established a procedure to identify unaffected individuals with relatively high polygenic risk for schizophrenia, and contrasted them with risk-matched schizophrenia cases to generate the first known "polygenic resilience score" that represents the additive contributions to SZ resistance by variants that are distinct from risk loci. The resilience score was derived from data compiled by the Psychiatric Genomics Consortium, and replicated in three independent samples. This work establishes a generalizable framework for finding resilience variants for any complex, heritable disorder
How Biology Handles Nitrite
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- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
- Abyzov Alexej
- Achsel Tilmann
- Adams Mark
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Agiananda Feranindhya
- Akbarian Schahram
- Al Eissa Mariam
- Albus Margot
- Alexander Madeline
- Alizadeh Behrooz Z.
- Alptekin Köksal
- Als Thomas D.
- Amin Farooq
- Amir Nurmiati
- Andreassen Ole A.
- Andres-Alonso Maria
- Antoni Ronald
- Arango Celso
- Arolt Volker
- Arranz Maria J.
- Arrojo Manuel
- Arsianti Tiana
- Ashley-Koch Allison
- Asmarahadi Asmarahadi
- AtbaĆoÄlu EĆref Cem
- Athanasiu Lavinia
- Atkinson Elizabeth G.
- Awasthi Swapnil
- Ayub Muhammad
- Azevedo Maria Helena
- Bacanu Silviu A.
- Bagni Claudia
- Bakker Steven
- Bass Nicholas J.
- Baune Bernhard T.
- BayĂ©s Ălex
- Begemann Martin
- Belangero Sintia Iole
- Belliveau Richard A.
- Bender Stephan
- Bene Judit
- Benner Christian
- Benyamin Beben
- Bergen Sarah E.
- Bertolino Alessandro
- Biederer Thomas
- Bigdeli Tim B.
- Black Donald W.
- Blasi Giuseppe
- Bobes Julio
- Bonassi Stefano
- Braff David
- Bramon Elvira
- Bramon Elvira
- Braun Alice
- Bray Nicholas J.
- Breen Gerome
- Breen Michael
- Bressan Rodrigo Affonseca
- Bromet Evelyn J.
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- Brown Miguel
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- Bruggeman Richard
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- Bryois Julien
- Buccola Nancy G.
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- Yao Lijing
- Yolken Robert
- Yu Xin
- Yue Weihua
- Yusnadewi Suzy
- Zai Clement C.
- Zandi Peter
- Zeng Jian
- Zhang Wen
- Zhou Wei
- Zhu Feng
- Zimprich Fritz
- Ăçok Alp
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.11Nsciescopu
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
- Abyzov Alexej
- Achsel Tilmann
- Adams Mark
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Agiananda Feranindhya
- Akbarian Schahram
- Al Eissa Mariam
- Albus Margot
- Alexander Madeline
- Alizadeh Behrooz Z.
- Alptekin Köksal
- Als Thomas D.
- Amin Farooq
- Amir Nurmiati
- Andreassen Ole A.
- Andres-Alonso Maria
- Antoni Ronald
- Arango Celso
- Arolt Volker
- Arranz Maria J.
- Arrojo Manuel
- Arsianti Tiana
- Ashley-Koch Allison
- Asmarahadi Asmarahadi
- AtbaĆoÄlu EĆref Cem
- Athanasiu Lavinia
- Atkinson Elizabeth G.
- Awasthi Swapnil
- Ayub Muhammad
- Azevedo Maria Helena
- Bacanu Silviu A.
- Bagni Claudia
- Bakker Steven
- Bass Nicholas J.
- Baune Bernhard T.
- BayĂ©s Ălex
- Begemann Martin
- Belangero Sintia Iole
- Belliveau Richard A.
- Bender Stephan
- Bene Judit
- Benner Christian
- Benyamin Beben
- Bergen Sarah E.
- Bertolino Alessandro
- Biederer Thomas
- Bigdeli Tim B.
- Black Donald W.
- Blasi Giuseppe
- Bobes Julio
- Bonassi Stefano
- Braff David
- Bramon Elvira
- Bramon Elvira
- Braun Alice
- Bray Nicholas J.
- Breen Gerome
- Breen Michael
- Bressan Rodrigo Affonseca
- Bromet Evelyn J.
- Brose Nils
- Brown Miguel
- Brown Tyler C.
