Energy dependence of ϕ meson production at forward rapidity in pp collisions at the LHC

The production of $\phi$ mesons has been studied in pp collisions at LHC energies with the ALICE detector via the dimuon decay channel in the rapidity region $2.5< y < 4$. Measurements of the differential cross section $\mathrm{d}^2\sigma /\mathrm{d}y \mathrm{d}p_{\mathrm {T}}$ are presented as a function of the transverse momentum ($p_{\mathrm {T}}$) at the center-of-mass energies $\sqrt{s}=5.02$, 8 and 13 TeV and compared with the ALICE results at midrapidity. The differential cross sections at $\sqrt{s}=5.02$ and 13 TeV are also studied in several rapidity intervals as a function of $p_{\mathrm {T}}$, and as a function of rapidity in three $p_{\mathrm {T}}$ intervals. A hardening of the $p_{\mathrm {T}}$-differential cross section with the collision energy is observed, while, for a given energy, $p_{\mathrm {T}}$ spectra soften with increasing rapidity and, conversely, rapidity distributions get slightly narrower at increasing $p_{\mathrm {T}}$. The new results, complementing the published measurements at $\sqrt{s}=2.76$ and 7 TeV, allow one to establish the energy dependence of $\phi$ meson production and to compare the measured cross sections with phenomenological models. None of the considered models manages to describe the evolution of the cross section with $p_{\mathrm {T}}$ and rapidity at all the energies.publishedVersio

Thieno[3,2‑<i>b</i>]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration

Lysine specific demethylase 1 KDM1A (LSD1) regulates histone methylation and it is increasingly recognized as a potential therapeutic target in oncology. We report on a high-throughput screening campaign performed on KDM1A/CoREST, using a time-resolved fluorescence resonance energy transfer (TR-FRET) technology, to identify reversible inhibitors. The screening led to 115 hits for which we determined biochemical IC₅₀, thus identifying four chemical series. After data analysis, we have prioritized the chemical series of <i>N</i>-phenyl-4<i>H</i>-thieno­[3, 2-<i>b</i>]­pyrrole-5-carboxamide for which we obtained X-ray structures of the most potent hit (compound <b>19</b>, IC₅₀ = 2.9 μM) in complex with the enzyme. Initial expansion of this chemical class, both modifying core structure and decorating benzamide moiety, was directed toward the definition of the moieties responsible for the interaction with the enzyme. Preliminary optimization led to compound <b>90</b>, which inhibited the enzyme with a submicromolar IC₅₀ (0.162 μM), capable of inhibiting the target in cells

Thieno[3,2‑<i>b</i>]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure–Activity Relationship

The balance of methylation levels at histone H3 lysine 4 (H3K4) is regulated by KDM1A (LSD1). KDM1A is overexpressed in several tumor types, thus representing an emerging target for the development of novel cancer therapeutics. We have previously described (Part 1, DOI 10.1021.acs.jmedchem.6b01018) the identification of thieno­[3,2-<i>b</i>]­pyrrole-5-carboxamides as novel reversible inhibitors of KDM1A, whose preliminary exploration resulted in compound <b>2</b> with biochemical IC₅₀ = 160 nM. We now report the structure-guided optimization of this chemical series based on multiple ligand/KDM1A-CoRest cocrystal structures, which led to several extremely potent inhibitors. In particular, compounds <b>46</b>, <b>49</b>, and <b>50</b> showed single-digit nanomolar IC₅₀ values for in vitro inhibition of KDM1A, with high selectivity in secondary assays. In THP-1 cells, these compounds transcriptionally affected the expression of genes regulated by KDM1A such as CD14, CD11b, and CD86. Moreover, <b>49</b> and <b>50</b> showed a remarkable anticlonogenic cell growth effect on MLL-AF9 human leukemia cells

The ecological transition of the extreme energy events experiment

The need for reducing the emission of gases, potentially contributing to the greenhouse effect and climate change, has impacted many fields, including scientific research. The Extreme Energy Event (EEE) collaboration started, already several years ago, a series of tests aiming at finding a more eco-friendly replacement for the gases used in the Multigap Resistive Plate Chambers (MRPCs) of its network. These tests identified a promising binary gas mixture, and data taking has begun with a subset of the telescopes of the EEE network, making EEE the first experiment in the world completely implemented with MRPCs and operating with an eco-friendly gas mixture. Here the results of the tests and a preliminary comparison of the telescope performance measured with the standard (non eco-friendly) and the new eco-friendly gas mixtures are presented and discussed

