67 research outputs found
Can teaching agenda-setting skills to physicians improve clinical interaction quality? A controlled intervention
- Author
- A Girgis
- A Girgis
- AD Federman
- CS Chan
- Dana G Safran
- DB Langille
- DG Safran
- DG Safran
- DG Safran
- DL Roter
- DL Roter
- E Krupat
- Esosa G Odigie
- HB Beckman
- Hector P Rodriguez
- HP Rodriguez
- J Cornuz
- J Murphy
- JA Sliwa
- JB Brown
- JE Montgomery
- K Rost
- KM Markakis
- L Fallowfield
- LJ Finocchio
- M Stewart
- Michael P Anastario
- MJ Sise
- NL Keating
- RC Smith
- Richard M Frankel
- RR Moral
- T Stein
- Ted von Glahn
- TS Stein
- WF Baile
- William H Rogers
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>Physicians and medical educators have repeatedly acknowledged the inadequacy of communication skills training in the medical school curriculum and opportunities to improve these skills in practice. This study of a controlled intervention evaluates the effect of teaching practicing physicians the skill of "agenda-setting" on patients' experiences with care. The agenda-setting intervention aimed to engage clinicians in the practice of initiating patient encounters by eliciting the full set of concerns from the patient's perspective and using that information to prioritize and negotiate which clinical issues should most appropriately be dealt with and which (if any) should be deferred to a subsequent visit.</p> <p>Methods</p> <p>Ten physicians from a large physician organization in California with baseline patient survey scores below the statewide 25th percentile participated in the agenda-setting intervention. Eleven physicians matched on baseline scores, geography, specialty, and practice size were selected as controls. Changes in survey summary scores from pre- and post-intervention surveys were compared between the two groups. Multilevel regression models that accounted for the clustering of patients within physicians and controlled for respondent characteristics were used to examine the effect of the intervention on survey scale scores.</p> <p>Results</p> <p>There was statistically significant improvement in intervention physicians' ability to "explain things in a way that was easy to understand" (p = 0.02) and marginally significant improvement in the overall quality of physician-patient interactions (p = 0.08) compared to control group physicians. Changes in patients' experiences with organizational access, care coordination, and office staff interactions did not differ by experimental group.</p> <p>Conclusion</p> <p>A simple and modest behavioral training for practicing physicians has potential to positively affect physician-patient relationship interaction quality. It will be important to evaluate the effect of more extensive trainings, including those that work with physicians on a broader set of communication techniques.</p
Pain, power and patience - A narrative study of general practitioners' relations with chronic pain patients
- Author
- A Werner
- AD Wasan
- Annika Brorsson
- B Olsson
- C Bieber
- C Glenton
- C Kohler Riessman
- C Kohler Riessman
- C May
- Caroline Wachtler
- D Waters
- DT Kenny
- EE Johansson
- EG Mishler
- F Goodyear-Smith
- H Breivik
- J Lidbeck
- JP Gee
- K Denzin N
- K Hamberg
- K Malterud
- MA Stewart
- Margareta Troein
- Mia Hemborg Kristiansson
- N Elder
- NM Leila
- R Nisell
- RR Moral
- S Steihaug
- S Steihaug
- T Greenhalgh
- W Labov
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- Author
- A Ciechanover
- A Criollo
- A Degterev
- A Degterev
- A Degterev
- A Gross
- A Hochreiter-Hufford
- A Kaczmarek
- A Linkermann
- A Linkermann
- A Linkermann
- A Linkermann
- A Nagasaka
- A Oberst
- A Oberst
- A Pogrebniak
- A Rebbaa
- A Strasser
- A Villunger
- AA Fatokun
- AA Mailleux
- AC Schinzel
- AD Dam
- AG Fraser
- AJ Schile
- AM Chinnaiyan
- AM Chinnaiyan
- AM Choi
- AM Verhagen
- AU Lindner
- AV Vaseva
- B D Dynlacht
- B Joseph
- B La Scola
- B La Scola
- B Levine
- B R Stockwell
- B Zhivotovsky
- B Zhivotovsky
- BA Gibson
- BB Wolf
- BH Han
- C Borner
- C Brenner
- C Brenner
- C Brenner
- C Brenner
- C Du
- C Garrido
- C Garrido
- C López-Otín
- C M Rodrigues
- C Munoz-Pinedo
- C Muñoz-Pinedo
- C Scaffidi
- C Scheller
- C Volbracht
- C Volbracht
- CM Haynes
- CO Bellamy
- CP Baines
- CP Baines
- CP Dillon
- D Adam
- D Andrews
- D C Rubinsztein
- D Chandra
- D Denton
- D Denton
- D Denton
- D Denton
- D Denton
- D E Bredesen
- D Grander
- D J Klionsky
- D R Green
- D Raoult
- D Ren
- D Vercammen
- D Vercammen
- D Vercammen
- D Xue
- D Zhu
- DA Fruman
- DC Rubinsztein
- DE Bredesen
- DJ Klionsky
- DL Berry
- DL Vaux
- DM Moujalled
- DM Moujalled
- DM Underhill
- DR Green
- DR Green
- DV Krysko
- DV Krysko
- DW Zhang
- E Basso
- E Candi
