706 research outputs found
Mapping task-switching in frontal cortex through neuropsychological group studies
This paper considers evidence provided by large neuropsychological group studies and meta-analyses of functional imaging experiments on the location in frontal cortex of the subprocesses involved in the carrying out of task-switching paradigms. The function of the individual subprocesses is also considered in the light of analyses of the performance of normal subjects
Compensated Row-Column Ultrasound Imaging System Using Edge-Guided Three Dimensional Random Fields
The row-column method is a simplification technique used to reducethe complexity of a fully addressed 2-D array. Although itgreatly reduces the number of physical connections required aswell as the amount of data to be handled, it still has limitations; itsimaging data output is sparse, it suffers from speckle noise, and itsspatially-dependant point spread function is riddled with edge artifacts.In this work, we propose a row-column ultrasound imagingsystem, termed CRUIS3D, that uses a 3-D edge-guided randomfield approach to compensate for the limitations of the row-columnmethod. Tests on CRUIS3D and previously published row-columnsystems show the effectiveness of our proposed system as a toolfor enhancing 3-D row-column ultrasound imaging
Inflation and Brane Gases
We investigate a new way of realizing a period of cosmological inflation in
the context of brane gas cosmology. It is argued that a gas of co-dimension one
branes, out of thermal equilibrium with the rest of the matter, has an equation
of state which can - after stabilization of the dilaton - lead to power-law
inflation of the bulk. The most promising implementation of this mechanism
might be in Type IIB superstring theory, with inflation of the three large
spatial dimensions triggered by ``stabilized embedded 2-branes''. Possible
applications and problems with this proposal are discussed.Comment: 7 pages, uses REVTeX, version to appear in Phys. Rev.
Vortices and dynamics in trapped Bose-Einstein condensates
I review the basic physics of ultracold dilute trapped atomic gases, with
emphasis on Bose-Einstein condensation and quantized vortices. The hydrodynamic
form of the Gross-Pitaevskii equation (a nonlinear Schr{\"o}dinger equation)
illuminates the role of the density and the quantum-mechanical phase. One
unique feature of these experimental systems is the opportunity to study the
dynamics of vortices in real time, in contrast to typical experiments on
superfluid He. I discuss three specific examples (precession of single
vortices, motion of vortex dipoles, and Tkachenko oscillations of a vortex
array). Other unusual features include the study of quantum turbulence and the
behavior for rapid rotation, when the vortices form dense regular arrays.
Ultimately, the system is predicted to make a quantum phase transition to
various highly correlated many-body states (analogous to bosonic quantum Hall
states) that are not superfluid and do not have condensate wave functions. At
present, this transition remains elusive. Conceivably, laser-induced synthetic
vector potentials can serve to reach this intriguing phase transition.Comment: Accepted for publication in Journal of Low Temperature Physics,
conference proceedings: Symposia on Superfluids under Rotation (Lammi,
Finland, April 2010
Frequency and Significance of Coronary Artery Disease and Myocardial Bridging in Patients With Hypertrophic Cardiomyopathy
The etiology of chest pain in hypertrophic cardiomyopathy (HC) is diverse and includes coronary artery disease (CAD) as well as HC-specific causes. Myocardial bridging (MB) has been associated with HC, chest pain, and accelerated atherosclerosis. We compared HC patients with age-, gender- and CAD pre-test probability-matched outpatients presenting with chest pain to investigate differences in the presence of MB and CAD using coronary computed tomography angiography (CCTA). We studied 84 HC patients who underwent CCTA and compared these with 168 matched controls (age 54 ± 11 years, 70% men, pre-test probability 12% [5% to 32%]). MB, calcium score, plaque morphology and presence and extent of CAD were assessed for each patient. Linear mixed models were used to assess differences between cases and controls. MB was more often seen in HC patients (50% vs 25%, p <0.001). Calcium score and the presence of obstructive CAD were similar in both groups (9 [0 to 225] vs 4 [0 to 82] and 18% vs 19%; p = 0.22 and p = 0.82). In the HC group, MB was associated with pathogenic DNA variants (p = 0.04), but not with the presence of chest pain (74% vs 76%, p = 0.8), nor with worse outcome (log-rank p = 0.30). In conclusion, the prevalence and extent of CAD was equal among patients with and without HC, demonstrating that pre-test risk prediction using the CAD Consortium clinical risk score performs well in HC patients. MB was twice as prevalent in the HC group compared with matched controls, but was not associated with chest pain or decreased event-free survival in these patients
Torsion Constraints in the Randall--Sundrum Scenario