- Bruggeman Richard
- Bryois Julien
- Bryois Julien
- Buccola Nancy G.
- Buckley Peter F.
- Buckner Randy L.
- Buxbaum Joseph D.
- Bybjerg-Grauholm Jonas
- Byerley William F.
- BĂžrglum Anders D.
- Cahn Wiepke
- Cairns Murray J.
- Calkins Monica E.
- Campion Dominique
- Carlyle Becky
- Carr Vaughan J.
- Castle David
- Catts Stanley V.
- Cervilla Jorge A.
- Chambert Kimberley D.
- Chan Raymond C. K.
- Charney Alex
- Chaumette Boris
- Chen Chia-Yen
- Chen Wei J.
- Cheng Wei
- Cheung Eric F. C.
- Chong Siow Ann
- Chua John Jia En
- Cichon Sven
- Cloninger C. Robert
- Coba Marcelo P.
- Coetzee Gerard
- Cohen David
- Collier David A.
- Collier David A.
- Consoli AngĂšle
- Cordeiro Quirino
- Cornelisse L. Niels
- Corvin Aiden
- Costas Javier
- Crawford Gregory
- Crepo-Facorro Benedicto
- Crespo-Facorro Benedicto
- Curtis Charles
- Curtis David
- Dai Nan
- Daly Mark J.
- Davidson Michael
- Davis Kenneth L.
- de Haan Lieuwe
- de Haan Lieuwe
- de Jong Arthur P. H.
- de Juan-Sanz Jaime
- Degenhardt Franziska
- DeLisi Lynn E.
- Demontis Ditte
- Dennison Charlotte A.
- Diatri H.
- Dickerson Faith
- Dieterich Daniela C.
- Dikeos Dimitris
- Dinan Timothy
- Djatmiko Prianto
- Djurovic Srdjan
- Domenici Enrico
- Donohoe Gary
- Dracheva Stella
- Duan Jubao
- Ducci Giuseppe
- Dudbridge Frank
- Ehrenreich Hannelore
- Emani Prashant
- Eriksson Johan G.
- Escott-Price Valentina
- Esko TÔnu
- Evalina None
- Fanous Ayman H.
- Faraone Stephen V.
- Farnham Peggy
- Fañanås Lourdes
- Feng Guoping
- Fiorentino Alessia
- Forstner Andreas
- Forti Marta Di
- Frank Josef
- Freedman Robert
- Frei Oleksandr
- Freimer Nelson B.
- Fromer Menachem
- Fromer Menachem
- Frustaci Alessandra
- Gadelha Ary
- Galeev Timur
- Galletly Cherrie
- Gandal Michael J.
- Gandal Mike
- Gareeva Anna
- Gareeva Anna
- Gawlik Micha
- Ge Tian
- Gejman Pablo V.
- Gennarelli Massimo
- Genovese Giulio
- Gershon Elliot S.
- Gerstein Mark
- Giannitelli Marianna
- Giase Gina
- Giegling Ina
- Gill Michael
- Girdhar Kiran
- Giusti-RodrĂguez Paola
- Glatt Stephen J.
- Godard Stephanie
- Goes Fernando
- Goldschmidt Hana L.
- Goldstein Jacqueline I.
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- Gonzålez Peñas Javier
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- Gopal Srihari
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- Greenwood Tiffany A.
- Grennan Kay
- Grove Jakob
- Gu Mengting
- Guerra Brittney
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- Gur Raquel E.
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- GĂŒlöksĂŒz Sinan
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- Hall Lynsey S.
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- Hartmann Annette M.
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- Henskens Frans A.
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- Hong Kyung Sue
- Hoogenraad Casper
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- Howrigan Daniel P.
- Huang Hailiang
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- Hultman Christina M.
- Hwu Hai-Gwo
- Hyde Thomas
- Hyman Steven E.
- Hyman Steven E.
- Ikeda Masashi
- Imig Cordelia
- Irmansyah Irmansyah
- Ismoyo Joni H.
- Iwata Nakao
- Iyegbe Conrad
- Iyegbe Conrad
- Jablensky Assen V.
- Jaffe Andrew
- Jahn Reinhard
- Jiang Shan
- Jiang Yan
- Joa Inge
- JuliĂ Antonio
- Jung Hwajin
- Jönsson Erik G.