- E F Wagner
- E H Baehrecke
- E H Cheng
- E Laane
- E Lugli
- E Murphy
- E Noch
- E S Alnemri
- E Tasdemir
- E White
- E White
- EA Minina
- EA Slee
- EA Slee
- EH Baehrecke
- EJ Park
- F Basit
- F Cecconi
- F Cecconi
- F Gonzalvez
- F K Chan
- F Madeo
- F Pietrocola
- F Verrier
- FC Kischkel
- FH Igney
- G A Rabinovich
- G Denecker
- G Hajnoczky
- G Kroemer
- G Kroemer
- G Kroemer
- G Kroemer
- G Kroemer
- G Kroemer
- G Kroemer
- G Lettre
- G M Fimia
- G Marino
- G Melino
- G Nuñez
- G Szabadkai
- G Trichonas
- G Van Loo
- GP Sims
- H Gronemeyer
- H Ichijo
- H Kanuka
- H Kenis
- H Khalil
- H Kim
- H L Tang
- H Pearson
- H Puthalakath
- H Puthalakath
- H Puthalakath
- H Varma
- H Wajant
- H Walczak
- H Walczak
- H Wang
- H Yoshida
- H Zhu
- H Zou
- H-U Simon
- HI Roach
- HL Tang
- HL Tang
- I Amelio
- I Martinou
- I Vitale
- IK Poon
- IP Nezis
- J A Cidlowski
- J E Chipuk
- J H Prehn
- J Hitomi
- J J Lemasters
- J Li
- J M Abrams
- J M Bravo-San Pedro
- J M Hardwick
- J M Penninger
- J Michels
- J P Medema
- J Sosna
- J Wu
- J Yang
- J Yuan
- J Yuan
- J Zhao
- J-C Marine
- J-C Martinou
- JA Rickard
- JC Reed
- JE Chipuk
- JE Chipuk
- JE Vince
- JF Kerr
- JG Albeck
- JG Albeck
- JH Shin
- JJ Lemasters
- JL Luo
- JM Hardwick
- JM Murphy
- JS Long
- JU Schweichel
- JW Upton
- K Bianchi
- K Blomgren
- K Kehe
- K Kuida
- K Kuida
- K Miyazaki
- K Newton
- K Nihira
- K Prabhakaran
- K Richter
- K S Ravichandran
- K Segawa
- K Tracy
- K-M Debatin
- KA Spriggs
- KC Zimmermann
- KN Alavian
- KR Knight
- L Altucci
- L Duprez
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Mondragon
- L Steinhart
- L Sun
- L Zitvogel
- LC Gomes
- M Ankarcrona
- M Annicchiarico-Petruzzelli
- M Arundine
- M Bonora
- M Campanella
- M Campanella
- M Chautan
- M D'Amelio
- M E Peter
- M Elgendy
- M Endres
- M Irmler
- M J Bertrand
- M Leist
- M Los
- M MacFarlane
- M Mediavilla-Varela
- M Muzio
- M O Hengartner
- M Okada
- M Overholtzer
- M Piacentini
- M V Blagosklonny
- M Woo
- M-L Gougeon
- MA Burguillos
- MA Hughes
- MA Mellen
- MA Mellen
- MA O'Donnell
- MB Jensen
- MC Wei
- ME Peter
- MJ Bertrand
- ML Coleman
- N Di Daniele
- N G Bazan
- N Holler
- N Honarpour
- N Mizushima
- N Mizushima
- N S Chandel
- N Tavernarakis
- N Vanlangenakker
- N Vanlangenakker
- N Vanlangenakker
- NJ Curtin
- NJ McCarthy
- NN Danial
- O Kepp
- O Kepp
- O Krysko
- P Bouillet
- P Golstein
- P J Jost
- P Kraft
- P Li
- P Mazzarello
- P Meier
- P Nicotera
- P Nicotera
- P Pacher
- P Pinton
- P Saikumar
- P Schotte
- P Vandenabeele
- P Vandenabeele
- P Vandenabeele
- P Vandenabeele
- PE Czabotar
- PG Clarke
- PJ Jost
- PS Brookes
- Q Remijsen
- Q Zhang
- R A Flavell
- R A Knight
- R A Lockshin
- R De Maria
- R Hakem
- R Rashmi
- R Rizzuto
- R Skouta
- R Weinlich
- RA Lockshin
- RA Lockshin
- RC Taylor
- RJ O'Brien
- RM del Moral
- RU Janicke
- RW Oppenheim
- S A Aaronson
- S A Lipton
- S Barut
- S Bhattacharyya
- S Dolma
- S Enzenmuller
- S Fulda
- S Fulda
- S Grootjans
- S He
- S J Martin
- S Jouan-Lanhouet
- S Kumar
- S Kumar
- S Melino
- S Morioka
- S Renolleau
- S Tan
- S Vallabhapurapu
- S W Tait
- S Zelenay
- SA Lakhani
- SA Susin
- SB Bratton
- SC Chow
- SJ Dixon
- SJ Dixon
- SJ Kim
- SJ Martin
- SJ Martin
- SM Knoblach
- SM Laster
- SM Srinivasula
- SN Willis
- SW Tait
- SW Tait
- SW Tait
- SW Tait
- SW Tait
- SW Yu
- SW Yu
- SY Chen
- T Hirsch
- T Ide
- T Kaufmann
- T Lindsten
- T M Dawson
- T Nakagawa
- T Nakamura
- T Panaretakis
- T Rudel
- T Tenev
- T Vanden Berghe
- T Vanden Berghe
- T Vanden Berghe
- T Vanden Berghe
- T Vanden Berghe
- TG Cotter
- TJ Daish
- TJ Fan
- TM Caserta
- U Moll
- V De Laurenzi
- V Giorgio
- V Gogvadze
- V L Dawson
- V Labi
- V M Dixit
- V Nikoletopoulou
- W Fiers
- W G Wood
- W Han
- W Han
- W Hou
- W Malorni
- W S El-Deiry
- W Zhang
- WJ Kaiser
- WJ Kaiser
- WS Yang
- WW Chen
- X Chen
- X Li
- X Liu
- X Luo
- X Pan
- XM Yin
- Y Ben-Neriah
- Y Dondelinger
- Y Dondelinger
- Y Eguchi
- Y Fuchs
- Y Li
- Y Liu
- Y Rong
- Y Shi
- Y Tsujimoto
- Y Wang
- Y Zaltsman
- YP Ow
- YS Cho
- Z Cai
- Z Song
- Z Wang
- Z Zakeri
- ZA Dunai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ‘accidental cell death’ (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. ‘Regulated cell death’ (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- Antón DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
- Babalis D
- Babini G
- Bachli EB
- Bader A
- Bader A
- Baena J
- Baidya DK
- Baikova VN
- Bakker J
- Balcázar LC
- Balcázar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
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- Barberet G
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- Beane A
- Beduneau G
- Beduneau G
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- Beeharry SD