Torsion appears due to fermions coupled to gravity and leads to the strongest
particle physics bounds on flat extra dimensions. In this work, we consider
torsion constraints in the case of a warped extra dimension with brane and bulk
fermions. From current data we obtain a 3-sigma bound on the TeV--brane mass
scale scale \Lambda_\pi > 2.2 (10) TeV for the AdS curvature k=1 (0.01) in
(reduced) Planck units. If Dirac or light sterile neutrinos reside on the
brane, the bound increases to 17 (78) TeV.Comment: typos corrected, matches the Phys. Rev. D versio
Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway
During early brain development, N-methyl-d-aspartate (NMDA) receptors are involved in cell migration, neuritogenesis, axon guidance and synapse formation, but the mechanisms which regulate NMDA receptor density and function remain unclear. The kynurenine pathway of tryptophan metabolism includes an agonist (quinolinic acid) and an antagonist (kynurenic acid) at NMDA receptors and we have previously shown that inhibition of the pathway using the kynurenine-3-monoxygenase inhibitor Ro61-8048 in late gestation produces rapid changes in protein expression in the embryos and effects on synaptic transmission lasting until postnatal day 21 (P21). The present study sought to determine whether any of these effects are maintained into adulthood. After prenatal injections of Ro61-8048 the litter was allowed to develop to P60 when some offspring were euthanized and the brains removed for examination. Analysis of protein expression by Western blotting revealed significantly reduced expression of the GluN2A subunit (32%) and the morphogenetic protein sonic hedgehog (31%), with a 29% increase in the expression of doublecortin, a protein associated with neurogenesis. No changes were seen in mRNA abundance using quantitative real-time polymerase chain reaction. Neuronal excitability was normal in the CA1 region of hippocampal slices but paired-pulse stimulation revealed less inhibition at short interpulse intervals. The amount of long-term potentiation was decreased by 49% in treated pups and recovery after low-frequency stimulation was delayed. The results not only strengthen the view that basal, constitutive kynurenine metabolism is involved in normal brain development, but also show that changes induced prenatally can affect the brains of adult offspring and those changes are quite different from those seen previously at weaning (P21). Those changes may be mediated by altered expression of NMDAR subunits and sonic hedgehog
The Crystallography of Color Superconductivity
We develop the Ginzburg-Landau approach to comparing different possible
crystal structures for the crystalline color superconducting phase of QCD, the
QCD incarnation of the Larkin-Ovchinnikov-Fulde-Ferrell phase. In this phase,
quarks of different flavor with differing Fermi momenta form Cooper pairs with
nonzero total momentum, yielding a condensate that varies in space like a sum
of plane waves. We work at zero temperature, as is relevant for compact star
physics. The Ginzburg-Landau approach predicts a strong first-order phase
transition (as a function of the chemical potential difference between quarks)
and for this reason is not under quantitative control. Nevertheless, by
organizing the comparison between different possible arrangements of plane
waves (i.e. different crystal structures) it provides considerable qualitative
insight into what makes a crystal structure favorable. Together, the
qualitative insights and the quantitative, but not controlled, calculations
make a compelling case that the favored pairing pattern yields a condensate
which is a sum of eight plane waves forming a face-centered cubic structure.
They also predict that the phase is quite robust, with gaps comparable in
magnitude to the BCS gap that would form if the Fermi momenta were degenerate.
These predictions may be tested in ultracold gases made of fermionic atoms. In
a QCD context, our results lay the foundation for a calculation of vortex
pinning in a crystalline color superconductor, and thus for the analysis of
pulsar glitches that may originate within the core of a compact star.Comment: 41 pages, 13 figures, 1 tabl
Cosmological Creation of D-branes and anti-D-branes
We argue that the early universe may be described by an initial state of
space-filling branes and anti-branes. At high temperature this system is
stable. At low temperature tachyons appear and lead to a phase transition,
dynamics, and the creation of D-branes. These branes are cosmologically
produced in a generic fashion by the Kibble mechanism. From an entropic point
of view, the formation of lower dimensional branes is preferred and
brane-worlds are exponentially more likely to form than higher dimensional
branes. Virtually any brane configuration can be created from such phase
transitions by adjusting the tachyon profile. A lower bound on the number
defects produced is: one D-brane per Hubble volume.Comment: 30 pages, 5 eps figures; v2 more references added; v3 section 4
slightly improve
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