- Kaeser Pascal S.
- Kahn René
- Kahn René S.
- Kam-Thong Tony
- Kamatani Yoichiro
- Karachanak-Yankova Sena
- Kebir Oussama
- Kefi Amira
- Keller Matthew C.
- Kelly Brian J.
- Kendler Kenneth S.
- Kennedy James L.
- Khalimah Siti
- Khrunin Andrey
- Khusnutdinova Elza
- Kim Eunjoon
- Kim Minsoo
- Kim Sung-Wan
- Kim Yunjung
- Kirov George
- Kitchen Robert
- Klovins Janis
- Knowles James A.
- Knowles James A.
- Kondratiev Nikolay
- Konte Bettina
- Koopmans Frank
- Koopmans Frank
- Kraft Julia
- Krebs Marie-Odile
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- Kusumadewi Irmia
- Kusumaningrum Profitasari
- Kusumawardhani Agung
- Kuzelova-Ptackova Hana
- KuÄinskas Vaidutis
- KuÄinskiene Zita Ausrele
- KĂ€hler Anna K.
- Lam Max
- Landi Stefano
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- Lawrie Stephen
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- Lencz Todd
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- Levinson Douglas F.
- Lewis Cathryn
- Li Miaoxin
- Li Mingfeng
- Li Qingqin S.
- Li Zhiqiang
- Lieberman Jeffrey
- Light Gregory A.
- Limborska Svetlana
- Lin Kuang
- Linszen Don H.
- Lipstein Noa
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- Liu Jianjun
- Liu Shuang
- Loughland Carmel M.
- Lubinski Jan
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- Mallet Jacques
- Marder Stephen R.
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- Martorell Lourdes
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- McGrath John J.
- McIntosh Andrew
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- McQuillin Andrew
- Medeiros Helena
- Meier Sandra
- Melegh Bela
- Melle Ingrid
- Menezes Paulo R.
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihra
- Mitjans Marina
- Molden Espen
- Molina Esther
- Molto MarĂa Dolores
- Mondelli Valeria
- Moran Jennifer L.
- Moreno Carmen
- Morgan Vera A.
- Morley Christopher P.
- Morris Derek W.
- Mors Ole
- Mortensen Preben B.
- Mowry Bryan J.
- Muntané Gerard
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- Myin-Germeys Inez
- MĂŒller-Myhsok Bertram
- Nasrun Martina W.
- Navarro Fabio
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- NenadiÄ Igor
- Nestadt Gerald
- Nikitina-Zake Liene
- Nimgaonkar Vishwajit
- Nordentoft Merete
- Noto Cristiano
- Nuechterlein Keith H.
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- Oh Sang-Yun
- Olincy Ann
- Ophoff Roel A.
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- Palotie Aarno
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- Panagiotaropoulou Georgia
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- Papadimitriou George N.
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- Pimm Jonathan
- Pinto Dalila
- Pirinen Matti
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- Polioudakis Damon
- Porteous David
- Posthuma Danielle
- Powell John
- Powell John
- Prasetyawan Prasetyawan
- Pratt Henry
- Pulver Ann E.
- Purcaro Michael
- Purcell Shaun
- Qi Ting
- Qin Shengying
- Quattrone Diego
- Quested Digby
- Radant Allen D.
- Rampino Antonio
- Rapaport Mark H.
- Rautanen Anna
- Reddy Tim
- Reichenberg Abraham
- Reza Muhammad
- Rhie Suhn
- Richards Alexander L.
- Rietschel Marcella
- Riley Brien P.
- Ripke Stephan
- Rivera Margarita
- Roe Cheryl
- Roffman Joshua L.
- Roth Julian
- Rothermundt Matthias
- Roussos Panagiotis
- Roussos Panos
- Rozowsky Joel
- Rujescu Dan
- Rujescu Dan
- Rutten Bart P. F.
- Ryan Timothy A.
- Safyuni N. S.
- Sahasrabudhe Dnyanada
- Saka Meram C.
- Saker-Delye Safaa
- Sala Carlo
- Salomaa Veikko
- Sanders Alan R.
- Sanders Stephan
- Sanjuan Julio
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- Schall Ulrich
- Schulze Thomas G.