- Beerepoot M
- Begzjav T
- Beishuizen A
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- Belletti A
- Bellissimo-Rodrigues F
- Belloli A
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- Bellver BQ
- Belmonte R
- Ben-Hamouda N
- Bendel S
- Bendel S
- Benyamina M
- Beretta S
- Berg R
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- Berghmans J
- Bernal FF
- Berric A
- Berrutti D
- Berthelsen RE
- Bertini P
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- Besevli SG
- Bestle MH
- Bettex D
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- Beunders R
- Bhasin D
- Bhattal MK
- Bhide S
- Bianchi I
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- Bianzina S
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- Bishop J
- Bissenova N
- Bisso MC
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- Bloomer MJ
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- CAPCRI Study
- Capellier G
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- Champigneulle B
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- Chemam S
- Chen CM
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- Chen CW
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- Chen YS
- Chen YS
- Cheng CC
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- Cheng CC
- Cheng KC
- Cheng YJ
- Chernyshuk S
- Chevret S
- Chhor V
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- Chiang CH
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- Chiappa C
- Chiou KR
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- Chiumello D
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- Cho Y
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- Christopher KB
- Chrétien JM
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- Cinnella G
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- Collange O
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- Contreras KM
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- Cook DJ
- Coombs M
- Cordeiro CP
- Cordero M
- Cordolcini V
- Cordovilla-Guardia S
- Cordón J
- Corona A
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- Curinga M
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- Cuthbertson BH
- Cutuli SL
- Câmara M
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- da Silva VZ
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- Dalhuisen A
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- Damås JK
- Das Neves A
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- Day A
- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
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- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
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- De la Torre MA
- De Maglie M
- De Maglie M
- de Molina FJ
- De Morton N
- de Oca Sandoval MA
- De Pascale G
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- De Sanctis F
- De Silva AP
- De Sousa I
- de Vera AP
- de Wilde W
- De Zani D
- Deblier I
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- Del Arco A
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- Del Olmo R
- Del Rosario CG
- Del Sorbo L
- Delgado CP
- Delgado MJ
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- Demirkiran O
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- Descotte E
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- Di Gregorio A
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- Dimopoulou IK
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- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
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- Espinasse F
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- FINNRESUSCI Study Group
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- Frontera PR
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- GETGAG/SEMICYUC
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- Idei M
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- Ignacio ML
- Iida A
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- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
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- IPREA Study Group
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- Janotka M
- Janotka M
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- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
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- Jeong IY
- Jeong WY
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- Jiménez GJ
- Jo YH
- Joachim J
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- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
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- Jun IG
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- Junior JM
