63 research outputs found
Efficient dynamic simulation of pH in processes associated to biofiltration of volatile inorganic pollutants
This work proposes a generic methodology to include the pH as a state variable in mathematical models of bioreactors. An ordinary differential equation for pH is stated and introduced into the general model structure of a biotrickling filter. All chemical equilibriums were considered and included into the model framework. A preliminary evaluation was performed by comparing results predicted by the model with experimental data obtained from the oxidation of thiosulfate by sulfide-oxidizing bacteria under alkaline conditions. The model was able to describe adequately the evolution of the main state variables including the pH for the initial complete oxidation of
thiosulfate. The methodology presented here can be easily adapted to other mathematical models dealing with biological waste treatment processes in which pH appears as a key factor.Postprint (published version
(1R,4R,5R)-1,3,4-Triphenyl-7-[(R)-1-phenylethyl]-2-oxa-3,7-diazaspiro[4.5]decan-10-one
In the title compound, C33H32N2O2, the polysubstituted piperidine ring adopts a chair conformation. The isoxazolidine ring is in an envelope conformation. In the crystal structure, intra- and intermolecular C—H⋯π interactions involving the phenyl rings are observed
Efecto de la variedad y localización en la composición química de guisante y soja destinadas a la alimentación animal
El guisante es una buena fuente de PB, especialmente las variedades cultivadas en Asturias pero siem -
pre con un menor contenido en PB y GB que la soja. En las dietas para monogástricos hay que recomendar el procesamiento de la cv Furious y las cv obtenidas en Aragón para reducir los posibles problemas causados por los inhibidores de la tripsina. En la soja, la cv Panoramix presentó el mejor
con tenido en PB en las tres localizaciones.Proyecto INPULSE, Gobierno de Aragón (grupo de investigación INPASS), personal técnico del Laboratorio de Valoración Nutritiva y Digestibilidad del CITA
Modelling adaptation strategies to climate change in Mediterranean small ruminant systems
PRIMA AdaptHerd projec
Effects of forage feeding and the inclusion of Quebracho in ewes’ diet on suckling lamb’s meat quality
Publishe
Galactic chemical abundance evolution in the solar neighborhood up to the Iron peak
We have developed a detailed standard chemical evolution model to study the
evolution of all the chemical elements up to the iron peak in the solar
vicinity. We consider that the Galaxy was formed through two episodes of
exponentially decreasing infall, out of extragalactic gas. In a first infall
episode, with a duration of 1 Gyr, the halo and the thick disk were
assembled out of primordial gas, while the thin disk formed in a second episode
of infall of slightly enriched extragalactic gas, with much longer timescale.
The model nicely reproduces the main observational constraints of the solar
neighborhood, and the calculated elemental abundances at the time of the solar
birth are in excellent agreement with the solar abundances. By the inclusion of
metallicity dependent yields for the whole range of stellar masses we follow
the evolution of 76 isotopes of all the chemical elements between hydrogen and
zinc. Those results are confronted with a large and recent body of
observational data, and we discuss in detail the implications for stellar
nucleosynthesis.Comment: 19 pages, 14 figures, submitted to A&
HumMeth27QCReport: an R package for quality control and primary analysis of Illumina Infinium methylation data
<p>Abstract</p> <p>Background</p> <p>The study of the human DNA methylome has gained particular interest in the last few years. Researchers can nowadays investigate the potential role of DNA methylation in common disorders by taking advantage of new high-throughput technologies. Among these, Illumina Infinium assays can interrogate the methylation levels of hundreds of thousands of CpG sites, offering an ideal solution for genome-wide methylation profiling. However, like for other high-throughput technologies, the main bottleneck remains at the stage of data analysis rather than data production.</p> <p>Findings</p> <p>We have developed <it>HumMeth27QCReport</it>, an R package devoted to researchers wanting to quickly analyse their Illumina Infinium methylation arrays. This package automates quality control steps by generating a report including sample-independent and sample-dependent quality plots, and performs primary analysis of raw methylation calls by computing data normalization, statistics, and sample similarities. This package is available at CRAN repository, and can be integrated in any Galaxy instance through the implementation of ad-hoc scripts accessible at Galaxy Tool Shed.</p> <p>Conclusions</p> <p>Our package provides users of the Illumina Infinium Methylation assays with a simplified, automated, open-source quality control and primary analysis of their methylation data. Moreover, to enhance its use by experimental researchers, the tool is being distributed along with the scripts necessary for its implementation in the Galaxy workbench. Finally, although it was originally developed for HumanMethylation27, we proved its compatibility with data generated with the HumanMethylation450 Bead Chip.</p
Higher D or Li: Probes of Physics beyond the Standard Model
Standard Big Bang Nucleosynthesis at the baryon density determined by the
microwave anisotropy spectrum predicts an excess of \li7 compared to
observations by a factor of 4-5. In contrast, BBN predictions for D/H are
somewhat below (but within ~2 \sigma) of the weighted mean of observationally
determined values from quasar absorption systems. Solutions to the \li7 problem
which alter the nuclear processes during or subsequent to BBN, often lead to a
significant increase in the deuterium abundance consistent with the highest
values of D/H seen in absorption systems. Furthermore, the observed D/H
abundances show considerable dispersion. Here, we argue that those systems with
D/H \simeq 4 \times 10^{-5} may be more representative of the primordial
abundance and as a consequence, those systems with lower D/H would necessarily
have been subject to local processes of deuterium destruction. This can be
accounted for by models of cosmic chemical evolution able to destroy in situ
Deuterium due to the fragility of this isotope.Comment: 22 pages, 8 figure
GeneSrF and varSelRF: a web-based tool and R package for gene selection and classification using random forest
<p>Abstract</p> <p>Background</p> <p>Microarray data are often used for patient classification and gene selection. An appropriate tool for end users and biomedical researchers should combine user friendliness with statistical rigor, including carefully avoiding selection biases and allowing analysis of multiple solutions, together with access to additional functional information of selected genes. Methodologically, such a tool would be of greater use if it incorporates state-of-the-art computational approaches and makes source code available.</p> <p>Results</p> <p>We have developed GeneSrF, a web-based tool, and varSelRF, an R package, that implement, in the context of patient classification, a validated method for selecting very small sets of genes while preserving classification accuracy. Computation is parallelized, allowing to take advantage of multicore CPUs and clusters of workstations. Output includes bootstrapped estimates of prediction error rate, and assessments of the stability of the solutions. Clickable tables link to additional information for each gene (GO terms, PubMed citations, KEGG pathways), and output can be sent to PaLS for examination of PubMed references, GO terms, KEGG and and Reactome pathways characteristic of sets of genes selected for class prediction. The full source code is available, allowing to extend the software. The web-based application is available from <url>http://genesrf2.bioinfo.cnio.es</url>. All source code is available from Bioinformatics.org or The Launchpad. The R package is also available from CRAN.</p> <p>Conclusion</p> <p>varSelRF and GeneSrF implement a validated method for gene selection including bootstrap estimates of classification error rate. They are valuable tools for applied biomedical researchers, specially for exploratory work with microarray data. Because of the underlying technology used (combination of parallelization with web-based application) they are also of methodological interest to bioinformaticians and biostatisticians.</p
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