On Making Good Games - Using Player Virtue Ethics and Gameplay Design Patterns to Identify Generally Desirable Gameplay Features

This paper uses a framework of player virtues to perform a theoretical exploration of what is required to make a game good. The choice of player virtues is based upon the view that games can be seen as implements, and that these are good if they support an intended use, and the intended use of games is to support people to be good players. A collection of gameplay design patterns, identified through their relation to the virtues, is presented to provide specific starting points for considering design options for this type of good games. 24 patterns are identified supporting the virtues, including RISK/REWARD, DYNAMIC ALLIANCES, GAME MASTERS, and PLAYER DECIDED RESULTS, as are 7 countering three or more virtues, including ANALYSIS PARALYSIS, EARLY ELIMINATION, and GRINDING. The paper concludes by identifying limitations of the approach as well as by showing how it can be applied using other views of what are preferable features in games

Choice and bias in random walks

We analyse the following random walk process inspired by the power-of-two-choice paradigm: starting from a given vertex, at each step, unlike the simple random walk (SRW) that always moves to a randomly chosen neighbour, we have the choice between two uniformly and independently chosen neighbours. We call this process the choice random walk (CRW). We first prove that for any graph, there is a strategy for the CRW that visits any given vertex in expected tim

Microbiology and atmospheric processes: Biological, physical and chemical characterization of aerosol particles

The interest in bioaerosols has traditionally been linked to health hazards for humans, animals and plants. However, several components of bioaerosols exhibit physical properties of great significance for cloud processes, such as ice nucleation and cloud condensation. To gain a better understanding of their influence on climate, it is therefore important to determine the composition, concentration, seasonal fluctuation, regional diversity and evolution of bioaerosols. In this paper, we will review briefly the existing techniques for detection, quantification, physical and chemical analysis of biological particles, attempting to bridge physical, chemical and biological methods for analysis of biological particles and integrate them with aerosol sampling techniques. We will also explore some emerging spectroscopy techniques for bulk and single-particle analysis that have potential for in-situ physical and chemical analysis. Lastly, we will outline open questions and further desired capabilities (e. g., in-situ, sensitive, both broad and selective, on-line, time-resolved, rapid, versatile, cost-effective techniques) required prior to comprehensive understanding of chemical and physical characterization of bioaerosols

An Exercise in Visualizing Colexification on a Semantic Map

This paper aims at investigating the polysemic patterns associated with the notion ‘soil/earth’ by using the semantic map model as a methodological tool. We focus on the applicability of the model to the lexicon, since most of past research has been devoted to the analysis of grammatical morphemes. The most concise result of our research is a diagrammatic visualization of the semantic spaces of twenty lexemes in nine different languages, mainly ancient languages belonging to the Indo-European and the Afro-Asiatic language families. The common semantic map for the various languages reveals that the semantic spaces covered by the investigated lexemes are often quite different from one another, although common patterns can also be detected. Our study highlights some shortcomings and methodological problems of previous analyses suggesting that a possible solution to these problems is the control of the data in the existing sources of the object languages. Finally, drawing upon the cognitive linguistics literature on the various types of semantic change, we show that some of the senses of the individual lexemes are the result of the function of such mechanisms as metaphor, metonymy, and generalization

Measurement of the Partial Cross Sections s(TT), s(LT) and [s(T)+epsilon*s(L)] of the p(e,e' pi+)n Reaction in the Delta(1232) Resonance

We report new precision p(e,e' pi+})n measurements in the Delta(1232) resonance at Q2 = 0.127(GeV/c)2 obtained at the MIT-Bates Out-Of-Plane scattering facility. These are the lowest, but non-zero, Q2 measurements in the pi+ channel. The data offer new tests of the theoretical calculations, particularly of the background amplitude contributions. The chiral effective field theory and Sato-Lee model calculations are not in agreement with this experiment

Measurements of the Generalized Electric and Magnetic Polarizabilities of the Proton at Low Q2 Using the VCS Reaction