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- Kaminsky GE
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- Kolnikova I
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- Kulkarni AP
- Kumari BK
- Kumbamu A
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- Kurmukov IA
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- Kwon HM
- Kwon WY
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- Labra C
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- Lafuente E
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- Latini R
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- Latini R
- Latorre J
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- Lombardo MD
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- Lopez-Gude MJ
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- MacKay A
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- Maghsoudi B
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- Martín-Loeches I
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- Martínez-Carmona JF
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- Mejías CR
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- Menendez R
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- Mercat A
- Mercat A
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- Merino-Vega D
- Messenger D
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- Midwinter MJ
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- Miguelena PR
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- Morán I
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- Okayama Research Investigation Organizing Network (ORION)investigators
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- PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre
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- Psarologakis C
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- Rapid Diagnosis of Infections in the Critically Ill Team
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- Rosario LE
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- Ruiz FC
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- Rutten AM
- Rydingsward JE
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- Sabeļņikovs O
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- Sandiumenge A
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- Santana MC
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- Santiago AI
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- Santos F
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- Sanz ER
- Sanz ER
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- Sanz NM
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- Savi C
- Savin I
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- Sawamura A
- Sawamura A
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- Spronk PE
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- St George’s University of London
- Stamm J
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- Stubbs C
- Stubbs C
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- Su F
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- Su PL
- Suchomel P
- Suh GJ
- Suh GJ
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- Wetz A
- Weyer CM
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- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
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- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
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- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
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- Zibandah N
- Zijlstra F
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- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
- Azambuja P
- Azevedo C
- Aziz FZ
- Baas P
- Baghirzada L
- Bai H-P
- Bai Y
- Baillie S
- Baines D
- Baio TH
- Bairaktari A
- Baker G
- Baker K-A
- Baker P
- Balain B
- Balaji P
- Balajonda N
- Balanescu A
- Balasubramaniam M
- Baldisserotto S
- Baldwin J
- Baldwin M
- Balfoussia D
- Bali C
- Bandeira ME
- Banerjee R
- Bankewitz C
- Banner-Goodspeed V
- Bao Q
- Barcraft-Barnes H
- Barneto L
- Barnett A
- Baroselli A
- Barraclough J
- Barras J-P
- Barrett S
- Barrett WJ
- Basanth S
- Batchelor N
- Bateman B
- Bates A
- Bates S
- Batista HD
- Bauchmuller K
- Bauer M
- Baumgarten G
- Baxter L
- Beaton C
- Beattie S
- Beavis V
- Bechan S
- Bejia T
- Belciu I
- Belda MT
- Bell G
- Bell R
- Bell S
- Bellandi M
- Bello J
- Beloeil H
- Belskiy V
- Ben-Menachem E
- Benavent P
- Benevento A
- Bengeri S
- Bennett C
- Bennett M
- Bennett R
- Bennett V
- Bentley C
- Beretta L
- Berg A
- Bergin C
- Bernard A
- Berntsen E
- Bertram W
- Bester D
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- Bignami E
