¿Se pueden alcanzar los objetivos de la escuela de Frankfurt mediante la teoría del reconocimiento? Reflexiones a propósito de la controversia en el campo de la filosofía política de Nancy Fraser y Axel Honneth

De los estudios en ciencias sociales de mayor impacto se deduce que la política de mercantilización y desestructuración de las instituciones del Estado social practicada en los últimos treinta años, pri mero en Gran Bretaña, los Estados Unidos y Nueva Zelanda y después en el continente europeo, generará formas de empleo que, cada vez más, serían experimentadas por las personas como pro blemáticas o amenazantes (cf ., p. ej ., Bourdieu et al., 1997, Castel, 2000 y 2005, así como Sennet 1998 y 2005). Parecen responsables de este hecho, ante todo, las exigencias de movilidad que aumentan con la flexibilización de las estructuras de empleo, así como también un fuerte incremento de las ocupaciones inestables y mal pagadas (como, por ejemplo, los trabajos tempora les o a tiempo parcial). Según la apreciación de destacados sociólogos, aquellas estructuras de ocupación resultan problemáticas para muchas personas no únicamente en sentido material, sino también en sentido normativo: no sólo acarrean una situación de conflict o en el mantenimiento de la propia vida, sino que también dificultan la formación del autoaprecio y de la autoestima de una parte de la ciudadanía. A la vista de esta circunstancias , no resulta sorprendente que las cuesti ones del mundo del trabajo hayan sido discutidas ampliamente por personas que se dedican tanto a las ciencias sociales y a la ética de la economía, como también a la filosofía política o social. Para la Teoría Crítica en la tradición de la Escuela de Frankfurt , la discusión sobre los modernos mundos del trabajo resulta tradicionalmente un tema central. La peculiaridad de su planteamiento (interdis ciplinar) consiste , según la convicción de dos de sus más prominentes representantes, en : fusionar aquellos planos que provienen de la filosofía moral, de la teoría de la sociedad y del análisis político, en una teoría crítica del capitalismo (Fraser & Honnet h, 2003: 10). Lo que se plantea en esta perspectiva es un análisis y una crítica

Towards a structure-based exciton Hamiltonian for the CP29 antenna of photosystem II

The exciton Hamiltonian pertaining to the first excited states of chlorophyll (Chl) a and b pigments in the minor light-harvesting complex CP29 of plant photosystem II is determined based on the recent crystal structure at 2.8 Å resolution applying a combined quantum chemical/electrostatic approach as used earlier for the major light-harvesting complex LHCII. Two electrostatic methods for the calculation of the local transition energies (site energies), referred to as the Poisson–Boltzmann/quantum chemical (PBQC) and charge density coupling (CDC) method, which differ in the way the polarizable environment of the pigments is described, are compared and found to yield comparable results, when tested against fits of measured optical spectra (linear absorption, linear dichroism, circular dichroism, and fluorescence). The crystal structure shows a Chl a/b ratio of 2.25, whereas a ratio between 2.25 and 3.0 can be estimated from the simulation of experimental spectra. Thus, it is possible that up to one Chl b is lost in CP29 samples. The lowest site energy is found to be located at Chl a604 close to neoxanthin. This assignment is confirmed by the simulation of wild-type-minus-mutant difference spectra of reconstituted CP29, where a tyrosine residue next to Chl a604 is modified in the mutant. Nonetheless, the terminal emitter domain (TED), i.e. the pigments contributing mostly to the lowest exciton state, is found at the Chl a611–a612–a615 trimer due to strong excitonic coupling between these pigments, with the largest contributions from Chls a611 and a612. A major difference between CP29 and LHCII is that Chl a610 is not the energy sink in CP29, which is presumably to a large extent due to the replacement of a lysine residue with alanine close to the TED

Computational Protein Design: Validation and Possible Relevance as a Tool for Homology Searching and Fold Recognition