The mean square polarizability radii of the proton have been measured for the first time in a virtual Compton scattering experiment performed at the MIT-Bates out-of-plane scattering facility. Response functions and polarizabilities obtained from a dispersion analysis of the data at Q2=0.06 GeV2/c2 are in agreement with O(p3) heavy baryon chiral perturbation theory. The data support the dominance of mesonic effects in the polarizabilities, and the increase of beta with increasing Q2 is evidence for the cancellation of long-range diamagnetism by short-range paramagnetism from the pion cloud

Investigation of the conjectured nucleon deformation at low momentum transfer

We report new precise H$(e,e^\prime p)\pi^0$ measurements at the $\Delta(1232)$ resonance at $Q^2= 0.127$ (GeV/c)$^2$ using the MIT/Bates out-of-plane scattering (OOPS) facility. The data reported here are particularly sensitive to the transverse electric amplitude ($E2$) of the $\gamma^* N\to\Delta$ transition. Analyzed together with previous data yield precise quadrupole to dipole amplitude ratios $EMR = (-2.3 \pm 0.3_{stat+sys} \pm 0.6_{model})$ and $CMR = (-6.1 \pm 0.2_{stat+sys}\pm 0.5_{model})$ and for $M^{3/2}_{1+} = (41.4 \pm 0.3_{stat+sys}\pm 0.4_{model})(10^{-3}/m_{\pi^+})$. They give credence to the conjecture of deformation in hadronic systems favoring, at low $Q^2$, the dominance of mesonic effects.Comment: 4 pages, 1figur

Discovery of the first dual GSK3 beta inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease

The formation of neurofibrillary tangles (NFTs), oxidative stress and neuroinflammation have emerged as key targets for the treatment of Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder. These pathological hallmarks are closely related to the over-activity of the enzyme GSK3β and the downregulation of the defense pathway Nrf2-EpRE observed in AD patients. Herein, we report the synthesis and pharmacological evaluation of a new family of multitarget 2,4-dihydropyrano[2,3-c]pyrazoles as dual GSK3β inhibitors and Nrf2 inducers. These compounds are able to inhibit GSK3β and induce the Nrf2 phase II antioxidant and anti-inflammatory pathway at micromolar concentrations, showing interesting structure-activity relationships. The association of both activities has resulted in a remarkable anti-inflammatory ability with an interesting neuroprotective profile on in vitro models of neuronal death induced by oxidative stress and energy depletion and AD. Furthermore, none of the compounds exhibited in vitro neurotoxicity or hepatotoxicity and hence they had improved safety profiles compared to the known electrophilic Nrf2 inducers. In conclusion, the combination of both activities in this family of multitarget compounds confers them a notable interest for the development of lead compounds for the treatment of AD

Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control

The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological oxidative stress and/or disrupted protein degradation by the proteasome. The aim of this study was to gain insights into the pathogenic mechanisms of selected DJ-1 missense mutations, by characterizing protein–protein interactions, core parameters of mitochondrial function, quality control regulation via autophagy, and cellular death following dopamine accumulation. We report that the DJ-1M26I mutant influences DJ-1 interactions with SUMO-1, in turn enhancing removal of mitochondria and conferring increased cellular susceptibility to dopamine toxicity. By contrast, the DJ-1D149A mutant does not influence mitophagy, but instead impairs Ca2+ dynamics and free radical homeostasis by disrupting DJ-1 interactions with a mitochondrial accessory protein known as DJ-1-binding protein (DJBP/EFCAB6). Thus, individual DJ-1 mutations have different effects on mitochondrial function and quality control, implying mutation-specific pathomechanisms converging on impaired mitochondrial homeostasis

Aspects of thermal behavior of Amynteo lignites, Northern Greece, determined by thermogravimetry

In this study, the burning profiles of seven lignite samples from Amynteo lignite mine, Northern Greece, were obtained using a thermogravimetry technique. The differentiation in the thermal behavior of the samples was investigated using DTG curves. The influence of inorganic constituents (expressed as major oxides content) was evaluated by correlate the major oxides content with burnout time and maximum weight loss rate. Samples from the intermediate lignite beds show a differentiation in their thermal behavior, related to the low sulfur and inorganic constituents content and attributable to their decreased thermal stability. There is a critical value of burnout time when correlate the sum of major oxides with burnout time. The inorganic content has a diverse relationship with burnout time beyond this critical value