A multiplexing architecture for mixed-signal CMOS fuzzy controllers

Limits to precision impose limits to the complexity of analog circuits, hence fuzzy analog controllers are usually oriented to fast low-power systems with low-medium complexity. This paper presents a strategy to preserve most of the advantages of an analog implementation, while allowing a marked increment in system complexity.The works in this papaer has been partially funded by the spanish C.I.C.Y.T. under contract TIC96-1392-C02-02 (SIVA

Scalar-tensor cosmological simulations

We present $N$-body cosmlogical simulations in the framework of the Newtonian limit of scalar-tensor theories of gravity. The scalar field is described by a modified Helmholtz equation with a source that is coupled to the standard Poisson equation of Newtonian gravity. The effective gravitational force is given by two contributions: the standard Newtonian potential plus a Yukawa potential stemming from massive scalar fields. In particular, we consider simulations of $\Lambda$CDM models and compute the density and velocity profiles of the most massive groups found at z=0.Comment: 6 pages, 6 figures. Recent Developments in Gravitation and Experimental Physics: 3rd Mexican Meeting of Mathematical and Experimental Physics. Edited by A. Macias, C. Laemmerzahl, and A. Camacho. (American Institute of Physics, 2008). Pag. 30

LFV in semileptonic τ\tau decays and μ−e\mu-e conversion in nuclei in SUSY-seesaw

Here we review the main results of LFV in the semileptonic tau decays $\tau \to \mu PP$ ($PP = \pi^+ \pi^-, \pi^0 \pi^0, K^+ K^-, K^0 \bar{K}^0$), $\tau \to \mu P$ ($P = \pi, \eta, \eta^{\prime}$), and $\tau \to \mu V$ ($V = \rho, \phi$) as well as in $\mu-e$ conversion in nuclei within SUSY-seesaw scenarios, and compare our predictions with the present experimental boundsComment: Talk given by M. J. Herrero in SUSY08 conference, Seou

Histiotus magellanicus (Chiroptera: Vespertilionidae) is not restricted to Subantarctic forests: first record for the Coastal Maulino Forest in central Chile

Te southern Big-Eared Brown Bat, Histiotus magellanicus, is a poorly known vespertilionid occurring only in southern Chile and Argentina, where it appears to be restricted to Valdivian Temperate Forests and Magellanic Subpolar Forests. Here we report the frst record of H. magellanicus in the Maulino Temperate Forest of central Chile, a Mediterranean-climate ecosystem, suggesting that the species might not be exclusive to subantarctic forests, as previously thought. Tis constitutes the northernmost continental record for the species, extending its range ca. 400 km the previous known northern locality.Fil: San Pedro, Annia Rodríguez. Universidad de Chile; ChileFil: Barquez, Ruben Marcos. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Programa de Investigación de Biodiversidad Argentina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Simonetti, Javier A.. Universidad de Chile; Chil

The asteroseismic ground-based observational counterpart of CoRoT

We present different aspects of the ground-based observational counterpart of the CoRoT satellite mission. We give an overview of the selected asteroseismic targets, the numerous instruments and observatories involved, and the first scientific results.Comment: 3 pages, 2 tables, 1 figure, to be published in the conference proceedings 'Stellar Pulsation: Challenges for Theory and Observation' (31 May - 5 June, Santa Fe, New Mexico, US), publishers: American Institute of Physic

APPROXIMATION OF LIMIT STATE SURFACES IN MONOTONIC MONTE CARLO SETTINGS

International audienceThis article investigates the theoretical convergence properties of the estimators produced by a numerical exploration of a monotonic function with multivariate random inputs in a structural reliability framework.The quantity to be estimated is a probability typically associated to an undesirable (unsafe) event and the function is usually implemented as a computer model. The estimators produced by a Monte Carlo numerical design are two subsets of inputs leading to safe and unsafe situations, the measures of which can be traduced as deterministic bounds for the probability. Several situations are considered, when the design is independent, identically distributed or not, or sequential. As a major consequence, a consistent estimator of the (limit state) surface separating the subsets under isotonicity and regularity arguments can be built, and its convergence speed can be exhibited. This estimator is built by aggregating semi-supervized binary classifiers chosen as constrained Support Vector Machines. Numerical experiments conducted on toy examples highlight that they work faster than recently developed monotonic neural networks with comparable predictable power. They are therefore more adapted when the computational time is a key issue

Review of the conference Dante and Music : University of Pennsylvania, Philadelphia, 5-6 November 2015

A general and efficient synthesis of 4,9-dihydro-1<i>H</i>-carbazoles from 3-allenylmethylindoles is reported. The process, catalyzed by a cationic gold­(I) complex, involves a formal C2–H bond activation of the indole unit by reaction with the allene. The nature of the substituents at the allylic and terminal positions of the allene moiety has a crucial effect on the regioselectivity of the cyclization, which is also influenced by the catalyst and the solvent employed. Moreover, some evidence of the contribution of different reaction routes is provided, which led us to propose a plausible multipathway mechanism consistent with all of the results described

Supplementary guidance: listening to staff: Autumn 2017

Kinases play a critical role in cellular signaling and are dysregulated in a number of diseases, such as cancer, diabetes, and neurodegeneration. Therapeutics targeting kinases currently account for roughly 50% of cancer drug discovery efforts. The ability to explore human kinase biochemistry and biophysics in the laboratory is essential to designing selective inhibitors and studying drug resistance. Bacterial expression systems are superior to insect or mammalian cells in terms of simplicity and cost effectiveness but have historically struggled with human kinase expression. Following the discovery that phosphatase coexpression produced high yields of Src and Abl kinase domains in bacteria, we have generated a library of 52 His-tagged human kinase domain constructs that express above 2 μg/mL of culture in an automated bacterial expression system utilizing phosphatase coexpression (YopH for Tyr kinases and lambda for Ser/Thr kinases). Here, we report a structural bioinformatics approach to identifying kinase domain constructs previously expressed in bacteria and likely to express well in our protocol, experiments demonstrating our simple construct selection strategy selects constructs with good expression yields in a test of 84 potential kinase domain boundaries for Abl, and yields from a high-throughput expression screen of 96 human kinase constructs. Using a fluorescence-based thermostability assay and a fluorescent ATP-competitive inhibitor, we show that the highest-expressing kinases are folded and have well-formed ATP binding sites. We also demonstrate that these constructs can enable characterization of clinical mutations by expressing a panel of 48 Src and 46 Abl mutations. The wild-type kinase construct library is available publicly via Addgene