Study of very forward energy and its correlation with particle production at midrapidity in pp and p-Pb collisions at the LHC

Abstract The energy deposited at very forward rapidities (very forward energy) is a powerful tool for characterising proton fragmentation in pp and p-Pb collisions. The correlation of very forward energy with particle production at midrapidity provides direct insights into the initial stages and the subsequent evolution of the collision. Furthermore, the correlation with the production of particles with large transverse momenta at midrapidity provides information complementary to the measurements of the underlying event, which are usually interpreted in the framework of models implementing centrality-dependent multiple parton interactions.Results about very forward energy, measured by the ALICE zero degree calorimeters (ZDCs), and its dependence on the activity measured at midrapidity in pp collisions at $$\sqrt{s}$$ s = 13 TeV and in p-Pb collisions at $$\sqrt{s_{\mathrm{NN}}}$$ s NN = 8.16 TeV are discussed. The measurements performed in pp collisions are compared with the expectations of three hadronic interaction event generators: PYTHIA 6 (Perugia 2011 tune), PYTHIA 8 (Monash tune), and EPOS LHC. These results provide new constraints on the validity of models in describing the beam remnants at very forward rapidities, where perturbative QCD cannot be used.</jats:p

( )Measurement of Prompt D-0, Lambda(+)(c), and Sigma(0,++)(c) (2455) Production in Proton-Proton Collisions at root s=13 TeV