International audienceBACKGROUND: Protein fold recognition usually relies on a statistical model of each fold; each model is constructed from an ensemble of natural sequences belonging to that fold. A complementary strategy may be to employ sequence ensembles produced by computational protein design. Designed sequences can be more diverse than natural sequences, possibly avoiding some limitations of experimental databases. METHODOLOGY/PRINCIPAL FINDINGS: WE EXPLORE THIS STRATEGY FOR FOUR SCOP FAMILIES: Small Kunitz-type inhibitors (SKIs), Interleukin-8 chemokines, PDZ domains, and large Caspase catalytic subunits, represented by 43 structures. An automated procedure is used to redesign the 43 proteins. We use the experimental backbones as fixed templates in the folded state and a molecular mechanics model to compute the interaction energies between sidechain and backbone groups. Calculations are done with the Proteins@Home volunteer computing platform. A heuristic algorithm is used to scan the sequence and conformational space, yielding 200,000-300,000 sequences per backbone template. The results confirm and generalize our earlier study of SH2 and SH3 domains. The designed sequences ressemble moderately-distant, natural homologues of the initial templates; e.g., the SUPERFAMILY, profile Hidden-Markov Model library recognizes 85% of the low-energy sequences as native-like. Conversely, Position Specific Scoring Matrices derived from the sequences can be used to detect natural homologues within the SwissProt database: 60% of known PDZ domains are detected and around 90% of known SKIs and chemokines. Energy components and inter-residue correlations are analyzed and ways to improve the method are discussed. CONCLUSIONS/SIGNIFICANCE: For some families, designed sequences can be a useful complement to experimental ones for homologue searching. However, improved tools are needed to extract more information from the designed profiles before the method can be of general use

Flatrate-Partys

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.Regelungen zur Bekämpfung des Alkoholmissbrauchs im Jugendschutz- und Gaststättengesetz – Gesetzgebungs-kompetenzen nach der Föderalismusreform im Bereich der Gaststätten – Übergangsregelung des Art. 125 a Abs. 1 GG –Berufsfreiheit des Art. 12 Abs. 1 GPeer Reviewe

Recognition and property in Hegel and the early Marx

The article attempts to show, first, that for Hegel the role of property is to enable persons both to objectify their freedom and to properly express their recognition of each other as free, and second, that the Marx of 1844 uses fundamentally similar ideas in his exposition of communist society. For him the role of ‘true property’ is to enable individuals both to objectify their essential human powers and their individuality, and to express their recognition of each other as fellow human beings with needs, or their ‘human recognition’. Marx further uses these ideas to condemn the society of private property and market exchange as characterised by ‘estranged’ forms of property and recognition. He therefore uses a structure of ideas which Hegel had used to justify the institutions of private property and market exchange in order to condemn those same institutions. It is concluded that Marx’s adoption from Hegel of the idea that property as the means of self-objectification and of expressed recognition, leaves his vision of communism open to the charge that in it, just as in market society, the relations between human beings are mediated by things

Erinnerung, Wertschätzung und das Recht zu vererben

Für die zeitgenössische Philosophie ist das Vererben ein Vermögenstransfer, der unter Gesichtspunkten sozialer Gerechtigkeit zu behandeln ist. Diese Untersuchungsperspektive ist angesichts der massiven Verteilungseffekte, die das Vererben zeitigt, ohne Frage sehr wichtig. Allerdings lässt sie einen Punkt unberücksichtigt: Das testamentarische Vererben kann wichtige Beiträge dazu leisten, dass wir Verstorbene, denen wir zu Lebzeiten nahestanden, in Erinnerung behalten und wertschätzen. Hierbei ist der monetäre Wert der vererbten Güter nicht entscheidend. Wie ich in meinem Aufsatz darlege, lässt sich mit diesem Befund erklären, warum die (von einer wachsenden Zahl von Gerechtigkeitstheoretikerinnen und -theoretikern geforderte) Abschaffung des Rechts zu vererben nicht nur von Vorteil sein würde, sondern auch mit ethischen Kosten verbunden wäre. Ein adäquater philosophischer Diskurs hätte diesen Befund (mit dem sich neoliberale oder rechtslibertaristische erbrechtliche Positionen nicht rechtfertigen lassen) angemessen zu berücksichtigen

