Probing exotic phenomena at the interface of nuclear and particle physics with the electric dipole moments of diamagnetic atoms: A unique window to hadronic and semi-leptonic CP violation

The current status of electric dipole moments of diamagnetic atoms which involves the synergy between atomic experiments and three different theoretical areas -- particle, nuclear and atomic is reviewed. Various models of particle physics that predict CP violation, which is necessary for the existence of such electric dipole moments, are presented. These include the standard model of particle physics and various extensions of it. Effective hadron level combined charge conjugation (C) and parity (P) symmetry violating interactions are derived taking into consideration different ways in which a nucleon interacts with other nucleons as well as with electrons. Nuclear structure calculations of the CP-odd nuclear Schiff moment are discussed using the shell model and other theoretical approaches. Results of the calculations of atomic electric dipole moments due to the interaction of the nuclear Schiff moment with the electrons and the P and time-reversal (T) symmetry violating tensor-pseudotensor electron-nucleus are elucidated using different relativistic many-body theories. The principles of the measurement of the electric dipole moments of diamagnetic atoms are outlined. Upper limits for the nuclear Schiff moment and tensor-pseudotensor coupling constant are obtained combining the results of atomic experiments and relativistic many-body theories. The coefficients for the different sources of CP violation have been estimated at the elementary particle level for all the diamagnetic atoms of current experimental interest and their implications for physics beyond the standard model is discussed. Possible improvements of the current results of the measurements as well as quantum chromodynamics, nuclear and atomic calculations are suggested.Comment: 46 pages, 19 tables and 16 figures. A review article accepted for EPJ

Contribution From Optical Course For The Educational Guidance Of Engineering Careers Students

The work shows the fundamental elements of an inclusive educational guidance conception of substantive university processes and results achieved at the Instituto Superior Politécnico José Antonio Echeverría of Havana in the contribution from optical course to develop it for the students in first and second year of the engineering programs, by means of lectures on holography and three-dimensional images of motivation and link with different specialties and the development of experimental facilities and methodology for the construction of holograms and anaglyph by students for engineering applications.9289 IEEE - The Photonics Society,International Commission for Optics (ICO),The Optical Society,The Society of Photo-Optical Instrumentation Engineers (SPIE)Collazo, B., Puentes, M., La orientacin en la actividad pedaggica ¿el maestro, un orientador? (1992) Editorial Pueblo y Educacin, , La HabanaCollazo, B., (2006) Modelo de Tutora Integral Para la Continuidad de Estudios Universitarios en Las Sedes Municipals, , Tesis de doctorado CubaRodrguez, S., (1997) Orientacin Universitaria y Evaluacin de la Calidad. Calidad de la Universidad: Orientacin y Evaluacin, , Apodaca P. y C. Lobato Eds, Barcelona, LaertesEcheverra, B., (1997) Los servicios de orientacin universitarios. Calidad en la universidad: Orientacin y evaluacin, pp. 112-136. , Apodaca P. y C. Lobato (Eds, Barcelona: LaertesMonge, M.C., (2009) Tutora y Orientacin Educative, , Nuevas competencies Las Rozas Wolters KluwerSantana, L.E., (2009) Orientacin Educativa e Intervencin Psicopedaggica Cambian Los Tiempos Cambian Las Responsabilidades Profesionales, , Pirmide MadridVieira, M.J., Vidal, J., Tendencias de la Educacin Superior Europea e implicaciones para la orientacin universitaria (2006) Revista Espaola de Orientacin y Psicopedagoga, 17 (1), pp. 75-97Jaime, R.A., La orientacin educativa como tarea inseparable de la Extensin Universitaria (2011) Revista Cuadernos de Educacin y Desarrollo, 3 (28)Daz, T., La Extensin: Un proceso formativo de la Universidad. Su relacin con otros procesos (2001) Conferencia Magistral Del VI Taller Internacional de Extensin Universitaria, , Memorias, CubaGonzlez, G., (2002) Extensin Universitaria: Una Visin un Cambio Necesario, , Conferencia de la III Convencin Internacional de Educacin Superior, Memorias, CubaOliveira, N., The notorial dynamic analisis of an artificial satellite: A pedagogical experiment in space education (2008) Revista Brasileira de Ensino de Fsica, 30 (1), p. 1401Serra, R., Alfonso, I., Herrera, R., Ferreira, D., Muramatsu, M., Soga, D., (2013) La Fsica y El Trabajo Cientfico Estudiantil en la formación Del Ingeniero Biomdico, , enviado a LAJFE en proceso de arbitraje, eneroSerra, R., (2004) La Utilizacin Del Holograma Como Medio de Enseñanza y de Educacin Social en Cuba A Travs Del Vnculo Investigación-Docencia-Extensin Universitaria, , Tesis Doctoral CubaSerra, R., Moreno, A., Magalhes, D., Muramatsu, M., Lemus, J., Haciendo hologramas en la escuela y en la casa (2010) Revista Brasileira de Ensino de Fsica, 32 (3), p. 3502Zottola, D., Hernndez, A., Serra, R., Anaglifos en la Enseñanza de la ingeniera biomdica (2011) Proc. of v Latin American Congress on Biomedical Engineering, , Haban