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- Sethi Anurag
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- Sharp Sally Isabel
- Sheng Morgan
- Shi Jianxin
- Shi Xu
- Shi Yongyong
- Shi Yongyong
- Shieh Annie
- Sidorenko Julia
- Siever Larry J.
- Sigurdsson Engilbert
- Silverman Jeremy M.
- Sim Kang
- Siste Kristiana
- Skarabis Nora
- Slominsky Petr
- Smalla Karl-Heinz
- Smit August B.
- Smoller Jordan W.
- So Hon-Cheong
- Sobell Janet L.
- St Clair David
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- Stahl Eli A.
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- Stefansson Kari
- StefĂĄnsson Hreinn
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- Strengman Eric
- Stroup T. Scott
- Stögmann Elisabeth
- Subramaniam Mythily
- Sugar Catherine A.
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- Svrakic Dragan M.
- Swarup Vivek
- Swerdlow Neal R.
- Szatkiewicz Jin P.
- Szekely Anna
- Söderman Erik
- SĂŒdhof Thomas C.
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- Takahashi Atsushi
- Terao Chikashi
- Thibaut Florence
- Thomas Paul D.
- Tobing Heriani
- Toncheva Draga
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- Torretta Silvia
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- Tsuang Debby W.
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- Vaaler Arne
- van Amelsvoort Therese
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- Verhage Matthijs
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- Verpelli Chiara
- Vilella Elisabet
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- Waddington John
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- Walter Henrik
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- Weisbrod Matthias
- Weiser Mark
- Weissman Sherman
- Weng Zhiping
- Wenwen Qin
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- Widiasih Natalia
- Wiguna Tjhin
- Wildenauer D. B.
- Wildenauer Dieter B.
- Williams Nigel M.
- Wiseman Jennifer
- Witt Heather
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- Won Hyejung
- Wood Shannon
- Wormley Brandon K.
- Wray Naomi R.
- Wu Feinan
- Wu Jing Qin
- Wu Yang
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- Xu Shuhua
- Xu Xuming
- Xu Zhida
- Yang Jian
- Yao Lijing
- Yolken Robert
- Yu Xin
- Yue Weihua
- Yusnadewi Suzy
- Zai Clement C.
- Zandi Peter
- Zeng Jian
- Zhang Wen
- Zhou Wei
- Zhu Feng
- Zimprich Fritz
- Ăçok Alp
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Schizophrenia has a heritability of 60â80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
- Author
- Abbott Liam
- Abdellaoui Abdel
- Adams Mark J.
- Adams Mark J.
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Air Tracy
- Air Tracy M.
- Akil Huda
- Albani Diego
- Albus Margot
- Alda Martin
- Alda Martin
- Alexander Madeline
- Alliey-Rodriguez Ney
- Als Thomas D.
- Als Thomas D.
- Amin Farooq
- Andlauer Till F. M.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Antilla Verneri
- Arolt Volker
- Arranz Maria J.
- Awasthi Swapnil
- Bacanu Silviu A.
- Bacanu Silviu-Alin
- Badner Judith A.
- Bakker Steven
- Band Gavin
- Barchas Jack D.
- Barroso Ines
- Barroso Ines
- Bass Nicholas
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- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Beekman Aartjan T. F.
- Begemann Martin
- Begemann Martin
- Bellenguez CĂ©line
- Belliveau Richard
- Belliveau Richard A.
- Bellivier Frank
- Bender Stephan
- Bene Judit
- Bergen Sarah E.
- Bergen Sarah E.
- Berger Klaus
- Bevilacqua Elizabeth
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
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- Blokland Gabriëlla A. M.
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- Boks Marco P.
- Boocock James
- Boomsma Dorret I.
- Boomsma Dorret I.
- Bortolato Marco
- Bralten Janita
- Bramon Elvira
- Bramon Elvira
- Bramon Elvira
- Bramon Elvira
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brown Matthew A.
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- Bruggeman Richard
- Bryois Julien
- Buccola Nancy G.
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- Byerley William
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- Byrne Enda M.
- BĂŠkvad-Hansen Marie
- BĂŠkvad-Hansen Marie
- BĂžen Erlend
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- BĂžrglum Anders D.
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- Chan Raymond C. K.
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- Chen Chia-Yen
- Chen Danfeng
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- Cheng Wei
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- Cloninger C. Robert
- Cohen David
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- Cormican Paul
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- Del Favero Jurgen
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- Deloukas Panos
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- Demontis Ditte
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- DePaulo J. Raymond
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- Derks Eske M.
