The properties of (sub)millimetre-selected galaxies as revealed by CANDELS HST WFC3/IR imaging in GOODS-South

We have exploited the HST CANDELS WFC3/IR imaging to study the properties of (sub-)mm galaxies in GOODS-South. After using the deep radio and Spitzer imaging to identify galaxy counterparts for the (sub-)mm sources, we have used the new CANDELS data in two ways. First, we have derived improved photometric redshifts and stellar masses, confirming that the (sub-)mm galaxies are massive (=2.2x10^11 M_solar) galaxies at z=1-3. Second, we have exploited the depth and resolution of the WFC3/IR imaging to determine the sizes and morphologies of the galaxies at rest-frame optical wavelengths, fitting two-dimensional axi-symmetric Sersic models. Crucially, the WFC3/IR H-band imaging enables modelling of the mass-dominant galaxy, rather than the blue high-surface brightness features which often dominate optical (rest-frame UV) images of (sub-)mm galaxies, and can confuse visual morphological classification. As a result of this analysis we find that >95% of the rest-frame optical light in almost all of the (sub-)mm galaxies is well-described by either a single exponential disk, or a multiple-component system in which the dominant constituent is disk-like. We demonstrate that this conclusion is consistent with the results of high-quality ground-based K-band imaging, and explain why. The massive disk galaxies which host luminous (sub-)mm emission are reasonably extended (r_e=4 kpc), consistent with the sizes of other massive star-forming disks at z~2. In many cases we find evidence of blue clumps within the sources, with the mass-dominant disk becoming more significant at longer wavelengths. Finally, only a minority of the sources show evidence for a major galaxy-galaxy interaction. Taken together, these results support the view that most (sub-)mm galaxies at z~2 are simply the most extreme examples of normal star-forming galaxies at that era.Comment: 30 pages, 9 figure

Predictors of selective laser trabeculoplasty success in open angle glaucoma or ocular hypertension: does baseline tonography have a predictive role?

BACKGROUND: The determinants of success of selective laser trabeculoplasty (SLT) in treatment-naïve patients with open angle glaucoma (OAG) and ocular hypertension (OHT) have not been understood fully. Therefore, we have conducted this study to explore the predictors of success. METHODS: This is a retrospective review of a pre-existing database of patients who had received primary SLT at St Thomas' Hospital, London, UK. Patients with OAG and OHT who had received primary 360° SLT treatment and had reliable baseline tonographic outflow facility (TOF) with minimum of 1 year of follow-up were included. Univariate and multivariate analyses were performed to find the determinants of success. RESULTS: One hundred and seventy-four patients between August 2006 and February 2010 had received primary 360° SLT treatment and had baseline TOF measurement. Of these, 72 subjects fulfilled the eligibility criteria. In multivariate regression analysis, the only variable associated with success was baseline intraocular pressure (IOP) (R^{2}=0.32, beta=-0.51, p<0.001, 95% CI -2.02 to -0.74). CONCLUSION: To our knowledge, this is the only study investigating the pretreatment TOF (measured with electronic Shiøtz tonography) and IOP as determinants of success 12 month's post-360° SLT in treatment-naïve patients with OAG and OHT. This study demonstrated that pretreatment IOP (and not TOF) is the only determinant of success after primary SLT therapy

Energetic Galaxy-Wide Outflows in High-Redshift Ultraluminous Infrared Galaxies Hosting AGN Activity

We present integral field spectroscopy observations, covering the [O III]4959,5007 emission-line doublet of eight high-redshift (z=1.4-3.4) ultra-luminous infrared galaxies (ULIRGs) that host Active Galactic Nuclei (AGN) activity, including known sub-millimetre luminous galaxies (SMGs). The targets have moderate radio luminosities that are typical of high-redshift ULIRGs (L(1.4GHz)=10^(24)-10^(25)W/Hz) and therefore are not radio-loud AGN. We de-couple kinematic components due to the galaxy dynamics and mergers from those due to outflows. We find evidence in the four most luminous systems (L([O III])\u3e~10^(43)erg/s) for the signatures of large-scale energetic outflows: extremely broad [O III] emission (FWHM ~ 700-1400km/s) across ~4-15kpc, with high velocity offsets from the systemic redshifts (up to ~850km/s). The four less luminous systems have lower quality data displaying weaker evidence for spatially extended outflows. We estimate that these outflows are potentially depositing energy into their host galaxies at considerable rates (~10^(43)-10^(45)erg/s); however, due to the lack of constraints on the density of the outflowing material and the structure of the outflow, these estimates should be taken as illustrative only. Based on the measured maximum velocities (v(max)~400-1400km/s) the outflows observed are likely to unbind some fraction of the gas from their host galaxies, but are unlikely to completely remove gas from the galaxy haloes. By using a combination of energetic arguments and a comparison to ULIRGs without clear evidence for AGN activity, we show that the AGN activity could be the dominant power source for driving all of the observed outflows, although star formation may also play a significant role in some of the sources

Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine.

