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A Search for Dark Higgs Bosons
Recent astrophysical and terrestrial experiments have motivated the proposal
of a dark sector with GeV-scale gauge boson force carriers and new Higgs
bosons. We present a search for a dark Higgs boson using 516 fb-1 of data
collected with the BABAR detector. We do not observe a significant signal and
we set 90% confidence level upper limits on the product of the Standard
Model-dark sector mixing angle and the dark sector coupling constant.Comment: 7 pages, 5 postscript figures, published version with improved plots
for b/w printin
Stability analysis and dynamics preserving nonstandard finite difference schemes for a malaria model
When both human and mosquito populations vary, forward bifurcation occurs if
the basic reproduction number R0 is less than one in the absence of disease-induced
death. When the disease-induced death rate is large enough R0 = 1 is a subcritical
backward bifurcation point. The domain for the study of the dynamics is reduced
to a compact and feasible region, where the system admits a speci c algebraic
decomposition into infective and non-infected humans and mosquitoes. Stability
results are extended and the possibility of backward bifurcation is clari ed. A
dynamically consistent nonstandard nite di erence scheme is designed.Yves Dumont was supported jointly by the French Ministry of Health and the
2007â2013 Convergence program of the European Regional Development Fund
(ERDF). Roumen Anguelov, Jean Lubuma, and Eunice Mureithi thank the South
African National Research Foundation for its support.http://www.tandfonline.com/loi/gmps20hb201
The Red Radio Ring: a gravitationally lensed hyperluminous infrared radio galaxy at z=2.553 discovered through the citizen science project SpaceWarps
We report the discovery of a gravitationally lensed hyperluminous infrared galaxy (intrinsic LIRâ1013âLâ) with strong radio emission (intrinsic L1.4âGHzâ1025WHzâ1) at z=2.553. The source was identified in the citizen science project SpaceWarpsthrough the visual inspection of tens of thousands of iJKs colour composite images of luminous red galaxies (LRGs), groups and clusters of galaxies and quasars. Appearing as a partial Einstein ring (reâ3 arcsec) around an LRG at z=0.2, the galaxy is extremely bright in the sub-millimetre for a cosmological source, with the thermal dust emission approaching 1âJy at peak. The redshift of the lensed galaxy is determined through the detection of the CO(3â2) molecular emission line with the Large Millimetre Telescope's Redshift Search Receiver and through [Oâiii] and Hα line detections in the near-infrared from Subaru/Infrared Camera and Spectrograph. We have resolved the radio emission with high-resolution (300-400âmas) eMERLIN L-band and Very Large Array C-band imaging. These observations are used in combination with the near-infrared imaging to construct a lens model, which indicates a lensing magnification of ÎŒâ10. The source reconstruction appears to support a radio morphology comprised of a compact (<250âpc) core and more extended component, perhaps indicative of an active nucleus and jet or lob
Focused molecular analysis of small cell lung cancer: feasibility in routine clinical practice
The Red Radio Ring: a gravitationally lensed hyperluminous infrared radio galaxy at z = 2.553 discovered through the citizen science project SPACE WARPS
This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society. © 2015 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society.We report the discovery of a gravitationally lensed hyperluminous infrared galaxy (intrinsic LIR â 1013âLâ) with strong radio emission (intrinsic L1.4âGHz â 1025 W Hzâ1) at z = 2.553. The source was identified in the citizen science project SPACE WARPS through the visual inspection of tens of thousands of iJKs colour composite images of luminous red galaxies (LRGs), groups and clusters of galaxies and quasars. Appearing as a partial Einstein ring (re â 3 arcsec) around an LRG at z = 0.2, the galaxy is extremely bright in the sub-millimetre for a cosmological source, with the thermal dust emission approaching 1âJy at peak. The redshift of the lensed galaxy is determined through the detection of the CO(3â2) molecular emission line with the Large Millimetre Telescope's Redshift Search Receiver and through [OâIII] and Hα line detections in the near-infrared from Subaru/Infrared Camera and Spectrograph. We have resolved the radio emission with high-resolution (300â400âmas) eMERLIN L-band and Very Large Array C-band imaging. These observations are used in combination with the near-infrared imaging to construct a lens model, which indicates a lensing magnification of ÎŒ â 10. The source reconstruction appears to support a radio morphology comprised of a compact (<250âpc) core and more extended component, perhaps indicative of an active nucleus and jet or lobe.Peer reviewedFinal Published versio