none1021siThe p(T)-differential production cross sections of prompt D-0, Lambda(c)+, and Sigma(0,++)(c) (2455) charmed hadrons are measured at midrapidity (vertical bar y vertical bar < 0.5) in pp collisions at root s. = 13 TeV. This is the first measurement of Sigma(0,++)(c) production in hadronic collisions. Assuming the same production yield for the three Sigma(0,++)(c) isospin states, the baryon-to-meson cross section ratios Sigma(0,+,++)(c)/D-0 and Lambda(+)(c)/D-0 are calculated in the transverse momentum (p(T)) intervals 2 < p(T) < 12 and 1 < p(T) < 24 GeV/c. Values significantly larger than in e(+)e(-) collisions are observed, indicating for the first time that baryon enhancement in hadronic collisions also extends to the Sigma(c). The feed-down contribution to Lambda(+)(c) production from Sigma(0,+,++)(c) is also reported and is found to be larger than in e(+)e(-) collisions. The data are compared with predictions from event generators and other phenomenological models, providing a sensitive test of the different charm-hadronization mechanisms implemented in the models.noneAcharya, S.; Adamova, D.; Adler, A.; Adolfsson, J.; Rinella, G. Aglieri; Agnello, M.; Agrawal, N.; Ahammed, Z.; Ahmad, S.; Ahn, S. U.; Ahuja, I; Akbar, Z.; Akindinov, A.; Al-Turany, M.; Alam, S. N.; Aleksandrov, D.; Alessandro, B.; Alfanda, H. M.; Alfaro Molina, R.; Ali, B.; Ali, Y.; Alici, A.; Alizadehvandchali, N.; Alkin, A.; Alme, J.; Alt, T.; Altenkamper, L.; Altsybeev, I; Anaam, M. N.; Andrei, C.; Andreou, D.; Andronic, A.; Angeletti, M.; Anguelov, V; Antinori, F.; Antonioli, P.; Anuj, C.; Apadula, N.; Aphecetche, L.; Appelshaeuser, H.; Arcelli, S.; Arnaldi, R.; Arsene, I. C.; Arslandok, M.; Augustinus, A.; Averbeck, R.; Aziz, S.; Azmi, M. D.; Badala, A.; Baek, Y. W.; Bai, X.; Bailhache, R.; Bailung, Y.; Bala, R.; Balbino, A.; Baldisseri, A.; Balis, B.; Ball, M.; Banerjee, D.; Barbera, R.; Barioglio, L.; Barlou, M.; Barnafoldi, G. G.; Barnby, L. S.; Barret, V; Bartels, C.; Barth, K.; Bartsch, E.; Baruffaldi, F.; Bastid, N.; Basu, S.; Batigne, G.; Batyunya, B.; Bauri, D.; Alba, J. L. Bazo; Bearden, I. G.; Beattie, C.; Belikov, I; Hechavarria, A. D. C. Bell; Bellini, F.; Bellwied, R.; Belokurova, S.; Belyaev, V; Bencedi, G.; Beole, S.; Bercuci, A.; Berdnikov, Y.; Berdnikova, A.; Bergmann, L.; Besoiu, M. G.; Betev, L.; Bhaduri, P. P.; Bhasin, A.; Bhat, M. A.; Bhattacharjee, B.; Bhattacharya, P.; Bianchi, L.; Bianchi, N.; Biernat, J.; Bilandzic, A.; Biro, G.; Biswas, S.; Blair, J. T.; Blau, D.; Blidaru, M. B.; Blume, C.; Boca, G.; Bock, F.; Bogdanov, A.; Boi, S.; Bok, J.; Boldizsar, L.; Bolozdynya, A.; Bombara, M.; Bond, P. M.; Bonomi, G.; Borel, H.; Borissov, A.; Bossi, H.; Botta, E.; Bratrud, L.; Braun-Munzinger, P.; Bregant, M.; Broz, M.; Bruno, G. E.; Buckland, M. D.; Budnikov, D.; Buesching, H.; Bufalino, S.; Bugnon, O.; Buhler, P.; Buthelezi, Z.; Butt, J. B.; Bysiak, S. A.; Caffarri, D.; Cai, M.; Caines, H.; Caliva, A.; Calvo Villar, E.; Camacho, J. M. M.; Camacho, R. S.; Camerini, P.; Canedo, F. D. M.; Carnesecchi, F.; Caron, R.; Castellanos, J. Castillo; Casula, E. A. R.; Catalano, F.; Sanchez, C. Ceballos; Chakraborty, P.; Chandra, S.; Chapeland, S.; Chartier, M.; Chattopadhyay, S.; Chattopadhyay, S.; Chauvin, A.; Chavez, T. G.; Cheshkov, C.; Cheynis, B.; Barroso, V. Chibante; Chinellato, D. D.; Cho, S.; Chochula, P.; Christakoglou, P.; Christensen, C. H.; Christiansen, P.; Chujo, T.; Cicalo, C.; Cifarelli, L.; Cindolo, F.; Ciupek, M. R.; Clai, G.; Cleymans, J.; Colamaria, F.; Colburn, J. S.; Colella, D.; Collu, A.; Colocci, M.; Concas, M.; Balbastre, G. Conesa; del