A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memory reconsolidation represents a potential therapeutic strategy, the role of astrocyte-neuron lactate transport in long-term conditioning has received little attention. By infusing an inhibitor of glycogen phosphorylase into the basolateral amygdala of rats, we report that disruption of astrocyte-derived lactate not only transiently impaired the acquisition of a cocaine-induced conditioned place preference but also persistently disrupted an established conditioning. The drug memory was rescued by L-Lactate co-administration through a mechanism requiring the synaptic plasticity-related transcription factor Zif268 and extracellular signal-regulated kinase (ERK) signalling pathway but not the brain-derived neurotrophic factor (Bdnf). The long-term amnesia induced by glycogenolysis inhibition and the concomitant decreased expression of phospho-ERK were both restored with L-Lactate co-administration. These findings reveal a critical role for astrocyte-derived lactate in positive memory formation and highlight a novel amygdala-dependent reconsolidation process, whose disruption may offer a novel therapeutic target to reduce the long-lasting conditioned responses to cocaine

CREST in the Nucleus Accumbens Core Regulates Cocaine Conditioned Place Preference, Cocaine-Seeking Behavior, and Synaptic Plasticity

Epigenetic mechanisms result in persistent changes at the cellular level that can lead to long-lasting behavioral adaptations. Nucleosome remodeling is a major epigenetic mechanism that has not been well explored with regards to drug-seeking behaviors. Nucleosome remodeling is performed by multi-subunit complexes that interact with DNA or chromatin structure and possess an ATP-dependent enzyme to disrupt nucleosome-DNA contacts and ultimately regulate gene expression. Calcium responsive transactivator (CREST) is a transcriptional activator that interacts with enzymes involved in both histone acetylation and nucleosome remodeling. Here, we examined the effects of knocking down CREST in the nucleus accumbens (NAc) core on drug-seeking behavior and synaptic plasticity in male mice as well as drug-seeking in male rats. Knocking down CREST in the NAc core results in impaired cocaine-induced conditioned place preference (CPP) as well as theta-induced long-term potentiation in the NAc core. Further, similar to the CPP findings, using a self-administration procedure, we found that CREST knockdown in the NAc core of male rats had no effect on instrumental responding for cocaine itself on a first-order schedule, but did significantly attenuate responding on a second-order chain schedule, in which responding has a weaker association with cocaine. Together, these results suggest that CREST in the NAc core is required for cocaine-induced CPP, synaptic plasticity, as well as cocaine-seeking behavior. SIGNIFICANCE STATEMENT This study demonstrates a key role for the role of Calcium responsive transactivator (CREST), a transcriptional activator, in the nucleus accumbens (NAc) core with regard to cocaine-induced conditioned place preference (CPP), self-administration (SA), and synaptic plasticity. CREST is a unique transcriptional regulator that can recruit enzymes from two different major epigenetic mechanisms: histone acetylation and nucleosome remodeling. In this study we also found that the level of potentiation in the NAc core correlated with whether or not animals formed a CPP. Together the results indicate that CREST is a key downstream regulator of cocaine action in the NAc

VLT-SINFONI integral field spectroscopy of low-z luminous and ultraluminous infrared galaxies

We present a 2D study of the internal extinction on (sub)kiloparsec scales of a sample of local (z < 0.1) LIRGs (10) and ULIRGs (7), based on near-infrared Paα, Brδ, and Brγ line ratios, obtained with VLT-SINFONI integral-field spectroscopy (IFS). The 2D extinction (AV) distributions of the objects, map regions of ~ 3 × 3 kpc (LIRGs) and ~ 12 × 12 kpc (ULIRGs), with average angular resolutions (FWHM) of ~0.2 kpc and ~0.9 kpc, respectively. The individual AV galaxy distributions indicate a very clumpy dust structure already on sub-kiloparsec scales, with values (per spaxel) ranging from AV ~ 1 to 20 mag in LIRGs, and from AV ~ 2 to 15 mag in ULIRGs. As a class, the median values of the distributions are AV = 5.3 mag and AV = 6.5 mag for the LIRG and ULIRG subsamples, respectively. In ~70% of the objects, the extinction peaks at the nucleus with values ranging from AV ~ 3 to 17 mag. Within each galaxy, the AV radial profile shows a mild decrement in LIRGs within the inner 2 kpc radius, while the same radial variation is not detected in ULIRGs, likely because of the lower linear scale resolution of the observations at the distance of ULIRGs. We evaluated the effects of the galaxy distance in the measurements of the extinction as a function of the linear scale (in kpc) of the spaxel (i.e. due to the limited angular resolution of the observations). If the distribution of the gas/dust and star-forming regions in local LIRGs (63 Mpc, 40 pc/spaxel on average) is the same for galaxies at greater distances, the observed median AV values based on emission line ratios would be a factor ~0.8 lower at the average distance of our ULIRG sample (328 Mpc, 0.2 kpc/spaxel), and a factor ~0.67 for galaxies located at distances of more than 800 Mpc (0.4 kpc/spaxel). This distance effect would have implications for deriving the intrinsic extinction in high-z star-forming galaxies and for subsequent properties such as star formation rate, star formation surface density, and KS- law, based on Hα line fluxes. If local LIRGs are analogues of the main-sequence star-forming galaxies at cosmological distances, the extinction values (AV) derived from the observed emission lines in these high-z sources would need to be increased by a factor 1.4 on average