- Bilolikar A
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- Birch J
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- Bodansky D
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- Boereboom C
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- Bouwman A
- Bouwman RA
- Bowrey S
- Boxall L
- Boyd C
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- Bradley J
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- Brandsborg B
- Breitenstein S
- Brennan A
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- Brenner L
- Brincat M
- Briscoe R
- Bristogiannis S
- Brooke J
- Brookes J
- Brookes M
- Brooks C
- Broomby R
- Brotto AF
- Brown A
- Brown CW
- Brown G
- Brown J
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- Brown R
- Browning J
- Bruma D
- Brunete T
- Brunswicker A
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- Bua E
- Buccimazza I
- Buckley S
- Buerkle C
- Buhre W
- Buhre W
- Buhrer T
- Builu PM
- Buise M
- Bullock C
- Bunwarie B
- Burns K
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- Burston B
- Burtenshaw A
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- Busuioc M
- Butryn I
- Butt G
- Byrne K
- Cabezuelo E
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- Cabral TDN
- Cabrini L
- Cacala S
- Cai F
- Cai Y
- Cain H
- Cairns C
- Cakova V
- Calderwood C
- Callaghan M
- Campbell D
- Campbell D
- Campbell D
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years
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- A'hern R
- A\u2019hern R
- Abe O
- Abe R
- Abu\u2010zahra Ht
- Af Trampe E
- Aft R
- Ahlgren J
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- Aihara T
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- Alberro Ja
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- Arnesson Lg
- Arriagada R
- Asmar L
- Asselain B
- Bahi J
- Balic M
- Ballester B
- Barlow W
- Barrett\u2010lee Pj
- Bartelink H
- Bartlett J
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- Forbes J
- Forbes Jf
- Formelli F
- Fornander T
- Forrest P
- Forsyth S
- Foster L
- Fountzilas G
- Fraile M
- Fredriksson I
- Frisell J
- Fumoleau P
- Fyles A
- G\uf6ransson E
- Gallen M
- Galligioni E
- Garaud P
- Garmo H
- Gazet Jc
- Gelber R
- Gelber Rd
- Gelman Rs
- Gelmon K
- George Wd
- Gerber B
- Gerv\ue1sio H
- Gettins L
- Geyer C
- Gianni L
- Giokas G
- Gluz O
- Gnant M
- Godwin J
- Goldhirsch A
- Goldstein Lj
- Goodwin P
- Gordilho J
- Gordon Nh
- Goss Pe
- Graham P
- Gralow J
- Gray R
- Greil R
- Griffon B
- Gubern Jm
- Gudgeon Ca
- Gundersen S
- H\uf8st H
- Hacking A
- Hackshaw A
- Hadji P
- Hakes T
- Hall E
- Hannisdal E
- Harbeck N
- Harris A
- Harris Jr
- Harvey Vj
- Hauer\u2010jensen M
- Hayat H
- Haybittle Jl
- Hayes Df
- Hayward Jl
- Henderson C
- Hercbergs A
- Hilfrich J
- Hill C
- Hinsley S
- Holdaway Im
- Holli K
- Holmberg L
- Horiguchi J
- Horsman Jm
- Hortobagyi G
- Houghton J
- Howell A
- Hozumi Y
- Hsu L
- Hudis Ca
- Huovinen R
- Hupperets Psgj
- Iiristo M
- Ikeda T
- Inbar Mj
- Ingle J
- Ingle Jn
- Inokuchi K
- Ivanov V
- Iwata H
- J\ue4nicke F
- Jack W
- Jackisch C
- Jackson Im
- Jacobsen Ab
- Jagsi R
- Jakesz R
- James S
- Janauer M
- Janer J
- Janni W
- Jensen Mb
- Joensuu H
- Johansen H
- Johansson U
- Jonat W
- Jones Se
- Jonsson H
- Julien Jp
- Jung Kh
- Karlsson P
- Kaufmann M
- Kay Rg
- Kerbrat P
- Kerr A
- Kikuchi K
- Kilburn L
- Killander F
- Kissin M
- Klefstrom P
- Klijn Jgm
- Kohno N
- Kondylis D
- Kooi M
- Korzeniowski S
- Koscielny S
- Koyama H
- Kreienberg R
- Krushen\u2010kosloski Jl
- Kunkler I
- Kwong Dlw
- L\uf6fgren L
- Larsimont D
- Ledermann J
- Lee M
- Lehingue Y
- Lemonnier J
- Lenner E
- Leonard Cf
- Leone B
- Lester J
- Levine M
- Levine Mn
- Lichter A
- Liedtke C
- Liefers Gj
- Liljegren G
- Linderholm Bk
- Lindman H
- Lindsay Ma
- Lindtner A
- Lindtner J
- Lioce M
- Lippman M
- Lissaios B
- Litton A
- Liu H
- Livingston R
- Llombart Ha
- Lohrisch C
- Loibl S
- Lopez M
- Love Rr
- Luporsi E
- Lythgoe Jp
- Mace Lesec\u2019h J
- Mackey J
- Mackinnon E
- Maibach R
- Makris A
- Mallon E
- Malmstr\uf6m P
- Mamounas Ep
- Mannu G
- Mansel Re
- Margreiter R
- Markopoulos C
- Marshall Hc
- Martelli G
- Marth C
- Martin Al
- Martin M
- Martin P
- Martino S
- Martoni A
- Marty M
- Mason Bh
- Masood Mb
- Masuda H
- Math\ue9 G
- Mauriac L
- Mavroudis D
- Mcardle Cs
- Mcgale P
- Mchugh T
- Meakin Jw
- Medina Jy
- Meier P
- Meisner C
- Michiels S
- Mihura J
- Misset Jl
- Mitchell Ak
- Miyashita M
- Mlineritsch B
- Monson K
- Monypenny Ij
- Moral A
- Morgan Dal
- Morimoto K
- Morris P
- Mouret\u2010fourme E
- Mouridsen H
- Mouridsen Ht
- Mukai H
- Murray E
- Murray N
- Musolino A
- Muss H
- Mustacchi G
- Namer M
- Neven P
- Nichol A
- Nicolucci A
- Nikolaidis P
- Nissen\u2010meyer R