Considerations for management strategy evaluation for small pelagic fishes
Management strategy evaluation (MSE) is the state-of-the-art approach for testing and comparing management strategies in a way that accounts for multiple sources of uncertainty (e.g. monitoring, estimation, and implementation). Management strategy evaluation can help identify management strategies that are robust to uncertainty about the life history of the target species and its relationship to other species in the food web. Small pelagic fish (e.g. anchovy, herring and sardine) fulfil an important ecological role in marine food webs and present challenges to the use of MSE and other simulation-based evaluation approaches. This is due to considerable stochastic variation in their ecology and life history, which leads to substantial observation and process uncertainty. Here, we summarize the current state of MSE for small pelagic fishes worldwide. We leverage expert input from ecologists and modellers to draw attention to sources of process and observation uncertainty for small pelagic species, providing examples from geographical regions where these species are ecologically, economically and culturally important. Temporal variation in recruitment and other life-history rates, spatial structure and movement, and species interactions are key considerations for small pelagic fishes. We discuss tools for building these into the MSE process, with examples from existing fisheries. We argue that model complexity should be informed by management priorities and whether ecosystem information will be used to generate dynamics or to inform reference points. We recommend that our list of considerations be used in the initial phases of the MSE process for small pelagic fishes or to build complexity on existing single-species models.publishedVersio
Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study
Background
Environmental enteropathy (EE), the adverse impact of frequent and numerous enteric infections on the gut resulting in a state of persistent immune activation and altered permeability, has been proposed as a key determinant of growth failure in children in low- and middle-income populations. A theory-driven systems model to critically evaluate pathways through which enteropathogens, gut permeability, and intestinal and systemic inflammation affect child growth was conducted within the framework of the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) birth cohort study that included children from eight countries.
Methods
Non-diarrheal stool samples (N = 22,846) from 1253 children from multiple sites were evaluated for a panel of 40 enteropathogens and fecal concentrations of myeloperoxidase, alpha-1-antitrypsin, and neopterin. Among these same children, urinary lactulose:mannitol (L:M) (N = 6363) and plasma alpha-1-acid glycoprotein (AGP) (N = 2797) were also measured. The temporal sampling design was used to create a directed acyclic graph of proposed mechanistic pathways between enteropathogen detection in non-diarrheal stools, biomarkers of intestinal permeability and inflammation, systemic inflammation and change in length- and weight- for age in children 0â2 years of age.
Findings
Children in these populations had frequent enteric infections and high levels of both intestinal and systemic inflammation. Higher burdens of enteropathogens, especially those categorized as being enteroinvasive or causing mucosal disruption, were associated with elevated biomarker concentrations of gut and systemic inflammation and, via these associations, indirectly associated with both reduced linear and ponderal growth. Evidence for the association with reduced linear growth was stronger for systemic inflammation than for gut inflammation; the opposite was true of reduced ponderal growth. Although Giardia was associated with reduced growth, the association was not mediated by any of the biomarkers evaluated.
Interpretation
The large quantity of empirical evidence contributing to this analysis supports the conceptual model of EE. The effects of EE on growth faltering in young children were small, but multiple mechanistic pathways underlying the attribution of growth failure to asymptomatic enteric infections had statistical support in the analysis. The strongest evidence for EE was the association between enteropathogens and linear growth mediated through systemic inflammation
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