Prenatal exposures and exposomics of asthma

This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental medi

Brine utilisation for cooling and salt production in wind-driven seawater greenhouses:Design and modelling

Brine disposal is a major challenge facing the desalination industry. Discharged brines pollute the oceans and aquifers. Here is it proposed to reduce the volume of brines by means of evaporative coolers in seawater greenhouses, thus enabling the cultivation of high-value crops and production of sea salt. Unlike in typical greenhouses, only natural wind is used for ventilation, without electric fans. We present a model to predict the water evaporation, salt production, internal temperature and humidity according to ambient conditions. Predictions are presented for three case studies: (a) the Horn of Africa (Berbera) where a seawater desalination plant will be coupled to salt production; (b) Iran (Ahwaz) for management of hypersaline water from the Gotvand dam; (c) Gujarat (Ahmedabad) where natural seawater is fed to the cooling process, enhancing salt production in solar salt works. Water evaporation per face area of evaporator pad is predicted in the range 33 to 83 m3/m2·yr, and salt production up to 5.8 tonnes/m2·yr. Temperature is lowest close to the evaporator pad, increasing downwind, such that the cooling effect mostly dissipates within 15 m of the cooling pad. Depending on location, peak temperatures reduce by 8–16 °C at the hottest time of year