Velocity-space sensitivity of the time-of-flight neutron spectrometer at JET

The velocity-space sensitivities of fast-ion diagnostics are often described by so-called weight functions. Recently, we formulated weight functions showing the velocity-space sensitivity of the often dominant beam-target part of neutron energy spectra. These weight functions for neutron emission spectrometry (NES) are independent of the particular NES diagnostic. Here we apply these NES weight functions to the time-of-flight spectrometer TOFOR at JET. By taking the instrumental response function of TOFOR into account, we calculate time-of-flight NES weight functions that enable us to directly determine the velocity-space sensitivity of a given part of a measured time-of-flight spectrum from TOFOR

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia:a Multinational Point Prevalence Study of Hospitalised Patients

Pseudornonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa-CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa-CAP. We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa. Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeruginosa-CAP. The prevalence of P. aeruginosa and antibiotic-resistant P. aeruginosa-CAP was 4.2% and 2.0%, respectively. The rate of P. aeruginosa CAP in patients with prior infection/colonisation due to P. aeruginosa and at least one of the three independently associated chronic lung diseases (i.e. tracheostomy, bronchiectasis and/or very severe chronic obstructive pulmonary disease) was 67%. In contrast, the rate of P. aeruginosa-CAP was 2% in patients without prior P. aeruginosa infection/colonisation and none of the selected chronic lung diseases. The multinational prevalence of P. aeruginosa-CAP is low. The risk factors identified in this study may guide healthcare professionals in deciding empirical antibiotic coverage for CAP patients

Long-range Angular Correlations On The Near And Away Side In P-pb Collisions At √snn=5.02 Tev

7191/Mar294

Relationship of edge localized mode burst times with divertor flux loop signal phase in JET

A phase relationship is identified between sequential edge localized modes (ELMs) occurrence times in a set of H-mode tokamak plasmas to the voltage measured in full flux azimuthal loops in the divertor region. We focus on plasmas in the Joint European Torus where a steady H-mode is sustained over several seconds, during which ELMs are observed in the Be II emission at the divertor. The ELMs analysed arise from intrinsic ELMing, in that there is no deliberate intent to control the ELMing process by external means. We use ELM timings derived from the Be II signal to perform direct time domain analysis of the full flux loop VLD2 and VLD3 signals, which provide a high cadence global measurement proportional to the voltage induced by changes in poloidal magnetic flux. Specifically, we examine how the time interval between pairs of successive ELMs is linked to the time-evolving phase of the full flux loop signals. Each ELM produces a clear early pulse in the full flux loop signals, whose peak time is used to condition our analysis. The arrival time of the following ELM, relative to this pulse, is found to fall into one of two categories: (i) prompt ELMs, which are directly paced by the initial response seen in the flux loop signals; and (ii) all other ELMs, which occur after the initial response of the full flux loop signals has decayed in amplitude. The times at which ELMs in category (ii) occur, relative to the first ELM of the pair, are clustered at times when the instantaneous phase of the full flux loop signal is close to its value at the time of the first ELM

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

DNA methylation quantitative trait locus (mQTL) analyses on 32,851 participants identify genetic variants associated with DNA methylation at 420,509 sites in blood, resulting in a database of >270,000 independent mQTLs.Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait locus (mQTL) analyses on 32,851 participants, identifying genetic variants associated with DNAm at 420,509 DNAm sites in blood. We present a database of >270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations. Identified mQTL associations explain 15-17% of the additive genetic variance of DNAm. We show that the genetic architecture of DNAm levels is highly polygenic. Using shared genetic control between distal DNAm sites, we constructed networks, identifying 405 discrete genomic communities enriched for genomic annotations and complex traits. Shared genetic variants are associated with both DNAm levels and complex diseases, but only in a minority of cases do these associations reflect causal relationships from DNAm to trait or vice versa, indicating a more complex genotype-phenotype map than previously anticipated.Molecular Epidemiolog

Electrochemical oxidation of ochratoxin A at a glassy carbon electrode and in situ evaluation of the interaction with deoxyribonucleic acid using an electrochemical deoxyribonucleic acid-biosensor

Ochratoxin A (OTA) is a fungal metabolite that occurs in foods, beverages, animal tissues, human blood and presents carcinogenic, teratogenic and nephrotoxic properties. This study concerns the redox properties of OTA using electrochemical techniques which have the potential for providing insights into the biological redox reactions of this molecule. The in situ evaluation of the OTA interaction with DNA using a DNA-electrochemical biosensor is also reported.http://www.sciencedirect.com/science/article/B6TF4-4N3GFN7-3/1/57e4418b7a355b04b0c0ad5eec1834e

Twenty-two years’ experience registering trials in a low-middle income country: The Peruvian Clinical Trial Registry

Este estudio analiza la evolución cuantitativa y cualitativa del Registro Peruano de Ensayos Clínicos durante los últimos 22 años. Métodos: Siguiendo un diseño transversal, revisamos todos los ensayos clínicos registrados en el Registro de Ensayos Clínicos de Perú durante 1995-2017. Descargamos y extrajimos todos los registros el 31 de marzo de 2018. Resumimos las variables cualitativas y las cuantitativas. Además, realizamos análisis de tendencias de los registros por año, fase clínica, junta de revisión institucional y participación infantil