Detecting high-functioning autism in adults using eye tracking and machine learning

This is an accepted manuscript of an article published by IEEE in IEEE Transactions on Neural Systems and Rehabilitation Engineering on 30/04/2020, available online: https://ieeexplore.ieee.org/document/9082703 The accepted version of the publication may differ from the final published version.The purpose of this study is to test whether visual processing differences between adults with and without highfunctioning autism captured through eye tracking can be used to detect autism. We record the eye movements of adult participants with and without autism while they look for information within web pages. We then use the recorded eye-tracking data to train machine learning classifiers to detect the condition. The data was collected as part of two separate studies involving a total of 71 unique participants (31 with autism and 40 control), which enabled the evaluation of the approach on two separate groups of participants, using different stimuli and tasks. We explore the effects of a number of gaze-based and other variables, showing that autism can be detected automatically with around 74% accuracy. These results confirm that eye-tracking data can be used for the automatic detection of high-functioning autism in adults and that visual processing differences between the two groups exist when processing web pages.Published versio

“Keep it simple!”: an eye-tracking study for exploring complexity and distinguishability of web pages for people with autism

A major limitation of the international well-known standard web accessibility guidelines for people with cognitive disabilities is that they have not been empirically evaluated by using relevant user groups. Instead, they aim to anticipate issues that may arise following the diagnostic criteria. In this paper, we address this problem by empirically evaluating two of the most popular guidelines related to the visual complexity of web pages and the distinguishability of web-page elements. We conducted a comparative eye-tracking study with 19 verbal and highly independent people with autism and 19 neurotypical people on eight web pages with varying levels of visual complexity and distinguishability, with synthesis and browsing tasks. Our results show that people with autism have a higher number of fixations and make more transitions with synthesis tasks. When we consider the number of elements which are not related to given tasks, our analysis shows that they look at more irrelevant elements while completing the synthesis task on visually complex pages or on pages whose elements are not easily distinguishable. To the best of our knowledge, this is the first empirical behavioural study which evaluates these guidelines by showing that the high visual complexity of pages or the low distinguishability of page elements causes non-equivalent experience for people with autism.Published onlin

TRPM2 channel-mediated cell death: an important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions

Oxidative stress resulting from the accumulation of high levels of reactive oxygen species is a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One common mechanism for oxidative stress damage is via the disruption of intracellular ion homeostasis to induce cell death. TRPM2 is a non-selective Ca2+-permeable cation channel with a wide distribution throughout the body and is highly sensitive to activation by oxidative stress. Recent studies have collected abundant evidence to show its important role in mediating cell death induced by miscellaneous oxidative stress-inducing pathological factors, both endogenous and exogenous, including ischemia/reperfusion and the neurotoxicants amyloid-β peptides and MPTP/MPP+ that cause neuronal demise in the brain, myocardial ischemia/reperfusion, proinflammatory mediators that disrupt endothelial function, diabetogenic agent streptozotocin and diabetes risk factor free fatty acids that induce loss of pancreatic β-cells, bile acids that damage pancreatic acinar cells, renal ischemia/reperfusion and albuminuria that are detrimental to kidney cells, acetaminophen that triggers hepatocyte death, and nanoparticles that injure pericytes. Studies have also shed light on the signalling mechanisms by which these pathological factors activate the TRPM2 channel to alter intracellular ion homeostasis leading to aberrant initiation of various cell death pathways. TRPM2-mediated cell death thus emerges as an important mechanism in the pathogenesis of conditions including ischemic stroke, neurodegenerative diseases, cardiovascular diseases, diabetes, pancreatitis, chronic kidney disease, liver damage and neurovascular injury. These findings raise the exciting perspective of targeting the TRPM2 channel as a novel therapeutic strategy to treat such oxidative stress-associated diseases

Thermo elastic analysis of functionally graded rotating disks with temperature-dependent material properties: uniform and variable thickness

A thermo elastic analysis is presented for axisymmetric rotating disks made of functionally graded material (FGM) with variable thickness. Material properties are assumed to be temperature-dependent and graded in the radial direction according to a grading index power law distribution. The temperature field considered is assumed to be uniformly distributed over the disk surface and varied in the radial direction. Semi-analytical solutions for the displacement field are given for solid disk and annular disk under free-free and fixed-free boundary conditions. The effects of the thermal field, the material grading index and the geometry of the disk on the displacement and stress fields are investigated. Results of this study emphasize on the crucial role of the temperature-dependent properties in a high temperature environment. A comparison of these results with the reported ones in the literature that is temperature-dependent versus temperature-independent suggests that a functionally graded rotating disk with concave thickness profile can work more efficiently than the one with uniform thickness irrespective of whether the material properties are assumed to be temperature-dependent or temperature-independen