Testing the Coulomb/Accessible Surface Area solvent model for protein stability, ligand binding, and protein design

<p>Abstract</p> <p>Background</p> <p>Protein structure prediction and computational protein design require efficient yet sufficiently accurate descriptions of aqueous solvent. We continue to evaluate the performance of the Coulomb/Accessible Surface Area (CASA) implicit solvent model, in combination with the Charmm19 molecular mechanics force field. We test a set of model parameters optimized earlier, and we also carry out a new optimization in this work, using as a target a set of experimental stability changes for single point mutations of various proteins and peptides. The optimization procedure is general, and could be used with other force fields. The computation of stability changes requires a model for the unfolded state of the protein. In our approach, this state is represented by tripeptide structures of the sequence Ala-X-Ala for each amino acid type X. We followed an iterative optimization scheme which, at each cycle, optimizes the solvation parameters and a set of tripeptide structures for the unfolded state. This protocol uses a set of 140 experimental stability mutations and a large set of tripeptide conformations to find the best tripeptide structures and solvation parameters.</p> <p>Results</p> <p>Using the optimized parameters, we obtain a mean unsigned error of 2.28 kcal/mol for the stability mutations. The performance of the CASA model is assessed by two further applications: (i) calculation of protein-ligand binding affinities and (ii) computational protein design. For these two applications, the previous parameters and the ones optimized here give a similar performance. For ligand binding, we obtain reasonable agreement with a set of 55 experimental mutation data, with a mean unsigned error of 1.76 kcal/mol with the new parameters and 1.47 kcal/mol with the earlier ones. We show that the optimized CASA model is not inferior to the Generalized Born/Surface Area (GB/SA) model for the prediction of these binding affinities. Likewise, the new parameters perform well for the design of 8 SH3 domain proteins where an average of 32.8% sequence identity relative to the native sequences was achieved. Further, it was shown that the computed sequences have the character of naturally-occuring homologues of the native sequences.</p> <p>Conclusion</p> <p>Overall, the two CASA variants explored here perform very well for a wide variety of applications. Both variants provide an efficient solvent treatment for the computational engineering of ligands and proteins.</p

Zeitschrift für Praktische Philosophie / Beruht das Recht zu vererben auf einer Fiktion? : Auf dem Weg zu einer philosophischen Theorie des Erbrechts

In dem vorliegenden Beitrag rekonstruiere ich die linkslibertaristische Kritik des Rechts zu vererben, die Hillel Steiner ausgearbeitet hat, und prüfe, ob diese Kritik zufriedenstellend ist. Ich komme zu dem Ergebnis, dass Steiner in dem von ihm angelegten rechtstheoretischen Rahmen die von vielen Philosophen und Rechtswissenschaftlern angenommene rechtliche Gleichartigkeit des Vererbens und des Verschenkens mit überzeugenden Argumenten in Frage stellt, seinerseits aber das Recht zu vererben mit einer Theorie kritisiert, die gerechtigkeitstheoretische und sozialtheoretische Bedenken hervorruft. Wie ich abschließend darlege, geben die erzielten Untersuchungsergebnisse Aufschluss über das ontologische Profil des Rechts zu vererben und die Eigentümlichkeit dieser Art der Eigentumsübertragung; sie eignen sich deshalb als Ausgangspunkt einer philosophischen Theorie des Erbrechts.In this paper I analyse Hillel Steiners left-libertarian critique of the right to bequeath. I explain why, given his theory of rights, Steiner is correct to question what many political philosophers and legal scholars take for granted: namely, that bequeathing and donating are essentially the same thing from a legal point of view. Nevertheless, I argue that Steiners critique of the right to bequeath ultimately fails to achieve its goals since it is founded upon a theory of justice that is problematic and offers an explanation of legal phenomena that is unconvincing. The paper concludes by reflecting on the ontological profile of the right to bequeath and the peculiarity of this type of transfer of ownership and so prepares the groundwork for a philosophical theory of inheritance law.(VLID)267019