- Nitz U
- Nogaret Jm
- Nomura Y
- Nordenskj\uf6ld B
- Norton L
- Notter G
- Oates Gd
- Ogawa M
- Ohashi Y
- Ohno S
- Osborne Ck
- Owen Jr
- Pai Vr
- Paik S
- Palmer Mk
- Palshof T
- Paltuev R
- Pan H
- Panieri E
- Pannuti F
- Panzarella T
- Paradiso A
- Paridaens R
- Parker D
- Parton M
- Parulekar W
- Passalacqua R
- Pastorino S
- Pater Jl
- Paterson Ahg
- Patnick J
- Pe\uf1alva G
- Peek U
- Pellegrini F
- Pennert K
- Perbeck L
- Peretz T
- Perez E
- Perrone F
- Peto R
- Petruzelka L
- Pfeiler G
- Philippson C
- Piccart M
- Piccart Mj
- Pierce L
- Pierce Lj
- Pinder S
- Pinder Se
- Pirozzoli Mc
- Poole C
- Poortmans P
- Portnoj Sm
- Possinger K
- Powell J
- Powles Tj
- Pribylova O
- Price Jj
- Price Kn
- Pritchard Ki
- Pronzato P
- Puig P
- Raina V
- Ramos M
- Rauschecker H
- Ravdin P
- Ravdin Pm
- Rea D
- Read S
- Redmond C
- Regan M
- Regan Mm
- Reid M
- Reinertsen Kv
- Ro J
- Robert N
- Robertson J
- Robertson Jfr
- Robinson E
- Roch\ue9 H
- Rodenhuis S
- Rojo R
- Romain S
- Romestaing P
- Rossbach J
- Rotmensz N
- Rotstein S
- Rouhento K
- Royle Gt
- Rubagotti A
- Rubens Rd
- Rubino C
- Rudenstam Cm
- Rutgers E
- Ryd\ue9n L
- S\uf6derberg M
- Saarto T
- Sacco M
- Sadoon M
- Safra T
- Sainz Mg
- Sakai K
- Salmon Rj
- Sandelin K
- Santesteban P
- Sauer R
- Sauerbrei W
- Sawa K
- Sayer J
- Schauer A
- Scheurlen H
- Schmid P
- Schmitt M
- Schumacher M
- Segui Ma
- Seifert M
- Semiglazov V
- Senanayake F
- Senn Hj
- Serra C
- Sertoli Mr
- Sestak I
- Sevelda P
- Shan Y
- Shao Yf
- Shapiro Cl
- Shepherd Le
- Shien T
- Simmonds Pd
- Singer Cf
- Skilton D
- Skolyszewski J
- Skoog L
- Slamon D
- Sledge G
- Smart D
- Smith Dc
- Smith Ie
- Sohn Hc
- Sol\ue0 M
- Solarnau L
- Solin Lj
- Solomayer E
- Solsona J
- Sonoo H
- Sparano J
- Sparano Ja
- Spittle M
- Spooner D
- St\uf6ger H
- Stallard S
- Steger Gg
- Steinberg S
- Stewart Hj
- Stroner P
- Sugimachi K
- Suman Vj
- Svane G
- Swain S
- Swindell R
- Takao S
- Takatsuka Y
- Takei H
- Talbot D
- Taylor C
- Taylor M
- Th\ufcrlimann B
- Thomssen C
- Thuerlimann B
- Tinterri C
- Tobias Js
- Toi M
- Tominaga T
- Tormey Dc
- Trampisch Hj
- Treurniet\u2010donker Ad
- Tu D
- Tulusan Ah
- Tutt A
- Uchino J
- Ueo H
- Untch M
- Vakaet L
- Valagussa P
- Valentini M
- Vallejo Ct
- Van De Velde Ao
- Van De Velde Cjh
- Van Den Bogaert W
- Van Dongen Ja
- Van Poznak C
- Van Putten Wlj
- Van Tinteren H
- Varhaug Je
- Veloso E
- Venturini M
- Vermorken Jb
- Veronesi U
- Viale G
- Vidal S
- Vilcoq Jr
- Von Minckwitz G
- W\ue4rnberg F
- Wadstr\uf6m C
- Wallgren A
- Wallwiener D
- Wang X
- Wang Y
- Wang Z
- Weiss Rb
- Werner Id
- Whelan T
- Wickerham L
- Wilcken N
- Williams L
- Winer E
- Winter Mc
- Wittes R
- Wolmark N
- Wood W
- Yamashita J
- Yarnold Jr
- Yosef Hma
- Yoshida M
- Yoshimoto M
- Zambetti M
- Zhao Db
- Zielinski Cc
- Zwenger A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment
Leptonic CP violating effective action for Dirac and Majorana neutrinos
- Author
- A Hernandez
- A Lue
- A Tranberg
- A Tranberg
- AD Sakharov
- AJ Buras
- B Aubert
- B Pontecorvo
- B Pontecorvo
- B Winstein
- C Garcia-Recio
- C Giunti
- C Jarlskog
- Carmen García-Recio
- DD Stancil
- E Elizalde
- E Witten
- EA Paschos
- F Halzen
- FJ Moral-Gamez
- FP An
- G Bertone
- G Hinshaw
- H Burkhardt
- H-Y Cheng
- J Beringer
- J Bernabeu
- J Charles
- J García-Bellido
- J Schechter
- J Schechter
- J Smit
- J Wess
- JF Donoghue
- JG Morfin
- JH Christenson
- JK Ahn
- JS Bell
- JS Dowker
- JW Negele
- K Abe
- K Hirata
- K Huang
- KN Abazajian
- L Wolfenstein
- L Álvarez-Gaumé
- LL Salcedo
- LL Salcedo
- LL Salcedo
- LL Salcedo
- LL Salcedo
- LL Salcedo
- LL Salcedo
- Lorenzo Luis Salcedo
- M Dine
- M Gell-Mann
- M Kobayashi
- M Neubert
- M Pospelov
- M Trodden
- MC Gonzalez-Garcia
- ME Shaposhnikov
- NG Pletnev
- RD Ball
- RI Nepomechie
- RM Bionta
- RN Mohapatra
- SL Adler
- SR Elliott
- SW Hawking
- T Brauner
- T Brauner
- T Ibrahim
- T Konstandin
- T Morii
- T Schwetz
- T Yanagida
- WA Bardeen
- X Zhang
- Y Abe
- Y Grossman
- Z Maki
- Z-z Xing
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials
- Author
- A'Hern R
- Abe O
- Abe O
- Abe R
- Abu-Zahra HT
- af Trampe E
- Aft R
- Ahlgren J
- Ahn J-H
- Albain K
- Albano J
- Alberro JA
- Amadori D
- Anderson H
- Andre F
- Arnesson L-G
- Arriagada R
- Asmar L
- Asselain B
- Bahi J
- Balic M
- Ballester B
- Bamia C
- Barlow W
- Barrett-Lee PJ
- Bartelink H
- Bartlett JMS
- Bartlett JMS
- Bartsch R
- Basso SMM
- Bastert G
- Bastiaannet E
- Bastiaannet E
- Bates T
- Baum M
- Belfiglio M
- Bell R
- Benraadt J
- Bergh J
- Berry D
- Bijker N
- Bishop H
- Blamey RW
- Bliss J
- Bliss JM
- Blohmer JU
- Blomqvist C
- Boccardo F
- Boddington C
- Bogaerts J
- Bonadonna G
- Bondesso T
- Bonneterre J