- Dikeos Dimitris
- Dinan Timothy
- Direk Nese
- Djurovic Srdjan
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- Eriksson Johan
- Escott-Price Valentina
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- Friedl Marion
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- Frye Mark
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- Gade Katrin
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- Gaspar Héléna A.
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- Gejman Pablo V.
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- Genovese Giulio
- Georgieva Lyudmila
- Geschwind Daniel
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- Giannoulatou Eleni
- Giegling Ina
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- Gill Michael
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- Gillman Matthew
- Giusti-RodrĂguez Paola
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- Goldstein Jacqueline I.
- Goldstein Jaqueline
- Goldstein Jill M.
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- Golimbet Vera
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- Schoevers Robert
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- Shen Ling
- Shi Jianxin
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- Shilling Paul D.
- Shyn Stanley I.
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M.
- Sim Kang
- Sinnamon Grant C. B.
- Sirignano Lea
- Skajaa Kristjar
- Sklar Pamela
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- Smeland Olav B.
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- Smoller Jordan W.
- So Hon-Cheong
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- Spencer Chris C. A.
- Spencer Chris C. A.
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- Spijker Anne T.
- St Clair David
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- Stahl Eli
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- Stefansson Hreinn
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- Stefansson Kari
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- Steinberg Stacy
- Steinberg Stacy
- Steinberg Stacy
- Steixner-Kumar Agnes
- Stogmann Elisabeth
- Strange Amy
- Stranger Barbara E.
- Straub Richard E.
- Strauss John S.
- Streit Fabian
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- Streit Fabian
- Strengman Eric
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- Szelinger Szabolcs
- SĂĄnchez-Mora Cristina
- Söderman Erik
- Tansey Katherine E.
- Tashakkori-Ghanbaria Avazeh
- Teismann Henning
- Teumer Alexander
- Teumer Alexander
- Thirumalai Srinivas
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- Thompson Wesley
- Thomson Pippa A.
- Thorgeirsson Thorgeir E.
- Thorgeirsson Thorgeir E.
- Tiemeier Henning
- Tiemeier Henning
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- Toncheva Draga
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- Tooney Paul A.
- Tosato Sarah
- Traglia Michela
- Traylor Matthew
- Trembath Richard C.
- Treutlein Jens
- Treutlein Jens
- Trubetskoy Vassily
- Trubetskoy Vassily
- Trzaskowski Maciej
- Trzaskowski Maciej
- Uher Rudolf
- Uher Rudolf
- Uitterlinden André G.
- Umbricht Daniel
- Vaaler Arne E.
- Van der Auwera Sandra
- Van der Auwera Sandra
- van Hemert Albert M.
- Van Os Jim
- Van Os Jim
- Vedder Helmut
- Veijola Juha
- Viktorin Alexander
- Viktorin Alexander
- Vincent John B.
- Visscher Peter M.
- Visscher Peter M.
- Viswanathan Ananth C.
- Vukcevic Damjan
- Völker Uwe
- Völzke Henry
- Waddington John
- Waller Matthew
- Walsh Dermot
- Walshe Muriel
- Walters James T. R.
- Walters Raymond K.
- Wang Dai
- Wang Qiang
- Wang Weiqing
- Wang Yunpeng
- Wang Yunpeng
- Watson Stanley J.
- Webb Bradley T.
- Webb Bradley T.
- Weickert Cynthia Shannon
- Weickert Thomas W.
- Weinberger Daniel R.
- Weinberger Daniel R.
- Weinsheimer Shantel Marie
- Weisbrod Matthias
- Weiser Mark
- Weiss Lauren A.
- Weissman Myrna M.
- Weissman Myrna M.
- Wellmann JĂŒrgen
- Wendland Jens R.
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Weston Paul
- Whitehead Pavlides Jennifer M.
- Whittaker Pamela
- Widaa Sara
- Wiersma Durk
- Wildenauer Dieter B.
- Willemsen Gonneke
- Willemsen Gonneke
- Williams Nigel M.
- Williams Stephanie
- Winham Stacey J.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Wolen Aaron R.
- Wong Emily H. M.
- Wood Nicholas W.
- Wormley Brandon K.