Valle, Z. Conesa; Contin, G.; Contreras, J. G.; Coquet, M. L.; Cormier, T. M.; Cortese, P.; Cosentino, M. R.; Costa, F.; Costanza, S.; Crochet, P.; Cuautle, E.; Cui, P.; Cunqueiro, L.; Dainese, A.; Damas, F. P. A.; Danisch, M. C.; Danu, A.; Das, I; Das, P.; Das, P.; Das, S.; Dash, S.; De, S.; De Caro, A.; de Cataldo, G.; De Cilladi, L.; de Cuveland, J.; De Falco, A.; De Gruttola, D.; De Marco, N.; De Martin, C.; De Pasquale, S.; Deb, S.; Degenhardt, H. F.; Deja, K. R.; Dello Stritto, L.; Delsanto, S.; Deng, W.; Dhankher, P.; Di Bari, D.; Di Mauro, A.; Diaz, R. A.; Dietel, T.; Ding, Y.; Divia, R.; Djuvsland, O.; Dixit, D. U.; Dmitrieva, U.; Do, J.; Dobrin, A.; Doenigus, B.; Dordic, O.; Dubey, A. K.; Dubla, A.; Dudi, S.; Dukhishyam, M.; Dupieux, P.; Dzalaiova, N.; Eder, T. M.; Ehlers, R. J.; Eikeland, V. N.; Eisenhut, F.; Elia, D.; Erazmus, B.; Ercolessi, F.; Erhardt, F.; Erokhin, A.; Ersdal, M. R.; Espagnon, B.; Eulisse, G.; Evans, D.; Evdokimov, S.; Fabbietti, L.; Faggin, M.; Faivre, J.; Fan, F.; Fantoni, A.; Fasel, M.; Fecchio, P.; Feliciello, A.; Feofilov, G.; Fernandez Tellez, A.; Ferrero, A.; Ferretti, A.; Feuillard, V. J. G.; Figiel, J.; Filchagin, S.; Finogeev, D.; Fionda, F. M.; Fiorenza, G.; Flor, F.; Flores, A. N.; Foertsch, S.; Foka, P.; Fokin, S.; Fragiacomo, E.; Frajna, E.; Fuchs, U.; Funicello, N.; Furget, C.; Furs, A.; Gaardhoje, J. J.; Gagliardi, M.; Gago, A. M.; Gal, A.; Galvan, C. D.; Ganoti, P.; Garabatos, C.; Garcia, J. R. A.; Garcia-Solis, E.; Garg, K.; Gargiulo, C.; Garibli, A.; Garner, K.; Gasik, P.; Gauger, E. F.; Gautam, A.; Ducati, M. B. Gay; Germain, M.; Ghosh, P.; Ghosh, S. K.; Giacalone, M.; Gianotti, P.; Giubellino, P.; Giubilato, P.; Glaenzer, A. M. C.; Glassel, P.; Goh, D. J. Q.; Gonzalez, V; Gonzalez-Trueba, L. H.; Gorbunov, S.; Gorgon, M.; Gorlich, L.; Gotovac, S.; Grabski, V; Graczykowski, L. K.; Greiner, L.; Grelli, A.; Grigoras, C.; Grigoriev, V; Grigoryan, A.; Grigoryan, S.; Groettvik, O. S.; Grosa, F.; Grosse-Oetringhaus, J. F.; Grosso, R.; Guardiano, G. G.; Guernane, R.; Guilbaud, M.; Gulbrandsen, K.; Gunji, T.; Gupta, A.; Gupta, R.; Guzman, S. P.; Gyulai, L.; Habib, M. K.; Hadjidakis, C.; Halimoglu, G.; Hamagaki, H.; Hamar, G.; Hamid, M.; Hannigan, R.; Haque, M. R.; Harlenderova, A.; Harris, J. W.; Harton, A.; Hasenbichler, J. A.; Hassan, H.; Hatzifotiadou, D.; Hauer, P.; Havener, L. B.; Hayashi, S.; Heckel, S. T.; Hellbar, E.; Helstrup, H.; Herman, T.; Hernandez, E. G.; Herrera Corral, G.; Herrmann, F.; Hetland, K. F.; Hillemanns, H.; Hills, C.; Hippolyte, B.; Hofman, B.; Hohlweger, B.; Honermann, J.; Hong, G. H.; Horak, D.; Hornung, S.; Horzyk, A.; Hosokawa, R.; Hristov, P.; Hughes, C.; Huhn, P.; Humanic, T. J.; Hushnud, H.; Husova, L. A.; Hutson, A.; Hutter, D.; Iddon, J. P.; Ilkaev, R.; Ilyas, H.; Inaba, M.; Innocenti, G. M.; Ippolitov, M.; Isakov, A.; Islam, M. S.; Ivanov, M.; Ivanov, V; Izucheev, V; Jablonski, M.; Jacak, B.; Jacazio, N.; Jacobs, P. M.; Jadlovska, S.; Jadlovsky, J.; Jaelani, S.; Jahnke, C.; Jakubowska, M. J.; Jalotra, A.; Janik, M. A.; Janson, T.; Jercic, M.; Jevons, O.; Jonas, F.; Jones, P. G.; Jowett, J. M.; Jung, J.; Jung, M.; Junique, A.; Jusko, A.; Kaewjai, J.; Kalinak, P.; Kalweit, A.; Kaplin, V; Kar, S.; Uysal, A. Karasu; Karatovic, D.; Karavichev, O.; Karavicheva, T.; Karczmarczyk, P.; Karpechev, E.; Kazantsev, A.; Kebschull, U.; Keidel, R.; Keijdener, D. L. D.; Keil, M.; Ketzer, B.; Khabanova, Z.; Khan, A. M.; Khan, S.; Khanzadeev, A.; Kharlov, Y.; Khatun, A.; Khuntia, A.; Kileng, B.; Kim, B.; Kim, C.; Kim, D.; Kim, D. J.; Kim, E. J.; Kim, J.; Kim, J. S.; Kim, J.; Kim, J.; Kim, J.; Kim, M.; Kim, S.; Kim, T.; Kirsch, S.; Kisel, I; Kiselev, S.; Kisiel, A.; Kitowski, J. P.; Klay, J. L.; Klein, J.; Klein, S.; Klein-Boesing, C.; Kleiner, M.; Klemenz, T.; Kluge, A.; Knospe, A. G.; Kobdaj, C.; Koehler, M. K.; Kollegger, T.; Kondratyev, A.; Kondratyeva, N.; Kondratyuk, E.; Konig, J.; Konigstorfer, S. A.; Konopka, P. J.; Kornakov, G.; Koryciak, S. D.; Koska, L.; Kotliarov, A.; Kovalenko, O.; Kovalenko, V; Kowalski, M.; Kralik, I; Kreis, L.; Krivda, M.; Krizek, F.; Gajdosova, K. Krizkova; Kroesen, M.; Kruger, M.; Kryshen, E.; Krzewicki, M.; Kuhn, C.; Kuijer, P. G.; Kumaoka, T.; Kumar, D.; Kumar, L.; Kumar, N.; Kundu, S.; Kurashvili, P.; Kurepin, A.; Kurepin, A. B.; Kuryakin, A.; Kushpil, S.; Kvapil, J.; Kweon, M. J.; Kwon, J. Y.; Kwon, Y.; La Pointe, S. L.; La Rocca, P.; Lai, Y. S.; Lakrathok, A.; Lamanna, M.; Langoy, R.; Lapidus, K.; Larionov, P.; Laudi, E.; Lautner, L.; Lavicka, R.; Lazareva, T.; Lea, R.; Lehrbach, J.; Lemmon, R. C.; Leon Monzon, I; Lesser, E. D.; Lettrich, M.; Levai, P.; Li, X.; Li, X. L.; Lien, J.; Lietava, R.; Lim, B.; Lim, S. H.; Lindenstruth, V; Lindner, A.; Lippmann, C.; Liu, A.; Liu, J.; Lofnes, I. M.; Loginov, V; Loizides, C.; Loncar, P.; Lopez, J. A.; Lopez, X.; Lopez Torres, E.; Luhder, J. R.; Lunardon, M.; Luparello, G.; Ma, Y. G.; Maevskaya, A.; Mager, M.; Mahmoud, T.; Maire, A.; Malaev, M.; Malik, N. M.; Malik, Q. W.; Malinina, L.; Mal'Kevich, D.; Mallick, N.; Malzacher, P.; Mandaglio, G.; Manko, V; Manso, F.; Manzari, V; Mao, Y.; Mares, J.; Margagliotti, G., V; Margotti, A.; Marin, A.; Markert, C.; Marquard, M.; Martin, N. A.; Martinengo, P.; Martinez, J. L.; Martinez, M., I; Garcia, G. Martinez; Masciocchi, S.; Masera, M.; Masoni, A.; Massacrier, L.; Mastroserio, A.; Mathis, A. M.; Matonoha, O.; Matuoka, P. F. T.; Matyja, A.; Mayer, C.; Mazuecos, A. L.; Mazzaschi, F.; Mazzilli, M.; Mazzoni, M. A.; Mdhluli, J. E.; Mechler, A. F.; Meddi, F.; Melikyan, Y.; Menchaca-Rocha, A.; Meninno, E.; Menon, A. S.; Meres, M.; Mhlanga, S.; Miake, Y.; Micheletti, L.; Migliorin, L. C.; Mihaylov, D. L.; Mikhaylov, K.; Mishra, A. N.; Modak, A.; Mohanty, A. P.; Mohanty, B.; Khan, M. Mohisin; Moravcova, Z.; Mordasini, C.; De Godoy, D. A. Moreira; Moreno, L. A. P.; Morozov, I; Morsch, A.; Mrnjavac, T.; Muccifora, V; Mudnic, E.; Muehlheim, D.; Muhuri, S.; Mulligan, J. D.; Mulliri, A.; Munhoz, M. G.; Munzer, R. H.; Murakami, H.; Murray, S.; Musa, L.; Musinsky, J.; Myrcha, J. W.; Naik, B.; Nair, R.; Nandi, B. K.; Nania, R.; Nappi, E.; Naru, M. U.; Nassirpour, A. F.; Nath, A.; Nattrass, C.; Neagu, A.; Nellen, L.; Nesbo, S., V; Neskovic, G.; Nesterov, D.; Nielsen, B. S.; Nikolaev, S.; Nikulin, S.; Nikulin, V; Noferini, F.; Noh, S.; Nomokonov, P.; Norman, J.; Novitzky, N.; Nowakowski, P.; Nyanin, A.; Nystrand, J.; Ogino, M.; Ohlson, A.; Okorokov, V. A.; Oleniacz, J.; Da Silva, A. C. Oliveira; Oliver, M. H.; Onnerstad, A.; Oppedisano, C.; Ortiz Velasquez, A.; Osako, T.; Oskarsson, A.; Otwinowski, J.; Oyama, K.; Pachmayer, Y.; Padhan, S.; Pagano, D.; Palasciano, A.; Pan, J.; Panebianco, S.; Pareek, P.; Park, J.; Parkkila, J. E.; Pathak, S. P.; Patra, R. N.; Paul, B.; Pazzini, J.; Pei, H.; Peitzmann, T.; Peng, X.; Pereira, L. G.; Da