- Borovik R
- Bowden S
- Bradley R
- Brain E
- Bramwell VH
- Braun S
- Braybrooke J
- Brenner H
- Broadwater G
- Brookes C
- Brufsky AM
- Bryant AJS
- Bundred NJ
- Burrett JA
- Buyse M
- Buzdar AU
- Caffier H
- Calais G
- Camerini T
- Cameron D
- Cameron D
- Camisa R
- Canavese G
- Canney P
- Cardoso F
- Carlomagno C
- Carpenter TJ
- Carrasco E
- Carstense J
- Castiglione M
- Castiglione M
- Celebiogl F
- Chen BE
- Chetty U
- Chetty U
- Chia SKL
- Chilvers CED
- Chlebowski RT
- Christiaens R
- Christiansen P
- Cirrincione C
- Clarke M
- Coates A
- Coleman RE
- Coleman RE
- Coleman RE
- Coles CE
- Colleoni M
- Collett V
- Collins J
- Comis RL
- Coombes RC
- Corcoran N
- Costa A
- Costa SD
- Crowley J
- Cufer T
- Cunningham MP
- Cutter D
- Cuzick J
- Cuzick J
- Dafni U
- Dahlberg K
- Dalesio O
- Davidson NE
- Davies C
- Davies C
- Davis HL
- de la Huerta R
- de La Lande B
- de Lafontan B
- De Laurentiis M
- de Oliveira CF
- de Pablo JL
- De Placido S
- De Salvo GL
- de Schryver A
- de Vries EGE
- Del Bianco P
- Delaloge S
- Delaloge S
- Delmestri A
- Delozier T
- Dent DM
- Deshpande N
- Deulofeu P
- Deutsch GP
- Di Leo A
- di Martino L
- Di Mauro MG
- Dixon JM
- Dodwell D
- Dodwell D
- Dolci S
- Douglas P
- Duane F
- Dubois JB
- Dufmats M
- Dunn J
- Durand M
- Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
- EBCTCG
- EBCTCG
- Eidtmann H
- Eierman W
- Ejlertsen B
- Ejlertsen B
- Ellis IO
- Ellis IO
- Ellis P
- Enomoto K
- Erazo A
- Evans V
- Ewertz M
- Ewing GH
- Fabregas R
- Fargeot P
- Fehm T
- Fentiman IS
- Fentiman IS
- Fernando I
- Fesl C
- Firth LA
- Fitzal F
- Focan C
- Fohler H
- Fohlin H
- Forbes J
- Forbes JF
- Forbes JF
- Formelli F
- Fornander T
- Forrest P
- Forsyth S
- Forsyth S
- Foster L
- Fountzilas G
- Fraile M
- Francis PA
- Fredriksson I
- Frisell J
- Fumoleau P
- Fyles A
- Gallen M
- Galligioni E
- Garaud P
- Garmo H
- Gazet JC
- Gelbe RD
- Gelman RS
- Gelmon K
- George WD
- George WS
- Gerber B
- Gervasio H
- Gettins L
- Gianni L
- Giokas G
- Gluz O
- Gnant M
- Godwin J
- Goldhirsch A
- Goldhirsch A
- Goldstein LJ
- Goransson E
- Gordilho J
- Gordon NH
- Goss PE
- Gralow J
- Gray R
- Gray R
- Gray R
- Greil R
- Griffon B
- Gubern JM
- Gudgeon CA
- Hacking A
- Hacking A
- Hackshaw A
- Hadji P
- Hakes T
- Hall E
- Harbeck N
- Harbeck N
- Harris JR
- Harvey VJ
- Hayat H
- Haybittle JL
- Hayes D
- Hayes D
- Hayes D
- Hayward JL
- Henderson C
- Hercbergs A
- Hilfrich J
- Hill C
- Hinsley S
- Holdaway IM
- Holli K
- Holmberg L
- Horiguchi J
- Horsman JM
- Hortobagyi G
- Host H
- Houghton J
- Howell A
- Hozumi J
- Hsu L
- Hudis CA
- Huovinen R
- Hupperets PSGJ
- Iiristo M
- Ikeda T
- Inbar MJ
- Inokuchi K
- Iwata H
- Jack W
- Jackisch C
- Jakesz R
- James S
- Janauer M
- Janer J
- Janni W
- Jensen M-B
- Jensen MB
- Joensuu H
- Johansson U
- Jonat W
- Jones SE
- Julien JP
- Jung KH
- Jänicke F
- Karlsson P
- Karpov A
- Kaufmann M
- Kaufmann M
- Kay RG
- Kerbrat P
- Kerr A
- Kikuchi K
- Kikuchi K
- Kilburn L
- Killander F
- Klefstrom P
- Klijn JGM
- Kohno N
- Koliou G-A
- Kondylis D
- Kooi M
- Korzeniowski S
- Koscienly S
- Koyama H
- Kreienberg R
- Krushen-Kosloski JL
- Kunkler I
- Kwong DLW
- Larsimont D
- Ledermann J
- Lee M
- Lehingue Y
- Lemonnier J
- Lenner E
- Leonard CF
- Leone B
- Lesec'h JM
- Lester J
- Levine MN
- Liedtke C
- Liefers GJ
- Linderholm BK
- Lindman H
- Lindsay MA
- Lindtner A
- Lindtner J
- Lissaios B
- Litton A
- Liu H
- Livingston R
- Llombart HA
- Lofgren L
- Lohrisch C
- Loib S
- Lopez M
- Love RR
- Lumachi F
- Luporsi E
- Mackey J
- MacKinnon E
- Maibach R
- Mallon E
- Malmstrom P
- Mannu G
- Manousou K
- Mansel RE
- Margreiter R
- Markopoulos C
- Marshall HC
- Martelli G
- Marth C
- Martin AL
- Martin M
- Martin M
- Martin M
- Martin P
- Martino S
- Martoni A
- Marty M
- Mason BH
- Masood MB
- Masuda H
- Mauriac L
- Mavroudis D
- McArdle CS
- McGale P
- McHugh T
- Meakin JW
- Medina JY
- Meier P
- Meisner C
- Michiels S
- Mihura J
- Miyashita M
- Mlineritsch B
- Moebus V
- Monson K
- Monypenny IJ
- Moral A
- Morgan DAL
- Morris P
- Mouret-Fourme E
- Mouridsen H
- Mouridsen HT
- Murray E
- Murray N
- Musolino A
- Muss H
- Mustacchi G
- Namer M
- Neven P
- Nichol A
- Nicolucci A
- Nikolaidis P
- Nissen-Meyer R
- Nitz U
- Nogaret JM
- Nomura Y
- Nordenskjold B
- Norton L
- Norton L
- Notter G
- Oates GD
- Ogawa M
- Ohashi Y
- Osborne CK
- Owen JR
- Pai VR
- Pan HC
- Panieri E
- Pannuti F
- Panzarella T
- Paridaens R
- Parker D
- Parulekar W
- Passalacqua R
- Pater JL
- Paterson AHG
- Patnick J
- Peek U
- Pellegrini F
- Penalva G
- Perbeck L
- Peretz T
- Perrone F
- Peto R
- Peto R
- Petruzelka L
- Pfeiler G
- Philippson C
- Piccart MJ
- Pierce LJ
- Pinder S
- Pinder SE
- Pirozzoli MC
- Poole C
- Poortmans PM
- Portnoj SL