- Wray Naomi R.
- Wray Naomi R.
- Wray Naomi R.
- Wu Jing Qin
- Wu Jing Qin
- Wu Yang
- Xi Hualin S.
- Xi Hualin Simon
- Xi Simon
- Xu Wei
- Yang Jian
- Yao Yin
- Yolken Robert H.
- Young Allan H.
- Zai Clement C.
- Zandi Peter
- Zhang Futao
- Zhang Peng
- Zheng Xuebin
- Zimprich Fritz
- Zöllner Sebastian
- Ăsby Urban
- ĆwiÄ tkowska Beata
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Mass spectrometryâbased forest tree metabolomics
- Author
- Abraham PE
- Abreu e Lima F
- Abril N
- Acharya BR
- Ahuja I
- Aizat WM
- Alseekh S
- Alseekh S
- Ana Margarida Rodrigues
- Anderegg WRL
- AnderssonâGunnerĂ„s S
- Angelcheva L
- Ara T
- Arabidopsis Genome Initiative
- Arbona V
- Arndt SK
- Arrabal C
- Atkinson NJ
- Baginsky S
- Baker EAG
- Bakkali F
- Bari R
- Barros C
- Bartels B
- Bedon F
- Berger S
- Bino RJ
- Birol I
- Blanch JS
- BlaĆŸenoviÄ I
- Blodner C
- Boerjan W
- Boher P
- Bolton MD
- Boughton BA
- Boughton BA
- Brazma A
- Brosché M
- Brouwers NC
- Brunner I
- BrÀutigam K
- Budzinski IGF
- Businge E
- CadahĂa E
- Cai Q
- Canales J
- Canbay HS
- Carla AntĂłnio
- Carrasco A
- Carroll AJ
- Cañas RA
- Celedon PAF
- Chagné D
- Chano V
- Chaves I
- Chazdon RL
- Chen J
- Chen P
- Chen Q
- Chen S
- Cheng L
- Chong J
- Considine E
- Correia B
- Correia B
- Correia B
- Coruh C
- Craine JM
- CĂ©lia Miguel
- Dauwe R
- Deborde C
- Delatorre C
- Dettmer K
- Dhuli P
- Diego N
- Dobrowolska I
- Donat MG
- Druart N
- Du M
- Dudareva N
- Durack PJ
- Durand TC
- EchevarrĂaâZomeño S
- Eckert AJ
- Eller ASD
- Ellison D
- Ensminger I
- EPPO
- Erb M
- EscandĂłn M
- Etalo DW
- Eyles A
- Fan F
- Fan F
- Fang C
- Faria JMS
- Fernandez i Marti A
- Fernie AR
- Fernie AR
- Fernie AR
- Fernie AR
- FerryâDumazet H
- Fiehn O
- Fiehn O
- Fiehn O
- Fiehn O
- Fiehn O
- Fiehn O
- Fiehn O
- Figueiredo AC
- Figueiredo AC
- Fox H
- Frainay C
- Francisco LR
- Fuente B
- Fuente B
- Fukuda K
- Futai K
- FĂŒrtauer L
- Galindo GonzĂĄlez LM
- GargalloâGarriga A
- Gaspar D
- Gillet LC
- Gion JM
- Goff SA
- Gomes NGM
- GonzalezâIbeas D
- Grene R
- GroĂkinsky DK
- Gruffudd HR
- Gstaiger M
- Guerra FP
- GuerreroâSanchez VM
- Gullberg J
- Hall DE
- Hamanishi ET
- Hantao LW
- Hare PD
- Harfouche A
- Harfouche A
- Harfouche A
- Haug K
- Hayden KJ
- He CY
- Hefer CA
- Heredia UL
- Hirata A
- Hoffman DE
- Holliday JA
- Hu WJ
- Huaying Z
- Hummel J
- Hummel J
- Ikegami M
- Ingvarsson PK
- InĂȘs Chaves
- IPCC Core Writing Team
- Janz D
- JaramilloâCorrea JP
- Johnsen Ă
- Jorge I
- Jorge TF
- Jorge TF
- Jorge TF
- JorrĂnâNovo JV
- Kang JW
- Kang JW
- Keenan RJ
- Kelly LJ
- Keszei A
- Keszei A
- Kim HK
- Kind T