Costa, H. Pereira; Peresunko, D.; Perez, G. M.; Perrin, S.; Pestov, Y.; Petrovici, M.; Pezzi, R. P.; Piano, S.; Pikna, M.; Pillot, P.; Pinazza, O.; Pinsky, L.; Pinto, C.; Pisano, S.; Planinic, M.; Pliquett, F.; Poghosyan, M. G.; Polichtchouk, B.; Politano, S.; Poljak, N.; Pop, A.; Porteboeuf-Houssais, S.; Porter, J.; Pozdniakov, V; Prasad, S. K.; Preghenella, R.; Prino, F.; Pruneau, C. A.; Pshenichnov, I; Puccio, M.; Qiu, S.; Quaglia, L.; Quishpe, R. E.; Ragoni, S.; Rakotozafindrabe, A.; Ramello, L.; Rami, F.; Ramirez, S. A. R.; Ramos, A. G. T.; Rancien, T. A.; Raniwala, R.; Raniwala, S.; Rasanen, S. S.; Rath, R.; Ravasenga, I; Read, K. F.; Redelbach, A. R.; Redlich, K.; Rehman, A.; Reichelt, P.; Reidt, F.; Reme-ness, H. A.; Renfordt, R.; Rescakova, Z.; Reygers, K.; Riabov, A.; Riabov, V; Richert, T.; Richter, M.; Riegler, W.; Riggi, F.; Ristea, C.; Rode, S. P.; Cahuantzi, M. Rodriguez; Roed, K.; Rogalev, R.; Rogochaya, E.; Rogoschinski, T. S.; Rohr, D.; Rohrich, D.; Rojas, P. F.; Rokita, P. S.; Ronchetti, F.; Rosano, A.; Rosas, E. D.; Rossi, A.; Rotondi, A.; Roy, A.; Roy, P.; Roy, S.; Rubini, N.; Rueda, O., V; Rui, R.; Rumyantsev, B.; Russek, P. G.; Rustamov, A.; Ryabinkin, E.; Ryabov, Y.; Rybicki, A.; Rytkonen, H.; Rzesa, W.; Saarimaki, O. A. M.; Sadek, R.; Sadovsky, S.; Saetre, J.; Saha, S. K.; Saha, S.; Sahoo, B.; Sahoo, P.; Sahoo, R.; Sahoo, S.; Sahu, D.; Sahu, P. K.; Saini, J.; Sakai, S.; Sambyal, S.; Samsonov, V; Sarkar, D.; Sarkar, N.; Sarma, P.; Sarti, V. M.; Sas, M. H. P.; Schambach, J.; Scheid, H. S.; Schiaua, C.; Schicker, R.; Schmah, A.; Schmidt, C.; Schmidt, H. R.; Schmidt, M. O.; Schmidt, M.; Schmidt, N., V; Schmier, A. R.; Schotter, R.; Schukraft, J.; Schutz, Y.; Schwarz, K.; Schweda, K.; Scioli, G.; Scomparin, E.; Seger, J. E.; Sekiguchi, Y.; Sekihata, D.; Selyuzhenkov, I; Senyukov, S.; Seo, J. J.; Serebryakov, D.; Sevcenco, A.; Shaba, T. J.; Shabanov, A.; Shabetai, A.; Shahoyan, R.; Shaikh, W.; Shangaraev, A.; Sharma, A.; Sharma, H.; Sharma, M.; Sharma, N.; Sharma, S.; Sharma, U.; Sheibani, O.; Shigaki, K.; Shimomura, M.; Shirinkin, S.; Shou, Q.; Sibiriak, Y.; Siddhanta, S.; Siemiarczuk, T.; Silva, T. F.; Silvermyr, D.; Simonetti, G.; Singh, B.; Singh, R.; Singh, R.; Singh, R.; Singh, V. K.; Singhal, V; Sinha, T.; Sitar, B.; Sitta, M.; Skaali, T. B.; Skorodumovs, G.; Slupecki, M.; Smirnov, N.; Snellings, R. J. M.; Soncco, C.; Song, J.; Songmoolnak, A.; Soramel, F.; Sorensen, S.; Sputowska, I; Stachel, J.; Stan, I; Steffanic, P. J.; Stiefelmaier, S. F.; Stocco, D.; Storehaug, I; Storetvedt, M. M.; Stylianidis, C. P.; Suaide, A. A. P.; Sugitate, T.; Suire, C.; Suljic, M.; Sultanov, R.; Sumbera, M.; Sumberia, V; Sumowidagdo, S.; Swain, S.; Szabo, A.; Szarka, I; Tabassam, U.; Taghavi, S. F.; Taillepied, G.; Takahashi, J.; Tambave, G. J.; Tang, S.; Tang, Z.; Tarhini, M.; Tarzila, M. 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Nuclear modification factor of light neutral-meson spectra up to high transverse momentum in p–Pb collisions at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.svg"><mml:msqrt><mml:mrow><mml:msub><mml:mrow><mml:mi>s</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="normal">NN</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:msqrt><mml:mo linebreak="goodbreak" linebreakstyle="after">=</mml:mo><mml:mn>8.16</mml:mn></mml:math> TeV