- Possinger K
- Powell J
- Pribylova O
- Price JJ
- Price KN
- Pritchard KI
- Pritchard KI
- Pritchard KI
- Puig P
- Ramos M
- Rauschecker H
- Ravdin PM
- Rea D
- Rea D
- Read S
- Regan MM
- Reid M
- Robert N
- Robinson E
- Roche H
- Rodenhuis S
- Rojo R
- Romain S
- Romestaing P
- Rossbach J
- Rotmensz N
- Rotstein S
- Rouhento K
- Royle GT
- Rubagotti A
- Rubens RD
- Rubino C
- Rudenstam CM
- Rutgers E
- Ryden L
- Saarto T
- Sacco M
- Sadoon M
- Safra T
- Sainz MG
- Sakai K
- Salmon RJ
- Sandelin K
- Santesteban P
- Sauer R
- Sauerbrei W
- Sawa K
- Sayer J
- Schauer A
- Schem C
- Scheurlen H
- Schmid P
- Schmitt M
- Schumacher M
- Schumacher M
- Segui MA
- Seifert M
- Senanayake F
- Senn HJ
- Senn HJ
- Serra C
- Sestak I
- Sestak I
- Sevelda P
- Shan Y
- Shao YF
- Shapiro CL
- Shepherd LE
- Shien T
- Simmonds PD
- Singer CF
- Skilton D
- Skolyszewski J
- Skoog L
- Sledge G
- Smith DC
- Soderberg M
- Sohn HC
- Sola M
- Solarnau L
- Solin LJ
- Solomayer E
- Solsona J
- Sonoo H
- Sparano JA
- Spittle M
- Spooner D
- Stallard S
- Steger GG
- Stewart HJ
- Stoeger H
- Stroner P
- Sugimachi K
- Sundqvist M
- Svane G
- Swindell R
- Takao S
- Takei H
- Taylor C
- Thomssen C
- Thuerlimann B
- Thurlimann B
- Tinterri C
- Tobias JS
- Toi M
- Tominaga T
- Tormey DC
- Trampisch HJ
- Treurniet-Donker AD
- Trialists GROCTA
- Tu D
- Tulusan AH
- Uchino J
- Untch M
- Untch M
- Vakaet L
- Valagussa P
- Valagussa P
- Valentini M
- Vallejo CT
- van de Velde AO
- van de Velde CJH
- van de Velde CJH
- van de Velde CJH
- Van den Bogaert W
- van Dongen JA
- van Putten WLJ
- van Tinteren H
- Veloso E
- Vermorken JB
- Veronesi U
- Viale G
- Vidal S
- Vilcoq JR
- von Minckwitz G
- Wadstrom C
- Wallgren A
- Wallwiener D
- Wang X
- Wang Y
- Wang Z
- Warnberg F
- Weiss RB
- Werner ID
- Whelan T
- Wilcken N
- Williams L
- Winer E
- Winter MC
- Wittes R
- Wood W
- Yamashita J
- Yarnold JR
- Yosef HMA
- Yoshida M
- Yoshimoto M
- Zavagno G
- Zhao DB
- Zielinski CC
- Zwenger A
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background
Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of tumour characteristics on outcome with a collaborative meta-analysis of individual patient data from relevant randomised trials.
Methods
We obtained information about prerandomisation tumour characteristics, clinical tumour response, surgery, recurrence, and mortality for 4756 women in ten randomised trials in early breast cancer that began before 2005 and compared NACT with the same chemotherapy given postoperatively. Primary outcomes were tumour response, extent of local therapy, local and distant recurrence, breast cancer death, and overall mortality. Analyses by intention-to-treat used standard regression (for response and frequency of breast-conserving therapy) and log-rank methods (for recurrence and mortality).
Findings
Patients entered the trials from 1983 to 2002 and median follow-up was 9 years (IQR 5–14), with the last follow-up in 2013. Most chemotherapy was anthracycline based (3838 [81%] of 4756 women). More than two thirds (1349 [69%] of 1947) of women allocated NACT had a complete or partial clinical response. Patients allocated NACT had an increased frequency of breast-conserving therapy (1504 [65%] of 2320 treated with NACT vs 1135 [49%] of 2318 treated with adjuvant chemotherapy). NACT was associated with more frequent local recurrence than was adjuvant chemotherapy: the 15 year local recurrence was 21·4% for NACT versus 15·9% for adjuvant chemotherapy (5·5% increase [95% CI 2·4–8·6]; rate ratio 1·37 [95% CI 1·17–1·61]; p=0·0001). No significant difference between NACT and adjuvant chemotherapy was noted for distant recurrence (15 year risk 38·2% for NACT vs 38·0% for adjuvant chemotherapy; rate ratio 1·02 [95% CI 0·92–1·14]; p=0·66), breast cancer mortality (34·4% vs 33·7%; 1·06 [0·95–1·18]; p=0·31), or death from any cause (40·9% vs 41·2%; 1·04 [0·94–1·15]; p=0·45).
Interpretation
Tumours downsized by NACT might have higher local recurrence after breast-conserving therapy than might tumours of the same dimensions in women who have not received NACT. Strategies to mitigate the increased local recurrence after breast-conserving therapy in tumours downsized by NACT should be considered—eg, careful tumour localisation, detailed pathological assessment, and appropriate radiotherapy
Value of Biochemical Markers in the Management of Disseminated Prostatic Cancer
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- 'S. Karger AG'
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A Case Study Looking at the Effectiveness of Deep Dry Needling for the Management of Hypertonia
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- 'The Haworth Press'
- Publication date
- Field of study
- …