- Kleiber A
- Kohler A
- Kohli A
- Kopka J
- Kopka J
- Kopka J
- Kopka J
- KosovĂĄ K
- Kovalchuk A
- Krasensky J
- Kreuzwieser J
- Kreuzwieser J
- Kuroda H
- Kurth F
- Kusano M
- Kusano M
- KĂŒlheim C
- Law B
- Lee IH
- Li QF
- Li WF
- Liao HL
- Lisec J
- Liu JJ
- Liu Q
- Lu M
- Ludwig C
- Lundmark T
- LĂłpezâAljorna A
- LĂłpezâHidalgo C
- LĂŒpke M
- Maboreke HR
- Makkonen M
- Marmiroli M
- Martens L
- Martins MCM
- Mast S
- Mata AT
- McQuilton P
- Meehl GA
- MeijĂłn M
- Meireles B
- Meyer FE
- Michotey C
- Miguel M
- Mildrexler D
- Mittler R
- Mittler R
- Mokochinski JB
- Morel A
- Mota M
- Mota M
- Muchero W
- Myburg AA
- Naidoo S
- Nakabayashi R
- Neale DB
- Neale DB
- Neale DB
- Neale DB
- Netzer F
- Ning K
- Niu S
- Niu SH
- Nystedt B
- Obata T
- Obudulu O
- Okazaki Y
- Oliver SG
- Orchard S
- Pacifici M
- Padovan A
- Pan X
- Parchman TL
- Pascual J
- Pascual J
- Patton MF
- Pautasso M
- Pedrioli PG
- Pereira A
- PereiraâLeal JB
- Peter GF
- Peters K
- Pimentel CS
- Plomion C
- Plomion C
- Porta N
- Ramegowda V
- Ramos AM
- Ramsfield TD
- Rellstab C
- Resende MDV
- Ricardo CPP
- Riedlmeier M
- Riikonen J
- RivasâUbach A
- RivasâUbach A
- Robinson AR
- RoccaâSerra P
- Rodrigues AM
- Rodrigues AM
- Rodrigues AS
- RodrĂguezâCalcerrada J
- Rojas CM
- RomeroâRodrĂguez MC
- Rubiolo P
- Rupasinghe TWT
- Ryu M
- Salek RM
- Sansone SA
- Santos C
- Schubert OT
- Schwachtje J
- Sebastiana M
- Seidl R
- Sergeant K
- SghaierâHammami B
- Shukla AK
- SimĂłn BF
- SimĂłn BF
- Skogerson K
- Smith JA
- Soliman T
- Sollars ESA
- Sork VL
- Sork VL
- Souza LP
- Spicer RA
- Spicer RA
- Spokevicius AV
- Srivastava V
- Stall S
- Stevens KA
- Stitt M
- Sturrock RN
- Sturtevant D
- Sud M
- Sumner LW
- Sun YH
- Suzuki N
- SĂĄezâLaguna E
- Tarkka MT
- Tautenhahn R
- Taylor CF
- TaĂŻbi K
- Teixeira RT
- Teixeira RT
- Telfer E
- Tenenboim H
- Tholl D
- Thumma BR
- Tohge T
- Tohge T
- Trapp S
- Tschaplinski TJ
- Tuskan GA
- Töpfer N
- Valcu CM
- Valdés AE
- ValeroâGalvĂĄn J
- Vallarino JG
- Valledor L
- Valledor L
- Veach AM
- Veluthakkal R
- Verma V
- Villar E
- Vinaixa M
- Visser EA
- Visser EA
- Wachowiak W
- Wan LC
- Wang D
- Wang L
- Wang X
- Wang Z
- Warren CR
- Warren CR
- Watanabe M
- Weckwerth W
- Wegrzyn JL
- Welter S
- Westermann AJ
- Wilkinson MD
- Wingfield MJ
- Witzell J
- Wong CM
- Wong YF
- Wu Q
- Yakovlev IA
- Yamashita M
- Yeh TF
- Yu J
- Zamany A
- Zandalinas SI
- Zaynab M
- Zhang H
- Zhang Q
- Zhang QJ
- Zhang Y
- Zhu FY
- Zhu FY
- Zhu FY
- Zimin AV
- zu Castell W
- Zulak KG
- ÄwiekâKupczyĆska H
- Publication venue
- 'Wiley'
- Publication date
- Field of study