Neutral pion (π0) and η meson production cross sections were measured up to unprecedentedly high transverse momenta (pT) in p–Pb collisions at √sNN = 8.16 TeV. The mesons were reconstructed via their two-photon decay channel in the rapidity interval −1.3 10 GeV/c, leaving essentially no room for final state energy loss. The new data provide strong constraints for nuclear parton distribution and fragmentation functions over a broad kinematic range and are compared to model predictions as well as previous results at √sNN = 5.02 TeV

Pseudorapidity distributions of charged particles as a function of mid- and forward rapidity multiplicities in pp collisions at √s = 5.02, 7 and 13 TeV

The multiplicity dependence of the pseudorapidity density of charged particles in proton–proton (pp) collisions at centre-of-mass energies √s = 5.02, 7 and 13 TeV measured by ALICE is reported. The analysis relies on track segments measured in the midrapidity range (|η|<1.5). Results are presented for inelastic events having at least one charged particle produced in the pseudorapidity interval |η|<1. The multiplicity dependence of the pseudorapidity density of charged particles is measured with mid- and forward rapidity multiplicity estimators, the latter being less affected by autocorrelations. A detailed comparison with predictions from the PYTHIA 8 and EPOS LHC event generators is also presented. The results can be used to constrain models for particle production as a function of multiplicity in pp collisions